ATI Templates
The eight standardized ATI Active Learning templates from Pediatrics Edition 11 (book pages A1–A16). Click a template to expand it, then switch tabs to study each worked example. Track your study progress with the checkboxes — single tap = reviewed, double tap = mastered.
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The provision of therapeutic care in settings, by personnel, and through the use of interventions that eliminate or minimize the psychological and physical distress experienced by children and their families in the health care system.
Three principles:
- Prevent or minimize separation from family
- Promote a sense of control
- Prevent or minimize bodily injury and pain
Underlying Principles
- Family-centered care is foundational
- Developmentally appropriate communication
- Honesty about procedures (children sense deception)
- Empowerment through choices when possible
- Pain prevention before procedures (proactive)
- Therapeutic play to process and rehearse
- Cluster care to minimize disruption
Nursing Interventions
- Topical anesthetic (EMLA cream, LMX-4) 30–60 min before venipuncture or IM injection
- Use the smallest appropriate needle
- Avoid IM injections when possible
- Encourage parental presence during procedures
- Use comfort positioning (parent's lap) instead of restraint when possible
- Allow child to make choices: "Which arm?" "Stickers or band-aid?"
- Cover IV insertion site with self-adherent gauze
- Provide distraction (bubbles, music, tablet, breathing techniques)
- Treat pain with appropriate analgesics, not just non-pharmacologic methods
- Use child life specialists for procedural preparation
- Honor the child's "safe spaces" — perform painful procedures in treatment room, not bed
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Pain is the 5th vital sign and must be assessed regularly in children. Pain assessment in children requires age-appropriate tools, recognition of developmental and verbal limitations, and use of physiological and behavioral cues for non-verbal children.
Underlying Principles
- Self-report is the gold standard when developmentally appropriate
- Match the tool to the child's age and cognitive ability
- Use the SAME scale consistently for one child
- Behavioral and physiological measures supplement (not replace) self-report
- Consider cultural, developmental, and individual differences
- Pain is what the child says it is
Nursing Interventions
By age:
- NIPS — preterm and term neonates (facial expression, cry, breathing, arm/leg movement, arousal; 0–7)
- CRIES — neonate to 6 months postoperatively (Crying, Requires O₂, Increased VS, Expression, Sleeplessness; 0–10)
- FLACC — 2 months to 7 years OR any nonverbal child (Face, Legs, Activity, Cry, Consolability; 0–10)
- Wong-Baker FACES — 3 years and older (smiling to crying faces; 0–10)
- Numeric (0–10) — 5–7 years and older with understanding of numbers
- Visual analog scale — adolescents
Documentation: record score, location, quality, what relieves/aggravates, intervention given, and reassessment score (typically 30–60 min after intervention).
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Family-centered care is the philosophy and practice that recognizes the family as the constant in a child's life and works to support and respect the family's role as the primary caregiver and decision-maker. It is a partnership between healthcare providers and the family.
Core elements:
- Respect, dignity, and inclusion of all family members
- Information sharing — accurate, timely, and unbiased
- Participation in care and decision-making
- Collaboration with families at all levels
Underlying Principles
- The family is the constant in the child's life; healthcare providers come and go
- Families are the experts on their child
- Cultural diversity must be acknowledged and respected
- Family strengths and individuality should be recognized
- Different methods of coping are recognized as valid
- Information needs vary by family and developmental stage
- Continuity of care and emotional support promote well-being
- Sibling needs must be addressed
- Empowerment and self-determination are essential
- Encourage family-to-family support
Nursing Interventions
- Welcome family members to participate in all aspects of care
- Provide information in understandable language; use teach-back method
- Include family in care planning, rounds, and decision-making
- Encourage parents to remain with child during procedures when possible
- Respect cultural and religious beliefs (food, modesty, rituals)
- Provide written materials in family's preferred language
- Use interpreters when needed (not family members for medical translation)
- Address siblings' needs and questions
- Connect families to peer support groups
- Allow flexible visitation policies
- Provide private space for family discussions
- Involve family in discharge planning early
- Acknowledge family's expertise on their child
- Avoid judgmental statements about family choices
- Coordinate care across providers and settings
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Erik Erikson's theory describes 8 stages of psychosocial development across the lifespan. Each stage has a developmental task (psychosocial crisis) that must be successfully resolved to develop the corresponding ego strength. Failure to resolve leads to difficulties in subsequent stages.
Underlying Principles
Pediatric stages (birth to ~20):
| Stage | Age | Crisis |
|---|---|---|
| 1 | Birth–1 yr (Infant) | Trust vs. Mistrust — develops trust when needs are consistently met |
| 2 | 1–3 yr (Toddler) | Autonomy vs. Shame/Doubt — exercises will, independence, self-control |
| 3 | 3–6 yr (Preschool) | Initiative vs. Guilt — initiates activities, imaginative play; guilt if criticized |
| 4 | 6–12 yr (School-age) | Industry vs. Inferiority — develops sense of competence through achievement |
| 5 | 12–20 yr (Adolescent) | Identity vs. Role Confusion — develops sense of self, identity, future direction |
Nursing Interventions
Infant — promote trust:
- Respond promptly and consistently to needs
- Hold during feeds
- Keep parent present during hospitalization
- Maintain consistent caregivers
Toddler — promote autonomy:
- Offer choices ("red cup or blue cup?")
- Allow self-feeding, dressing within reason
- Use minimal restraints; comfort positioning
- Don't shame negativism or tantrums
- Respect rituals and routines
Preschool — promote initiative:
- Use therapeutic play; medical play with dolls
- Praise efforts
- Allow safe exploration
- Provide simple, concrete explanations
- Reassure that illness/procedures are NOT punishment
School-age — promote industry:
- Allow involvement in care
- Provide collections, projects, schoolwork
- Praise effort and accomplishment
- Respect privacy and modesty
- Use accurate medical terminology
Adolescent — promote identity:
- Respect privacy and confidentiality
- Allow control in decisions
- Encourage peer contact
- Provide accurate information about body changes
- Help maintain school connections, social roles
- Respect emerging independence
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Jean Piaget's theory describes how children construct understanding through interaction with the environment. Four stages from infancy through adulthood, each marked by qualitatively different ways of thinking. Knowing the stages helps nurses tailor education and explanations to children at developmental level.
Underlying Principles
| Stage | Age | Key Features |
|---|---|---|
| Sensorimotor | Birth–2 yr | Learn through senses and motor actions; object permanence (~9 mo); circular reactions; symbol use emerging |
| Preoperational | 2–7 yr | Symbolic thinking, language explosion; egocentric (cannot see others' view); magical thinking; animism (objects have feelings); centration (focus on one feature); lack of conservation; transductive reasoning |
| Concrete Operations | 7–11 yr | Logical thinking about concrete things; conservation (volume, mass, number); reversibility; classification; serialization; cause-and-effect; less egocentric |
| Formal Operations | 11 yr–adult | Abstract thinking; hypothetical reasoning; deductive logic; future-oriented thinking; can think about thinking (metacognition) |
Nursing Interventions
Sensorimotor (infant/toddler):
- Provide sensory stimulation
- Use objects to demonstrate (toys, dolls)
- Allow exploration with all senses
- Don't expect understanding of cause-effect in young infant
- Use simple language
- Parent presence essential
Preoperational (toddler/preschool):
- Use simple, concrete language
- Use therapeutic play, dolls, toys to explain procedures
- Show equipment before using
- Avoid abstract terms ("take your appendix" — child thinks it will be carried away)
- Magical thinking: reassure that illness is NOT punishment for thoughts or actions
- Use simple analogies (IV = "straw for medicine")
- Expect egocentric responses
- Don't lie about painful procedures
Concrete Operations (school-age):
- Provide concrete, factual explanations
- Use simple diagrams, models
- Anatomy textbook diagrams appropriate
- Allow questions; answer honestly
- Involve in decisions when possible
- Reassure that illness has cause and treatment
Formal Operations (adolescent):
- Provide abstract explanations
- Use medical terminology with explanation
- Discuss "why" — pathophysiology
- Engage in decision-making
- Discuss consequences and future implications
- Respect emerging autonomy
- Provide written materials, internet resources (with guidance)
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Therapeutic play uses play activities as a means to help children cope with illness, hospitalization, procedures, and emotional concerns. Play is considered the "work of childhood" and a critical part of atraumatic care. Specialized child life specialists provide structured therapeutic play, but nurses also incorporate it throughout care.
Underlying Principles
Functions of play:
- Promotes normal development (cognitive, motor, social, emotional)
- Provides outlet for emotions (anger, fear, anxiety)
- Allows mastery and control in unfamiliar environment
- Increases sense of self-confidence and self-worth
- Provides distraction during procedures
- Develops trust with healthcare providers
- Allows assessment of child's understanding and concerns
- Maintains familiar routines
Types of play:
- Energy-release play: physical activity, releases pent-up emotions (punching bags, running, throwing balls)
- Dramatic (medical) play: child role-plays with medical equipment, dolls — preparation for procedures and processing experience
- Creative expression: art, music, writing — emotional outlet
- Diversional play: helps pass time, provides enjoyment (video games, books, crafts)
Play by developmental stage:
- Infant: solitary play, sensorimotor (rattles, mobiles, mirrors)
- Toddler: parallel play (alongside others without true interaction)
- Preschool: associative play (similar activities with others)
- School-age: cooperative play (group activities with goals, rules)
- Adolescent: socialized play (sports, music, screens)
Nursing Interventions
General principles:
- Provide a safe, welcoming play environment
- Include age-appropriate toys, games, art supplies
- Involve child life specialist when available
- Offer toys/activities child can handle physically
- Allow child to choose activities
- Don't force participation
- Allow child to direct play
- Avoid using restraint as punishment
Preparation for procedures:
- Use dolls with simulated equipment (IVs, casts, NG tube, dressings)
- Demonstrate procedure on doll first
- Let child handle equipment when safe
- Use medical play with stethoscope, BP cuff, syringes (no needles)
- Read pediatric medical books
- Show pictures/videos of procedures
During procedures:
- Distraction tools: bubbles, pinwheels, music, tablets, virtual reality
- Allow child to hold favorite toy
- Comfort positioning (with parent)
- Sing songs, count, deep breathing
Post-procedure:
- Allow child to play through experience
- "Doctor play" — child becomes the doctor/nurse to gain mastery
- Drawing about hospital experience
- Praise courage
Environmental:
- Playroom (sanctuary — no procedures done here)
- Bring familiar items from home (favorite blanket, toy)
- Decorations age-appropriate
- Window for outside view
- Allow sibling visits when possible
For infants/toddlers:
- Familiar sounds (music, parent's voice)
- Cuddling, rocking
- Comfort objects (blanket, pacifier)
- Skin-to-skin (especially infants)
- Mobiles, rattles, books
For school-age/adolescents:
- Schoolwork to maintain continuity
- Tablets, video games
- Crafts, art, music
- Access to peers (in-person or virtual)
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Primitive (involuntary) neonatal reflexes are present at birth and disappear at predictable ages. Their presence indicates intact neurologic function; persistence beyond expected age may indicate neurologic problems (e.g., cerebral palsy). Absence at birth may indicate dysfunction.
Underlying Principles
| Reflex | Stimulus | Response | Disappears |
|---|---|---|---|
| Sucking | Object touches mouth/lips | Begins sucking | 10–12 mo |
| Rooting | Touch corner of mouth | Head turns toward stimulus, mouth opens | 3–4 mo |
| Moro (Startle) | Sudden movement, loud noise, sudden head drop | Arms abduct, fingers fan, then flex inward (embrace) | 3–6 mo |
| Tonic neck (Fencing) | Turn head to one side | Arm/leg on side facing extends, opposite arm/leg flexes | 3–4 mo |
| Palmar grasp | Pressure on palm | Fingers curl around object | 3 mo |
| Plantar grasp | Pressure on ball of foot | Toes curl down | 8–9 mo |
| Babinski | Stroke lateral foot up to toes | Toes fan out, big toe extends (normal in infants) | 1 yr |
| Stepping (Walking) | Hold upright; feet touch surface | Alternating stepping motion | 3–4 wk |
| Gallant (Trunk incurvation) | Stroke along spine while prone | Hips swing toward stimulus side | 4 wk |
Nursing Interventions
Assessment:
- Assess reflexes in routine newborn exam
- Document presence, symmetry
- Note timing of disappearance at follow-up exams
- Asymmetric Moro → may indicate brachial plexus injury, fracture, or hemiparesis
- Absent Moro at birth → CNS depression, sedation
Education for parents:
- Reflexes are normal and expected — not voluntary actions yet
- Different ages of disappearance — track at well-child visits
- Some reflexes (sucking, rooting) help with feeding
- Moro may surprise parents (looks like startle) — comfort by holding
- Stepping reflex looks like walking but is reflexive, not voluntary
- Babinski response NORMAL in infants but ABNORMAL in older children/adults (would indicate upper motor neuron problem)
- Persistence of primitive reflexes past expected age may need evaluation (CP, ID)
- Don't test for "walking" reflex to encourage early walking — has no developmental benefit
- Voluntary motor skills (purposeful grasp, sitting, walking) emerge as primitive reflexes integrate
Clinical implications:
- Absent reflexes → CNS dysfunction, prematurity, sedation, sepsis
- Asymmetric reflexes → focal lesion or injury (brachial plexus, fracture)
- Persistent reflexes → neurodevelopmental concern
- Brisk Moro → neurologic excitability (drug withdrawal, hypocalcemia)
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Immunization is one of the most cost-effective public health interventions. Active immunization (vaccines) stimulates immune system to produce antibodies and memory cells. Passive immunization (immunoglobulins) provides immediate, temporary protection. Pediatric schedule is established by ACIP (Advisory Committee on Immunization Practices), CDC, AAP, and AAFP.
Underlying Principles
Types of vaccines:
- Live attenuated: weakened pathogen; produces strong, lasting immunity (MMR, varicella, rotavirus, LAIV nasal flu, BCG)
- Inactivated (killed): killed pathogen; may need boosters (IPV, hepatitis A, inactivated flu)
- Subunit/Recombinant/Conjugate: pieces of pathogen (HepB, HPV, Hib, PCV, MCV)
- Toxoid: inactivated toxin (DTaP, Tdap)
- mRNA: contains genetic instructions (COVID-19)
Pediatric schedule highlights (CDC):
| Age | Vaccines |
|---|---|
| Birth | HepB |
| 2 mo | HepB, RV, DTaP, Hib, PCV, IPV |
| 4 mo | RV, DTaP, Hib, PCV, IPV |
| 6 mo | HepB, RV, DTaP, Hib, PCV, IPV, flu (annual starting 6 mo) |
| 12–15 mo | MMR, varicella, HepA, Hib, PCV |
| 18 mo | HepA (2nd dose) |
| 4–6 yr | DTaP, IPV, MMR, varicella (boosters) |
| 11–12 yr | Tdap, HPV (begin), MCV4 |
| 16 yr | MCV4 booster, MenB (shared decision) |
Contraindications and precautions:
- Anaphylactic reaction to vaccine component: contraindication to that vaccine
- Immunocompromised: avoid LIVE vaccines (MMR, varicella, rotavirus, LAIV) — including chemo, high-dose steroids (≥ 2 mg/kg/day prednisone × ≥ 14 days), HIV with low CD4
- Pregnancy: avoid live vaccines (MMR, varicella)
- Moderate-severe illness: defer (mild illness OK)
- History of GBS within 6 weeks of prior flu vaccine — caution
- Egg allergy: typically NOT a contraindication to flu vaccine (newer guidelines)
NOT contraindications (common misconceptions):
- Mild illness, low-grade fever
- Antibiotic use
- Mild reaction to prior vaccine (soreness, low fever)
- Premature birth (give per chronological age)
- Breastfeeding
- Recent exposure to disease
- Family history of vaccine reactions
Common side effects:
- Local: pain, redness, swelling at injection site
- Systemic: low-grade fever, fussiness, sleepiness
- Rash with MMR (5–10 days), varicella (10–14 days) — mild
- Severe reactions are RARE
- Anaphylaxis: extremely rare (~1 per million)
Nursing Interventions
Pre-vaccination:
- Review immunization history (paper records, registry)
- Screen for contraindications, precautions
- Provide Vaccine Information Statement (VIS) — required by law
- Address parent concerns (don't dismiss)
- Use evidence-based communication
- Verify correct vaccine, dose, route per protocol
- Atraumatic care preparation
Administration:
- 5 rights of medication
- Correct route, site (IM, SQ, oral, intranasal)
- Correct needle size
- Most pediatric IM vaccines: vastus lateralis (infants), deltoid (older)
- Comfort measures: position with parent, breastfeeding, sucrose, distraction, EMLA cream
- Give in opposite limbs if multiple
- 2-finger separation if multiple in same limb
- Some can be given simultaneously (most can be given same day)
- Aspiration NOT routinely required
- Apply bandage
Post-vaccination:
- Observe 15 minutes (some 30) for immediate reactions
- Document in chart and immunization registry
- Provide aftercare instructions
- Discuss expected side effects
- Acetaminophen or ibuprofen for fever/soreness (NOT before for prophylaxis — may decrease antibody response)
Catch-up immunizations:
- Children behind on schedule — catch-up per ACIP guidelines
- Minimum intervals must be followed
- Don't restart series — pick up where left off
- Can give multiple vaccines same day
Special populations:
- Premature: give per chronological age (not corrected)
- Travel: additional vaccines may be needed
- Immunocompromised: modified schedule
- Pregnant adolescents: avoid live
- Breastfeeding moms: most vaccines safe
Addressing hesitancy:
- Listen to concerns without judgment
- Share science-based information
- Acknowledge importance of vaccines for community immunity
- Discuss diseases vaccines prevent (some parents have never seen)
- Address specific concerns (autism debunked, vaccine ingredients explained)
- Strong recommendation from trusted provider effective
- Document refusal if persistent
Storage and handling:
- Cold chain critical (most refrigerated 35–46°F)
- Some frozen (varicella, MMRV)
- Monitor temperatures
- Reconstitute properly
- Use within specified time after reconstitution
- Discard expired vaccines
Reporting:
- VAERS (Vaccine Adverse Event Reporting System) — report adverse events
- VICP (Vaccine Injury Compensation Program) — federal program for compensation
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Pediatric death is uniquely devastating and developmentally complex. Children's understanding of death evolves with cognitive development. Family-centered, developmentally-appropriate care includes palliative care, pain management, communication, and bereavement support. Pediatric palliative care can be integrated alongside curative treatment, not just at end of life.
Underlying Principles
Child's concept of death by developmental age:
| Age | Concept of Death |
|---|---|
| Infant/Toddler (0–3) | No concept; reacts to separation, anxiety, pain; senses parent emotion; needs comfort, routine, presence |
| Preschool (3–6) | Death seen as TEMPORARY and REVERSIBLE (like sleep, going away); magical thinking — may believe their thoughts/behavior caused death; egocentric; literal interpretation; fear of separation, abandonment, the unknown |
| School-age (6–12) | Begins to understand death is PERMANENT, UNIVERSAL, IRREVERSIBLE (by age 9–10); concrete thinking; may personify death; fear of mutilation, pain, abandonment; ask specific questions; concerned about who will care for them and family |
| Adolescent (12+) | Adult understanding of death; abstract thinking; consider future losses; existential concerns; "personal fable" — sense of invincibility despite knowledge; struggle with meaning, identity, body changes from illness; concerns about peers, missing milestones |
Family/Sibling responses:
- Anticipatory grief
- Each family member grieves differently
- Siblings often "forgotten mourners" — may feel guilty, jealous, displaced
- Parents may neglect their own needs
- Marital strain common
- Cultural and religious factors influence grief
- Bereaved siblings at risk for psychological problems
Kübler-Ross stages of grief (not linear): denial, anger, bargaining, depression, acceptance
Pediatric palliative care principles:
- Begins at DIAGNOSIS of life-threatening illness (not just end of life)
- Concurrent with curative treatment
- Multidisciplinary
- Goal: quality of life
- Aggressive symptom management
- Family-centered
- Decision support, advance care planning
- Bereavement support
Hospice eligibility (typically):
- Life expectancy ≤ 6 months if disease follows usual course
- Patient/family decision to focus on comfort
- Can include some disease-directed therapies in pediatric hospice
Nursing Interventions
Symptom management:
- Pain: opioids, adjuvants; don't under-treat for fear of "addiction" in dying child
- Dyspnea: opioids, oxygen, position
- Nausea/vomiting: antiemetics
- Anxiety: benzodiazepines, environmental measures
- Constipation
- Secretions: anticholinergics (atropine, scopolamine)
- Seizures
Communication with child:
- Be honest — children sense when something is wrong; lies erode trust
- Use developmentally appropriate language
- Use the words "death" and "dying" (not "passed away," "went to sleep" — which scares them about bedtime)
- Allow questions, answer truthfully
- Listen for the question behind the question
- Acknowledge emotions
- Use stories, books, art
- Allow child to express fears, wishes
- Don't force conversation if child not ready
- Some children want to plan their funeral, write letters, make memories
- Reassure child not at fault
- Address pain, comfort, who will be with them
Communication with family:
- Honest, compassionate communication
- Use clear language (not jargon)
- Family meetings for major decisions
- Involve interpreters when needed
- Respect cultural and religious beliefs
- Address concerns about pain, suffering
- Goals-of-care discussions
- Advance directives, MOLST/POLST
- Code status decisions
- Location of death (home, hospital, hospice)
Siblings:
- Include in discussions appropriately
- Allow visits
- Acknowledge their experience
- Provide age-appropriate explanations
- Don't exclude — they imagine worse than reality
- Watch for changes in behavior, school, appetite
- School coordination, counselor
- Maintain routines when possible
- Allow them to participate in caregiving if they want (within reason)
Spiritual/cultural:
- Spiritual care/chaplaincy
- Religious rituals, prayer, sacraments
- Cultural practices around death
- Memory-making: photos, hand/foot prints, hair, art, recordings
At time of death:
- Allow family time with child
- Don't rush
- Help family bathe, hold, dress child if desired
- Provide privacy
- Cultural and religious practices honored
- Allow siblings, friends to say goodbye if family wishes
- Discuss autopsy, organ donation if appropriate
Bereavement:
- Follow-up contact (cards, calls, anniversary)
- Bereavement support groups
- Refer to community resources
- Mental health referral if complicated grief
- Sibling-specific bereavement programs
- Acknowledge anniversaries
Staff:
- Self-care, supervision
- Debriefing
- Peer support
- Recognize moral distress
- Avoid burnout
- Honor each child cared for
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Pediatric vital signs are age-specific — adult parameters do NOT apply. Critical to know normal ranges by age to recognize deviations indicating illness. Includes heart rate, respiratory rate, blood pressure, temperature, oxygen saturation, and pain level. Vital signs change significantly during childhood, particularly in infancy and early childhood.
Underlying Principles
Normal vital sign ranges by age (awake):
| Age | HR (bpm) | RR (breaths/min) | Systolic BP (mmHg) |
|---|---|---|---|
| Newborn | 100-160 | 30-60 | 60-90 |
| Infant (1-12 mo) | 100-160 | 30-60 | 70-100 |
| Toddler (1-3 yr) | 90-150 | 24-40 | 80-110 |
| Preschool (3-6 yr) | 80-140 | 22-34 | 80-110 |
| School-age (6-12 yr) | 70-110 | 18-30 | 90-120 |
| Adolescent (12+) | 60-100 | 12-20 | 100-130 |
Temperature (normal): 36.5-37.5°C (97.7-99.5°F)
- Rectal most accurate (newborns, severely ill)
- Axillary (least accurate; for screening)
- Oral (≥ 4 years, cooperative)
- Tympanic (≥ 3 months; varies by technique)
- Temporal artery (newer; good for screening)
- Fever: >38°C (100.4°F) — concerning in infants < 3 months (sepsis workup), tolerable in older
Oxygen Saturation: Normal ≥ 95% on room air (most healthy children). Newborns may transiently be lower.
Estimating BP (SBP) by formula:
- SBP = 90 + (2 × age in years) — older approximation
- SBP 5th percentile = 70 + (2 × age in years) — minimum acceptable
- For accurate BP, use age- and height-specific tables (e.g., AAP HTN guidelines)
- BP cuff: width should cover 40% of upper arm circumference
Influences on Vital Signs:
- ↑ during fever, crying, agitation, activity, pain, fear
- ↓ during sleep, sedation
- Always assess in context
- Trends are more important than single readings
Red flag vital signs (general):
- Sustained tachycardia (compensated shock)
- Tachypnea (respiratory distress, fever, acidosis, shock)
- Bradycardia in pediatrics → impending arrest (especially with hypoxia)
- Hypotension is a LATE sign in pediatric shock (children compensate well, then crash)
- Apnea
- Hypothermia in infants (sepsis)
- SpO₂ < 92% on room air
Nursing Interventions
Pediatric Early Warning Score (PEWS):
- Scoring system for behavior, cardiovascular, respiratory
- Triggers escalation of care
Best practices for measurement:
Heart rate:
- Apical for full minute in children < 2 years (irregular rhythms common, accuracy)
- Brachial or radial pulse for older children
- Femoral useful in shock states
- Auscultate over 4th-5th ICS, midclavicular line
- Count for 1 full minute in infants and young children
Respiratory rate:
- Count BEFORE disturbing child (when calm or sleeping if possible)
- Observe abdominal movement in infants (diaphragmatic breathing)
- Count for 1 full minute (irregularity common in infants — periodic breathing)
- Assess effort: retractions, nasal flaring, grunting, head bobbing, accessory muscle use
Blood pressure:
- Use age-/height-appropriate cuff size
- Cuff bladder covers 40% of arm circumference
- Manual BP more accurate in young children/sick infants
- Compare to age/height/sex norms
- 4-extremity BP if cardiac concerns (coarctation)
- Routine in children ≥ 3 years at well visits; younger if indicated
Temperature:
- Rectal: most accurate; standard for newborns, sick infants; insert 1 inch
- Axillary: least accurate (lower than core); safe for newborns
- Oral: only in cooperative children ≥ 4 years
- Tympanic: > 3 months; technique-dependent
- Temporal: non-invasive, accurate for screening
Pulse oximetry:
- Probe on finger, toe, or foot
- Verify good waveform/signal
- Adjust for movement, cold extremities
- Pre-ductal (right hand) vs post-ductal (foot) — newborns with cyanosis to assess for cardiac issue
Pain:
- Use age-appropriate scale (covered in separate template)
Documentation:
- Document all vital signs
- Note position (sleeping, calm, agitated)
- Note any interventions
- Recognize abnormal values for age
- Trends matter more than single readings
Recognize shock states:
- Compensated shock: tachycardia + delayed cap refill + cool extremities + altered mental status WITH normal BP
- Hypotension is LATE — when it occurs, decompensation is severe
- Quick recognition saves lives
Special considerations:
- Newborn: assess immediately after birth (Apgar at 1, 5 min)
- Infants: cluster care to avoid waking
- Toddler/preschool: minimize fear; use parent for security
- School-age: explain
- Adolescent: privacy, normal adult-like
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Includes physical abuse, sexual abuse, emotional/psychological abuse, and neglect (physical, emotional, medical, educational). Munchausen syndrome by proxy / Factitious Disorder Imposed on Another is a form of medical child abuse. Nurses are mandated reporters by law in all 50 states. Reporting protects the child; the legal system investigates and determines outcomes.
Underlying Principles
Types of maltreatment:
- Physical abuse: non-accidental injury (bruises, burns, fractures, head trauma, abdominal injury)
- Sexual abuse: any sexual contact with a child; sexually transmitted infections; pregnancy in young adolescent
- Emotional/psychological: rejection, terrorizing, isolating, exploiting, witnessing domestic violence
- Neglect: failure to provide basic needs (food, shelter, clothing, medical care, supervision, education); most common type
- Medical neglect: failure to provide necessary medical care
- Munchausen syndrome by proxy: caregiver fabricates or causes illness in child to gain attention
- Bullying: peer-to-peer maltreatment
Red flags for physical abuse:
- Story doesn't match injury (developmentally, anatomically, or by mechanism)
- Inconsistent explanations
- Delay in seeking care
- Suspicious injuries:
- "TEN-4 FACES" bruising in < 4 years — Torso, Ear, Neck, < 4 years; Frenulum, Auricular area, Cheek, Eye, Sclera
- Bruises in non-walking infants ("those who don't cruise rarely bruise")
- Patterned bruises (belt, cord, hand, bite)
- Burns: stocking-glove (immersion), cigarette, branded shape
- Multiple injuries different healing stages
- Spiral fractures in non-ambulatory child
- Posterior rib fractures (from squeezing/shaking)
- Metaphyseal corner/bucket-handle fractures (long bone in infants — pathognomonic)
- Subdural hematoma in infant ("shaken baby") — often with retinal hemorrhages
- Abdominal trauma without obvious cause
- Genital injuries
- STIs in pre-pubertal children
- Pregnancy in young adolescent
Behavioral red flags in child:
- Regression in development
- Behavior changes (withdrawal, aggression, fear)
- Hypervigilance, startles easily
- Sexualized behavior inappropriate for age
- Knowledge of sexual matters beyond age
- Sleep disturbances, nightmares
- School problems, declining grades
- Avoiding home or specific person
- Eating disorders
- Self-harm, suicidality
- Substance abuse
- Running away
- Reports abuse (often the child tells someone)
Behavioral red flags in caregiver:
- Inappropriate response (overly calm or overly emotional)
- Story changes or is implausible
- Blaming child or sibling
- Hostility, defensiveness
- Frequent ED visits, doctor shopping
- Refusing to leave child alone with provider
- Substance abuse, mental illness
- Domestic violence in home
- Caregiver was abused as a child
- Social isolation, lack of support
Risk factors for maltreatment:
- Child: prematurity, disability, chronic illness, behavioral problems, infants (highest risk for abuse)
- Caregiver: young parent, single parent, substance abuse, mental illness, history of abuse, poverty, stress, lack of support, unrealistic expectations
- Environment: poverty, social isolation, domestic violence, unsafe housing
Legal framework:
- CAPTA (Child Abuse Prevention and Treatment Act)
- State-specific laws — every state has Mandated Reporter laws
- Mandated reporters: nurses, doctors, teachers, social workers, mental health professionals, law enforcement, daycare workers, others (varies by state)
- Required to report SUSPICION (not proof) of abuse/neglect
- Failure to report can result in criminal/civil penalty
- Good faith reports protected from liability
- Reports may be made anonymously (in some states)
Nursing Interventions
Assessment:
- Thorough history and physical (private setting)
- Interview child alone when possible (age-appropriate; without caregiver present for suspicious cases)
- Document EXACT statements ("quotes")
- Document all physical findings with precise location, size, color, shape
- Photograph injuries (with consent and per facility policy)
- Skeletal survey for children < 2 years if suspected physical abuse
- Head CT/MRI if head injury or unexplained neurologic findings
- Retinal exam (shaken baby syndrome)
- Sexual abuse exam: forensic exam by trained provider (SANE — Sexual Assault Nurse Examiner) within 72-96 hours of acute event
- STI testing (sexual abuse)
- Toxicology if substance exposure suspected
- Don't lead, suggest, or interrogate child — open-ended questions
Reporting:
- Report SUSPICION — you don't need proof
- Report to: Child Protective Services (CPS), local law enforcement, or both (varies by state)
- Most states have hotline numbers (e.g., 1-800-4-A-CHILD national)
- Report ASAP — typically within 24 hours, immediately verbally then written
- Document the report (date, time, person spoken to)
- Follow institutional policy
- You DON'T need permission of supervisor (but inform them)
- Continue to provide medical care regardless of reporting
- Don't confront caregiver before reporting (may endanger child or compromise investigation)
- Tell parent that report has been made (after reporting)
Nursing interventions:
- Ensure child's safety first — admit to hospital if needed for protection during investigation
- Treat physical injuries
- Provide emotional support — believe the child, validate
- Build trust; allow child to talk at own pace
- Don't promise confidentiality you can't keep
- Don't pressure for details
- Use multidisciplinary team (child abuse pediatrics, social work, mental health)
- Provide developmentally appropriate explanations
- Coordinate with CPS, law enforcement, legal
- Refer to mental health services
- Document objectively (just facts, no opinions)
- Photograph injuries per protocol
- Preserve evidence (clothing, etc.) for sexual abuse
- Support to non-offending caregiver
- Educate family on positive parenting strategies (prevention)
- Identify and report repeat injuries
- Follow-up planning
Prevention efforts (community level):
- Parent education programs
- Home visiting programs (Nurse-Family Partnership)
- Anticipatory guidance at well-child visits
- Stress management resources
- Substance abuse treatment
- Mental health services
- Domestic violence interventions
- Safe Haven laws (allow surrender of newborns without prosecution)
- Mandatory reporting
- Public awareness campaigns
- Crib distribution programs
- Shaken baby education for new parents
- Period of PURPLE Crying education
Caring for the nurse:
- Vicarious trauma is real — debriefing, supervision, self-care
- Be informed about resources
Related Content
Sequence of life-saving measures during cardiac/respiratory arrest in infants and children. Pediatric arrest is typically respiratory in origin (vs. cardiac in adults) — leads to asphyxial arrest. Early high-quality CPR and rapid intervention improve outcomes. Includes recognition, activating emergency response, CPR, and AED use.
Underlying Principles
Age categories:
- Infant: < 1 year (excluding newborns immediately at birth — separate NRP protocol)
- Child: 1 year to puberty (signs of puberty)
- Adult: puberty and older
BLS Sequence (lone rescuer; AHA C-A-B):
- Scene safety
- Check responsiveness: tap and shout (infant: tap foot)
- If unresponsive: shout for help; have someone call 911 + get AED
- If alone with unresponsive child: if witnessed sudden collapse → call 911 first (likely cardiac); if unwitnessed/asphyxial → start CPR for 2 min then call 911
- Check pulse (≤ 10 seconds):
- Infant: brachial artery (inner upper arm)
- Child: carotid or femoral
- If no pulse OR pulse < 60 with poor perfusion: begin compressions
Compressions:
| Age | Hand/Finger | Depth | Rate |
|---|---|---|---|
| Infant | 2 fingers (lone); 2 thumbs encircling (2 rescuers); lower 1/2 sternum | 1.5 inches (4 cm) — about 1/3 AP chest depth | 100-120/min |
| Child | 1 or 2 hands (heel of hand); lower 1/2 sternum | 2 inches (5 cm) — about 1/3 AP chest depth | 100-120/min |
| Adolescent | 2 hands | 2-2.4 inches (5-6 cm) | 100-120/min |
Compression principles:
- Push hard, push fast
- Allow full chest recoil (between compressions)
- Minimize interruptions (< 10 sec)
- Switch compressors every 2 min to avoid fatigue
- Hard, flat surface preferred
Compression-to-ventilation ratio:
- Lone rescuer (infant or child): 30:2
- 2 rescuers (infant or child): 15:2
- Advanced airway in place: continuous compressions 100-120/min + 1 breath every 2-3 sec (20-30/min)
Ventilations:
- Each breath over 1 second
- Just enough volume to make chest rise
- Avoid excessive ventilation (↑ intrathoracic pressure → ↓ venous return)
- Mouth-to-mouth-and-nose for infants; mouth-to-mouth for children with nose pinched
- BVM with appropriate-sized mask
AED use:
- Use AS SOON AS available
- Pediatric pads/dose attenuator preferred for < 8 years or < 25 kg
- If only adult pads available — use them rather than nothing
- Infant: anterior-posterior placement
- Child: standard anterior-lateral or AP
- Follow AED prompts
- Resume compressions immediately after shock
- Continue 5 cycles (~2 min) before reassessing
Pediatric-specific considerations:
- Respiratory cause MOST COMMON — adequate ventilation crucial
- Pulse rate < 60 bpm with poor perfusion in child = start CPR (different from adult criteria)
- Foreign body airway obstruction more common
- Better outcomes with rapid recognition
- Hypothermia: continue CPR longer; "not dead until warm and dead"
Choking management (FBAO):
- Infant: 5 back blows + 5 chest thrusts (NO abdominal thrusts — liver injury)
- Child: Abdominal thrusts (Heimlich)
- If unresponsive: CPR (look in mouth before breaths)
Special situations:
- Drowning: prioritize ventilation; start with rescue breaths (5 initial)
- Trauma: c-spine precautions, jaw thrust (don't use head-tilt/chin-lift)
- Asphyxial arrest: start with compressions but prompt ventilation important
Nursing Interventions
Recognition:
- Identify cardiac/respiratory arrest quickly
- Look for: unresponsiveness, no normal breathing (only gasping is NOT normal), no pulse
- Differentiate from sleep, seizure, syncope
Quality CPR:
- Push hard, push fast (rate 100-120/min, depth 1/3 AP chest)
- Allow complete chest recoil
- Minimize interruptions (< 10 seconds)
- Avoid excessive ventilation
- Switch rescuers every 2 min
- Pulse and rhythm check every 2 min (≤ 10 sec)
Equipment for in-hospital BLS:
- BVM with appropriately-sized pediatric masks
- Oral and nasal airways (sized to patient)
- Suction
- AED or defibrillator with pediatric pads
- Crash cart with appropriate-sized supplies
- Broselow tape (length-based emergency reference for weight, drug doses, equipment sizes)
Team roles (in-hospital):
- Code leader
- Compressor(s)
- Airway/ventilations
- Medication/IV access
- Recorder/timer
- Family support person
- Communication
Documentation:
- Time of arrest
- Time CPR started, who initiated
- Time of each intervention (drugs, shocks, intubation)
- Pulse and rhythm checks
- Resuscitation team members
- End-of-event status (ROSC, transferred, deceased)
- Family notification and presence
Post-cardiac arrest care:
- Optimize ventilation (don't hyperventilate)
- Optimize hemodynamics
- Targeted temperature management (consider)
- Manage seizures
- Monitor for re-arrest
- Investigate cause
Family presence:
- AHA supports family presence during resuscitation with support person
- Allows family to witness efforts, ask questions, say goodbye if needed
- Designated support person to explain
Prevention strategies:
- Address common causes: SIDS prevention, immunizations, safe sleep, drowning prevention, choking hazards, car safety, helmet use, recognize and treat respiratory illness early
- Caregiver CPR training
- Asthma action plans, anaphylaxis epinephrine training
- Sports cardiac screening
- Lay rescuer training programs
Education for families:
- Teach BLS/CPR to caregivers
- Emphasize calling 911
- Emphasize chest compressions (even if not comfortable with breaths)
- Post emergency numbers
- Have AED accessibility in schools, public spaces
Survival outcomes:
- In-hospital arrest: ~30-40% survival to discharge with good neurologic outcome
- Out-of-hospital arrest: lower (~10%)
- Bystander CPR doubles or triples survival
- Early recognition + early high-quality CPR + early advanced care = best outcome
Description of Procedure
Gold standard diagnostic test for cystic fibrosis. Measures the concentration of chloride in sweat collected by pilocarpine iontophoresis. CF patients have abnormally high sweat chloride due to defective CFTR protein.
Procedure:
- Pilocarpine applied to a small area of skin (forearm) using a mild electrical current to stimulate sweating
- Sweat collected on filter paper or coil for 30 minutes
- Chloride content measured
- Test takes ~1 hour total; painless
- At least 75 mg of sweat needed for accurate result
Indications
- Positive newborn screen for CF (immunoreactive trypsinogen elevated)
- Symptoms suggestive of CF: chronic respiratory infections, failure to thrive, steatorrhea, meconium ileus
- Family history of CF
- Salty-tasting skin reported by parent
- Confirmation of CF diagnosis
Interpretation of Findings
Sweat chloride values:
- > 60 mEq/L (60 mmol/L) = DIAGNOSTIC FOR CF
- 40–59 mEq/L = intermediate/borderline (needs further evaluation, repeat testing, genetic testing)
- < 30 mEq/L (children) or < 40 mEq/L (adults) = CF unlikely
Should be performed twice on separate days for confirmation. Genetic testing for CFTR mutations confirms diagnosis when sweat test borderline.
Nursing Interventions (pre, intra, post)
- Ensure infant is at least 2 weeks old and weighs at least 2 kg for accurate test
- Child should be well-hydrated
- Child should NOT be edematous, hypoproteinemic, malnourished (can give false-negative)
- Do not apply lotions, creams, or oils to test arm prior to test
- Stay with child during test (45–60 minutes)
- Distraction with toys, books
- Educate family that the test is painless
- May feel slight tingling during pilocarpine application
Potential Complications
- Generally very safe; rare side effects
- Mild skin irritation at electrode site
- Rarely: small electrical burn (very rare)
- False results if: inadequate sweat collected, edema, dehydration, hypoproteinemia
- False negatives in mild CF mutations
Nursing Interventions
- Monitor patient for any of the listed complications during and after the procedure
- Take vital signs per protocol with attention to baseline changes
- Provide post-procedure care including site assessment and patient education
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Procedure is painless
- Child may feel slight tingling during electrical stimulation phase
- No fasting required
- Maintain hydration before and after test
- Test takes about an hour total
- Results usually available within 24–48 hours
- If positive, will need genetic confirmation and referral to CF center
- Two positive tests confirm diagnosis
Description of Procedure
Tuberculin skin test (TST) to screen for exposure to Mycobacterium tuberculosis. Purified protein derivative (PPD) is injected intradermally; positive result indicates exposure (NOT active disease).
Procedure:
- 0.1 mL of PPD injected intradermally on the volar surface of forearm
- 5–15 degree angle, bevel up
- Creates small bleb (wheal) of 6–10 mm
- Do NOT massage site
- Read at 48–72 hours by trained professional
- Measure INDURATION (raised area) in millimeters — NOT erythema
Indications
- Children at high risk for TB exposure
- Contact with active TB case
- Travel to endemic areas
- Immigration from high-prevalence countries
- Symptoms suggestive of TB
- HIV-positive children
- Children receiving immunosuppressive therapy
- Pre-employment for healthcare workers (older children/adolescents)
- Routine screening NOT recommended for low-risk children
Interpretation of Findings
Measure induration (palpable raised area), NOT redness. Read in millimeters.
Positive results by risk:
- ≥ 5 mm: HIV+, recent contact with active TB, fibrotic CXR, immunosuppressed (transplant, ≥ 15 mg prednisone/day)
- ≥ 10 mm: children < 4 yr; chronic conditions (DM, CKD, leukemia, lymphoma); recent immigrants; injection drug users; medically underserved; high-risk healthcare settings; mycobacteriology lab workers; children exposed to high-risk adults
- ≥ 15 mm: persons with no known risk factors
Positive test = TB exposure; does NOT distinguish latent vs active TB; requires chest X-ray, sputum culture (if able), symptoms review.
Nursing Interventions (pre, intra, post)
- Document site of injection
- Do NOT massage or cover with tight bandage
- Mark site if not easily found
- Have child return in 48–72 hours for reading
- Trained professional must read result
- If positive: chest X-ray, possible IGRA, infectious disease referral
- For positive children: workup for active TB; if latent, treat with isoniazid × 9 months
Potential Complications
- Generally very safe
- Mild itching, swelling at site
- Rarely: ulceration, blistering (positive reaction is intense)
- False positives: BCG vaccine recipients (overseas), non-tuberculous mycobacteria
- False negatives: immunocompromised, severe malnutrition, recent infection, anergy
- BCG vaccination doesn't typically cause prolonged reactivity; positive PPD should still be evaluated
Nursing Interventions
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Assess for allergic reaction (rash, urticaria, dyspnea); have epinephrine, oxygen, and emergency equipment at bedside
- Reposition every 2 hr; pressure-relief devices; daily skin assessment; nutritional support
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Need to return in 48–72 hours for reading (most important!)
- Cannot interpret yourself — must be read by trained provider
- Don't scratch, rub, or cover site
- Mild itching or swelling is expected
- If reaction extends or causes problems, contact provider
- If positive, additional testing will be needed
- Positive test does NOT necessarily mean active TB
- BCG vaccination history is important to disclose
- IGRA blood test may be alternative (not affected by BCG)
Description of Procedure
Insertion of a hollow needle into the subarachnoid space (between L3-L4 or L4-L5 in pediatrics) to collect cerebrospinal fluid (CSF) for analysis or administer medications/anesthesia. Sterile procedure performed by physician/APN.
Indications
Diagnostic:
- Suspected meningitis or encephalitis
- Subarachnoid hemorrhage
- Inflammatory CNS conditions (Guillain-Barré, MS)
- CNS malignancy
- Measurement of intracranial pressure
- Pseudotumor cerebri
Therapeutic:
- Administration of intrathecal chemotherapy (leukemia)
- Removal of CSF in pseudotumor cerebri
- Spinal anesthesia
Interpretation of Findings
Normal CSF: clear, colorless, opening pressure 10–20 cm H₂O, WBC < 5/mm³, glucose 50–80 mg/dL (2/3 of serum), protein 15–45 mg/dL
Bacterial meningitis:
- Cloudy/purulent
- ↑↑ WBC (neutrophils predominate)
- ↓ glucose
- ↑↑ protein
- ↑ opening pressure
- Positive Gram stain and culture
Viral meningitis:
- Clear
- ↑ WBC (lymphocytes predominate)
- Normal glucose
- Normal or slightly ↑ protein
- Normal opening pressure
Nursing Interventions (pre, intra, post)
Pre-procedure:
- Verify informed consent
- Check coagulation studies (rule out bleeding disorder)
- Assess for ↑ ICP signs (LP contraindicated if increased ICP — herniation risk; CT first if suspected)
- Apply EMLA cream 30–60 min before procedure
- NPO per institutional protocol
- Empty bladder
During procedure:
- Positioning: side-lying with knees drawn to chest, neck flexed, OR sitting up leaning forward (infants)
- "Cat's back" or fetal position to open intervertebral spaces
- Hold child firmly to prevent sudden movement
- Maintain airway and respirations (especially infants in flexed position)
- Continuous monitoring (pulse ox, observation)
- Provide distraction, comfort
Post-procedure:
- Keep child flat 4–6 hours (older children — reduces post-LP headache)
- Encourage fluids
- Monitor neurologic status
- Assess insertion site for leakage, swelling, hematoma
- Pain management as needed
Potential Complications
- Post-LP headache — common (esp. older children); from CSF leak; bedrest, fluids, caffeine help
- Local pain at site
- Bleeding (rare, more risk with coagulopathy)
- Cerebral herniation — feared complication if increased ICP; ALWAYS rule out before LP
- Infection (meningitis from procedure — rare with sterile technique)
- Nerve damage (very rare)
- CSF leak
- Backache
Nursing Interventions
- Monitor for bleeding (assess site, vital signs, Hgb/Hct); apply pressure as indicated; notify provider for hemodynamic instability
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Assess pain (location, character, scale) frequently; administer ordered analgesia; reposition for comfort
- Perform neuro checks; institute seizure precautions if appropriate; report changes in LOC
- Provide therapeutic communication; reduce environmental stressors; involve family; offer anxiolytics if ordered
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Explain procedure simply and honestly to age-appropriate level
- Will feel pressure but should not feel sharp pain (with anesthetic)
- Importance of holding still during procedure
- EMLA cream will be applied to reduce pain
- Stay flat for several hours after to reduce headache risk
- Drink extra fluids
- Headache may occur; report severe headache, neck stiffness
- Report fever, severe pain, leakage at site, neurologic changes
- Allow parent to remain with younger child (comfort)
Description of Procedure
Universal screening of all newborns for early detection of metabolic, genetic, and endocrine disorders. Heel stick blood sample collected on filter paper. Each state determines which conditions are screened; typically includes 30+ disorders.
Procedure:
- Warm heel with warm compress to increase blood flow
- Cleanse with alcohol; allow to dry
- Puncture lateral aspect of heel (outer side) with sterile lancet
- Wipe away first drop; collect blood drops on filter paper circles
- Allow paper to air dry
- Apply pressure with sterile gauze
- Send to state lab
Indications
- Universal — required by law for ALL newborns
- Performed at 24–48 hours of age, AFTER infant has ingested protein (formula or breast milk)
- May need repeat at 1–2 weeks if early discharge
- Repeat for blood transfusion recipients
Interpretation of Findings
Common conditions screened (varies by state — > 30 disorders):
- Phenylketonuria (PKU) — phenylalanine metabolism
- Congenital hypothyroidism — ↑ TSH, ↓ T4
- Galactosemia — galactose-1-phosphate uridyltransferase deficiency
- Sickle cell disease — hemoglobin electrophoresis
- Cystic fibrosis — ↑ immunoreactive trypsinogen (IRT)
- Congenital adrenal hyperplasia (CAH) — ↑ 17-hydroxyprogesterone
- Biotinidase deficiency
- MCAD deficiency
- Maple syrup urine disease
- And many others
Positive screen requires confirmatory testing — does NOT confirm diagnosis.
Nursing Interventions (pre, intra, post)
- Ensure infant has been feeding 24+ hours before test (need protein intake for accurate PKU result)
- Heel stick technique: warm heel first (improves blood flow), use lateral aspect (avoid medial — calcaneal nerve), don't squeeze (causes hemolysis)
- Apply pressure with gauze afterward
- Comfort infant (skin-to-skin, breastfeeding, sucrose pacifier)
- Document time of feeding before test (for PKU)
- Re-screen at 1–2 weeks if early discharge or first screen done < 24 hr
- If positive, notify family promptly, refer to specialist
- Avoid using TPN, blood products from screening site
Potential Complications
- Pain (transient)
- Bruising at puncture site
- Infection (rare with sterile technique)
- Damage to underlying tissue if punctured incorrectly (use lateral heel only)
- False positives common — confirmation needed
- False negatives if infant not yet eating protein, or transfused
Nursing Interventions
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Assess pain (location, character, scale) frequently; administer ordered analgesia; reposition for comfort
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Universal screening — required for all newborns
- Detects rare but serious conditions early — allows for early treatment
- Brief discomfort from heel stick — comfort measures help (skin-to-skin, feeding, sucrose)
- Results available in 1–2 weeks
- "Positive" screen does NOT mean diagnosis — confirmatory testing follows
- If positive, follow-up testing is critical — do not delay
- Repeat screen needed if discharged before 24 hours of age
- Inform any future care providers of newborn screen results
- Most screens are normal — provider will only contact if abnormal
Description of Procedure
Non-invasive ultrasound imaging of the heart and great vessels. Uses high-frequency sound waves to visualize cardiac structures, function, and blood flow patterns. Gold standard for diagnosing structural heart defects in children. No radiation.
Types:
- Transthoracic (TTE): probe on chest wall — standard pediatric exam
- Transesophageal (TEE): probe in esophagus — better views, requires sedation
- Fetal echo: performed prenatally (typically 18–22 weeks gestation)
Indications
- Suspected congenital heart defect (murmur, cyanosis, abnormal pulses)
- Follow-up of known CHD
- Heart failure evaluation
- Endocarditis (with risk factors or known)
- Kawasaki disease (assess coronary arteries — baseline, 2 wk, 6–8 wk)
- Cardiomyopathy
- Rheumatic fever follow-up
- Pre/post cardiac surgery
- Family history of CHD
- Down syndrome, Turner syndrome, Marfan syndrome (associated cardiac defects)
- Chest pain in child > cardiac cause suspected
- Syncope evaluation
Interpretation of Findings
- Visualizes cardiac chambers, valves, septa, great vessels
- Assesses chamber size, wall thickness, function (ejection fraction)
- Identifies valve abnormalities (stenosis, regurgitation)
- Detects septal defects (VSD, ASD, AV canal)
- Evaluates great vessels (transposition, coarctation, PDA)
- Color Doppler shows blood flow direction and velocity
- Pericardial effusion identification
- Coronary arteries (especially for Kawasaki)
- Reports include: anatomy description, function (% EF), flow patterns, gradients across valves
Nursing Interventions (pre, intra, post)
Pre-procedure:
- Routine echo is non-invasive — no special prep usually needed
- For TEE: NPO, possible sedation, IV access
- For sedation: pre-procedure assessment, NPO per protocol
- Position supine; left side for some views
- Comfort measures, distraction (TV, movie, parent present)
- Warm room/blanket (gel can be cold)
During procedure:
- Apply ultrasound gel to chest
- Probe placed at standard locations (parasternal, apical, subcostal, suprasternal)
- Procedure typically 30–60 minutes
- Infant may need to be still — feeding, swaddling, pacifier helps
- Toddler may need distraction or sedation
Post-procedure:
- Wipe gel off skin
- Resume normal activity
- Results available immediately or via cardiology consult
- For TEE: monitor return to baseline LOC, gag reflex; NPO until gag returns
Potential Complications
- TTE: essentially no complications — non-invasive, no radiation
- TEE: risk of esophageal injury (rare), aspiration during sedation, sedation-related events
- Anxiety/distress from procedure (especially toddlers)
- Misinterpretation if poor windows (obesity, lung overlay)
- Difficulty in uncooperative or moving child
Nursing Interventions
- Assess respiratory rate, effort, and SpO₂; position to optimize ventilation; have suction/oxygen ready
- Provide therapeutic communication; reduce environmental stressors; involve family; offer anxiolytics if ordered
- Implement fall precautions; bed in low position; call light in reach; assess fall risk regularly
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Procedure is painless and uses sound waves (no radiation)
- Gel feels cool/wet but doesn't hurt
- Child needs to lie still — may need infant feeding or sedation
- Procedure takes 30–60 minutes
- Cardiologist will explain findings
- For TEE: NPO before, sore throat after is normal
- Routine for many pediatric heart conditions — followed serially
- Allow child to bring favorite toy or video
Description of Procedure
Measurement of bilirubin (unconjugated and conjugated) in newborns to assess for hyperbilirubinemia and risk of bilirubin neurotoxicity (kernicterus).
Two methods:
- Transcutaneous bilirubin (TcB): non-invasive; meter pressed against skin (sternum or forehead); screening tool
- Serum bilirubin (TSB): heel stick or venipuncture; measures total + direct (conjugated) bilirubin; confirms diagnosis and guides treatment
Indications
- Universal screening of newborns at 24–48 hours of age (TcB or TSB)
- Visual jaundice
- Risk factors: prematurity, breastfeeding difficulties, hemolytic disease, bruising, cephalohematoma, family history
- Decreased feeding, lethargy
- Yellow extension beyond face (cephalocaudal — sclera, chest, abdomen, palms/soles = severe)
- Follow-up to monitor response to phototherapy
Interpretation of Findings
Plot value on Bhutani nomogram based on hour of life and risk factors.
Risk zones:
- High-risk zone — phototherapy threshold (varies with gestational age, hours of life)
- High-intermediate, low-intermediate, low-risk zones
Total serum bilirubin levels:
- Term newborn at 24 hr: > 12 mg/dL → workup
- At 48 hr: > 15 mg/dL → workup, phototherapy threshold
- At 72 hr: > 17 mg/dL → consider phototherapy
- > 20 mg/dL or rapidly rising → urgent phototherapy
- > 25 mg/dL → exchange transfusion may be needed
Direct (conjugated) bilirubin:
- > 2 mg/dL or > 20% of total = pathologic; workup for biliary atresia, hepatitis, sepsis
Nursing Interventions (pre, intra, post)
Transcutaneous (TcB):
- Calibrate device per manufacturer
- Place on clean skin (sternum or forehead)
- Avoid skin with discoloration (bruising, hemangioma)
- Multiple readings for accuracy
- If high, confirm with serum bilirubin
Serum (TSB):
- Heel stick (lateral heel only)
- Or venipuncture for higher accuracy
- Note hours of life precisely
- Note feeding (breast vs formula)
- Comfort measures: swaddling, sucrose pacifier, breastfeeding during draw
- Direct bilirubin if total very elevated or prolonged jaundice (> 2 weeks)
General:
- Document time of test (interpret by hours of life)
- Plot on Bhutani nomogram
- Continue monitoring per protocol
- Assess for risk factors: prematurity, blood incompatibility, hemolysis, breastfeeding issues, infection, family history
Potential Complications
- TcB: virtually no complications (non-invasive)
- TSB heel stick: pain, bruising, infection (rare)
- Inaccurate TcB if recent phototherapy (skin is bleached), dark skin, jaundice extends beyond TcB threshold (TcB underestimates at high levels)
- Missed diagnosis if not screened or screened too late
- Untreated severe hyperbilirubinemia → kernicterus (bilirubin encephalopathy) — irreversible neurologic damage
Nursing Interventions
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Assess pain (location, character, scale) frequently; administer ordered analgesia; reposition for comfort
- Perform neuro checks; institute seizure precautions if appropriate; report changes in LOC
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Some yellowing of skin is common in newborns (physiologic jaundice)
- Universal screening helps detect dangerous levels early
- Encourage frequent breastfeeding (8–12× daily) or formula feeding
- Adequate feeding promotes bilirubin excretion through stool
- Recognize warning signs: increasing yellowing (especially to palms/soles), poor feeding, lethargy, high-pitched cry, arched back → seek immediate care
- If discharge before 48 hours, follow-up bilirubin check within 1–2 days
- Bilirubin typically peaks at 3–5 days of life in term infants; later in preterm
- Phototherapy is effective treatment if needed
- Sunlight is NOT recommended treatment (skin damage, dehydration, temperature instability)
Physical Development
- Weight: quadruples birth weight by 30 mo (~22–28 lb at 2 yr)
- Height: 2.5–3 inches/year
- Anterior fontanel closes by 18 months
- 20 deciduous teeth by 30 mo
- Vision: 20/40
Gross motor:
- Walks alone (12–15 mo)
- Runs (18 mo)
- Jumps in place (24 mo)
- Kicks ball (24 mo)
- Pedals tricycle (3 yr)
Fine motor: builds 2-block tower (15 mo) → 4-block (18 mo) → 8-block (2 yr); copies circle (3 yr).
Toilet training readiness typically emerges 18–24 mo.
Cognitive Development
Piaget: Sensorimotor → Preoperational at ~2 yr (egocentric, magical thinking, animism).
Language:
- ~50 words at 18 mo
- 300+ words and 2-word phrases at 2 yr
- Combines into simple sentences by 3 yr
Cognitive features:
- Object permanence fully established
- Trial-and-error problem solving
- Cannot conserve (mass, volume, number)
- Centration — focuses on one feature at a time
Psychosocial Development
Erikson: Autonomy vs. Shame and Doubt — child needs to assert independence.
Hallmark behaviors:
- Negativism ("no!") — normal expression of autonomy
- Ritualism — predictable routines provide security
- Temper tantrums — frustration with limits
- Physiologic anorexia — appetite decreases, picky eating
- Separation anxiety peaks (protest, despair, detachment phases)
- Develops sense of self ("me," "mine")
Age-Appropriate Activities
Parallel play — plays next to but not with other children.
Favorite activities / toys:
- Push-pull toys
- Stacking blocks, simple puzzles
- Crayons (large), finger painting
- Pretend household items (toy phones, dolls)
- Music and dancing
- Reading picture books
- Outdoor play (slides, ride-on toys)
- Sandbox / water play (supervised)
Health Promotion
- Anticipatory guidance: autonomy ("no!"), temper tantrums, ritualism, separation anxiety are normal
- Toilet training when readiness signs present (typically 18–24 mo); don't force
- Safety priority — drowning, poisoning, falls, choking, motor vehicle (rear-facing until 2 yr)
- Physiologic anorexia is normal — offer variety, don't force; family meals at table
- Discipline: consistent, brief time-outs (1 min per year of age); redirect
- Limit screen time (none under 18 mo per AAP); promote active play
- Dental visits every 6 mo
Immunizations
15 mo visit: Hib (final), PCV13 (final)
15–18 mo visit: DTaP #4, MMR #1 (if not given at 12 mo), Varicella #1 (if not given at 12 mo)
18 mo: HepA #2
4–6 yr visit: DTaP #5, IPV final, MMR #2, Varicella #2
Annual influenza vaccine from 6 mo onward.
Review immunization status at every visit; catch up if behind per CDC catch-up schedule.
Health Screening
- Well-child visits: 15 mo, 18 mo, 24 mo, 30 mo, then yearly
- Height, weight, head circumference plotted
- BMI starting at 2 yr
- Lead screening at 12 and 24 mo (per state)
- Hemoglobin at 12 mo
- Autism screening at 18 and 24 mo (M-CHAT)
- Developmental screening (ASQ) routinely
- Vision and hearing screening as available
- Dental visits every 6 mo
Nutrition
- ~1,000 cal/day
- Transition to whole milk at 1 yr; whole milk until 2 yr
- 16–24 oz milk/day MAX (excess milk → iron deficiency, satiety blunts appetite)
- 3 meals + 2 healthy snacks/day; small portions ("rule of tablespoons" — 1 Tbsp per year of age)
- Family meals at table; expose to variety
- Avoid sweetened beverages; limit juice (4 oz max/day)
- Choking hazards still relevant: hot dogs, hard candy, grapes, nuts, popcorn
- Allow self-feeding; accept messiness
- Physiologic anorexia is normal — do not force-feed
Injury Prevention
Car seat:
- Rear-facing until 2 yr (longer if seat allows)
- Forward-facing with harness 2–4 yr
Top-cause injuries (constant supervision needed):
- Drowning — pools, bathtubs (an inch of water is enough); pool fences
- Poisoning — lock all medications/cleaners; post Poison Control 1-800-222-1222
- Falls — stair gates, window guards (windows screens do NOT prevent falls)
- Burns — cookware handles in, hot water < 120°F
- Choking — see Nutrition
- Motor vehicle — supervise around driveways
Discipline: consistent, brief time-outs (1 min per year of age); redirect; choose battles.
Physical Development
Growth:
- Weight doubles by 5–6 mo, triples by 12 mo
- Height ↑ 50% by 12 mo
- Head circumference: ~1 cm/mo for 6 mo, then ~0.5 cm/mo
- Posterior fontanel closes by 2–3 mo
- Anterior fontanel remains open in infancy
- First teeth (lower central incisors) erupt 6–10 mo
Gross motor: 2 mo lifts head 45°; 4 mo rolls front→back; 6 mo sits supported; 8 mo sits unsupported; 9 mo crawls/pulls to stand; 10 mo cruises; 12 mo stands alone, first steps.
Fine motor: 4 mo brings hands to midline; 6 mo palmar grasp; 9 mo pincer grasp emerging; 12 mo refined pincer.
Primitive reflexes: Moro disappears 4 mo; tonic neck 4 mo; palmar grasp 3 mo; plantar grasp 9 mo; Babinski 12 mo.
Cognitive Development
Piaget: Sensorimotor stage (6 substages)
- Birth–1 mo: reflexive activity
- 1–4 mo: primary circular reactions (own body)
- 4–8 mo: secondary circular reactions (interest in environment)
- 8–12 mo: coordination of secondary schemes; object permanence emerges ~9 mo
Language:
- 2 mo: coos
- 4 mo: laughs
- 6 mo: babbles (consonants)
- 9 mo: "mama," "dada" non-specific
- 12 mo: 1–3 words with meaning
Psychosocial Development
Erikson: Trust vs. Mistrust — consistent caregiver response builds trust.
Social/emotional milestones:
- 2 mo: social smile
- 6 mo: laughs at peek-a-boo
- 6–8 mo: stranger anxiety begins
- 9–18 mo: separation anxiety
- 9 mo: waves bye-bye
- 12 mo: shows preferences, points to wants
Attachment to primary caregiver is the central developmental task.
Age-Appropriate Activities
Solitary play / onlooker play — plays alone or observes others; does not yet interact with peers.
Favorite toys / activities:
- Rattles, mobiles (high contrast for young infants)
- Soft blocks, stacking cups
- Mirrors (self-discovery)
- Peek-a-boo (reinforces object permanence)
- Simple cause-and-effect toys
- Reading board books
- Tummy time (encourages strength, prevents flat head)
Health Promotion
- Well-child visits at 1, 2, 4, 6, 9, 12 months — growth plotted, developmental screening, anticipatory guidance
- Build trust through consistent caregiver response (Erikson stage)
- Safe sleep continued through first year; rear-facing car seat in back seat
- Childproofing intensifies as mobility ↑ (6+ months) — cabinet locks, outlet covers, gates
- Adhere to vaccination schedule (catch up if behind)
- Transition: solids at 6 mo · whole milk at 1 yr · self-feeding skills
Immunizations
Birth: HepB #1
2 mo: HepB #2, DTaP, Hib, IPV, PCV13, RV
4 mo: DTaP, Hib, IPV, PCV13, RV
6 mo: HepB #3, DTaP, Hib, IPV, PCV13, RV; annual flu starting 6 mo
12 mo: MMR, Varicella, HepA, PCV13 (booster), Hib (booster)
Document responses; check for contraindications before each visit.
Health Screening
- Well-child visits: 1 wk, 1 mo, 2 mo, 4 mo, 6 mo, 9 mo, 12 mo
- Length, weight, head circumference plotted at each visit
- Newborn screening (blood spot) within 24–48 hr of birth
- Hearing screening before discharge
- Vision/red reflex at each visit
- Hemoglobin at 9–12 mo (iron deficiency)
- Lead screening per state guidelines
- Developmental screening (e.g., ASQ) at 9 mo
- Dental visit by 1 yr
Nutrition
- Breast milk or iron-fortified formula exclusively for first 6 months
- Vitamin D 400 IU/day for all breastfed infants from birth
- Iron supplement for breastfed infants 4 mo+ if not getting iron from solids
- Introduce solids at 6 mo: single-ingredient iron-fortified cereal first; advance one new food at a time every 3–5 days
- Avoid honey before 1 yr (botulism risk)
- Avoid cow's milk before 1 yr (iron deficiency, GI bleeding)
- Choking hazards to avoid: hot dogs, hard candy, whole grapes, popcorn, nuts
- Whole milk from 1–2 yr, then transition to lower-fat
Injury Prevention
Sleep safety:
- "Back to sleep" — supine for sleep (SIDS prevention)
- Firm mattress; no soft bedding, blankets, pillows, stuffed animals
- Room-share without bed-share for first 6+ months
Transportation:
- Rear-facing car seat in back seat until at least age 2 (longer if possible)
- Never leave child unattended in vehicle
Home safety:
- Childproofing as mobility ↑ (cabinet locks, outlet covers, gates)
- Hot water heater < 120°F
- Smoke and CO detectors
- Constant supervision near water (drowning prevention)
- Lock medications; post Poison Control number
Physical Development
Growth:
- Weight gain ~5 lb/year
- Height: 2–3 inches/year
- Body more proportionate (longer limbs)
- 20 deciduous teeth (all in by age 3)
- Loss of first deciduous teeth around age 6
Gross motor:
- 3 yr: rides tricycle, alternates feet up stairs, jumps in place
- 4 yr: skips, hops on one foot, throws ball overhand, descends stairs alternating feet
- 5 yr: skips alternating feet, jumps rope, balances on alternating feet
Fine motor:
- 3 yr: copies circle, builds tower of 9 blocks, dresses self with supervision
- 4 yr: copies cross, uses scissors, dresses self independently
- 5 yr: copies square, prints name, ties shoelaces (5–6 yr), uses fork
Cognitive Development
Piaget: Preoperational stage (2–7 yr)
- Magical thinking, animism (inanimate objects have feelings)
- Egocentric thinking — everything is from own perspective
- Centration — focuses on one feature at a time
- Cannot conserve (mass, volume, number)
- Transductive reasoning — links unrelated events
- Symbolic thinking, pretend play
Language:
- 3 yr: 3–4 word sentences; vocabulary 900 words; asks "why?"
- 4 yr: complete sentences; 1500 words; tells stories
- 5 yr: 2100+ words; uses past/present/future tense; tells age and address
Concept of death: sees as temporary, reversible (magical thinking).
Psychosocial Development
Erikson: Initiative vs. Guilt — child takes initiative, develops sense of purpose; guilt if criticized or restricted.
Behaviors:
- Fears: dark, monsters, abandonment, body mutilation
- Imaginary friends (developmentally normal)
- Beginning to share, take turns
- Sex play / masturbation may emerge — handle with redirection, not shame
- Gender identity awareness
- Moral development: external rules; punishment-avoidance focus (Kohlberg preconventional)
Age-Appropriate Activities
Associative play — plays with others, different activities but no rules or formal organization.
Cooperative play emerges late preschool — organized play with rules (simple).
Favorite activities:
- Dress-up, role play (doctor, teacher, parent)
- Pretend play with dolls, action figures
- Tricycle, bicycle with training wheels
- Simple board games, puzzles
- Coloring, painting, drawing
- Sandbox, water play
- Reading aloud (still important)
- Songs, simple dances
Health Promotion
- Kindergarten readiness — social skills, basic literacy/numeracy, ability to follow directions
- 4–6 yr immunization boosters: DTaP, IPV, MMR, Varicella before school entry
- Annual vision/hearing screening (objective testing now possible)
- Safety teaching: car seat → booster after 4 yr, bike helmets, water safety, stranger awareness, "good touch/bad touch"
- Magical thinking and imaginary friends are developmentally normal
- Fears (dark, monsters, body mutilation) common — validate, don't dismiss
- Dental every 6 mo; encourage independence with self-care
Immunizations
4–6 yr visit (the "kindergarten boosters"):
- DTaP #5
- IPV final dose
- MMR #2
- Varicella #2
Annual influenza vaccine from 6 mo onward.
Check immunization status before school entry. Many states require documentation for kindergarten registration.
Health Screening
- Well-child visits: annually 3 yr through 6 yr
- Height, weight, BMI plotted
- Blood pressure annually starting at 3 yr
- Vision and hearing screening annually (objective testing now possible)
- Lead screening per state guidance
- Dental visits every 6 mo — first dental exam should already have occurred by age 1
- Pre-school readiness assessment (around age 5)
- Developmental and behavioral screening
Nutrition
- Calorie needs: 1200–1400 kcal/day
- Appetite less than toddler; food jags continue (eating one food for days)
- 3 meals + 2 healthy snacks/day
- Limit cow's milk to 16–24 oz/day
- Limit juice to 4–6 oz/day
- Avoid sweetened beverages
- Encourage variety; allow choice
- Family meals important
- Choking hazards still: whole grapes, hot dogs, hard candy, popcorn, nuts
Injury Prevention
Car safety:
- Forward-facing with harness; booster after age 4 (per height/weight)
- Bike helmet always
Water safety: never alone; swim lessons; pool fence; life vests on boats.
Other safety teaching:
- Sun protection (sunscreen, hat)
- Stranger awareness without instilling fear
- Fire safety: stop, drop, roll; smoke detector test monthly
- Gun safety: store unloaded, locked, separate from ammunition
- Bike, pedestrian safety
- Burns prevention
- Teach basic personal information (name, age, parent's number)
- "Good touch / bad touch" body safety
Physical Development
Growth: slow, steady ("calm before adolescent spurt")
- Weight: 5–7 lb/year
- Height: 2 inches/year
- Growth spurts often precede puberty (girls ~10, boys ~12)
- Permanent teeth begin emerging at ~age 6; all permanent in by ~age 12 (except wisdom)
- Improved coordination, strength, endurance
- Fine motor skills refined
Gross motor: riding bike confidently, skipping, jumping rope, swimming, throwing/catching/kicking with accuracy.
Fine motor: writing (cursive in older), typing, crafts, building models, musical instruments.
Cognitive Development
Piaget: Concrete Operations (7–11 yr)
- Logical thinking about concrete situations
- Conservation — understands volume/mass/number stay same despite appearance
- Reversibility — can mentally reverse actions
- Classification and serialization
- Decentered thinking — considers multiple features
- Cause-and-effect reasoning
- Less egocentric
- Cannot yet think abstractly (formal operations comes later)
Moral (Kohlberg): Conventional level — rules based on what authorities say; "good boy/good girl"; seeks approval.
Concept of death: by age 9–10 understands death is permanent, universal, irreversible.
Psychosocial Development
Erikson: Industry vs. Inferiority — develops sense of competence through achievement and mastery; feels inferior if unsuccessful.
Hallmarks:
- Peer relationships paramount; same-sex friendships
- Develops sense of justice, fairness
- Self-esteem ties to school performance, sports, social standing
- "Best friends" relationships intense
- Collections, clubs, secret codes common
- Increased independence from family
- Bullying concerns — assess proactively
Age-Appropriate Activities
Cooperative play with rules. Loves group activities, organized sports, scouts, clubs.
Favorite activities:
- Organized sports (T-ball, soccer, gymnastics, dance)
- Board games, card games (likes rules, fairness)
- Video games (limit screen time)
- Crafts, model building, collecting (rocks, cards, stickers)
- Reading independently
- Music and art classes
- Outdoor play (bikes, jump rope, hopscotch)
- Sleepovers, parties (age-appropriate)
Health Promotion
- Anticipatory guidance: school adjustment, peer relationships, bullying prevention, growing independence
- 11–12 yr tween vaccines: Tdap, HPV series (start at 9–11), Meningococcal MCV4
- Sports safety — helmets, mouth guards, sports physicals; watch for overuse injuries
- Mental health screening — assess for anxiety, depression, school avoidance; ask about bullying
- Healthy habits: 60+ min activity daily, limit screen time, balanced nutrition, adequate sleep
- Scoliosis screening (10–12 yr); annual vision; dental every 6 mo
- Begin basic sex education; gun and internet safety
Immunizations
11–12 yr visit:
- Tdap booster (one dose)
- HPV series — start at 9–11 yr; 2 doses if started before 15 yr, 3 doses if started after
- Meningococcal MCV4 (first dose)
Annual influenza vaccine.
Catch up any missing childhood immunizations.
Health Screening
- Well-child visits annually
- Height, weight, BMI, BP at each visit
- Vision and hearing annually (especially before school year)
- Scoliosis screening 10–12 yr
- Dental visits every 6 mo
- Lipid screening per AAP (universal 9–11 yr)
- School performance/learning disability screening
- Mental health screening (depression, anxiety) — particularly with peer concerns
- Tanner stage assessment as puberty approaches
Nutrition
- Calorie needs: 1600–2200 kcal/day (varies by activity)
- Balanced meals; family meals remain important
- Pack lunch from home if school lunch concerns
- Calcium: 3 servings/day (bone growth)
- Iron especially in pre-pubertal girls (menstruation begins)
- Limit sweetened beverages, fast food
- Watch for emerging eating disorders (especially in girls 10+)
- Healthy snacking; avoid skipping meals
- Limit juice; encourage water
Injury Prevention
Transportation:
- Bike helmet always; reflective gear
- Sports gear: mouth guards, helmets, pads
- Booster seat until 4'9" tall AND 8–12 yr
- Pedestrian safety; walk-to-school routes
Activity: 60+ min physical activity daily; limit recreational screen time (< 2 hr/day).
Sports injuries common (overuse, growth-plate injuries) — encourage skill development over winning.
Safety teaching:
- Internet safety; no personal info online
- Gun safety: store unloaded, locked, separate from ammunition
- Fire safety; escape plan
- Water safety: never alone; supervise
- Stranger safety; predator awareness
- Anti-bullying skills
- Begin basic sex education
Physical Development
Growth spurt:
- Females: 8–14 yr (peaks Tanner stages 2–3, age 11–12). Reach mature height ~2 yr after menarche.
- Males: 10–16 yr (peaks Tanner stages 3–4, age 13–14). May grow until 18–20.
Tanner stages (sexual maturity ratings 1→5):
- Female: breast development → pubic hair → menarche (avg age 12; typically AFTER peak height velocity)
- Male: testicular enlargement → pubic hair → penile lengthening → spermarche (~13 yr)
Other: wisdom teeth emerge (17–25); voice changes (M); facial/body hair; acne; body odor (apocrine glands); increased muscle mass.
Cognitive Development
Piaget: Formal Operations (11 yr–adult)
- Abstract thinking
- Hypothetical reasoning
- Deductive logic
- Future-oriented thinking; considers possibilities, alternatives
- Metacognition — can think about thinking
- Considers others' perspectives
- Idealistic thinking; may critique social structures
Moral (Kohlberg): Post-conventional level (some adolescents) — morality based on principles, not just rules; questions authority; develops personal values.
Note: Adolescent brain not fully mature until mid-20s — risk-assessment and impulse control still developing.
Psychosocial Development
Erikson: Identity vs. Role Confusion — develops sense of self, identity, future direction; role confusion if unable to consolidate identity.
Hallmarks:
- Identity formation — exploration of who they are
- Peer relationships paramount — peer influence often outweighs parental
- Romantic and sexual relationships develop
- Career exploration begins
- Sexual orientation and gender identity may become salient
- Body image concerns common
- Increased risk-taking behavior
- Mood swings; emotional intensity
- "Personal fable" (feeling unique, invincible) and "imaginary audience"
Age-Appropriate Activities
Largely peer-driven. Activities chosen to align with peer group and emerging identity.
Typical activities:
- Organized sports, dance, cheerleading
- Music (band, choir, lessons)
- Drama, art, journalism
- Clubs, student government
- Volunteer work, service trips
- Part-time employment (especially older adolescents)
- Social media, gaming, video content (manage screen time)
- Dating, group hangouts, parties
- Driving (with graduated licensing)
Encourage activities that build mastery and identity.
Health Promotion
- Confidentiality in care (HIPAA exceptions: suicide/homicide risk, abuse, communicable disease)
- Sexual health: contraception, STI prevention/screening, consent, healthy relationships; Pap starts at 21
- Mental health screening annually — depression, anxiety, suicide risk (ask directly), eating disorders
- Substance use: CRAFFT or similar screening; alcohol, marijuana, vaping, opioids, prescription misuse
- Motor vehicle safety — leading cause of death: seatbelt, no texting/impaired driving, graduated licensing
- Vaccines: complete HPV series, MenACWY booster at 16, MenB shared decision-making 16–23
- Healthy lifestyle habits to carry into adulthood; sports physicals; sun protection
Immunizations
11–12 yr (review/start):
- Tdap booster (one dose)
- HPV series — 2 doses (started < 15 yr) or 3 doses (started 15+ yr)
- Meningococcal MCV4 #1
16 yr:
- Meningococcal MCV4 booster
- Meningococcal B (MenB) — shared clinical decision-making, ages 16–23
Annual influenza vaccine.
COVID-19 vaccine per current recommendations.
Health Screening
- Well visits annually
- Height, weight, BMI, BP at each visit
- Vision and hearing as needed
- Scoliosis screening (girls 10–12, boys 13–14)
- Sexual health: STI screening for sexually active (chlamydia/gonorrhea annually in sexually active females ≤25; HIV at least once 15–18 yr)
- Pap smear: begin at 21 yr (not earlier)
- Mental health screening annually — depression, anxiety, suicidal ideation
- Substance use screening — CRAFFT or similar
- Dental visits every 6 mo; orthodontic evaluation
- Sports physical annually if competing
- Lipid screening once 17–21 yr
Nutrition
- Calorie needs: 2000–3000 kcal/day (highest during growth spurt)
- Iron especially important (menstruation, growth)
- Calcium ~1300 mg/day (bone development critical — peak bone mass)
- Vitamin D, folate (folate critical for sexually active females)
- Watch for eating disorders (anorexia, bulimia, binge eating disorder)
- Watch for skipping meals, dieting fads
- Encourage family meals when possible
- Hydration; limit sugary drinks, energy drinks
- Caffeine intake awareness (sleep, anxiety)
Injury Prevention
Motor vehicle — leading cause of death in adolescents:
- Seatbelt always
- NO texting/phone use while driving
- NO driving under the influence
- Graduated driver's license recommended (limit passengers, night driving)
Substance use prevention: alcohol, marijuana, prescription misuse, vaping/e-cigarettes, opioids — discuss confidentially.
Other safety:
- Firearm safety — leading method in adolescent suicide
- Suicide screening — ask directly; means restriction
- Internet/social media safety; cyberbullying; sexting consequences
- Helmet use (bike, skateboard, motorcycle)
- Sun protection (rising melanoma risk)
- Activity: 60+ min daily; sports physicals; avoid overuse injuries; strength training appropriate with supervision after 12 yr
- Sexual health: contraception, STI prevention, consent, healthy relationships
Expected Pharmacological Action
Positive inotrope (↑ force of myocardial contraction); negative chronotrope (↓ heart rate); slows AV node conduction.
Therapeutic Use
- Heart failure (CHF)
- Supraventricular tachydysrhythmias
- Cardiomyopathy
Complications
Digoxin toxicity (most important concern):
- Early signs: nausea, vomiting, anorexia, bradycardia
- Other: visual disturbances (halos, yellow-green), dysrhythmias, lethargy
- Narrow therapeutic window: 0.8–2 ng/mL
- Antidote: digoxin immune Fab (Digibind)
Contraindications/Precautions
- Hypersensitivity
- Ventricular fibrillation
- Heart block (without pacemaker)
- Caution with renal impairment, hypokalemia, hypothyroidism
Interactions
- Hypokalemia ↑ toxicity risk — diuretics, corticosteroids potentiate
- Quinidine, verapamil, amiodarone ↑ digoxin levels
- Antacids ↓ absorption
Evaluation of Medication Effectiveness
- Improved cardiac output: ↑ urine output, ↓ peripheral edema, ↓ dyspnea
- HR within target range
- Adequate weight gain in infants
- Improved feeding tolerance
- No signs of toxicity
Medication Administration
- PO or IV (rarely IM in peds)
- Pediatric dose: based on weight (microgram dosing)
- Use calibrated dropper or oral syringe
- Give 1 hr before or 2 hr after meals (better absorption)
- Do not mix with other medications or foods
Nursing Interventions
- Count apical pulse for full 1 minute BEFORE every dose
- Hold and notify provider if HR <: infants < 90–110, children < 70, adolescents < 60 bpm
- Monitor digoxin levels, potassium, BUN/creatinine
- Recognize toxicity signs early
- Verify dose with 2 nurses (high-alert medication)
Client Education
- Give at same time daily
- If dose missed, give within 4 hr or skip — never double dose
- If child vomits within 15 min, do NOT re-administer
- Don't mix with food or fluids; give in mouth (cheek)
- Report signs of toxicity immediately
- Keep medication in safe location (looks like candy)
Expected Pharmacological Action
Replaces endogenous insulin; promotes cellular uptake of glucose; promotes glycogen, fat, and protein synthesis; inhibits gluconeogenesis and lipolysis.
Therapeutic Use
- Type 1 diabetes mellitus (lifelong replacement)
- Type 2 diabetes when other therapies inadequate
- Diabetic ketoacidosis (DKA — IV regular insulin)
- Hyperkalemia (with dextrose)
Complications
- Hypoglycemia — most common; shakiness, sweating, tachycardia, confusion, seizure
- Lipodystrophy at injection sites (rotate sites)
- Weight gain
- Local injection site reactions
- Somogyi effect (rebound morning hyperglycemia from nocturnal hypoglycemia)
- Dawn phenomenon (early-morning hyperglycemia)
Contraindications/Precautions
- Hypoglycemia
- Hypersensitivity to a specific insulin product
Interactions
- Beta-blockers may MASK hypoglycemia symptoms
- Corticosteroids, thiazides ↑ blood glucose (may need ↑ insulin)
- Alcohol potentiates hypoglycemia
- Salicylates potentiate hypoglycemia
Evaluation of Medication Effectiveness
- Blood glucose within target range (varies by age)
- HbA1c < 7.5% (pediatric goal)
- No frequent hypo- or hyperglycemia
- Normal growth and development
- Absence of ketones
Medication Administration
Types:
- Rapid (lispro/Humalog, aspart/NovoLog): onset 15 min, peak 30–90 min
- Short (regular): onset 30 min, peak 2–3 hr
- Intermediate (NPH): onset 1–2 hr, peak 4–12 hr
- Long (glargine/Lantus, detemir/Levemir, degludec/Tresiba): no peak, 24 hr
Routes:
- SQ injection (preferred) — abdomen fastest, then arm, thigh, buttock
- IV (regular insulin only) for DKA
- Insulin pump (CSII)
Mixing: Draw clear (regular/rapid) BEFORE cloudy (NPH). Do not mix glargine with anything.
Nursing Interventions
- Verify dose with 2 nurses (high-alert)
- Check blood glucose before administration
- Rotate injection sites within same anatomic area
- Refrigerate unopened vials; store opened at room temp 28 days
- Do not freeze or shake vigorously
- Monitor for hypoglycemia (most common acute complication)
Client Education
- Carbohydrate counting and insulin-to-carb ratio
- Recognize and treat hypoglycemia (15-15 rule: 15 g fast-acting carb, recheck in 15 min)
- Glucagon emergency injection for severe hypoglycemia
- Sick day rules: never stop insulin, check glucose and ketones q2–4 hr, hydrate
- Site rotation to prevent lipodystrophy
- Adjust insulin for exercise (may need carb snack)
- Wear medical alert ID
Expected Pharmacological Action
Selectively stimulates beta-2 adrenergic receptors in bronchial smooth muscle → bronchodilation; rapid onset (5–15 min), duration 3–6 hours.
Therapeutic Use
- Rescue treatment of acute bronchospasm in asthma
- Exercise-induced bronchoconstriction (15 min before activity)
- Bronchospasm in COPD, bronchiolitis (trial use)
- Hyperkalemia (drives K into cells)
Complications
- Tachycardia, palpitations
- Tremor, jitteriness, nervousness
- Headache
- Hypokalemia (with high doses)
- Hyperglycemia
- Cough, throat irritation
- Paradoxical bronchospasm (rare)
Contraindications/Precautions
- Hypersensitivity
- Caution: cardiovascular disease, hyperthyroidism, diabetes, seizure disorder
Interactions
- Beta-blockers — antagonize effect
- Diuretics — ↑ hypokalemia risk
- MAO inhibitors, TCAs — ↑ cardiovascular effects
- Digoxin — risk of arrhythmias
Evaluation of Medication Effectiveness
- Improved breath sounds (resolved wheezing)
- Decreased work of breathing
- ↑ SpO₂
- ↑ peak flow
- ↓ symptoms
- ↓ rescue inhaler use over time (with good asthma control)
Medication Administration
Routes:
- MDI (metered-dose inhaler) with spacer — preferred for most children; 2–4 puffs q4–6h PRN
- Nebulizer: 0.083% solution 2.5 mg in 3 mL NS over 5–15 min
- Oral (rarely used — more side effects, less effective)
- IV (severe exacerbation only — rare in peds)
MDI Technique:
- Shake inhaler
- Attach spacer
- Exhale fully
- Place mouthpiece in mouth (or mask over face for young child)
- Actuate and inhale slowly over 3–5 seconds
- Hold breath 10 seconds
- Wait 1 minute between puffs
- Rinse mouth if combined with steroid
Nursing Interventions
- Auscultate lungs before and after administration
- Monitor pulse, BP, respiratory rate
- Pre-treatment SpO₂
- Encourage use BEFORE inhaled corticosteroid (opens airways for steroid delivery)
- Monitor for response (improved breath sounds, ↓ work of breathing, ↑ SpO₂)
- Verify proper inhaler technique frequently
- Watch for tremor, tachycardia
Client Education
- Use ONLY when needed — not as daily controller
- Frequent need (> 2× per week) means asthma not well controlled — see provider
- If using before exercise, take 15 minutes prior
- Proper inhaler/spacer technique
- Clean inhaler weekly
- Track use (rescue inhaler) — write down or use app
- Always carry rescue inhaler
- Replace when empty (count actuations, expiration date)
- Expected side effects: shakiness, fast heartbeat (usually resolves quickly)
- Report: persistent symptoms, worsening despite use
Expected Pharmacological Action
Provides exogenous pancreatic enzymes (lipase, amylase, protease) to replace deficient endogenous enzymes → enables digestion and absorption of fats, carbohydrates, and proteins.
Therapeutic Use
- Cystic fibrosis with pancreatic insufficiency
- Chronic pancreatitis
- Pancreatectomy
- Other malabsorption conditions
Complications
- Constipation
- Diarrhea
- Abdominal cramps, nausea
- Hyperuricemia (high doses)
- Fibrosing colonopathy (very high doses — rare)
- Perianal irritation in infants if capsule contents on skin
Contraindications/Precautions
- Hypersensitivity to porcine protein (most products are porcine-derived)
- Acute pancreatitis (active inflammation)
Interactions
- Iron supplements (may decrease iron absorption)
- Calcium and magnesium-containing antacids (may decrease enzyme effectiveness)
- Not significant clinically with most medications
Evaluation of Medication Effectiveness
- Normal stool consistency, less frequent
- ↓ steatorrhea (greasy, foul-smelling stools)
- ↑ weight gain (especially with high-calorie diet)
- Improved growth and development
- ↓ abdominal cramping
- Improved nutritional status (fat-soluble vitamin levels)
Medication Administration
Critical points:
- Give with EVERY meal AND snack containing fat or protein
- Dose based on age, weight, fat content of meal (usually 500–2500 units lipase/kg/meal)
- Start with first bite of food
- DO NOT crush, chew, or break capsules (enteric-coated to protect enzymes from stomach acid)
- For young children: open capsule, sprinkle contents on SMALL amount of NON-PROTEIN food (applesauce, yogurt) — DO NOT mix with large amount or hot food
- Don't hold contents in mouth (ulceration risk)
- Drink water after
- If meal > 30 minutes, may give half dose at start, half mid-meal
Nursing Interventions
- Verify dose is appropriate for fat content of meal
- Monitor stools (should normalize: less greasy, less frequent, less foul)
- Monitor weight and growth
- Educate family on administration
- Assess for perianal irritation in infants
- Ensure adequate hydration
- Coordinate with dietitian on caloric and fat intake
Client Education
- MUST take with all meals and snacks containing fat
- Do NOT crush, chew, or break capsules
- For young children: open capsule, sprinkle on small amount of applesauce (acidic, non-protein)
- Do NOT mix with milk, ice cream, or hot food
- Have water available; encourage drinking after
- Start with first bite of food
- Travel with extra supply (especially when eating out)
- Expected: normal-appearing stools (not greasy or foul)
- Report: ↑ steatorrhea, weight loss, abdominal pain
- Wipe mouth/wash hands after to prevent skin irritation
Expected Pharmacological Action
Increases release and blocks reuptake of dopamine and norepinephrine in the CNS → enhanced focus, attention, impulse control.
Therapeutic Use
- Attention-deficit/hyperactivity disorder (ADHD) — most common
- Narcolepsy
Complications
- Appetite suppression, weight loss — most common
- Growth suppression (long-term — height/weight)
- Insomnia, sleep disturbance
- Headache, irritability
- Tachycardia, hypertension
- Tics (caution in family history of Tourette)
- Anxiety, jitteriness
- Dependence/abuse (Schedule II controlled substance)
- Rare: psychosis, mania, suicidal ideation
Contraindications/Precautions
- Cardiovascular disease, structural heart abnormalities
- Hyperthyroidism
- Glaucoma
- History of substance abuse
- Concurrent MAOI use (or within 14 days)
- Severe anxiety, agitation
- Tourette syndrome (caution)
Interactions
- MAOIs — hypertensive crisis (contraindicated)
- Antihypertensives — antagonized
- TCAs — increased levels
- SSRIs — increased levels
- Anticonvulsants — increased levels
- Caffeine — additive stimulant effect
Evaluation of Medication Effectiveness
- Improved attention, focus
- ↓ hyperactivity, impulsivity
- Improved academic performance
- Better social interactions
- Maintained or improved growth (with appropriate monitoring)
- No significant adverse effects
Medication Administration
- Schedule II controlled substance — strict prescribing rules
- PO; immediate-release (multiple daily doses) or extended-release (single daily dose)
- Give morning and noon (avoid late doses → insomnia)
- Extended-release: take WHOLE; do NOT crush or chew
- Can be given with or without food (but food helps minimize GI upset)
- "Drug holidays" sometimes used on weekends/summer to mitigate growth suppression (controversial)
Nursing Interventions
- Cardiovascular screening before starting (HR, BP, family history of sudden cardiac death)
- Baseline height, weight, BP, HR; monitor at each visit
- Growth charts — plot at every visit
- Sleep assessment
- Mental status, mood, behavior
- Educate family on side effects and monitoring
- Coordinate with school (medication during school hours, behavior observation)
- Secure storage (controlled substance, abuse potential)
Client Education
For child/family:
- Take in morning (AM and noon if immediate-release); not after 4 PM (insomnia)
- Take with breakfast (helps with appetite)
- Encourage nutrient-dense meals before medication kicks in (breakfast, after-school snack, dinner)
- Monitor appetite, growth
- Watch for mood/behavior changes
- Keep secure — risk of diversion
- Don't share or sell — illegal
- Don't stop abruptly (some)
- Recognize concerning signs: chest pain, palpitations, vision changes, severe mood changes → call provider
- School coordination, IEP/504 plan
- Behavioral strategies alongside medication
Expected Pharmacological Action
Inhibits prostaglandin synthesis in the CNS; analgesic and antipyretic effects without significant anti-inflammatory or platelet effects.
Therapeutic Use
- Mild to moderate pain
- Fever reduction
- Post-vaccination discomfort
- Post-operative pain (in combination)
- Safer than NSAIDs in many situations (no GI bleed risk, no platelet effect)
Complications
- Hepatotoxicity (with overdose) — most serious; can cause liver failure
- Rare: rash, blood dyscrasias
- Stevens-Johnson syndrome (rare)
- Hypotension (IV form)
Contraindications/Precautions
- Hypersensitivity
- Severe hepatic impairment
- Caution: chronic alcohol use (in older patients)
- Avoid combining with other acetaminophen products
Interactions
- Warfarin (↑ effect with regular use)
- Alcohol (↑ hepatotoxicity)
- Other hepatotoxic drugs
- Carbamazepine, phenytoin (↑ hepatotoxicity)
Evaluation of Medication Effectiveness
- Decreased pain (pain scale)
- Reduced fever (rechecked 30–60 min after dose)
- Improved comfort, sleep, activity
- No signs of hepatotoxicity
Medication Administration
Pediatric dosing:
- 10–15 mg/kg/dose PO/PR q4–6h
- Max: 75 mg/kg/day (not to exceed 4 g/day in adolescents)
- Available: liquid, chewable tablets, suppositories, IV (Ofirmev)
- Always use weight-based dosing in children, NOT age-based
- Use correct measuring device (oral syringe, not kitchen spoon)
- Check formulation strength carefully (infant drops vs children's liquid have different concentrations — now standardized to 160 mg/5 mL)
Nursing Interventions
- Verify weight-based dosing
- Check for other acetaminophen products (combination cold medicines)
- Monitor temperature, pain response
- Assess for liver dysfunction with chronic use (LFTs)
- Antidote for overdose: N-acetylcysteine (Mucomyst)
- Recognize signs of toxicity: nausea, vomiting, diaphoresis, RUQ pain, jaundice, confusion
Client Education
- Always use weight-based dosing, not age
- Use the measuring device that comes with the product
- Read labels carefully — many cold medicines contain acetaminophen
- Do NOT exceed maximum dose in 24 hours
- Space doses at least 4 hours apart
- Keep out of reach of children (overdose dangerous)
- If overdose suspected: call Poison Control immediately (1-800-222-1222)
- Don't use in infants < 3 months without provider approval
- Avoid alcohol when on regular acetaminophen
- Generic equally effective
Expected Pharmacological Action
Replaces iron stores; iron is essential for hemoglobin synthesis and oxygen transport. Heme iron from animal sources better absorbed; non-heme iron requires vitamin C for optimal absorption.
Therapeutic Use
- Iron deficiency anemia
- Prophylaxis in high-risk infants (preterm, exclusively breastfed > 4 months)
- Adolescent menstruating females
- Athletes
Complications
- GI upset, nausea, abdominal cramps
- Constipation (most common) OR diarrhea
- Black/tarry stools (EXPECTED — not bleeding)
- Teeth staining (liquid form)
- OVERDOSE: leading cause of pediatric poisoning death — small amounts can be lethal
- Toxicity signs: nausea, vomiting, abdominal pain, hematemesis, melena, hypotension, shock, hepatic failure, metabolic acidosis
Contraindications/Precautions
- Hypersensitivity
- Hemochromatosis, hemosiderosis
- Hemolytic anemias not associated with iron deficiency
- Active peptic ulcer disease
Interactions
- ↓ absorption: antacids, milk/dairy, tea, coffee, tetracyclines, quinolones
- ↑ absorption: vitamin C (ascorbic acid)
- Levothyroxine — separate by 4 hr
- Decreased absorption of fluoroquinolones
Evaluation of Medication Effectiveness
- Increased reticulocyte count (1 week)
- Increased Hgb, Hct (3–4 weeks)
- Increased ferritin
- Resolution of symptoms: ↓ fatigue, improved color
- Improved cognitive function, appetite
Medication Administration
Dose:
- 3–6 mg/kg/day elemental iron PO divided BID-TID
- Various preparations have different elemental iron content (ferrous sulfate ~20%, ferrous gluconate ~12%, ferrous fumarate ~33%)
Administration tips:
- Give between meals (1 hour before or 2 hours after) for best absorption
- If GI upset, give with food (slightly reduces absorption but improves tolerance)
- Give with vitamin C source (orange juice) to enhance absorption
- Avoid with milk, dairy, tea, coffee, antacids — reduce absorption
- Liquid form: use a straw or dropper at back of mouth; brush teeth after (prevents staining)
- Brush teeth after liquid dose
- Don't mix with antacids
Nursing Interventions
- Verify dose appropriate for weight
- Educate on correct administration
- Monitor CBC: reticulocyte ↑ in 1 week; Hgb begins to rise in 1–2 weeks, normalizes 4–8 weeks
- Continue therapy 2–3 months AFTER Hgb normalizes (replenish stores)
- Monitor stool (should be black/tarry — expected; if also bloody, that's different)
- Address constipation (↑ fluids, fiber, stool softener)
- Watch for overdose signs in family
- Antidote: deferoxamine (chelation)
Client Education
- KEEP OUT OF REACH OF CHILDREN — childproof bottle, locked cabinet
- Black/tarry stools are EXPECTED — not bleeding
- May cause constipation — increase fluids and fiber
- Take between meals for best absorption
- Take with vitamin C (orange juice) to boost absorption
- AVOID giving with milk, dairy, tea, coffee, antacids — reduce absorption
- Use straw for liquid; brush teeth after
- Foods rich in iron: red meat, fish, poultry, beans, lentils, iron-fortified cereals, spinach, dried fruits
- Continue iron 2–3 months after blood count normalizes
- Recognize overdose: nausea, vomiting, abdominal pain — call Poison Control IMMEDIATELY
- Limit cow's milk in toddlers (< 24 oz/day) to prevent iron deficiency
Expected Pharmacological Action
Synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive effects. Suppresses inflammation, immune response, and adrenal cortex function (with long-term use).
Therapeutic Use
- Nephrotic syndrome (induction and maintenance)
- Asthma exacerbations
- Inflammatory bowel disease
- Autoimmune disorders (JIA, lupus)
- Allergic reactions, anaphylaxis
- Croup (single dose)
- Some malignancies (ALL induction)
- Organ transplant rejection prevention
Complications
Short-term:
- Mood changes (euphoria, irritability, depression)
- Insomnia
- Increased appetite, weight gain
- Hyperglycemia
- GI upset
- Acne
Long-term (cumulative):
- Growth suppression (concern in children)
- Cushingoid features: moon face, buffalo hump, truncal obesity, striae
- Osteoporosis, fractures
- Hypertension
- Cataracts, glaucoma
- Increased infection risk (immunosuppression)
- Adrenal suppression
- Avascular necrosis of bone
- Hypokalemia
- Skin thinning, easy bruising
- Hyperglycemia → diabetes
- Psychiatric symptoms
- Cataracts
Contraindications/Precautions
- Systemic fungal infections
- Live virus vaccines (during treatment)
- Caution: peptic ulcer, diabetes, hypertension, infections, osteoporosis, psychiatric conditions
Interactions
- NSAIDs — ↑ GI bleeding risk
- Potassium-wasting diuretics — additive hypokalemia
- Vaccines (live attenuated — avoid)
- Anticoagulants — varied effect
- Diabetic medications — ↓ effect (hyperglycemia)
- Phenytoin, rifampin, carbamazepine — ↓ prednisone levels
- Macrolides — ↑ prednisone levels
Evaluation of Medication Effectiveness
- Disease-specific improvement (e.g., resolution of proteinuria in nephrotic syndrome, decreased asthma symptoms)
- Reduced inflammation
- Minimal side effects
- Stable growth (or as expected)
- No infections
Medication Administration
- Available: tablets, oral solution, injectable (methylprednisolone)
- Give with food to reduce GI upset
- Take in the morning (mimics natural cortisol; reduces insomnia)
- Use lowest effective dose for shortest duration
- NEVER stop abruptly after chronic use — TAPER to allow adrenal recovery
- Doses > 2 weeks generally need tapering
- Different doses for different conditions (e.g., nephrotic syndrome 2 mg/kg/day → tapered)
Nursing Interventions
- Monitor BP, weight, growth (in children)
- Monitor glucose, electrolytes (especially K)
- Watch for signs of infection (may be masked)
- Educate about avoiding sick contacts
- Mood monitoring
- Bone health: calcium, vitamin D supplementation; weight-bearing exercise
- GI protection (PPI or H2 blocker, especially with NSAIDs)
- Never discontinue abruptly — adrenal crisis risk
- Stress dosing for surgery, illness
- Medical alert ID for chronic users
- Annual eye exams (cataracts, glaucoma)
Client Education
- Take with food, preferably in the morning
- Never stop suddenly — must taper
- Expected side effects: mood changes, weight gain, increased appetite, sleep changes
- Long-term: may slow growth in children, weakened bones
- Avoid live vaccines (MMR, varicella, FluMist) during treatment
- Avoid contact with people with chickenpox or measles
- Get inactivated flu vaccine yearly
- Recognize infection signs (fever, redness, fatigue) — may be subtle
- Adequate calcium and vitamin D intake
- Weight-bearing exercise to protect bones
- Increased thirst, urination, hunger — could be hyperglycemia
- Avoid NSAIDs unless prescribed
- Wear medical alert ID for chronic use
- Stress doses needed for surgery, infections, injuries
- Watch for stretch marks, easy bruising, slow healing
Expected Pharmacological Action
Powerful adrenergic agonist; activates alpha and beta receptors. Effects: bronchodilation (β2), vasoconstriction (α1), increased heart rate and contractility (β1), and stabilization of mast cells (anti-anaphylactic).
Therapeutic Use
- Anaphylaxis — drug of choice; first-line
- Severe asthma exacerbation (sometimes)
- Cardiac arrest (resuscitation)
- Nebulized racemic epinephrine — moderate-severe croup
- Topical: hemostasis, with local anesthetics
- Pediatric ALS protocols
Complications
- Tachycardia, palpitations
- Hypertension
- Tremor, anxiety
- Headache
- Pallor
- Arrhythmias (especially with high doses)
- Myocardial ischemia (older patients)
- Hypokalemia
- Hyperglycemia
- "Rebound" effect with nebulized racemic epi (croup) — watch for 2–4 hr post-dose
- Necrosis at injection site if extravasation
Contraindications/Precautions
- Almost no absolute contraindications when used for anaphylaxis (life-saving)
- Caution: cardiovascular disease, hypertension, hyperthyroidism
- Avoid IM in lateral aspect of thigh in patients with peripheral vascular disease (if alternative available)
Interactions
- Beta-blockers — antagonize effect (may need higher dose for anaphylaxis)
- Tricyclic antidepressants, MAO inhibitors — ↑ effects, hypertensive crisis risk
- Halogenated anesthetics — arrhythmia risk
- Digoxin — arrhythmias
Evaluation of Medication Effectiveness
- Anaphylaxis: improvement in BP, HR, breathing, edema, urticaria
- Asthma: improved breath sounds, ↓ wheezing
- Croup: ↓ stridor, ↓ work of breathing
- Cardiac: return of spontaneous circulation
Medication Administration
Anaphylaxis:
- IM injection into ANTEROLATERAL THIGH (vastus lateralis) — fastest absorption
- Auto-injector (EpiPen, Auvi-Q): 0.15 mg pediatric (children < 30 kg / 66 lb), 0.3 mg adult
- 1:1000 (concentration 1 mg/mL): 0.01 mg/kg, max 0.3–0.5 mg, IM/SC
- Repeat every 5–15 min as needed
Cardiac arrest:
- 0.01 mg/kg IV/IO of 1:10,000 concentration, repeat q3–5 min
Nebulized racemic epi (croup):
- 0.5 mL of 2.25% in 3 mL NS via nebulizer
- Observe 2–4 hours after (rebound)
Nursing Interventions
- For anaphylaxis: give immediately, do NOT delay
- Call 911 even after giving epinephrine
- Continuous monitoring after dose (HR, BP, respiratory)
- Recognize biphasic anaphylaxis (recurrence 1–8 hours later)
- IV access
- Position supine with legs elevated (anaphylaxis)
- Oxygen
- Other medications: H1 and H2 blockers, corticosteroids, bronchodilators (adjuncts, not replacements)
- For croup: observe at least 2 hours post-treatment
- Auto-injector teaching for patients with allergies
Client Education
For patients with anaphylaxis risk (food allergies, etc.):
- Always carry epinephrine auto-injector — TWO if possible
- Replace before expiration date (check monthly)
- Use immediately for serious allergic reaction
- Don't wait for symptoms to worsen
- Inject into outer thigh; can go through clothing
- Hold 10 seconds, count slowly
- Call 911 immediately after injection
- Go to ER even if feeling better (biphasic reaction)
- May need second dose if symptoms continue
- Sit/lie down after injection (NOT standing — blood pressure can drop)
- Side effects: shaky, fast heart rate, anxiety — normal, will pass
- Wear medical alert ID
- Action plan for school/daycare
- Train family, friends, teachers
- Avoid known allergens
- Allergy specialist for desensitization (if applicable)
Expected Pharmacological Action
Inhibits sodium and chloride reabsorption in the ascending loop of Henle → potent diuresis. Onset within minutes IV, 30–60 min PO. Lasts 2–6 hours.
Therapeutic Use
- Heart failure (pulmonary edema, fluid overload)
- Nephrotic syndrome (with severe edema)
- Hypertension
- Chronic kidney disease
- Hyperkalemia
- Hypercalcemia
- Bronchopulmonary dysplasia (BPD) — for fluid management
Complications
- Hypokalemia (most common) — can be severe
- Hyponatremia, hypochloremia
- Hypocalcemia, hypomagnesemia
- Dehydration, hypovolemia, hypotension
- Metabolic alkalosis
- Ototoxicity (with high doses or rapid IV infusion)
- Hyperglycemia
- Hyperuricemia
- Photosensitivity
- Allergic reactions (sulfonamide allergy)
- Nephrotoxicity (with aminoglycosides)
Contraindications/Precautions
- Hypersensitivity (sulfonamide cross-reactivity)
- Severe electrolyte depletion until corrected
- Anuria
- Caution: hepatic disease (electrolyte loss → encephalopathy), gout
Interactions
- Digoxin: hypokalemia → ↑ digoxin toxicity
- Aminoglycosides: ↑ ototoxicity, nephrotoxicity
- Lithium: ↑ lithium levels
- Corticosteroids: additive hypokalemia
- NSAIDs: ↓ diuretic effect
- Antihypertensives: additive hypotension
- Probenecid: ↓ diuresis
Evaluation of Medication Effectiveness
- Increased urine output
- Decreased edema
- Weight loss (1–2 lb/day in fluid overload — gradual)
- Improved breath sounds (resolution of crackles)
- Decreased BP
- Improved respiratory effort
- No electrolyte imbalances
Medication Administration
Pediatric dose:
- PO: 1–2 mg/kg/dose q6–12h (max 6 mg/kg/day)
- IV: 1 mg/kg/dose; give slowly over 1–2 min (faster causes ototoxicity)
- Continuous IV infusion in some critical care situations
Tips:
- Give in morning (or morning + early afternoon if BID) — avoids nighttime urination
- Take with food if GI upset
- Light-sensitive (protect from light)
- Adequate K intake or supplementation
Nursing Interventions
- Strict I&O
- Daily weight (same time, scale, clothing)
- Monitor BP, HR (orthostatic if ambulatory)
- Monitor electrolytes (especially K) frequently
- Monitor renal function (BUN, creatinine)
- Assess for dehydration: dry mucous membranes, ↓ skin turgor, sunken fontanel
- Assess edema, lung sounds (crackles → pulmonary edema)
- Monitor blood glucose (hyperglycemia)
- Watch for hypokalemia signs: muscle weakness, fatigue, arrhythmias, leg cramps
- Watch for ototoxicity: tinnitus, hearing changes (especially with rapid IV)
- Coordinate K supplementation or K-sparing diuretic if needed
- Educate about timing
Client Education
- Take in morning to avoid nighttime urination
- Will increase urination — plan for bathroom access
- Increase potassium intake: bananas, oranges, raisins, potatoes, beans, spinach, tomatoes, dried fruits
- Or take potassium supplement as prescribed
- Stand up slowly (orthostatic hypotension)
- Daily weight at home, same time, same scale
- Report rapid weight loss/gain (> 2–3 lbs in a few days)
- Sun protection (photosensitivity)
- Monitor for dehydration in hot weather, illness
- Recognize hypokalemia: muscle weakness, leg cramps, fatigue, irregular heartbeat
- Report ringing in ears, hearing changes
- Don't stop suddenly without provider
- Take regularly even if feeling better
- Sulfa allergy: tell all providers
Expected Pharmacological Action
Stabilizes neuronal membranes by blocking sodium channels → decreases neuronal excitability and prevents propagation of seizure activity. Narrow therapeutic range (10–20 mcg/mL).
Therapeutic Use
- Generalized tonic-clonic seizures
- Focal/partial seizures
- Status epilepticus (IV — fosphenytoin preferred for IV)
- NOT effective for absence seizures
Complications
Common:
- Gingival hyperplasia (gum overgrowth) — important in pediatrics
- Hirsutism (excess hair growth)
- Drowsiness, ataxia, confusion (dose-related)
- Nystagmus, diplopia
- GI upset, nausea
- Skin rash
Serious:
- Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) — life-threatening; check HLA-B*1502 in some populations
- Hepatotoxicity
- Blood dyscrasias (agranulocytosis, thrombocytopenia, megaloblastic anemia)
- Hypotension, bradycardia (rapid IV)
- Cardiac arrhythmias (IV)
- Purple glove syndrome (extravasation IV)
- Osteopenia/osteoporosis (long-term)
- Fetal hydantoin syndrome (teratogenic — cleft lip/palate, cardiac defects, developmental delay)
- Toxicity: nystagmus → ataxia → confusion → coma at higher levels
Contraindications/Precautions
- Hypersensitivity
- Sinus bradycardia, heart block (IV form)
- Pregnancy (teratogenic — category D)
- Caution: hepatic impairment, hypoalbuminemia (free phenytoin higher)
Interactions
- Many drug interactions! Phenytoin is potent CYP inducer
- Warfarin: variable (initial ↑, then ↓)
- Oral contraceptives: ↓ effectiveness (additional contraception needed)
- Digoxin: ↓ levels
- Folic acid: ↓ phenytoin levels (and phenytoin causes folate deficiency)
- Antacids: ↓ absorption (separate by 2 hours)
- CNS depressants: additive effects
- Carbamazepine, phenobarbital: complex interactions
- Valproate: ↑ free phenytoin
Evaluation of Medication Effectiveness
- Decreased seizure frequency and severity
- Therapeutic blood level (10–20 mcg/mL)
- No toxicity signs
- No major side effects
- Improved quality of life
Medication Administration
PO:
- 5 mg/kg/day divided BID-TID (children); titrate to therapeutic level
- Suspension: SHAKE WELL (poor mixing causes inconsistent dosing)
- Take with food (reduces GI upset)
- Separate from antacids (2 hours)
- Don't mix with G-tube/NG feedings (binds to tube feeding — must hold feeds 1 hour before and 2 hours after)
IV (use fosphenytoin preferred):
- Status epilepticus: 15–20 mg/kg loading dose
- Infuse slowly — NO faster than 50 mg/min (children: 1 mg/kg/min)
- Use 0.9% saline only (precipitates with D5W)
- Use in-line filter
- Monitor cardiac status during infusion (bradycardia, hypotension, arrhythmias)
- Large-bore IV; flush with saline
- Risk of extravasation → purple glove syndrome (severe tissue damage)
Nursing Interventions
- Monitor blood levels (therapeutic 10–20 mcg/mL)
- Monitor for toxicity signs: nystagmus, ataxia, slurred speech, confusion
- Cardiac monitoring with IV use
- Frequent vital signs
- Watch for rash → STOP DRUG (SJS risk)
- Monitor CBC, LFTs periodically
- Dental care: meticulous oral hygiene, frequent dental visits
- Reinforce importance of compliance
- NEVER discontinue abruptly — taper to prevent status epilepticus
- Pregnancy testing in adolescent females; contraception counseling
- Folic acid supplementation
- Avoid alcohol
Client Education
- Take exactly as prescribed; do NOT skip or stop without provider
- SHAKE liquid suspension well before each dose
- Take with food
- Meticulous oral hygiene — brush after meals, floss daily, regular dental visits (reduces gum overgrowth)
- May cause hirsutism (extra hair growth) — cosmetic concern
- Drowsiness common, especially initially — caution with driving (adolescents)
- If rash develops → STOP and call provider immediately (SJS risk)
- Avoid alcohol
- Avoid drug interactions — tell all providers, pharmacists
- Birth control: oral contraceptives less effective; need backup method
- Pregnancy: teratogenic — discuss with provider before conceiving
- Wear medical alert ID
- Carry medication when traveling
- Regular blood tests to check drug levels
- Don't take with antacids or feedings — separate by 2 hours
- Recognize toxicity: vision changes, unsteady walking, confusion
- Continue prenatal vitamins with folic acid (if applicable)
Expected Pharmacological Action
Inhibits ribonucleotide reductase → decreased DNA synthesis. In sickle cell disease, primary mechanism is induction of fetal hemoglobin (HbF), which inhibits sickle hemoglobin polymerization → less RBC sickling → fewer vaso-occlusive crises.
Therapeutic Use
- Sickle cell disease (disease-modifying — most common pediatric indication)
- Reduces frequency of pain crises
- Reduces acute chest syndrome episodes
- Reduces transfusion needs
- Reduces hospitalization rates
- Improves survival
- FDA-approved for SCD in adults and children ≥ 2 years
- Also used for: chronic myeloid leukemia, polycythemia vera, essential thrombocytopenia (adults)
Complications
Hematologic (most common, dose-limiting):
- Myelosuppression — neutropenia, thrombocytopenia, anemia
- Reversible with dose adjustment
Other:
- GI: nausea, vomiting, anorexia, mouth ulcers
- Skin: hyperpigmentation, rash, hair thinning
- Photosensitivity
- Headache, dizziness
- Renal: ↑ BUN, creatinine
- Hepatic: mild elevations
- Long-term concerns:
- Potential effect on fertility (males — reduced sperm count; females — possibly safe)
- Teratogenic (pregnancy category D)
- Theoretical secondary malignancy risk (no clear evidence in SCD use)
Contraindications/Precautions
- Pregnancy (teratogenic)
- Hypersensitivity
- Severe bone marrow suppression
- Caution: renal impairment, hepatic impairment
- HIV co-infection (consult specialist)
Interactions
- Other myelosuppressive drugs — additive marrow suppression
- Antiretrovirals (didanosine) — additive toxicity
- Live vaccines — avoid
Evaluation of Medication Effectiveness
- ↑ fetal hemoglobin (HbF) — usually 20–30%
- ↑ MCV (macrocytosis — expected sign of response)
- ↑ hemoglobin
- Decreased pain crises
- Decreased acute chest syndrome
- Decreased transfusion requirements
- Decreased hospitalizations
- Improved quality of life
Medication Administration
- Capsule (oral) — most common
- Liquid formulation available for children
- Starting dose typically 15–20 mg/kg/day, titrate up to maximum tolerated dose (MTD) — typically 30–35 mg/kg/day
- Take at same time each day
- With or without food
- Don't open capsules (cytotoxic — wear gloves to handle)
- Pharmacist may need to compound liquid
- Adequate hydration
Nursing Interventions
- Baseline CBC, reticulocyte count, HbF level, LFTs, renal function
- Pregnancy testing (adolescent females)
- Monitor CBC every 2 weeks initially, then every 1–3 months once stable
- Adjust dose for hematologic toxicity (hold for ANC < 1500 or platelets < 80,000)
- Monitor HbF response (typically rises in 3–6 months)
- Encourage hydration
- Photoprotection (sunscreen)
- Avoid pregnancy (both partners need contraception)
- Educate that benefits accrue over months
- Don't handle without gloves (cytotoxic)
- Avoid live vaccines
- Encourage flu vaccine (inactivated), pneumococcal vaccines
- Folate supplementation (alongside hydroxyurea for SCD)
- Continue penicillin prophylaxis until age 5 (SCD standard)
Client Education
- Hydroxyurea is a "disease-modifying" medication for sickle cell — DOES NOT cure but reduces complications
- Take EVERY day as prescribed — works best with consistent use
- Effects may not be seen for several months
- Reduces pain crises, hospitalizations, and complications
- Improves long-term outcomes
- Adequate hydration daily
- Use sunscreen (photosensitivity)
- Will need frequent blood tests — important for safety
- Don't open or crush capsules — handle with gloves; pharmacist can prepare liquid for children
- Recognize signs of marrow suppression: easy bruising, bleeding, infection, fatigue, pallor
- Report fever > 38.5°C (101.3°F) — could indicate serious infection during neutropenia
- Continue all other sickle cell care (penicillin prophylaxis, vaccines, folic acid)
- Contraception essential — teratogenic; both males and females need to avoid conception
- Adolescent males: fertility may be affected; sperm banking offered (discuss with provider)
- Don't take live vaccines
- Get annual flu vaccine, pneumococcal vaccines (inactivated)
- Pharmacy disposal of unused medication (don't flush; cytotoxic)
- Notify all providers of medication
Expected Pharmacological Action
Recombinant DNA-produced form of human growth hormone identical to pituitary GH. Stimulates linear growth, increases cell number and size in tissues, enhances protein synthesis, mobilizes fat stores, increases lean body mass, and stimulates IGF-1 production by the liver.
Therapeutic Use
- Growth hormone deficiency (pediatric and adult)
- Turner syndrome (short stature)
- Prader-Willi syndrome
- Small for gestational age (SGA) with failure to catch up by age 2-4
- Chronic renal insufficiency (prior to transplant)
- Idiopathic short stature (controversial; FDA-approved)
- SHOX gene deficiency
- Noonan syndrome
- HIV-associated wasting (adults)
- Short bowel syndrome
Complications
Common (generally well-tolerated):
- Injection site reactions
- Mild fluid retention, edema
- Headache
- Mild arthralgia, myalgia
- Carpal tunnel-like symptoms (uncommon in children)
Serious (uncommon):
- Pseudotumor cerebri (intracranial hypertension) — headache, vomiting, vision changes; need ophthalmology evaluation; usually requires dose reduction
- Slipped capital femoral epiphysis (SCFE) — hip/knee pain, limp; emergent ortho
- Worsening scoliosis in those with pre-existing
- Insulin resistance, glucose intolerance, type 2 diabetes
- Pancreatitis (rare)
- Lipoatrophy (with poor rotation)
- Tumor recurrence (concerns — current evidence does not support, but monitor)
- Antibody formation (rare clinical impact)
- Hypothyroidism may emerge
- Adrenal insufficiency may emerge (if panhypopituitarism)
Contraindications/Precautions
- Active malignancy
- Closed epiphyses (if for height purposes)
- Acute critical illness
- Active proliferative or severe non-proliferative diabetic retinopathy
- Prader-Willi syndrome with severe obesity or severe respiratory impairment (deaths reported)
- Allergy to component
- Caution: diabetes, hypothyroidism (treat first), intracranial lesion (must be stable), scoliosis
Interactions
- Glucocorticoids — may inhibit growth response of GH; if both required, balance carefully
- Insulin/oral hypoglycemics — may need dose adjustment (GH ↑ insulin resistance)
- Estrogen (oral) — may reduce GH effect
- Anticonvulsants — limited interaction
- Thyroid hormone — GH may unmask central hypothyroidism (may need T4 replacement)
Evaluation of Medication Effectiveness
- ↑ growth velocity (esp first year — typically >2× pre-treatment velocity)
- ↑ height percentile
- ↑ IGF-1 into normal range
- Eventual attainment of near-adult height in genetic potential range
- Improved body composition
- Improved quality of life and self-esteem
- No serious adverse effects
- Stable lab values
Medication Administration
- Subcutaneous injection (typically — some IM)
- Daily dose at bedtime (mimics physiologic release) — or weekly with newer long-acting formulations (Skytrofa, Sogroya)
- Sites: abdomen, thigh, upper arm, buttock — ROTATE sites to prevent lipoatrophy/lipohypertrophy
- Various pen devices or vials with syringes
- Refrigerate (some can be room temperature for short period after reconstitution)
- Don't shake vigorously (may inactivate)
- Mix gently by rolling
- Use within specified time after reconstitution
- Dose: weight-based, varies by indication (~0.16-0.35 mg/kg/week divided)
- Dose increased as patient grows
Nursing Interventions
- Baseline: height, weight, growth velocity, bone age, IGF-1, glucose, thyroid, lipids
- Endocrine evaluation completed first
- Confirm appropriate diagnosis with stim testing
- Teach injection technique to family and child (as age-appropriate)
- Monitor growth response (height every 3 months — first response is increased growth velocity in first 6-12 months)
- Adjust dose for body weight/surface area as child grows
- Monitor IGF-1 (response, dosing)
- Annual bone age
- Monitor: glucose, HbA1c, thyroid (TSH, T4), lipids periodically
- Assess for side effects: headaches, vision changes, hip/knee pain, scoliosis, edema
- Annual ophthalmology exam (pseudotumor cerebri risk)
- Hip and spine exam each visit
- Document growth velocity
- Address psychosocial impact
- Encourage adherence
- Continue until: epiphyseal closure, near-adult height, growth velocity drops < 2 cm/year, or per provider
Client Education
- Daily injections (or weekly with long-acting) until growth complete
- Treatment may continue for years
- Best results require strict adherence
- Improvement: increased growth velocity over months; final adult height varies
- Won't make child taller than genetic potential
Injection technique:
- Rotate sites (abdomen, thighs, upper arms, buttocks) each injection
- Use different site each day
- Pinch up skin (subcutaneous, not muscle)
- Insert at 45-90° per device
- Don't reuse needles
- Dispose of sharps properly
- Inject at bedtime (mimics natural rhythm)
- Refrigerate medication
- Don't shake vigorously
- Bring extra supplies when traveling; insulated bag for cold storage
Side effects:
- Mild and uncommon; report:
- Severe headache, vision changes, vomiting (pseudotumor cerebri) — emergent
- Hip or knee pain, limp (SCFE) — emergent
- Worsening spinal curvature
- Persistent injection site reactions
- Increased urination, thirst (diabetes)
- Fluid retention, edema
- Joint or muscle aches
Monitoring:
- Endocrine visits every 3-6 months
- Periodic labs (glucose, thyroid, IGF-1)
- Bone age X-rays annually
- Annual eye exam
- Monitor scoliosis if present
- School and daycare may need education about administration if midday dose
Cost/Access:
- Expensive; insurance coverage variable
- Manufacturer assistance programs available
- iPLEDGE-like programs not required (unlike isotretinoin)
Description of Skill
Administration of medication into a muscle, providing rapid absorption. Pediatric IM injections require careful site selection based on age, muscle development, and medication volume.
Indications
- Immunizations
- Medications poorly absorbed orally
- Quick effect required
- Patient unable to take PO
- Specific medications requiring IM route (vitamin K, naloxone, epinephrine)
Outcomes/Evaluation
- Medication delivered safely and effectively
- No injection-related injury (nerve, vessel damage)
- Minimal pain and trauma
- Expected medication effect achieved
- No infection at site
Nursing Interventions (pre, intra, post)
Site selection by age:
- Infants (birth – 12 mo): vastus lateralis (anterolateral thigh) — preferred; well-developed muscle, free of major vessels/nerves
- Toddlers (1–3 yr): vastus lateralis still preferred
- Children 3+ yr: deltoid (small volumes ≤ 1 mL) or ventrogluteal (preferred for larger volumes) — safer than dorsogluteal in children
- Avoid dorsogluteal in children < 3 years (sciatic nerve risk)
Needle size:
- Infant: 22–25G, 5/8 – 1 inch
- Toddler: 22–25G, 5/8 – 1 inch
- Child: 22–25G, 1 – 1.5 inches (varies by muscle size)
Volume limits:
- Infants: 0.5 mL/site
- Toddlers: 0.5–1 mL/site
- Children 3+ yr: 1–2 mL/site
- Adolescents: 1.5–3 mL/site (deltoid max 1 mL, vastus lateralis up to 5 mL)
Technique:
- Verify 10 rights of medication administration
- Apply EMLA cream 30–60 min before (atraumatic care) if not emergent
- Use a 90° angle (perpendicular to muscle)
- Stabilize site with non-dominant hand
- Quick insertion
- Aspirate is NOT routinely required for vaccines or vastus lateralis/deltoid sites per CDC
- Inject slowly; withdraw quickly
- Apply pressure (don't massage if Z-track)
- Cover with small bandage
- Comfort and praise child
Potential Complications
- Pain at injection site
- Bruising, hematoma
- Bleeding
- Infection (rare with sterile technique)
- Nerve injury (sciatic if dorsogluteal in child)
- Muscle damage if same site used repeatedly
- Anaphylaxis (especially vaccines)
- Vasovagal response in older children/adolescents
Nursing Interventions
- Monitor for bleeding (assess site, vital signs, Hgb/Hct); apply pressure as indicated; notify provider for hemodynamic instability
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Assess pain (location, character, scale) frequently; administer ordered analgesia; reposition for comfort
- Assess for allergic reaction (rash, urticaria, dyspnea); have epinephrine, oxygen, and emergency equipment at bedside
- Implement fall precautions; bed in low position; call light in reach; assess fall risk regularly
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Explain procedure honestly to age-appropriate level
- Use comfort positioning (parent's lap, hugging position)
- EMLA cream can reduce pain
- Distraction techniques (bubbles, music, tablet)
- Praise child afterward
- Sticker or small reward
- Don't lie about pain ("just a pinch")
- Apply ice or warm pack for soreness after
- Monitor for vaccine side effects (fever, fussiness, redness)
- Report immediately: difficulty breathing, severe swelling, persistent crying
Description of Skill
Modified IM injection technique used to prevent medication from leaking back into subcutaneous tissue. The skin and SQ tissue are displaced laterally before injection, creating a "Z" pattern when released — sealing medication in the muscle.
Indications
- Medications that irritate or stain SQ tissue:
- Iron dextran (most common indication)
- Hydroxyzine
- Vistaril
- Penicillin G benzathine
- Any medication that can cause tissue irritation, staining, or pain when reaching SQ tissue
Outcomes/Evaluation
- Medication contained within muscle
- No leak-back into SQ tissue
- No skin discoloration or irritation at site
- Minimal pain
- Effective medication delivery
Nursing Interventions (pre, intra, post)
Procedure:
- Verify 10 rights of medication administration
- Draw up medication; add 0.2–0.5 mL of air bubble (some institutions) to clear needle after injection
- Change needle after drawing (if irritating medication)
- Position patient with site exposed
- Identify ventrogluteal site (preferred) — never deltoid for Z-track
- Cleanse with alcohol; allow to dry
- Pull skin and SQ tissue 1–1.5 inches laterally with non-dominant hand
- Hold skin taut throughout injection
- Insert needle at 90° angle into muscle
- Aspirate to check for blood return (if positive, withdraw and start over)
- Inject slowly (10 seconds per mL)
- Wait 10 seconds before withdrawal (allows muscle to absorb)
- Withdraw needle quickly
- Release skin AFTER needle is withdrawn — creates Z-track that seals medication in
- Do NOT massage site (forces medication back through track)
- Cover with small bandage
- Document site, medication, dose, time
- Rotate sites if multiple injections
Potential Complications
- Local pain
- Bleeding/bruising
- Tissue staining (especially iron) if technique improper
- Tissue irritation/abscess
- Anaphylaxis (medication-specific)
- Damage to underlying structures if wrong site
Nursing Interventions
- Monitor for bleeding (assess site, vital signs, Hgb/Hct); apply pressure as indicated; notify provider for hemodynamic instability
- Assess pain (location, character, scale) frequently; administer ordered analgesia; reposition for comfort
- Assess for allergic reaction (rash, urticaria, dyspnea); have epinephrine, oxygen, and emergency equipment at bedside
- Perform neuro checks; institute seizure precautions if appropriate; report changes in LOC
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Explain procedure simply
- Site will be displaced before injection
- Don't massage after — would defeat purpose
- Avoid strenuous activity at site for 24 hours
- Mild soreness expected
- Report: severe pain, drainage, redness, fever
- For iron dextran: may stain skin if technique fails — this is permanent
Description of Skill
Administration of topical medications to the eye (ophthalmic), ear (otic), or nose (nasal) of pediatric patients. Each route has specific positioning, technique, and developmental considerations.
Indications
- Eye: conjunctivitis, glaucoma, post-op care, allergies, mydriatic exams
- Ear: otitis externa, otitis media (with intact TM), cerumen impaction
- Nose: congestion, allergic rhinitis, vasoconstrictors
Outcomes/Evaluation
- Medication delivered accurately to intended site
- Minimal distress
- Therapeutic effect achieved
- No systemic side effects
- No infection or trauma
Nursing Interventions (pre, intra, post)
Eye (Ophthalmic) Drops:
- Wash hands; warm bottle to body temp
- Position child supine with head slightly hyperextended OR seated with head tilted back
- For infants: may need to wait until eyes open spontaneously or gently retract eyelids
- Ask child to look up
- Pull lower lid down to expose conjunctival sac
- Instill drop in conjunctival sac, NOT directly on eyeball
- Avoid touching dropper to eye or eyelid (contamination)
- Have child close eyes gently (don't squeeze)
- Apply gentle pressure to inner canthus (nasolacrimal duct) for 1 minute — reduces systemic absorption
- Wipe excess from outer to inner canthus
- Wait 5 min between different eye medications
Ear (Otic) Drops:
- Warm bottle to body temp (cold drops cause vertigo)
- Position child on side with affected ear UP
- < 3 yr: pull pinna DOWN and BACK (straightens immature canal)
- ≥ 3 yr: pull pinna UP and BACK
- Instill prescribed number of drops along canal wall
- Gently massage tragus or insert cotton ball loosely (if ordered)
- Keep child side-lying for 5–10 minutes
- Apply to other ear if needed
Nasal Drops/Sprays:
- Have child blow nose first (or suction with bulb syringe for infants)
- Position child supine with head hyperextended OR sitting with head tilted back
- Instill prescribed drops into each nostril
- For spray: aim toward lateral wall of nostril (not septum)
- Have child breathe through mouth during instillation
- Keep position for 1–2 minutes after
- Encourage breath-holding briefly
- Wipe nose; don't blow immediately after
Potential Complications
- Eye: contamination, scratched cornea, systemic absorption (atropine), allergic reaction
- Ear: vertigo (cold drops), pain, perforation (if tympanic membrane already ruptured)
- Nose: nosebleed, rebound congestion (overuse), systemic absorption (vasoconstrictors)
- General: inaccurate dose, missed dose, infection
Nursing Interventions
- Monitor for bleeding (assess site, vital signs, Hgb/Hct); apply pressure as indicated; notify provider for hemodynamic instability
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Assess pain (location, character, scale) frequently; administer ordered analgesia; reposition for comfort
- Assess for allergic reaction (rash, urticaria, dyspnea); have epinephrine, oxygen, and emergency equipment at bedside
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Wash hands before and after
- Warm bottles to body temperature
- Don't touch dropper to body (contamination)
- Discard if dropper contaminated
- Use only prescribed; don't share between people
- Follow positioning instructions to ensure full absorption
- Store as directed (some refrigerate, some room temperature)
- Discard at expiration or as directed (often 4 weeks after opening for eye drops)
- Report worsening symptoms, allergic reactions, persistent pain
- Don't mix different drops in same eye/ear — wait 5 minutes
Description of Skill
Insertion of a tube through the nose, past the pharynx, down the esophagus, and into the stomach. Used for feeding, medication administration, gastric decompression, or aspirating stomach contents.
Indications
- Enteral feeding when child unable to take adequate PO
- Medication administration
- Gastric decompression (bowel obstruction, post-op ileus)
- Gastric lavage (poisoning — controversial)
- Aspirating gastric contents for analysis
Outcomes/Evaluation
- NG tube successfully placed in stomach (confirmed by gastric aspiration with pH 1–4 and/or X-ray)
- Patient tolerates feeds/medications without aspiration
- Adequate nutrition or decompression achieved
- No complications
Nursing Interventions (pre, intra, post)
Tube size by age:
- Newborn: 5–8 Fr
- Infant: 8 Fr
- Toddler/young child: 8–10 Fr
- Older child: 10–14 Fr
- Adolescent: 14–16 Fr
Procedure:
- Verify order and check size, tube type
- Explain procedure (or distract young child)
- Position infant supine with head elevated, older child sitting with head slightly flexed
- Measure tube length: NEX method (Nose to Earlobe to Xiphoid process) or NEMU method
- Mark measured length
- Lubricate tip with water-soluble lubricant
- Insert through largest nostril; advance to nasopharynx
- Have child swallow (sip water) at posterior pharynx if able
- Advance smoothly to mark
- If resistance, coughing, choking, cyanosis — STOP, withdraw
- Verify placement:
- Aspirate gastric contents and check pH (gastric < 4)
- X-ray confirmation for initial placement and high-risk infants
- Auscultation alone is NOT a reliable method per evidence-based practice
- Secure with tape (cheek, not nose, in infants)
- Document length inserted (cm at nostril)
Ongoing care:
- Check placement before each use
- Flush with water before/after medications and feedings (5–10 mL)
- Use liquid medications when available
- Inspect nostril for breakdown
- Reposition tape to alternate cheek
Potential Complications
- Aspiration if misplaced in trachea
- Nasal mucosa injury, bleeding
- Pressure injury at nostril
- Sinusitis
- Vomiting during insertion (aspiration risk)
- Esophageal/gastric perforation (rare)
- Intracranial placement if basilar skull fracture (contraindication)
- Tube obstruction
- Dislodgement
- Aspiration of feeds if tube migrates
Nursing Interventions
- Monitor for bleeding (assess site, vital signs, Hgb/Hct); apply pressure as indicated; notify provider for hemodynamic instability
- Assess respiratory rate, effort, and SpO₂; position to optimize ventilation; have suction/oxygen ready
- Administer antiemetics as ordered; small frequent intake; monitor for dehydration and electrolyte loss
- Reposition every 2 hr; pressure-relief devices; daily skin assessment; nutritional support
- Implement fall precautions; bed in low position; call light in reach; assess fall risk regularly
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Explain purpose simply to child
- May feel uncomfortable during insertion but should not be severely painful
- Swallowing during insertion helps tube go down
- Once in place, child should not feel constant pain
- Importance of not pulling on tube
- How to check placement at home (if going home with tube)
- Recognize tube dislodgement (visible movement, vomiting)
- Care at home: flushing, securing tape, signs of irritation
- When to call provider: severe pain, breathing difficulty, no return of gastric contents
- Encourage saliva swallowing to prevent dryness
Description of Skill
Standardized newborn assessment performed at 1 and 5 minutes after birth to evaluate the newborn's transition to extrauterine life and need for resuscitation. May be repeated at 10 minutes if 5-min score < 7.
Created by Dr. Virginia Apgar in 1952. Scoring 0–2 for each of 5 categories; total 0–10.
Indications
- Universal assessment of ALL newborns
- At 1 minute and 5 minutes after birth
- Repeat at 10 minutes if 5-min score < 7
- Continued reassessments q5 min until score ≥ 7 or 20 min
- Used during resuscitation
Outcomes/Evaluation
- Identification of newborn requiring resuscitation
- Score documented in newborn record
- Communication to neonatal team if low
- Score 7–10: minimal/no difficulty
- Score 4–6: moderate distress (often need stimulation, O₂)
- Score 0–3: severe distress (require resuscitation)
Nursing Interventions (pre, intra, post)
5 components (mnemonic: Appearance, Pulse, Grimace, Activity, Respirations):
| Sign | 0 | 1 | 2 |
|---|---|---|---|
| Appearance (Color) | Pale/blue | Acrocyanosis | Pink all over |
| Pulse (HR) | Absent | < 100 | ≥ 100 |
| Grimace (Reflex) | No response | Grimace | Vigorous cry |
| Activity (Tone) | Limp | Some flexion | Active motion |
| Respirations | Absent | Slow, weak | Strong cry |
Assessment timing:
- 1 minute: rapid initial assessment
- 5 minutes: more predictive of long-term outcome
- 10 min: if 5-min still low
- Continue q5 min × 20 min if needed
Resuscitation does NOT wait for scoring — intervene as needed.
Potential Complications
- The Apgar score itself has no complications — it's an assessment tool
- Inaccurate scoring may delay appropriate intervention
- Score should never delay needed resuscitation
- Low score predicts higher risk of cerebral palsy, neonatal mortality (especially persistent low scores)
Nursing Interventions
- Continuously assess for complications during and after the skill
- Maintain aseptic/sterile technique as indicated
- Escalate per facility policy if adverse outcomes occur
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Explain to parents what Apgar score is and reassure
- 5-minute score is most predictive — minor differences from 1-min to 5-min often improve as baby transitions
- Score of 7+ usually = well newborn
- Lower scores may require oxygen, suction, stimulation — does NOT mean baby is permanently damaged
- Most babies with initial low scores improve quickly with help
- Persistent low scores may indicate need for NICU observation
- Score doesn't predict long-term outcomes alone — many other factors
Description of Skill
Simple, non-invasive technique to clear nasal and oral secretions in infants and young children using a bulb syringe (handheld, soft rubber bulb with tapered tip). Most common airway clearance method used at home and in healthcare settings.
Indications
- Nasal congestion in infants (obligate nose breathers)
- Removal of mucus, formula, or amniotic fluid (newborn)
- Pre-feeding to enable nursing/bottle
- Before sleep
- Bronchiolitis, URI, RSV (frequent use needed)
- Infants with feeding difficulties due to congestion
Outcomes/Evaluation
- Clear airways
- Improved breathing comfort
- Better feeding
- Improved oxygen saturation if monitored
- No trauma to nasal mucosa
Nursing Interventions (pre, intra, post)
Equipment:
- Bulb syringe (sterilize before first use; rinse between uses)
- Saline nasal drops (optional, helps loosen thick mucus)
- Tissues
Procedure:
- Wash hands
- If thick mucus, instill 2–3 drops of saline in each nostril 1–2 minutes before suctioning (loosens secretions)
- Hold infant upright or in lap with head supported
- Compress (squeeze) the bulb FIRST (with thumb)
- Then insert the tip:
- For nose: into side of nare, NOT straight back (avoid trauma to septum)
- For mouth: into side of cheek/mouth
- Slowly release bulb compression to create suction
- Remove from nare/mouth
- Empty bulb onto tissue by squeezing
- Repeat as needed
- Suction MOUTH before NOSE when both needed — suctioning nose first can cause infant to gasp and aspirate oral secretions
Important points:
- Do NOT compress bulb while in nostril/mouth (would blow secretions in)
- Suction only when needed, not routinely (over-suctioning irritates mucosa)
- Tip should NOT go deep — just inside opening
- Multiple gentle passes better than one forceful
- Allow breaths between suctions
- Clean bulb between uses (warm soapy water, squeeze multiple times to clean inside)
Sterilization:
- Wash with warm soapy water
- Rinse with clean water
- Allow to air dry (squeeze out all water)
- Some can be sterilized in dishwasher (top rack)
Potential Complications
- Nasal mucosa irritation, bleeding (excessive suctioning)
- Vagal stimulation (rare; bradycardia)
- Trauma to nasal septum from incorrect insertion
- Aspiration if suctioning nose first when oral secretions present
- Worsened congestion from rebound swelling (over-suctioning)
- Infection if bulb not cleaned (contamination)
Nursing Interventions
- Monitor for bleeding (assess site, vital signs, Hgb/Hct); apply pressure as indicated; notify provider for hemodynamic instability
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Assess respiratory rate, effort, and SpO₂; position to optimize ventilation; have suction/oxygen ready
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Bulb suctioning is helpful but should NOT be overused
- Suction when needed: before feeds, before sleep, with congestion
- Maximum 2–3 times per day usually adequate
- Saline drops loosen thick mucus before suctioning
- Always compress bulb BEFORE inserting
- Always go to side, not straight back
- Suction mouth first, then nose
- If bleeding occurs, stop and notify provider
- Clean bulb regularly
- Replace bulb periodically
- If congestion severe and not relieved, call provider
- Watch for breathing difficulty, poor feeding, irritability, fever, dehydration
- Humidifier may help
- Elevate head of crib slightly for sleep
- Avoid over-the-counter decongestants in infants (not safe under age 2)
Alterations in Health (Diagnosis)
Autosomal recessive hemoglobinopathy in which abnormal hemoglobin S (HbS) replaces normal hemoglobin A. Under conditions of low oxygen, dehydration, infection, or stress, HbS-containing RBCs change from disc to sickle (crescent) shape, leading to vaso-occlusion, hemolysis, and chronic anemia.
Pathophysiology Related to Client Problem
Sickled cells obstruct microvasculature → tissue ischemia and infarction. Chronic hemolysis → anemia and elevated bilirubin. The spleen is functionally damaged early (auto-infarction) → ↑ infection risk, especially encapsulated organisms (pneumococcus, H. influenzae).
Health Promotion and Disease Prevention
- Genetic counseling for affected families
- Newborn screening identifies disease early
- Folic acid supplementation for accelerated erythropoiesis
- Prophylactic penicillin from 2 mo to 5 yr
- Pneumococcal, meningococcal, and influenza vaccines
Risk Factors
- African, Mediterranean, Middle Eastern, Indian descent
- Both parents carriers (autosomal recessive)
- Triggers: infection, dehydration, hypoxia, acidosis, cold exposure, stress, high altitude
Expected Findings
Vaso-occlusive crisis (most common):
- Severe pain in extremities, back, abdomen, chest
- Dactylitis (hand-foot syndrome) often the first sign in infants
- Fever, swelling, joint pain
Other crises:
- Splenic sequestration: blood pooling in spleen → hypovolemic shock
- Aplastic crisis: ↓ RBC production, often parvovirus B19 trigger
- Acute chest syndrome: pulmonary infiltrates + chest pain + fever (life-threatening)
Laboratory Tests
- Hemoglobin electrophoresis — confirms HbS
- CBC: ↓ Hgb (6–9 g/dL), ↑ reticulocytes, peripheral smear shows sickle cells
- ↑ bilirubin (hemolysis)
- Newborn screen detects HbS
Diagnostic Procedures
- Sickle solubility test (Sickledex) — screening only, cannot distinguish trait from disease
- Transcranial Doppler annually (ages 2–16) — screens for stroke risk
Safety Considerations
- Maintain hydration (1.5–2× maintenance during crisis)
- Oxygen for hypoxia
- Avoid cold exposure, high altitudes, strenuous activity during crisis
- Prompt fever workup (sepsis precautions)
Complications
- Acute chest syndrome (leading cause of death)
- Stroke (especially ages 2–10)
- Splenic sequestration → shock
- Priapism in males
- Avascular necrosis of femoral head
- Renal failure, retinopathy, gallstones
Nursing Care
- Hydration, oxygenation, pain control, infection prevention — the four pillars
- IV fluids 1.5–2× maintenance
- Continuous pulse oximetry; supplemental O₂ if SpO₂ < 94%
- Pain management with opioids around the clock during crisis
- Warm compresses to painful areas (NOT cold)
- Rest with passive ROM
- Daily CBC, monitor for splenic sequestration
Medications
- Hydroxyurea — increases HbF production, reduces crises (monitor CBC, baseline reticulocyte count)
- Opioids for pain (morphine, hydromorphone); use PCA when age-appropriate
- Prophylactic penicillin 2 mo to 5 yr
- Folic acid daily
- Avoid NSAIDs if renal compromise
Therapeutic Procedures
- Blood transfusions for severe anemia or acute chest syndrome
- Exchange transfusion for stroke or priapism
- Hematopoietic stem cell transplant — only potential cure
Client Education
- Recognize and avoid triggers
- Maintain hydration always
- Promptly report fever > 38.5°C (101.3°F) — sepsis emergency
- Keep all vaccinations current
- Wear medical alert ID
- Genetic counseling for family planning
Interprofessional Care
- Hematology, pain management, social work, school nurse
- Sickle cell support groups
- Genetic counseling
Alterations in Health (Diagnosis)
Chronic inflammatory disorder of the airways characterized by recurrent reversible airway obstruction, bronchial hyperresponsiveness, and airway remodeling. Most common chronic disease of childhood.
Pathophysiology Related to Client Problem
Allergen or trigger exposure → mast cell degranulation, eosinophil infiltration → airway inflammation, bronchospasm, mucus hypersecretion, and edema → reversible airflow obstruction. Chronic inflammation leads to airway remodeling.
Health Promotion and Disease Prevention
- Identify and avoid triggers
- Annual influenza vaccine
- Pneumococcal vaccine
- Smoke-free environment
- Allergen-proof bedding for dust mite allergy
Risk Factors
- Family history of asthma or atopy
- Allergies (food, environmental)
- Eczema, allergic rhinitis (atopic triad)
- Prematurity, low birth weight
- Secondhand smoke exposure
- Triggers: viral infections, allergens, exercise, cold air, smoke, stress
Expected Findings
- Wheezing (expiratory more than inspiratory)
- Cough (often nocturnal)
- Dyspnea, prolonged expiration
- Use of accessory muscles, retractions, nasal flaring
- Tripod position
- Tachypnea, tachycardia
- Silent chest = ominous (severe obstruction)
Laboratory Tests
- ABG: respiratory alkalosis early; respiratory acidosis if worsening
- CBC: eosinophilia common
- ↑ serum IgE if allergic component
Diagnostic Procedures
- Pulmonary function tests (PFTs) — ↓ FEV1, ↓ FEV1/FVC ratio; reversible with bronchodilator
- Peak expiratory flow rate (PEFR) — green zone > 80%, yellow 50–80%, red < 50%
- Chest X-ray (rule out other causes)
Safety Considerations
- Recognize early signs of exacerbation
- Always have rescue inhaler available
- Asthma action plan in writing
- Notify school of medications and emergency plan
Complications
- Status asthmaticus — life-threatening exacerbation unresponsive to standard treatment
- Respiratory failure
- Pneumothorax
- Atelectasis
- Airway remodeling with chronic poor control
Nursing Care
- Position upright (Fowler's/tripod)
- Oxygen for SpO₂ < 92%
- Continuous pulse oximetry during exacerbation
- Frequent respiratory assessment (lung sounds, work of breathing)
- IV access for severe exacerbation
- Stay calm, decrease anxiety (escalates symptoms)
Medications
Quick-relief (rescue):
- Short-acting beta-2 agonist (albuterol) — first-line rescue, MDI with spacer or nebulizer
- Ipratropium (in severe exacerbation)
- Systemic corticosteroids (prednisone, methylprednisolone)
Long-term control:
- Inhaled corticosteroids (fluticasone, budesonide) — first-line controller
- LABA (salmeterol) — never alone, always with ICS
- Leukotriene modifiers (montelukast)
- Mast cell stabilizers (cromolyn)
- Omalizumab (severe allergic asthma)
Therapeutic Procedures
- MDI with spacer technique
- Nebulizer treatments
- Peak flow monitoring
Client Education
- MDI/spacer technique: shake, exhale, slow inhale 3–5 sec, hold 10 sec, rinse mouth after ICS
- Peak flow zones (green/yellow/red) and corresponding actions
- Identify and avoid triggers
- Take controller daily even when feeling well
- Use rescue inhaler 15 min before exercise if needed
Interprofessional Care
- Pulmonology, allergy/immunology, respiratory therapy
- School nurse coordination
- Asthma educator
Alterations in Health (Diagnosis)
Autosomal recessive disorder caused by mutations in the CFTR gene (cystic fibrosis transmembrane conductance regulator) on chromosome 7. Most common life-shortening genetic disorder in Caucasians.
Pathophysiology Related to Client Problem
Defective CFTR protein → abnormal chloride transport across epithelial cells → thick, sticky secretions in lungs, pancreas, intestines, sweat glands, reproductive tract. Leads to chronic lung disease, pancreatic insufficiency, malabsorption, and infertility.
Health Promotion and Disease Prevention
- Genetic counseling and carrier screening
- Newborn screening (IRT — immunoreactive trypsinogen)
- Aggressive infection prevention (handwashing, vaccines)
- Annual influenza vaccine
- Pneumococcal vaccine
Risk Factors
- Both parents carriers (autosomal recessive)
- Caucasian descent (~1 in 3,500 births)
- Family history of CF
Expected Findings
Respiratory:
- Chronic productive cough
- Recurrent pulmonary infections (Pseudomonas aeruginosa, Staphylococcus aureus)
- Wheezing, crackles
- Barrel chest, clubbing
- Nasal polyps
GI:
- Meconium ileus (newborn — earliest sign)
- Steatorrhea (foul, bulky, greasy stools)
- Failure to thrive despite voracious appetite
- Rectal prolapse
Other:
- Salty-tasting skin
- Delayed puberty, infertility (males almost always sterile)
Laboratory Tests
- Sweat chloride test > 60 mEq/L = diagnostic
- Genetic testing for CFTR mutations
- 72-hour fecal fat collection
- Glucose tolerance test (CFRD screening yearly after age 10)
Diagnostic Procedures
- Chest X-ray: hyperinflation, infiltrates, bronchiectasis
- PFTs (annually)
- Sputum cultures regularly
Safety Considerations
- Strict infection control (mask in healthcare settings)
- Patient with CF should not interact with other CF patients (cross-contamination)
- Glucose monitoring
Complications
- Respiratory failure (leading cause of death)
- Pneumothorax, hemoptysis
- Cor pulmonale
- CF-related diabetes (CFRD)
- Liver disease, cirrhosis
- Distal intestinal obstruction
- Osteoporosis
Nursing Care
- Airway clearance therapy 2–4× daily: chest physiotherapy (CPT), high-frequency chest wall oscillation vest, PEP device
- Aerosolized medications BEFORE airway clearance
- Encourage exercise
- Monitor weight, growth
- Sputum cultures regularly
Medications
- Pancrelipase (Creon) — pancreatic enzyme replacement with all meals and snacks; open capsules into non-protein food (applesauce) for young children; do NOT crush; do NOT mix with hot foods
- Fat-soluble vitamins (ADEK) daily
- Dornase alfa (Pulmozyme) — mucolytic, inhaled daily
- Hypertonic saline nebulized
- Inhaled antibiotics (tobramycin, aztreonam) for chronic Pseudomonas
- CFTR modulators (ivacaftor, lumacaftor) for specific mutations
- Bronchodilators
Therapeutic Procedures
- Chest physiotherapy/postural drainage
- Lung transplantation (advanced disease)
Client Education
- High-calorie, high-protein, high-fat diet (150% of normal caloric needs)
- Take pancreatic enzymes with EVERY meal and snack
- Salt supplementation in hot weather
- Daily airway clearance
- Recognize signs of pulmonary exacerbation
- Plan for transition to adult care
Interprofessional Care
- CF center care team: pulmonology, GI, endocrinology, dietitian, social work, respiratory therapy, psychology
- CF Foundation support
Alterations in Health (Diagnosis)
Autoimmune destruction of pancreatic beta cells → absolute insulin deficiency. Most common type of diabetes in children. Requires lifelong insulin replacement.
Pathophysiology Related to Client Problem
Autoantibodies attack pancreatic beta cells → ↓ insulin production → cells cannot uptake glucose → hyperglycemia. Without insulin, body breaks down fat for energy → ketone production → diabetic ketoacidosis (DKA).
Health Promotion and Disease Prevention
- Identify at-risk children (family history, autoantibody testing)
- Early symptom recognition
- Cannot prevent type 1 — focus on early diagnosis and management
Risk Factors
- Genetic predisposition (HLA-DR3, HLA-DR4)
- Family history of type 1 diabetes
- Other autoimmune conditions (celiac, Hashimoto thyroiditis)
- Peak onset 4–6 yr and 10–14 yr
Expected Findings
Classic triad (3 Ps):
- Polyuria (excessive urination, may include enuresis in toilet-trained child)
- Polydipsia (excessive thirst)
- Polyphagia (excessive hunger)
Other findings:
- Weight loss despite increased appetite
- Fatigue, irritability
- Blurred vision
- Recurrent infections (yeast, UTI)
DKA findings: Kussmaul respirations, fruity breath, abdominal pain, nausea/vomiting, dehydration, altered LOC.
Laboratory Tests
- Random blood glucose > 200 mg/dL with symptoms
- Fasting blood glucose ≥ 126 mg/dL
- HbA1c ≥ 6.5% (goal < 7.5% in pediatrics)
- Positive islet cell antibodies, GAD antibodies
- ↓ C-peptide
- Ketones in urine/blood
Diagnostic Procedures
- Continuous glucose monitor (CGM) for ongoing management
- SMBG (self-monitoring blood glucose) before meals and at bedtime
Safety Considerations
- Medical alert ID at all times
- Glucagon emergency kit available
- School plan and trained staff
- Sick day rules to prevent DKA
- Monitor for hypoglycemia (especially overnight)
Complications
- DKA — life-threatening, requires IV insulin, fluids, electrolyte correction
- Hypoglycemia — most common acute complication; treat with 15 g fast-acting carb (15-15 rule)
- Long-term: retinopathy, nephropathy, neuropathy, cardiovascular disease
- Dawn phenomenon vs Somogyi effect (check 3 AM glucose to distinguish)
Nursing Care
- Monitor blood glucose 4× daily minimum
- Coordinate insulin with meals and activity
- Recognize and treat hypoglycemia
- Rotate injection sites to prevent lipodystrophy
- Annual eye exam, kidney screening, foot care
- Psychosocial support — chronic disease in children
Medications
Insulin (lifelong):
- Rapid-acting (Humalog, NovoLog): onset 15 min, peak 30–60 min, duration 3–5 hr
- Short-acting (regular): onset 30 min, peak 2–3 hr
- Intermediate (NPH): onset 1–2 hr, peak 4–12 hr
- Long-acting (Lantus, Levemir, Tresiba): onset 1 hr, no peak, 24 hr duration
- Basal-bolus regimen most common
- Insulin pump (CSII) option for many children
Therapeutic Procedures
- Subcutaneous insulin injection (abdomen, thigh, arm)
- Continuous subcutaneous insulin infusion (insulin pump)
- Continuous glucose monitoring
Client Education
- Carbohydrate counting
- Insulin administration technique
- Recognize/treat hypoglycemia (15 g carb, recheck in 15 min)
- Sick day rules: never stop insulin; check glucose and ketones every 2–4 hr; hydrate; call provider if vomiting
- Exercise considerations (carb snack, glucose monitoring)
- Foot care, eye exams
Interprofessional Care
- Pediatric endocrinology
- Certified diabetes educator
- Dietitian
- School nurse
- Mental health (depression risk)
Alterations in Health (Diagnosis)
Congenital absence of ganglion cells (parasympathetic nerves) in a segment of the colon, most commonly the rectosigmoid region. The aganglionic segment cannot relax → functional obstruction.
Pathophysiology Related to Client Problem
Absence of Meibner and Auerbach plexus ganglion cells → no peristalsis in affected segment → stool accumulates proximal to the aganglionic section → dilation of normal bowel proximally (megacolon).
Health Promotion and Disease Prevention
- No prevention — congenital
- Higher incidence in children with Down syndrome (screen)
- Early identification prevents complications
Risk Factors
- Family history
- Male predominance (4:1)
- Down syndrome (10× increased risk)
- Other congenital anomalies
Expected Findings
Newborn:
- Failure to pass meconium within 24–48 hours (most reliable finding)
- Abdominal distention
- Bilious vomiting
- Refusal to feed
Older infant/child:
- Chronic constipation
- Ribbon-like, foul-smelling stools
- Failure to thrive
- Visible peristalsis
- Palpable fecal mass
Laboratory Tests
- CBC (rule out infection)
- Electrolytes (rule out imbalance)
Diagnostic Procedures
- Rectal biopsy — gold standard; confirms absence of ganglion cells
- Anorectal manometry — shows failure of internal sphincter relaxation
- Contrast enema — shows narrow segment with proximal dilation
- Abdominal X-ray — distended bowel loops
Safety Considerations
- NPO until evaluated
- Monitor for enterocolitis (life-threatening)
- Daily abdominal girth measurement
- Strict I&O
Complications
- Enterocolitis — life-threatening; fever, explosive diarrhea, abdominal distention, sepsis
- Bowel perforation
- Failure to thrive
- Postoperative: anastomotic leak, stricture, fecal incontinence
Nursing Care
Preoperative:
- NPO, NG decompression
- IV fluids, electrolyte correction
- Daily abdominal girth measurement
- Prepare family for staged surgery and possible colostomy
Postoperative:
- NPO until bowel sounds return
- Monitor incision and stoma if present
- Pain management
- Strict I&O
- Watch for enterocolitis signs
Medications
- IV antibiotics if enterocolitis
- Postoperative analgesics
- Stool softeners after surgery
Therapeutic Procedures
- Surgical removal of aganglionic segment with pull-through (Soave, Swenson, or Duhamel procedure)
- Possible temporary colostomy for staged repair
Client Education
- Colostomy care (if applicable)
- Signs of enterocolitis to report (fever, foul-smelling stool, distention)
- Postoperative perineal care
- High-fiber diet, adequate fluids long-term
- Toilet training may be delayed
Interprofessional Care
- Pediatric surgery
- Enterostomal therapy (ostomy care)
- Pediatric GI
- Nutrition
Alterations in Health (Diagnosis)
Most common cyanotic congenital heart defect, characterized by four classic defects:
- Pulmonary stenosis
- Right ventricular hypertrophy
- Overriding aorta
- VSD (ventricular septal defect)
Mnemonic: PROV or "PROVe TOF"
Pathophysiology Related to Client Problem
Pulmonary stenosis ↑ right ventricular pressure → blood shunts right-to-left across VSD → deoxygenated blood enters systemic circulation → cyanosis. The overriding aorta also receives mixed blood. Severity of cyanosis depends on degree of pulmonary stenosis.
Health Promotion and Disease Prevention
- Genetic counseling (associated with 22q11.2 deletion / DiGeorge syndrome)
- Prenatal echocardiogram if risk factors
- Early identification and surgical planning
- Endocarditis prophylaxis for dental procedures
Risk Factors
- Genetic disorders (DiGeorge syndrome, Down syndrome)
- Maternal rubella, alcohol use, diabetes
- Family history of congenital heart disease
- Advanced maternal age
Expected Findings
- Cyanosis (degree varies); worsens with crying, feeding, exertion
- Loud systolic murmur (pulmonary stenosis)
- Hypercyanotic ("tet") spells — acute episodes of severe cyanosis triggered by crying, feeding, defecation
- Squatting (older children) — increases systemic vascular resistance, decreases R-to-L shunt
- Clubbing of fingers/toes (chronic hypoxia)
- Poor feeding, FTT
- Polycythemia
- Delayed growth and development
Laboratory Tests
- ↑ Hemoglobin and hematocrit (chronic hypoxia → polycythemia)
- ↑ RBC count
- ABG: ↓ PaO₂, may have respiratory alkalosis
Diagnostic Procedures
- Echocardiogram — definitive; visualizes all four defects
- Cardiac catheterization
- Chest X-ray: "boot-shaped" heart, decreased pulmonary vascularity
- ECG: right ventricular hypertrophy
- Pulse oximetry: ↓ SpO₂
Safety Considerations
- During tet spell: place infant in knee-chest position (or squat older child)
- Administer 100% oxygen via face mask
- Calm, quiet environment
- Morphine 0.1 mg/kg SQ/IV/IM to relax pulmonary infundibulum
- IV fluids to increase preload
- Cluster care to avoid agitation
Complications
- Hypercyanotic ("tet") spells
- Polycythemia → thrombus formation, stroke risk
- Brain abscess
- Bacterial endocarditis
- Heart failure
- Postoperative arrhythmias, residual VSD
Nursing Care
Acute care during tet spell:
- Knee-chest position immediately
- 100% O₂ via face mask
- Morphine per order
- Stay calm; comfort infant
- Notify provider
General nursing:
- Cluster care, allow rest
- Small frequent feedings; supplemental NG feeds if needed
- High-calorie nutrition
- Monitor for signs of HF, dehydration, infection
- Strict I&O
- Daily weights
- Maintain hydration (avoid hyperviscosity from polycythemia)
Medications
- Morphine 0.1 mg/kg — for tet spells
- Beta-blockers (propranolol) — prevent spells in some cases
- Iron supplements if anemic (prevents polycythemia complications)
- Prophylactic antibiotics before invasive dental procedures (SBE prophylaxis)
- Digoxin and diuretics for HF symptoms
Therapeutic Procedures
- Palliative shunt (Blalock-Taussig) — temporary if infant too small for complete repair
- Complete surgical repair usually at 6 months to 2 years: VSD closure + relief of pulmonary stenosis
- Cardiac catheterization (diagnostic and therapeutic)
Client Education
- Recognize tet spell triggers and management (knee-chest position)
- Adequate hydration (especially in heat, illness)
- Prevent infection (especially respiratory and dental)
- Endocarditis prophylaxis before dental procedures
- Feeding strategies (small frequent, supplemental feeds)
- Recognize signs of worsening: increased cyanosis, fatigue, poor feeding
- Activity as tolerated; restrict only if symptomatic
Interprofessional Care
- Pediatric cardiology, cardiothoracic surgery
- Cardiac ICU during surgery
- Nutritionist for growth concerns
- Early intervention services
- Genetic counseling (DiGeorge association)
Alterations in Health (Diagnosis)
Acute, systemic vasculitis primarily affecting small and medium-sized arteries, especially coronary arteries. Most common cause of acquired heart disease in children in developed countries. Three phases: acute (1–2 weeks), subacute (2–4 weeks), convalescent (up to 6–8 weeks).
Pathophysiology Related to Client Problem
Unknown etiology (possibly post-infectious/immune-mediated). Widespread inflammation of medium-sized arteries → coronary artery aneurysms in untreated patients. Risk of MI, sudden death. Self-limited but cardiac sequelae can be permanent.
Health Promotion and Disease Prevention
- Early recognition critical (treatment within 10 days reduces coronary aneurysm risk)
- No known prevention
- Cardiac follow-up after diagnosis
Risk Factors
- Children < 5 years (peak 18–24 months)
- Boys > girls
- Asian descent (especially Japanese)
- Late winter/early spring
Expected Findings
Diagnostic criteria (fever ≥ 5 days + 4 of 5):
- Bilateral conjunctival injection (no exudate)
- Rash (polymorphous, often in groin)
- Adenopathy (cervical lymphadenopathy > 1.5 cm, usually unilateral)
- Strawberry tongue, red cracked lips, oral mucosal changes
- Hands and feet: edema, erythema → later peeling of palms/soles
Mnemonic: BRASH + fever ≥ 5 days
Other: irritability, joint pain, abdominal pain
Laboratory Tests
- ↑ ESR, ↑ CRP (markers of inflammation)
- ↑ WBC with left shift
- ↑ platelets (especially in subacute phase, > 450,000)
- Mild anemia
- ↑ liver enzymes
- Sterile pyuria
Diagnostic Procedures
- Echocardiogram at diagnosis, 2 weeks, 6–8 weeks — assess for coronary aneurysms
- ECG — may show arrhythmias
- Diagnosis is CLINICAL — based on criteria
Safety Considerations
- Cardiac monitoring during acute phase
- Watch for IVIG reaction (anaphylaxis, fluid overload)
- Avoid live vaccines × 11 months after IVIG (MMR, varicella)
- Bleeding precautions with aspirin therapy
Complications
- Coronary artery aneurysms (15–25% untreated; 3–5% with IVIG)
- Myocardial infarction (rare but life-threatening)
- Myocarditis, pericarditis
- Arrhythmias
- Heart failure
- Sudden cardiac death
Nursing Care
- Monitor temperature, HR, BP frequently
- Daily weight, strict I&O (HF risk)
- Cardiac monitoring
- Comfort measures: cool compresses, soft foods (sore mouth), lubricated lips, lotion to peeling skin
- Quiet environment (irritability is significant)
- Frequent rest periods
- Skin care for peeling palms/soles
- Family education and emotional support (frightening illness)
Medications
Acute phase (first-line):
- IVIG (Intravenous Immunoglobulin) 2 g/kg single infusion over 8–12 hr — reduces coronary aneurysm risk; monitor for reaction
- High-dose aspirin 80–100 mg/kg/day divided q6h during febrile phase
Subacute/convalescent:
- Low-dose aspirin 3–5 mg/kg/day for antiplatelet effect (6–8 weeks or until normal echo)
- This is one of the few situations where aspirin IS given to children
Therapeutic Procedures
- Echocardiograms (baseline, 2 weeks, 6–8 weeks)
- If aneurysms: long-term cardiology follow-up, possible cardiac catheterization, anticoagulation
- Rarely: coronary artery bypass grafting
Client Education
- Aspirin therapy: importance, signs of bleeding to report
- Hold aspirin and call provider if child develops flu or chickenpox (Reye syndrome risk)
- Avoid live vaccines for 11 months post-IVIG
- Follow-up echocardiograms essential
- Recognize signs of cardiac complications (chest pain, irregular heartbeat)
- Skin care during peeling phase
Interprofessional Care
- Pediatric cardiology (long-term follow-up)
- Rheumatology consultation
- Infectious disease (ruling out other diagnoses)
- Social work / child life
Alterations in Health (Diagnosis)
Viral inflammation of the larynx, trachea, and bronchi causing upper airway obstruction with characteristic barking cough and inspiratory stridor. Most common cause of acute upper airway obstruction in children.
Pathophysiology Related to Client Problem
Viral infection (most often parainfluenza virus) → inflammation and edema of subglottic mucosa → airway narrowing → turbulent airflow → stridor, barking cough, hoarseness.
Health Promotion and Disease Prevention
- Frequent handwashing
- Annual influenza vaccine
- Avoid exposure to ill contacts
- Encourage breastfeeding for immunologic protection
Risk Factors
- Age 6 months to 5 years (peak 1–3 years)
- Boys > girls
- Fall and winter months
- History of croup (predisposed)
- Recent viral URI
Expected Findings
- Barking ("seal-like") cough — classic
- Inspiratory stridor
- Hoarseness, aphonia
- Low-grade fever (< 39°C / 102.2°F)
- Gradual onset, often worse at night
- Restlessness, anxiety
- Retractions, nasal flaring (worsening)
- Tachypnea, tachycardia
- Cyanosis (severe obstruction)
Westley Croup Score: stridor, retractions, air entry, cyanosis, LOC.
Laboratory Tests
- Usually not needed for diagnosis
- CBC may show viral pattern (lymphocytosis)
- ABG only if severe distress
Diagnostic Procedures
- Clinical diagnosis
- Lateral neck X-ray (if needed): "steeple sign" — subglottic narrowing
- Differentiate from epiglottitis: croup has barking cough, no drooling, less toxic appearance
Safety Considerations
- Maintain airway — most important
- Continuous pulse oximetry if moderate-severe
- Avoid agitating child (worsens stridor)
- Keep parents at bedside
- Have intubation equipment available for severe cases
Complications
- Respiratory failure
- Hypoxia
- Dehydration
- Secondary bacterial infection (rare)
- Rarely: airway obstruction requiring intubation
Nursing Care
Mild croup (home care):
- Cool mist humidifier
- Cool night air or steam from shower
- Encourage fluid intake
- Acetaminophen for fever
- Calm environment
Moderate-severe (hospital):
- Cool mist O₂ (or warm mist per protocol)
- Continuous pulse oximetry
- Position upright; allow parent to hold child
- Minimize crying (worsens stridor)
- IV fluids if poor PO intake
- Strict I&O
- Monitor for worsening (increased RR, retractions, listlessness, cyanosis)
Medications
- Nebulized racemic epinephrine — for moderate-severe stridor; rapid onset; monitor for rebound effect (observe 2–4 hr post-treatment)
- Dexamethasone (Decadron) 0.6 mg/kg PO/IV/IM single dose — anti-inflammatory; effects last 24–72 hr
- Acetaminophen for fever/discomfort
- Antibiotics NOT indicated (viral)
Therapeutic Procedures
- Nebulizer treatments
- Rarely: intubation for severe obstruction
Client Education
- Cool mist humidifier or cool night air may help
- Encourage fluids in small frequent amounts
- Recognize worsening signs: severe stridor at rest, retractions, drooling, listlessness, cyanosis — go to ED
- Most croup resolves in 3–7 days
- Cool mist therapy and steroids reduce severity
- Sit upright in shower for steam treatment at home
- Do NOT use cough suppressants (suppress airway clearance)
Interprofessional Care
- Respiratory therapy
- Pediatric ED, hospital pediatric unit
- PICU if severe
Alterations in Health (Diagnosis)
MEDICAL EMERGENCY — rapidly progressive inflammation of the epiglottis and surrounding supraglottic structures that can lead to complete airway obstruction. Less common since Hib vaccine but still life-threatening.
Pathophysiology Related to Client Problem
Bacterial infection (historically Haemophilus influenzae type B; now more often S. pneumoniae, S. aureus, S. pyogenes) → severe inflammation and edema of epiglottis → airway obstruction at supraglottic level.
Health Promotion and Disease Prevention
- Hib vaccine — primary prevention (has dramatically reduced incidence)
- Catch-up immunizations for those behind
- Early recognition and emergency response
Risk Factors
- Ages 2–8 years (classic), but can occur at any age
- Unvaccinated or incompletely vaccinated
- Immunocompromised state
Expected Findings
Classic "4 Ds":
- Drooling (inability to swallow secretions)
- Dysphagia
- Distress (respiratory)
- Dysphonia (muffled, "hot potato" voice)
Other findings:
- Rapid onset (hours)
- High fever (often > 39°C / 102.2°F)
- Anxious, toxic appearance, sitting forward
- Tripod position (sitting upright, leaning forward, chin extended)
- Inspiratory stridor
- Absence of cough (unlike croup)
- Sore throat
- Refusal to lie down
Laboratory Tests
- Blood cultures (after airway secured)
- CBC with differential — elevated WBC, left shift
- Do NOT take throat culture or examine throat before airway secured
Diagnostic Procedures
- DO NOT visualize the throat or use tongue depressor — can trigger complete obstruction
- Lateral neck X-ray (only if child stable and accompanied by airway team): "thumb sign" — swollen epiglottis
- Direct laryngoscopy in OR is gold standard
Safety Considerations
CRITICAL SAFETY:
- NO throat examination, tongue depressor, throat culture — can precipitate airway obstruction
- Keep child calm — anxiety worsens obstruction
- Parent stays with child at all times
- Do NOT lie child down — allow position of comfort (usually tripod)
- Have intubation/tracheostomy equipment at bedside
- NPO
- Transport to OR with anesthesia team for controlled intubation
Complications
- Complete airway obstruction — can be fatal
- Respiratory failure
- Sepsis
- Pulmonary edema (post-obstruction)
- Death (mortality > 80% without treatment, < 1% with prompt care)
Nursing Care
Pre-intubation:
- Allow child to remain in position of comfort, often upright in parent's arms
- Do NOT separate from parent
- Quiet, calm environment
- Minimal handling
- NPO
- Be prepared for emergent intubation/tracheostomy
- Have airway equipment at bedside
- Continuous pulse oximetry
- Notify anesthesia and ENT
Post-intubation:
- PICU admission
- Sedation to prevent self-extubation
- Monitor for extubation readiness (usually 24–48 hr)
- IV antibiotics
- IV fluids
Medications
- IV antibiotics — ceftriaxone, cefotaxime, or ampicillin-sulbactam (covers H. influenzae, S. pneumoniae); duration 7–10 days
- Antipyretics (acetaminophen)
- Sedation (post-intubation): midazolam, dexmedetomidine
- Rifampin prophylaxis for close contacts (if Hib confirmed)
Therapeutic Procedures
- Endotracheal intubation in OR with ENT/anesthesia on standby for emergent tracheostomy
- Direct laryngoscopy
- Most patients extubated in 24–48 hr
Client Education
Prevention:
- Importance of Hib vaccine series (2, 4, 6, 12–15 mo)
- Catch-up immunization
Acute education (post-resolution):
- Complete full antibiotic course
- Rifampin prophylaxis for household contacts if indicated
- Recognize signs of recurrence (rare)
- Follow-up appointments
Interprofessional Care
- Anesthesia and ENT on standby for airway management
- PICU team
- Infectious disease for antibiotic management
- Public health (if Hib — contact tracing)
Alterations in Health (Diagnosis)
Acute viral infection of the small airways (bronchioles) causing inflammation, edema, mucus accumulation, and partial obstruction. Most common lower respiratory tract infection in infants. Respiratory syncytial virus (RSV) is the most common cause.
Pathophysiology Related to Client Problem
Viral infection (most often RSV; also rhinovirus, adenovirus, influenza, parainfluenza) → bronchiolar inflammation → necrosis of epithelial cells → edema and mucus plugging → air trapping, atelectasis, hypoxia.
Health Promotion and Disease Prevention
- Hand hygiene — most effective prevention
- Avoid exposure to ill contacts
- Avoid secondhand smoke
- Breastfeeding (immunologic protection)
- Palivizumab (Synagis) monthly during RSV season for high-risk infants (premature, chronic lung disease, hemodynamically significant CHD)
Risk Factors
- Age < 2 years (especially < 6 months)
- Premature birth
- Chronic lung disease (BPD)
- Congenital heart disease
- Immunocompromised
- Daycare attendance, siblings, secondhand smoke
- Fall through early spring (RSV season)
Expected Findings
- URI prodrome: rhinorrhea, mild cough, low-grade fever (1–3 days)
- Progression to lower airway:
- Tachypnea, increased work of breathing
- Wheezing (expiratory)
- Cough (may be persistent, paroxysmal)
- Retractions, nasal flaring, grunting
- Diminished breath sounds, crackles
- Apnea (especially in infants < 2 mo)
- Poor feeding, dehydration
- Cyanosis (severe cases)
- Irritability, fatigue
Laboratory Tests
- RSV rapid antigen test or PCR (nasal wash/nasopharyngeal aspirate) — confirms diagnosis
- Pulse oximetry — assess oxygenation
- ABG only if severe
Diagnostic Procedures
- Clinical diagnosis primarily
- RSV nasal swab
- Chest X-ray (if needed): hyperinflation, atelectasis, may show infiltrates
Safety Considerations
- Contact + droplet precautions — gown, gloves, mask, dedicated equipment
- Meticulous hand hygiene
- Continuous pulse oximetry for moderate-severe cases
- Apnea monitoring (especially infants < 2 mo)
- Position to maintain airway patency
Complications
- Respiratory failure
- Apnea (life-threatening in young infants)
- Dehydration
- Secondary bacterial infection (otitis media, pneumonia)
- Future risk of asthma/reactive airway disease
- Death (rare in healthy infants; higher in high-risk groups)
Nursing Care
- Maintain airway, suction nares before feeds with bulb syringe
- Position with head elevated
- Cool humidified oxygen for SpO₂ < 90%
- Continuous pulse oximetry
- Frequent respiratory assessments
- Cluster care to allow rest
- Small frequent feedings; NG/IV fluids if unable to PO
- Daily weights, strict I&O
- Monitor for apnea (especially young infants)
- Strict hand hygiene and isolation precautions
Medications
- Mostly supportive care — no specific antiviral for routine RSV
- Bronchodilators (albuterol) — controversial; trial use; continue only if improvement
- Antipyretics for fever
- NOT routinely used: antibiotics (viral), systemic corticosteroids, ribavirin (reserved for severe immunocompromised)
- Palivizumab (Synagis): monthly IM prophylaxis during RSV season for HIGH-RISK infants only — NOT a treatment
Therapeutic Procedures
- Nasal suctioning (bulb syringe for mild; wall suction for severe)
- Supplemental O₂
- High-flow nasal cannula (HFNC)
- CPAP, mechanical ventilation in severe cases
Client Education
- Maintain hydration (small frequent fluids)
- Bulb suction technique before feeds and sleep
- Humidify air
- Recognize warning signs: increased work of breathing, refusal to feed, lethargy, cyanosis
- Hand hygiene to prevent spread
- Avoid secondhand smoke
- Most cases resolve in 7–10 days
- Cough may persist 2–4 weeks
Interprofessional Care
- Pediatric respiratory therapy
- PICU if severe
- Infection control
- Pediatrician follow-up
Alterations in Health (Diagnosis)
Hypertrophy and hyperplasia of the circular muscle of the pylorus → narrowing of the pyloric channel → progressive gastric outlet obstruction. Most common surgical condition in infants.
Pathophysiology Related to Client Problem
Pylorus muscle hypertrophies and thickens → narrows pyloric opening → ingested formula/breast milk cannot pass into duodenum → builds up in stomach → forceful projectile vomiting → dehydration, weight loss, metabolic alkalosis.
Health Promotion and Disease Prevention
- No known prevention
- Early identification with appropriate referral
- Genetic counseling if family history
Risk Factors
- Male infants (4:1 male:female)
- First-born
- Caucasian descent
- Family history
- Ages 2 weeks to 5 months (peak 3–6 weeks)
- Maternal smoking during pregnancy
- Bottle-feeding (slight increase)
Expected Findings
- Projectile (forceful, non-bilious) vomiting — classic; can shoot across the room
- Vomiting occurs immediately after feeding
- Infant remains hungry after vomiting
- Weight loss or failure to gain weight
- Dehydration: poor skin turgor, sunken fontanel, ↓ urine output
- Visible peristaltic waves moving across abdomen (L → R)
- "Olive-shaped" mass in epigastrium or RUQ (palpable in 70–90%)
- Fewer stools (constipation)
- Lethargy if severe dehydration
Laboratory Tests
- Hypochloremic, hypokalemic metabolic alkalosis (from loss of HCl in vomitus)
- ↑ pH, ↑ HCO₃⁻, ↓ Cl⁻, ↓ K⁻, ↓ Na⁺
- ↑ BUN (dehydration)
- Urinalysis: ↓ urine output, ↑ specific gravity
Diagnostic Procedures
- Abdominal ultrasound — gold standard; shows elongated, thickened pylorus (target sign / donut sign)
- Upper GI series (rarely needed) — "string sign" of narrow pyloric channel
Safety Considerations
- NPO until surgery
- NG tube to decompress stomach if severe vomiting
- IV access for fluid/electrolyte correction
- Strict I&O
- Weigh diapers
Complications
- Severe dehydration
- Electrolyte imbalance (hypokalemia, hypochloremic alkalosis)
- Failure to thrive
- Aspiration pneumonia
- Postoperative: wound infection, persistent vomiting (usually self-limited)
Nursing Care
Preoperative:
- NPO; NG decompression if severe
- IV fluids with potassium replacement (after voiding established)
- Correct electrolyte imbalances before surgery
- Monitor VS, hydration status
- Daily weights
- Strict I&O including emesis volume
Postoperative (after pyloromyotomy):
- NPO 4–6 hr post-op
- Begin clear feedings (Pedialyte) per protocol
- Advance to formula/breast milk slowly (small frequent feeds)
- Some vomiting expected for 24–48 hr post-op
- Position upright after feedings
- Pain management
- Monitor incision
- Most discharged within 24–48 hr
Medications
- IV fluids with electrolytes (D5 1/2 NS + KCl after voiding)
- Postoperative analgesics (acetaminophen)
- Antibiotic prophylaxis at surgery
Therapeutic Procedures
- Pyloromyotomy (Ramstedt procedure) — surgical incision of pyloric muscle (laparoscopic or open); definitive treatment
- Surgery once electrolytes corrected and infant rehydrated
Client Education
- Expected post-op course: some vomiting normal first 24–48 hr
- Feeding progression: small, frequent, slow
- Position upright after feeding, burp frequently
- Wound care: keep clean and dry; signs of infection to report
- Excellent prognosis after surgery — full recovery
- Follow-up appointment
- Recognize signs of dehydration or persistent vomiting beyond 48 hr
Interprofessional Care
- Pediatric surgery
- Pediatric anesthesia
- Pediatric GI (rarely needed)
- Nutritionist if FTT concerns
Alterations in Health (Diagnosis)
Telescoping of one part of the intestine into an adjacent part, most commonly at the ileocecal valve (ileocolic). Most common cause of intestinal obstruction in children 3 months to 3 years.
Pathophysiology Related to Client Problem
Proximal bowel segment (intussusceptum) telescopes into distal segment (intussuscipiens) → mesentery and blood vessels become trapped → venous compression → edema → ischemia → bowel necrosis if not relieved → perforation, peritonitis, shock.
Health Promotion and Disease Prevention
- No specific prevention for most cases
- Note historical association with original rotavirus vaccine (current formulations much lower risk)
- Early recognition critical
Risk Factors
- Age 3 months to 3 years (peak 6–12 months)
- Boys > girls (2:1)
- Recent viral illness
- Cystic fibrosis
- Meckel diverticulum (lead point)
- Polyps, tumors (lead points in older children)
Expected Findings
Classic triad (only in ~15%):
- Sudden severe colicky abdominal pain
- Vomiting
- Currant jelly stools (blood and mucus)
Other findings:
- Episodic crying, drawing knees to chest (during pain episodes)
- Periods of normal behavior between episodes initially, then progressively lethargic
- "Sausage-shaped" mass palpable in RUQ or right side
- Bilious vomiting (later — obstruction)
- Currant jelly stools (late sign — mucus + blood)
- Distended abdomen
- Hypovolemic shock if untreated
Laboratory Tests
- CBC: may show ↑ WBC, ↓ hematocrit if bleeding
- Electrolytes (rule out dehydration)
- Stool guaiac may be positive
Diagnostic Procedures
- Abdominal ultrasound — gold standard; shows "target sign" or "doughnut sign"
- Abdominal X-ray — may show obstruction signs
- Contrast or air enema — both diagnostic AND therapeutic (reduces 80–90%)
Safety Considerations
- NPO
- NG decompression
- IV access for fluids and possible surgery
- Monitor for perforation (sudden ↓ pain, ↑ HR, ↓ BP, peritonitis signs)
- Strict I&O
Complications
- Bowel ischemia and necrosis
- Bowel perforation
- Peritonitis
- Sepsis
- Hypovolemic shock
- Recurrence (5–15% after non-surgical reduction)
Nursing Care
Preoperative/pre-reduction:
- NPO, NG decompression
- IV fluids (often bolus to correct hypovolemia)
- Continuous monitoring
- Pain management (after diagnosis confirmed)
- Type and crossmatch (potential need for surgery)
- Strict I&O
Post-reduction (enema or surgical):
- Monitor for passage of normal brown stool — indicates successful reduction
- Observe for recurrence (signs: abdominal pain returns)
- Resume feeds gradually after passing brown stool
- Discharge often within 24 hr if successful enema reduction
Medications
- IV fluids (LR or NS bolus initially)
- Antibiotics if perforation suspected (broad-spectrum)
- Pain management (after diagnosis)
- Postoperative analgesics
Therapeutic Procedures
- Air or contrast enema under fluoroscopy — first-line treatment (80–90% successful)
- Surgery if enema unsuccessful, perforation, or lead point identified
- Manual reduction or bowel resection if necrotic
Client Education
- Recognize signs of recurrence (abdominal pain, vomiting, bloody stool)
- Brown stool indicates successful reduction
- Gradual return to normal feeding
- Most children recover fully
- Watch for signs of perforation if at home: severe pain, fever, distention → seek emergency care
- Follow-up appointment
Interprofessional Care
- Pediatric radiology (enema reduction)
- Pediatric surgery (on standby; needed if perforation or lead point)
- Pediatric GI
Alterations in Health (Diagnosis)
Clinical syndrome characterized by massive proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Minimal change nephrotic syndrome (MCNS) is the most common form in children (ages 2–7 yr); typically idiopathic and responsive to steroids.
Pathophysiology Related to Client Problem
Increased permeability of the glomerular basement membrane → massive protein loss in urine (especially albumin) → hypoalbuminemia → decreased oncotic pressure → fluid shifts into interstitial space → edema. Liver compensates by ↑ lipid synthesis → hyperlipidemia.
Health Promotion and Disease Prevention
- No specific prevention
- Recognize and treat infections promptly
- Monitor for relapse
Risk Factors
- Age 2–7 years (peak)
- Boys > girls (2:1)
- Recent viral illness (often triggers presentation)
- Family history (rare)
Expected Findings
- Generalized edema (anasarca) — periorbital (especially morning), peripheral, scrotal, abdominal (ascites)
- Weight gain
- Frothy/foamy urine (proteinuria)
- Decreased urine output
- Pallor, fatigue
- Anorexia, malabsorption
- Pleural effusion (respiratory distress)
- Hypertension (sometimes)
- Susceptibility to infection
Laboratory Tests
- Urinalysis: proteinuria (3–4+), hyaline/granular casts
- 24-hour urine protein > 3.5 g/day or urine protein/creatinine ratio > 2
- Hypoalbuminemia (serum albumin < 2.5 g/dL)
- Hyperlipidemia (↑ cholesterol, triglycerides)
- ↑ BUN, normal or near-normal creatinine (MCNS)
- ↓ serum total protein
- Electrolytes may show hyponatremia
- ↑ hematocrit (hemoconcentration)
Diagnostic Procedures
- Diagnosis clinical based on labs + findings
- Renal biopsy if atypical presentation or steroid-resistant
- Ultrasound of kidneys
Safety Considerations
- Infection precautions (low immunoglobulins → susceptible)
- Pneumococcal and varicella vaccines
- Avoid live vaccines while on high-dose steroids
- Skin care for edematous areas
- Fall precautions if severe ascites/respiratory compromise
Complications
- Infection (pneumococcal peritonitis, sepsis — leading cause of death)
- Thromboembolism (loss of antithrombin III in urine)
- Hypovolemia (intravascular volume depletion despite edema)
- Acute kidney injury
- Steroid side effects (with long-term use)
- Growth failure
- Relapse (very common)
Nursing Care
- Daily weight at same time, scale, clothing
- Strict I&O — measure urine output
- Daily abdominal girth (umbilicus level)
- Monitor BP closely
- Test urine for protein each void (dipstick)
- Skin care — turn frequently, gentle handling, keep edematous areas clean and dry
- Position to support edematous body parts
- Small, frequent meals (anorexia common)
- Activity as tolerated (rest periods)
- Infection prevention (limit visitors, hand hygiene)
- Psychosocial support — chronic relapsing disease
Medications
- Corticosteroids (prednisone) 2 mg/kg/day — first-line, until urine protein-free × 3 days, then taper over 2–3 months
- Diuretics (furosemide) for severe edema — cautiously (can worsen hypovolemia)
- Albumin (25%) IV — may be given before diuretic to pull fluid into vessels
- Immunosuppressants (cyclophosphamide, cyclosporine) — for steroid-resistant or frequent relapsers
- ACE inhibitors (reduce proteinuria)
- Statins for hyperlipidemia
- Antibiotics for infections
Therapeutic Procedures
- Renal biopsy (if needed)
- Paracentesis if severe ascites with respiratory compromise
Client Education
- Sodium-restricted diet during edematous phase (no added salt)
- Adequate protein intake
- Fluid management as prescribed
- Daily weights at home
- Test urine for protein at home (dipstick)
- Recognize signs of relapse (proteinuria, edema) → contact provider
- Recognize signs of infection (fever, abdominal pain, redness)
- Steroid administration: give with food, taper slowly, don't stop abruptly
- Recognize steroid side effects: moon face, weight gain, mood changes (these are expected)
- Keep vaccinations current (avoid live vaccines on high-dose steroids)
Interprofessional Care
- Pediatric nephrology
- Pediatric dietitian
- Pharmacy (steroid management)
- Social work
- School nurse
Alterations in Health (Diagnosis)
X-linked recessive bleeding disorder. Hemophilia A (classic) = factor VIII deficiency (80% of cases). Hemophilia B (Christmas disease) = factor IX deficiency. Severity: mild, moderate, severe (based on % of normal factor activity).
Pathophysiology Related to Client Problem
Deficiency in factor VIII (A) or IX (B) → impaired intrinsic coagulation cascade → prolonged bleeding after injury or spontaneous bleeding in severe disease. Primary hemostasis (platelet plug) is normal — initial clot forms but cannot stabilize.
Health Promotion and Disease Prevention
- Genetic counseling for affected families
- Prenatal testing available
- Newborn cord blood testing if family history
- Education on injury prevention
Risk Factors
- Male sex (X-linked recessive — affects males predominantly)
- Family history (mother is carrier)
- Spontaneous mutation in ~30% (no family history)
Expected Findings
- Prolonged bleeding after minor injury, dental procedures, surgery, circumcision
- Hemarthrosis — bleeding into joints (knees, ankles, elbows most common); pain, swelling, ↓ ROM, warmth
- Easy bruising
- Subcutaneous and intramuscular hematomas
- Epistaxis
- Bleeding after immunizations
- Hematuria, GI bleeding
- Intracranial bleeding (most serious)
- Severe: spontaneous bleeding without trauma
Laboratory Tests
- ↑ aPTT (intrinsic pathway prolonged)
- Normal PT, platelet count, bleeding time
- ↓ factor VIII assay (Hemophilia A) or factor IX (Hemophilia B)
- Severity by factor level: severe < 1%, moderate 1–5%, mild > 5%
- Genetic testing confirms diagnosis
Diagnostic Procedures
- Specific factor assay (definitive)
- Mixing studies if inhibitor suspected
- Imaging (CT, MRI) if internal bleeding suspected
Safety Considerations
- NO IM injections — use SQ or IV instead; if IM unavoidable, give factor first and apply firm pressure
- NO aspirin or NSAIDs (inhibit platelet function)
- NO contact sports — swimming, biking, golf, walking acceptable
- Soft toothbrush for oral care
- Electric razor (older children)
- Medical alert ID
- Padding for crawling/walking infants
- Helmet with bike riding
Complications
- Joint deformity and disability from repeated hemarthrosis (chronic arthropathy)
- Intracranial hemorrhage — most life-threatening
- Compartment syndrome from intramuscular bleeding
- Airway obstruction from neck/throat bleeding
- Inhibitor development (antibodies against factor) — complicates treatment
- Blood-borne infections (historical concern with older factor products)
Nursing Care
Acute bleeding (RICE):
- Rest the affected joint
- Ice to area
- Compression
- Elevation
- Administer factor replacement immediately
- Apply firm pressure to bleeding sites (15+ min for venipuncture)
- Pain management (NOT NSAIDs)
General care:
- Avoid IM injections, rectal temperatures
- Use small-gauge needle for venipuncture
- Soft toothbrush, electric razor
- Padded environment for active toddlers
- ROM exercises after acute episode to prevent contractures
- Psychosocial support — chronic disease
Medications
Factor replacement (cornerstone of treatment):
- Recombinant factor VIII or IX — given IV; on-demand for bleeds or prophylactic 2–3× weekly
- Dose calculation: factor units = weight × % factor desired × 0.5 (hemophilia A) or × 1 (hemophilia B)
- Desmopressin (DDAVP) — for mild hemophilia A; releases stored factor VIII
- Antifibrinolytics (aminocaproic acid, tranexamic acid) — useful for mucosal bleeding (oral, dental)
- Emicizumab — monoclonal antibody, monthly SQ for severe hemophilia A
- Avoid: aspirin, NSAIDs, IM injections
Therapeutic Procedures
- Joint aspiration (if severe hemarthrosis)
- Physical therapy after acute bleeds
- Synovectomy (chronic affected joints)
- Eventual joint replacement if severe arthropathy
Client Education
- Recognize signs of bleeding (joint pain/swelling, headache, weakness, blood in urine/stool)
- Home factor administration (older children, parents)
- RICE for acute bleeding
- NO aspirin, NSAIDs
- Avoid contact sports; safe activities: swimming, walking, bicycling with helmet
- Soft toothbrush, electric razor
- Medical alert ID at all times
- Genetic counseling for family members
- Avoid IM injections — use SQ alternatives or premedicate with factor
- Maintain dental hygiene to prevent need for procedures
Interprofessional Care
- Pediatric hematology (hemophilia treatment center)
- Physical therapy
- Genetic counseling
- Dental hygienist
- School nurse
- Social work, hemophilia support groups
Alterations in Health (Diagnosis)
Inflammation of the meninges (membranes surrounding the brain and spinal cord) caused by bacterial infection. Medical emergency requiring prompt diagnosis and antibiotic treatment.
Pathophysiology Related to Client Problem
Bacteria enter the CNS (hematogenous spread, direct extension from sinuses/middle ear, or skull defect) → multiply in CSF → trigger inflammatory response → increased ICP, cerebral edema, vasculitis, brain damage. Common pathogens by age: neonates — GBS, E. coli, Listeria; infants/children — S. pneumoniae, N. meningitidis, H. influenzae type B (if unvaccinated).
Health Promotion and Disease Prevention
- Vaccines: Hib, PCV13, meningococcal (MenACWY at 11–12 yr, booster at 16 yr; MenB optional for adolescents)
- Treat respiratory and ear infections promptly
- Hand hygiene
- Prophylactic antibiotics (rifampin) for close contacts of meningococcal cases
Risk Factors
- Age < 2 years (highest)
- Unvaccinated or incompletely vaccinated
- Crowded living conditions (dormitories, daycares)
- Immunocompromised state
- Recent ear infection, sinusitis, head trauma, neurosurgery
- CSF shunt
- Cochlear implants
Expected Findings
Classic triad: fever + nuchal rigidity + altered mental status
Infants:
- Bulging fontanel (late sign)
- High-pitched cry
- Poor feeding, vomiting
- Irritability or lethargy
- Hypothermia or fever
- Seizures
- Opisthotonos — arched back, hyperextended neck
Children:
- Severe headache
- Fever, chills
- Nuchal rigidity
- Photophobia
- Nausea, vomiting
- Kernig's sign — pain with knee extension while hip flexed
- Brudzinski's sign — hip/knee flexion when neck flexed
- Altered LOC, seizures
- Petechial/purpuric rash (especially meningococcal — emergency!)
Laboratory Tests
CSF analysis (lumbar puncture):
- Bacterial: ↑ WBC (neutrophils predominant), ↓ glucose, ↑ protein, cloudy/purulent, ↑ opening pressure
- Viral: ↑ WBC (lymphocytes), normal glucose, mildly ↑ protein, clear
- Gram stain and culture
Other:
- Blood cultures (often positive)
- CBC: ↑ WBC with left shift
- ↑ CRP, ESR
- Electrolytes, glucose
Diagnostic Procedures
- Lumbar puncture — diagnostic; check ICP first; contraindicated if signs of ↑ ICP (do CT first)
- CT or MRI brain (rule out mass, abscess)
- Blood cultures
Safety Considerations
- Droplet precautions for first 24 hr of effective antibiotics
- Seizure precautions
- Monitor for ↑ ICP (Cushing's triad: ↑ BP with widening pulse pressure, bradycardia, irregular respirations)
- Frequent neuro checks
- Strict I&O
- Quiet, dim room (photophobia)
Complications
- Death (10–15% mortality)
- Hearing loss (most common long-term complication — audiology evaluation post-illness)
- Cognitive impairment, learning disabilities
- Seizures (acute and chronic)
- Hydrocephalus
- SIADH (frequent — fluid restriction may be needed)
- DIC (especially meningococcal)
- Waterhouse-Friderichsen syndrome (adrenal hemorrhage with meningococcemia)
- Cerebral edema, herniation
Nursing Care
- Initiate droplet precautions immediately (until 24 hr of antibiotics)
- Frequent neuro assessments (LOC, pupils, motor, vital signs)
- Position with HOB elevated 30°, neutral neck
- Quiet, dim environment
- Continuous cardiopulmonary monitoring
- Strict I&O (SIADH risk — may need fluid restriction)
- Daily weights
- Seizure precautions and management
- Antipyretics for fever
- Pain management (cool compresses for headache)
- Hydration cautiously (avoid fluid overload)
- Skin care for prolonged immobility
Medications
- Empiric IV antibiotics IMMEDIATELY (do not delay for LP):
- Neonates: ampicillin + cefotaxime (or gentamicin)
- Older infants/children: ceftriaxone or cefotaxime + vancomycin
- Duration: 7–21 days depending on organism
- Corticosteroids (dexamethasone) — given before or with first antibiotic dose to reduce hearing loss (especially Hib)
- Antipyretics (acetaminophen)
- Anticonvulsants if seizures
- Rifampin prophylaxis for close contacts of meningococcal cases
Therapeutic Procedures
- Lumbar puncture
- Possible repeat LP if poor response
- Audiology evaluation after recovery
- Neurological follow-up
Client Education
- Recognize early signs (fever, headache, neck stiffness, rash) — seek care immediately
- Importance of completing full antibiotic course
- Vaccinations: Hib, PCV13, meningococcal
- Notify close contacts who may need prophylaxis
- Post-discharge audiology evaluation
- Developmental follow-up (cognitive, motor delays)
- Recognize signs of complications (seizures, hearing loss, developmental delay)
Interprofessional Care
- Pediatric infectious disease
- PICU
- Neurology
- Audiology (post-illness)
- Developmental specialist
- Public health (contact tracing for meningococcal)
Alterations in Health (Diagnosis)
Imbalance between production and absorption of cerebrospinal fluid (CSF) → excess CSF accumulates within the ventricular system → increased intracranial pressure and ventricular dilation. Can be communicating (impaired absorption) or non-communicating/obstructive.
Pathophysiology Related to Client Problem
Non-communicating (obstructive): blockage in CSF pathway (e.g., aqueductal stenosis, tumor, Chiari malformation) prevents flow → CSF accumulates proximally → ventricles dilate → ↑ ICP.
Communicating: impaired CSF reabsorption (post-hemorrhage, post-meningitis) → CSF accumulates → ventricles dilate.
Health Promotion and Disease Prevention
- Prenatal screening (ultrasound)
- Maternal folic acid (reduces neural tube defects)
- Prevent prematurity (reduces IVH risk)
- Prompt treatment of meningitis
- Helmet use for head injury prevention
Risk Factors
- Premature infants (IVH)
- Spina bifida / myelomeningocele (Arnold-Chiari II malformation)
- Intraventricular hemorrhage
- Meningitis
- Brain tumors
- Congenital malformations
- Head trauma
Expected Findings
Infants (open fontanels):
- Rapid head growth — head circumference crossing percentile lines
- Bulging anterior fontanel
- Widely separated sutures
- "Sunset eyes" — eyes deviated downward, sclera visible above iris
- Distended scalp veins
- Frontal bossing
- Poor feeding, irritability, lethargy
- High-pitched cry
- Vomiting
Children (closed sutures):
- Headache (especially morning)
- Vomiting (often without nausea, projectile)
- Behavioral changes, irritability
- Decline in school performance
- Papilledema
- Diplopia, blurred vision
- Ataxia
- Late: Cushing's triad, decreased LOC, seizures
Laboratory Tests
- CBC, electrolytes (baseline)
- CSF analysis if shunt suspected of infection
Diagnostic Procedures
- CT or MRI brain — confirms ventricular enlargement
- Cranial ultrasound (infants with open fontanel)
- Daily head circumference (infants)
- Ophthalmology exam (papilledema)
Safety Considerations
- Monitor for ↑ ICP signs (early: ↓ LOC; late: Cushing's triad)
- HOB elevated 30°, midline neck
- Avoid Valsalva (constipation prevention)
- Seizure precautions
- Strict I&O
- Frequent neuro assessments
Complications
- Permanent neurologic damage if untreated
- Cognitive impairment, developmental delays
- Vision problems (chronic papilledema)
- Death from herniation
- Shunt complications: infection (most common), obstruction, mechanical failure, overdrainage (slit ventricle syndrome), disconnection, migration
Nursing Care
Pre-shunt placement:
- HOB elevated 30°, midline head position
- Daily head circumference measurement (infants)
- Avoid increasing ICP (no straining, suctioning carefully)
- Frequent neuro assessment
- Small frequent feeds (vomiting risk)
- Support head when lifting infant
Post-VP shunt:
- Position FLAT or with HOB 15–30° initially (per surgeon — prevents overdrainage)
- Position with the operated side UP (do not lie on operated side) to prevent pressure on valve
- Strict I&O
- Frequent neuro checks
- Monitor incision sites (head AND abdomen for VP shunt) for infection, drainage, swelling
- Measure head circumference daily
- Pain management
- Anti-emetics if needed
- Slow position changes
Medications
- Antibiotics (peri-operative prophylaxis and if shunt infection)
- Acetazolamide and furosemide may temporize (reduce CSF production)
- Analgesics (acetaminophen) post-op
- Anti-seizure medications if indicated
Therapeutic Procedures
- Ventriculoperitoneal (VP) shunt — most common; CSF drains from ventricle to peritoneal cavity
- Ventriculoatrial (VA) shunt — less common
- Endoscopic third ventriculostomy (ETV) — alternative for obstructive hydrocephalus; creates internal CSF pathway
- Serial LPs in some infants (temporary)
- External ventricular drain (EVD) — temporary
Client Education
Shunt care:
- Recognize shunt malfunction signs:
- Infants: bulging fontanel, ↑ head circumference, sunset eyes, lethargy, vomiting, poor feeding, high-pitched cry
- Older children: headache (especially morning), vomiting, behavior changes, vision problems, lethargy, fever
- Recognize shunt infection: fever, redness/swelling along shunt tract, vomiting, lethargy
- Avoid contact sports (helmet for contact-risk activities)
- Lifelong follow-up
- Multiple shunt revisions likely (most need replacement during childhood)
- Developmental and educational support
Interprofessional Care
- Pediatric neurosurgery
- Pediatric neurology
- PICU
- Developmental pediatrician
- Physical, occupational, speech therapy
- Special education services
Alterations in Health (Diagnosis)
Life-threatening acute complication of diabetes mellitus characterized by hyperglycemia, ketosis, and metabolic acidosis. Most common in type 1 DM; can occur in type 2. Often the presenting event for new-onset T1DM in children.
Pathophysiology Related to Client Problem
Insulin deficiency → cells cannot uptake glucose → hyperglycemia → osmotic diuresis → dehydration. Body breaks down fat for energy → ketone production (beta-hydroxybutyrate, acetoacetate) → metabolic acidosis. Counter-regulatory hormones (glucagon, cortisol, epinephrine) worsen hyperglycemia.
Health Promotion and Disease Prevention
- Early recognition and treatment of T1DM
- Patient/family education on sick day management
- Never stop insulin (even when ill)
- Check glucose and ketones with illness or hyperglycemia
- Adequate hydration during illness
Risk Factors
- Type 1 diabetes (new diagnosis or established)
- Insulin omission (intentional or unintentional)
- Infection (most common precipitant in known diabetics)
- Illness, surgery, trauma, stress
- Insulin pump malfunction
- Adolescents (highest risk)
Expected Findings
Onset can be rapid:
- Polyuria, polydipsia, polyphagia (early)
- Weight loss
- Kussmaul respirations — deep, rapid breathing (compensating for acidosis)
- Fruity (acetone) breath odor
- Dehydration: dry mucous membranes, poor skin turgor, sunken eyes, ↓ urine output
- Abdominal pain, nausea, vomiting
- Confusion, altered LOC, coma
- Hypotension, tachycardia
- Hypothermia or normal temp (despite infection)
- Blurred vision
- Soft, sunken eyeballs
Laboratory Tests
Diagnostic criteria for DKA:
- Hyperglycemia > 200 mg/dL (often 300–800)
- Metabolic acidosis: pH < 7.3, bicarbonate < 15 mEq/L
- Ketones in blood (beta-hydroxybutyrate) and urine
Other:
- Anion gap acidosis (> 12)
- ↑ BUN, creatinine (dehydration)
- Initial K may be normal or ↑ (but TOTAL body K is DEPLETED — falls with insulin)
- ↑ WBC even without infection
- ↑ amylase, lipase
- Glucosuria, ketonuria
Diagnostic Procedures
- Continuous cardiac monitoring
- EKG (monitor for K changes)
- Hourly glucose, electrolytes
- Workup for precipitant (CBC, blood cultures, UA, CXR if infection suspected)
Safety Considerations
- PICU admission for moderate-severe DKA
- Continuous cardiac monitoring
- Monitor for cerebral edema (most feared complication in pediatric DKA)
- Frequent neuro checks
- Strict hourly I&O
- Slow correction of glucose to prevent cerebral edema
- Q1h glucose, q2–4h electrolytes
Complications
Cerebral edema (1% of cases; mortality 20–40%) — most feared complication; symptoms 4–12 hr into treatment
- Severe headache
- Decreased LOC
- Cushing's triad
- Treatment: mannitol or hypertonic saline, slow IV fluids
Other complications:
- Hypokalemia (rapid drop with insulin therapy)
- Hypoglycemia (overcorrection)
- Aspiration
- Acute kidney injury
- Death
Nursing Care
Initial management priorities:
- IV access, fluid resuscitation
- Continuous insulin infusion
- Electrolyte replacement
- Identify and treat precipitating cause
- Monitor for complications
Detailed nursing care:
- Fluid resuscitation: 10–20 mL/kg NS bolus over 1 hr; then 0.45–0.9% NS over 24–48 hr (avoid rapid fluid changes)
- Continuous insulin infusion 0.05–0.1 unit/kg/hr after initial fluid bolus
- Hourly blood glucose
- Q2h electrolytes initially
- Strict hourly I&O (Foley catheter often needed)
- Continuous cardiac monitoring
- Neuro checks q1h initially
- HOB elevated 30°
- When glucose drops below ~250–300: add D5 to IV fluids; do NOT stop insulin
- Add potassium to IV fluids when K trending normal (insulin drives K into cells)
- NPO until awake
- Reorient frequently (altered LOC)
- Family support and education
Medications
- Regular insulin IV infusion 0.05–0.1 unit/kg/hr — never bolus in children (cerebral edema risk)
- IV fluids: NS 10 mL/kg initially, then 0.45% NS; add D5 when glucose ~250 mg/dL
- Potassium replacement in IV fluids (after voiding established)
- Bicarbonate — controversial, only for severe acidosis (pH < 6.9)
- Antibiotics if infection precipitant
- Antiemetics (ondansetron)
- Mannitol or 3% saline for cerebral edema
Therapeutic Procedures
- IV insertion (often 2 large bore)
- Foley catheter for accurate I&O
- Cardiac monitoring
- Transition to SQ insulin once: pH > 7.3, bicarb > 15, child eating/drinking, ketones cleared
Client Education
Prevention of future DKA:
- Sick day rules:
- Never stop insulin (may need MORE during illness)
- Check blood glucose q2–4 hr
- Check urine/blood ketones if glucose > 250 mg/dL or ill
- Drink sugar-free fluids if glucose > 250; drink fluids with carbs if glucose < 250 and not eating
- Take small frequent sips of fluid
- Call provider for: persistent vomiting, ketones, glucose > 300 unrelieved by correction
Recognize early DKA signs:
- Polyuria, polydipsia, fruity breath, Kussmaul respirations
- Confusion, abdominal pain, vomiting
Interprofessional Care
- Pediatric endocrinology
- PICU intensivist
- Diabetes educator
- Dietitian
- Social work (especially if non-adherence)
- Mental health (depression, eating disorders contribute to recurrent DKA)
Alterations in Health (Diagnosis)
Acyanotic congenital heart defect with abnormal opening between right and left ventricles → left-to-right shunt → ↑ pulmonary blood flow → right ventricular workload. Most common CHD (~30%). Many close spontaneously.
Pathophysiology Related to Client Problem
Pressure gradient L → R through VSD → ↑ pulmonary blood flow → pulmonary HTN over time → right ventricular hypertrophy → eventual shunt reversal (Eisenmenger syndrome) if untreated.
Health Promotion and Disease Prevention
- Genetic counseling if family history
- Avoid teratogens during pregnancy
- Endocarditis prophylaxis for dental procedures (high-risk lesions)
Risk Factors
- Down syndrome
- Family history of CHD
- Maternal rubella, alcohol, diabetes
- Premature birth
Expected Findings
- Loud, harsh holosystolic murmur at LLSB
- Thrill at LLSB
- Tachypnea, tachycardia
- Diaphoresis with feedings
- Poor weight gain, FTT
- Frequent respiratory infections
- Signs of CHF if large defect
Laboratory Tests
- Normal CBC, electrolytes
- BNP elevated with CHF
Diagnostic Procedures
- Echocardiogram — definitive diagnosis
- ECG: LVH or biventricular hypertrophy
- Chest X-ray: cardiomegaly, ↑ pulmonary vascularity
- Cardiac catheterization
Safety Considerations
- Monitor for signs of CHF
- Endocarditis prophylaxis as indicated
- Cluster care during feeds (high O₂ demand)
Complications
- Heart failure
- Pulmonary HTN, Eisenmenger syndrome
- Bacterial endocarditis
- Failure to thrive
- Arrhythmias post-repair
Nursing Care
- Small, frequent feedings; high-calorie formula
- Cluster care, allow rest
- Strict I&O, daily weight
- Monitor for HF: tachypnea, tachycardia, edema, hepatomegaly
- Position semi-Fowler's for breathing
- Limit crying (use pacifier, swaddling)
Medications
- Digoxin for HF (with apical pulse check)
- Diuretics (furosemide) for fluid overload
- ACE inhibitors (afterload reduction)
- Iron supplements (treat anemia)
- Endocarditis prophylaxis (amoxicillin) before dental procedures
Therapeutic Procedures
- Small defects: spontaneous closure in 50% by age 5
- Surgical repair (patch closure) for large defects or symptomatic patients
- Cardiac catheterization with device closure (some defects)
Client Education
- High-calorie nutrition strategies
- Recognize HF signs (poor feeding, sweating, tachypnea)
- Prevent respiratory infections
- Endocarditis prevention with dental care
- Activity as tolerated
- Importance of follow-up echocardiograms
Interprofessional Care
- Pediatric cardiology
- Cardiothoracic surgery
- Dietitian for FTT
- Early intervention
Alterations in Health (Diagnosis)
Obstructive congenital heart defect with narrowing (constriction) of the aorta, usually just distal to the left subclavian artery near the ductus arteriosus. Causes ↑ pressure proximal (head, upper extremities) and ↓ pressure distal (lower extremities).
Pathophysiology Related to Client Problem
Aortic narrowing → ↑ LV afterload → LV hypertrophy → eventual HF. Distal hypoperfusion → ↓ pulses in lower extremities, claudication, possible renal hypoperfusion.
Health Promotion and Disease Prevention
- Routine four-extremity BP screening in pediatric exams
- Genetic counseling (Turner syndrome association)
- Endocarditis prophylaxis
Risk Factors
- Turner syndrome (10–20% of females with Turner have coarc)
- Male predominance overall
- Family history
- Bicuspid aortic valve (70% association)
Expected Findings
- BP higher in upper extremities than lower extremities
- Bounding upper extremity pulses; weak/absent femoral pulses
- Cool, mottled lower extremities
- Headache, epistaxis, dizziness (older children)
- Leg cramps with exercise
- Systolic murmur at LSB radiating to back
- Severe cases (infants): HF, shock
Laboratory Tests
- Renal function (chronic ↓ perfusion)
- Electrolytes
Diagnostic Procedures
- Four-extremity BP — upper > lower (key finding)
- Echocardiogram
- Chest X-ray: rib notching (older children), "3 sign"
- Cardiac catheterization
- CT/MRI angiography
Safety Considerations
- Monitor BP carefully (avoid hypertension)
- Pre-/postductal SpO₂ in neonates (differential cyanosis)
- Maintain ductus open with prostaglandin E1 in critical neonatal coarc
Complications
- Heart failure (especially neonates)
- Severe hypertension
- Aortic aneurysm/dissection
- Stroke
- Endocarditis
- Recoarctation after repair
Nursing Care
- Monitor BP in all four extremities
- Compare radial vs femoral pulses
- Cardiac and respiratory monitoring
- Strict I&O
- Provide opportunities for normal activities
- Postoperative: monitor BP (rebound HTN common), pulses, neuro status
Medications
- Prostaglandin E1 (alprostadil) — neonates; maintains ductal patency until repair
- Antihypertensives post-repair (beta-blockers, ACE inhibitors)
- Diuretics for HF
- Endocarditis prophylaxis
Therapeutic Procedures
- Surgical repair (resection with end-to-end anastomosis or subclavian flap)
- Balloon angioplasty with or without stent
- Repair usually in infancy or early childhood
Client Education
- Lifelong cardiology follow-up
- BP monitoring
- Recognize recoarctation signs (decreasing exercise tolerance)
- Endocarditis prophylaxis before dental procedures
- Activity restrictions only if hypertensive or other complications
Interprofessional Care
- Pediatric cardiology
- Cardiothoracic surgery
- Geneticist (Turner syndrome screen)
Alterations in Health (Diagnosis)
Congenital craniofacial malformations resulting from failure of fusion of facial structures during embryonic development. Cleft lip (CL) involves the upper lip; cleft palate (CP) involves the hard and/or soft palate. Can occur separately or together.
Pathophysiology Related to Client Problem
During weeks 4–12 of gestation, failure of fusion of maxillary and medial nasal processes → cleft lip; failure of palatal shelves to fuse → cleft palate. Multifactorial etiology: genetic + environmental factors.
Health Promotion and Disease Prevention
- Adequate folic acid intake (400 mcg/day) preconception
- Avoid teratogens during pregnancy (alcohol, smoking, phenytoin)
- Manage maternal diabetes
- Genetic counseling if family history
Risk Factors
- Family history (multifactorial inheritance)
- Maternal smoking, alcohol use
- Maternal diabetes
- Anti-epileptic medications during pregnancy (phenytoin)
- Folate deficiency
- Associated syndromes (Pierre Robin, 22q11.2 deletion)
- Asian and Native American descent
Expected Findings
Cleft lip:
- Visible cleft in upper lip (unilateral or bilateral)
- Often noted on prenatal ultrasound
- Visible at birth
Cleft palate:
- Opening in hard and/or soft palate
- Detected by oral inspection at birth (palpate roof of mouth)
- Difficulty feeding (poor seal, formula coming through nose)
- Frequent otitis media (eustachian tube dysfunction)
- Speech delays
Laboratory Tests
- No specific labs needed
- Genetic testing if syndromic features
Diagnostic Procedures
- Prenatal ultrasound (often detects CL)
- Physical examination at birth
- Inspection AND palpation of palate
Safety Considerations
- Monitor for aspiration during feeds
- Position upright during feeds
- Monitor weight gain
- Postoperative airway monitoring
Complications
- Feeding difficulties → FTT
- Recurrent otitis media → hearing loss
- Speech and language delays
- Dental abnormalities
- Psychosocial impact (appearance)
- Aspiration
- Postoperative: bleeding, infection, suture line breakdown
Nursing Care
Pre-operative feeding:
- Use specialty bottles/nipples (Haberman/Mead Johnson, Pigeon, Ross cleft palate nurser)
- Position upright during feeds; allow longer rest periods
- Burp frequently (swallowed air)
- Breastfeeding may still be possible with cleft lip alone
- Small, frequent feeds
- Daily weight, monitor growth
Postoperative cleft lip repair (cheiloplasty, around 3 months):
- Position on back or side (not prone — protects incision)
- Use elbow restraints to prevent rubbing
- Clean suture line gently per protocol
- Avoid pacifiers, no suctioning of mouth
- Use cup or specialty bottle
Postoperative cleft palate repair (palatoplasty, around 6–12 months):
- Position prone or side-lying initially (allows secretion drainage)
- Elbow restraints
- Soft diet (no straws, no hard foods, no objects in mouth)
- No oral suctioning, no tongue blades
- Pain management
Medications
- Acetaminophen for pain (preoperative and postoperative)
- Postoperative analgesia (per protocol; avoid IM injections in infants)
- Antibiotics if infection
Therapeutic Procedures
- Cleft lip repair (cheiloplasty): usually at 2–3 months ("rule of 10s": 10 weeks, 10 lb, Hgb 10)
- Cleft palate repair (palatoplasty): usually 6–12 months
- Speech therapy
- Orthodontics, dental work
- Multiple surgeries often needed throughout childhood
Client Education
- Specialty feeding techniques and equipment
- Importance of maintaining nutrition for surgery
- Postoperative care: positioning, elbow restraints, no objects in mouth
- Recognize postop complications (bleeding, infection)
- Frequent hearing checks
- Speech therapy importance
- Long-term follow-up with cleft team
- Emotional support (appearance, lengthy treatment course)
Interprofessional Care
- Cleft and craniofacial team: plastic surgery, ENT, dentistry, orthodontics
- Speech-language pathology
- Audiology
- Lactation consultant, dietitian
- Geneticist
- Social work, psychology
Alterations in Health (Diagnosis)
Non-progressive motor disorder caused by injury to the developing brain (before, during, or after birth) → permanent disorder of movement, posture, and motor function. Most common motor disability in childhood.
Pathophysiology Related to Client Problem
Brain injury during fetal development, birth, or first 2 years → abnormal motor control. Spastic (most common, 70–80%), dyskinetic, ataxic, or mixed. Lesion is non-progressive but manifestations may change as child grows.
Health Promotion and Disease Prevention
- Prenatal care, avoid teratogens
- Prevent prematurity
- Newborn neuroprotection (magnesium sulfate for preterm labor < 32 wk)
- Therapeutic hypothermia for HIE
- Maternal infection screening
Risk Factors
- Prematurity (especially < 32 weeks) — strongest risk factor
- Low birth weight
- Birth asphyxia, HIE
- Intraventricular hemorrhage
- Multiple gestation
- Maternal infection (chorioamnionitis)
- Kernicterus
- Postnatal: meningitis, head trauma, near-drowning
Expected Findings
Early signs (infancy):
- Delayed motor milestones
- Persistent primitive reflexes
- Hypertonia or hypotonia
- Poor head control
- Stiffness when handling
- Hand preference before 12 months
Older children:
- Spastic: scissoring gait, toe-walking, contractures
- Dyskinetic: involuntary movements (athetoid, chorea, dystonia)
- Ataxic: poor coordination, wide-based gait
- Associated: seizures (30–50%), intellectual disability (50%), vision problems, hearing impairment, speech delay, feeding difficulties
Laboratory Tests
- No specific lab — diagnosis clinical
- Workup to exclude metabolic causes if atypical
Diagnostic Procedures
- MRI brain — periventricular leukomalacia (preterm), focal lesions
- EEG if seizures
- Developmental assessment
- Vision and hearing evaluation
Safety Considerations
- Seizure precautions if epilepsy
- Aspiration risk (feeding)
- Skin breakdown prevention
- Fall prevention
- Mobility equipment safety
- Communication device safety
Complications
- Contractures, scoliosis, hip dislocation
- Aspiration pneumonia (most common cause of death)
- GERD, constipation, feeding difficulties → FTT
- Seizures
- Intellectual disability, learning disabilities
- Skin breakdown
- Osteoporosis (immobility)
Nursing Care
- Maximize function and independence
- Position to prevent contractures; perform ROM exercises
- Adequate nutrition (often need high-calorie, may need G-tube)
- Aspiration precautions during feeds (upright, slow, thickened liquids if needed)
- Skin care, frequent repositioning
- Adaptive equipment (wheelchair, AFOs, walker, communication devices)
- Anticipate longer time for ADLs
- Communicate at developmental level
- Encourage participation in age-appropriate activities
Medications
- Antispasmodics: baclofen (oral or intrathecal pump), diazepam, dantrolene
- Botulinum toxin (Botox) injections for focal spasticity
- Anticonvulsants if seizures
- Stool softeners for constipation
- PPI for GERD
- Anticholinergics for drooling (glycopyrrolate)
Therapeutic Procedures
- Physical therapy, occupational therapy, speech therapy (lifelong)
- Orthopedic surgery (tendon lengthening, hip surgeries)
- Selective dorsal rhizotomy
- Botulinum toxin injections
- Intrathecal baclofen pump
- Communication devices, AAC
- Equipment: AFOs, wheelchair, gait trainer
Client Education
- This is a non-progressive condition — manifestations may change with growth
- Importance of consistent therapy
- Adaptive equipment use
- Recognize feeding difficulties, aspiration risk
- Skin care, repositioning
- Special education and IEP rights
- Respite care for family
- Transition planning to adult care
Interprofessional Care
- Pediatric neurology, developmental pediatrician
- Physical, occupational, speech therapists
- Orthopedic surgery, neurosurgery
- Dietitian (often need G-tube)
- Special education team
- Social work, psychology, respite care
- Wheelchair clinic, AAC specialist
Alterations in Health (Diagnosis)
Failure of one or both testes to descend into the scrotum by birth. Most common genitourinary anomaly in male newborns. Testes form in abdomen and normally descend through the inguinal canal by birth.
Pathophysiology Related to Client Problem
Disruption of normal testicular descent during fetal development. Testis remains in abdomen or inguinal canal → exposure to higher core body temperature → potential for impaired spermatogenesis and ↑ risk of malignancy if not corrected.
Health Promotion and Disease Prevention
- Routine examination at well-child visits
- Early identification and referral
- Surgical correction by age 1 to optimize fertility
Risk Factors
- Premature birth (most common risk factor — 30% of preemies)
- Low birth weight
- Family history
- Maternal smoking, diabetes
- Cryptorchidism in twin
Expected Findings
- Empty scrotum on palpation (one or both sides)
- Hypoplastic (small) scrotum on affected side
- Testis may be palpable in inguinal canal
- Differential: retractile testis (descends with warmth/relaxation) — does NOT require treatment
- Most descend spontaneously by 3 months in term infants
Laboratory Tests
- If bilateral and non-palpable: hormonal testing (LH, FSH, testosterone) to rule out anorchia, genetic conditions
- Genetic testing if ambiguous genitalia
Diagnostic Procedures
- Physical examination (warm room, relaxed child)
- Imaging usually NOT indicated
- If non-palpable bilaterally: ultrasound, MRI, or laparoscopy
Safety Considerations
- Postoperative: avoid bicycle riding, straddling activities for 2–3 weeks
- Pain management after surgery
- Wound care
Complications
- Infertility (especially bilateral) — risk ↑ with later repair
- Testicular cancer — 4–10× ↑ risk (lifelong); cancer can occur in the contralateral normal testis too
- Testicular torsion
- Inguinal hernia (associated)
- Psychological effects
Nursing Care
Preoperative:
- Confirm location of testis on exam
- Routine preoperative care
- Education about procedure
Postoperative:
- Pain management
- Monitor incision sites (scrotum and inguinal)
- Ice/cold packs for swelling (per protocol)
- Loose-fitting diapers/clothing
- Avoid straddle toys, bicycles × 2–3 weeks
- Soft elastic to position testis in scrotum during healing
Medications
- Preoperative: hCG (rarely used in modern practice)
- Postoperative analgesics (acetaminophen, ibuprofen)
- Antibiotics if infection
Therapeutic Procedures
- Orchiopexy — surgical placement of testis in scrotum; ideally between 6–18 months
- Laparoscopic procedure if non-palpable
- Orchiectomy if non-viable testis
Client Education
- Importance of follow-up examinations
- Postoperative care: activity restrictions, wound care
- Self-testicular exam (older child/adolescent)
- Lifelong cancer surveillance — even after repair
- Fertility implications discussed at appropriate developmental stage
Interprofessional Care
- Pediatric urology
- Pediatric surgery
- Endocrinology (if bilateral, hormonal abnormality)
Alterations in Health (Diagnosis)
Most common renal malignancy in childhood. Embryonal tumor of the kidney usually unilateral, sometimes bilateral. Excellent prognosis with treatment (90% cure rate).
Pathophysiology Related to Client Problem
Embryonal renal tumor arising from primitive metanephric blastema. Most cases sporadic; some associated with genetic syndromes (WAGR, Beckwith-Wiedemann, Denys-Drash).
Health Promotion and Disease Prevention
- Surveillance ultrasound in high-risk children (associated syndromes)
- Educate parents NOT to palpate the abdomen if mass present
- Early identification
Risk Factors
- Age peak 2–3 years (most under 5 years)
- Associated syndromes: WAGR (Wilms, aniridia, GU malformation, mental retardation), Beckwith-Wiedemann, Denys-Drash, hemihypertrophy
- Family history
- Aniridia (absent iris)
Expected Findings
- Painless, firm abdominal mass — usually unilateral, does NOT cross midline (key — distinguishes from neuroblastoma)
- Often noted during bath or diaper change
- Abdominal pain (10% of cases)
- Hypertension (25%) — renin release
- Hematuria (15–30%)
- Fever, weight loss (advanced disease)
- Constipation
- Associated congenital anomalies if syndromic
Laboratory Tests
- CBC: anemia if bleeding
- Urinalysis: hematuria, proteinuria
- Renal function (BUN/creatinine)
- LFTs (rule out metastasis)
- VMA, HVA — normal (excludes neuroblastoma)
Diagnostic Procedures
- Abdominal ultrasound — initial imaging
- Abdominal CT or MRI — staging
- Chest X-ray and CT (lung metastases common)
- Bone scan, brain MRI (some subtypes)
- Surgical biopsy and tumor resection for definitive diagnosis
Safety Considerations
CRITICAL SAFETY:
- DO NOT PALPATE the abdomen — risk of tumor capsule rupture and seeding
- Post a "NO ABDOMINAL PALPATION" sign at bedside
- Educate all healthcare personnel and family
- Bath gently — avoid pressure on abdomen
Complications
- Tumor rupture (poor prognosis)
- Metastasis (lungs most common)
- Treatment toxicity (chemo, radiation, surgery)
- Late effects: secondary malignancy, infertility, renal dysfunction
- Hypertension
Nursing Care
Pre-operative:
- NO abdominal palpation — sign at bedside
- Handle gently, careful bathing
- Monitor BP (may be elevated)
- Routine preoperative care
- Surgery typically within 24–48 hr of diagnosis
Post-operative:
- Monitor for hemorrhage, infection
- Pain management
- Monitor renal function (especially with chemo, single kidney)
- I&O strictly
- Cancer-specific nursing care during chemo/radiation
Medications
- Chemotherapy: vincristine + dactinomycin (low-stage), add doxorubicin for higher-stage, additional agents for unfavorable histology
- Antiemetics (ondansetron)
- Antibiotics for febrile neutropenia
- Antihypertensives
- G-CSF if neutropenia
Therapeutic Procedures
- Surgical resection (nephrectomy)
- Chemotherapy (varies by stage and histology)
- Radiation (higher-stage disease)
- Treatment regimens highly protocoled (COG protocols)
Client Education
- Do not palpate or apply pressure to abdomen until tumor removed
- Treatment course, expected side effects
- Infection prevention during chemotherapy
- Recognize signs of febrile neutropenia (emergency)
- Nutrition support
- School re-entry planning
- Long-term follow-up for late effects
- Excellent prognosis with treatment
Interprofessional Care
- Pediatric oncology team
- Pediatric surgery, urology
- Radiation oncology
- Genetic counseling
- Child life specialist, social work
- School coordination
- Survivorship clinic
Alterations in Health (Diagnosis)
Most common nutritional deficiency anemia in children. Iron deficiency leads to inadequate hemoglobin production → microcytic, hypochromic anemia.
Pathophysiology Related to Client Problem
Decreased iron stores → ↓ heme synthesis → ↓ hemoglobin → reduced O₂-carrying capacity. Causes: inadequate intake (toddlers with high cow's milk), poor absorption, blood loss, increased demand (growth spurts, pregnancy in adolescents).
Health Promotion and Disease Prevention
- Iron-fortified formula or iron supplements for breastfed infants > 4 months
- Iron-fortified cereals at 6 months
- Limit cow's milk to < 24 oz/day after age 1
- Routine hemoglobin screening at 9–12 months and adolescence
- Adequate vitamin C intake (enhances absorption)
Risk Factors
- Premature infants (decreased iron stores)
- Exclusively breastfed beyond 4–6 months without iron supplementation
- Excessive cow's milk intake (> 24 oz/day) in toddlers
- Adolescents (rapid growth, menstruation, dietary restrictions)
- Vegetarian diet without proper planning
- Chronic blood loss (GI bleed)
- Lead poisoning
- Low socioeconomic status
Expected Findings
- Pallor (especially conjunctivae, palms, nail beds)
- Fatigue, weakness, irritability
- Tachycardia, possible flow murmur
- Poor weight gain
- Brittle nails, spoon-shaped nails (koilonychia — severe)
- Glossitis, angular cheilitis
- Pica (craving non-food items: ice, dirt, paint chips)
- Developmental delays if severe and chronic
- Cognitive impairment
Laboratory Tests
- ↓ Hemoglobin and hematocrit
- ↓ MCV (microcytic)
- ↓ MCH (hypochromic)
- ↑ RDW (variable cell size)
- ↓ serum iron
- ↓ ferritin (iron storage)
- ↑ TIBC (total iron binding capacity)
- ↓ transferrin saturation
- Reticulocyte count low initially
Diagnostic Procedures
- CBC with differential
- Iron studies (ferritin most sensitive for early deficiency)
- Reticulocyte count
- Stool guaiac (rule out GI bleed)
- Lead level (associated with IDA)
Safety Considerations
- Keep iron supplements in CHILD-PROOF container OUT OF REACH
- Iron is the #1 cause of pediatric poisoning deaths
- Antidote for iron overdose: deferoxamine
- Even small amounts can be toxic to a child
Complications
- Cognitive impairment (especially infants)
- Developmental delays
- Cardiomegaly, heart failure (severe)
- Lead poisoning (concurrent)
- Failure to thrive
- Iron overdose (accidental ingestion — toxic)
Nursing Care
- Dietary counseling — iron-rich foods
- Limit cow's milk to ≤ 24 oz/day
- Combine iron-rich foods with vitamin C (citrus, strawberries) to enhance absorption
- Avoid giving iron with milk, tea, antacids (decrease absorption)
- Administer iron between meals if tolerated; with food if GI upset
- Use straw or dropper at back of mouth (iron stains teeth)
- Brush teeth after liquid iron
- Monitor stool: should be black/tarry while on iron (expected — not bleeding)
- Reticulocyte count rises within 1 week of treatment
- Hemoglobin normalizes in 4–8 weeks; continue iron 2–3 months after normalization to replenish stores
Medications
Iron supplementation (ferrous sulfate, ferrous gluconate):
- 3–6 mg/kg/day elemental iron PO divided BID-TID
- Give between meals if tolerated (better absorption)
- With vitamin C (orange juice) to enhance absorption
- AVOID with milk, tea, antacids
- Side effects: GI upset, constipation, black stools, teeth staining
- Parenteral iron (iron dextran, iron sucrose) if oral failure — give Z-track IM
- Blood transfusion if severe (Hgb < 6)
Therapeutic Procedures
- Dietary modification
- Iron supplementation
- Treat underlying cause (GI bleed, lead exposure)
- Blood transfusion (severe)
Client Education
Iron-rich foods:
- Heme iron (better absorbed): red meat, poultry, fish, liver
- Non-heme iron: iron-fortified cereals, beans, lentils, tofu, spinach, raisins
- Vitamin C foods enhance non-heme iron absorption
Iron supplementation:
- Give as directed (often between meals)
- Black stools are expected (not bleeding)
- Use straw to avoid teeth staining
- Continue 2–3 months after Hgb normalizes
- Keep medication out of reach — accidental overdose can be fatal
Interprofessional Care
- Pediatrician
- Pediatric dietitian
- Pediatric GI (if chronic blood loss suspected)
- Public health/WIC (food assistance)
Alterations in Health (Diagnosis)
Heart's inability to meet the metabolic demands of the body. In pediatrics, most often secondary to congenital heart defects with L-to-R shunting or obstruction. Less commonly from cardiomyopathy, myocarditis.
Pathophysiology Related to Client Problem
Cardiac dysfunction → ↓ cardiac output → compensatory tachycardia, vasoconstriction, fluid retention (RAAS activation) → ↑ workload and pulmonary/systemic congestion → manifestations.
Health Promotion and Disease Prevention
- Identify CHDs prenatally or at newborn screening
- Endocarditis prophylaxis
- Annual influenza vaccine
- Prevent respiratory infections
- Adequate nutrition
Risk Factors
- Congenital heart defects (most common cause)
- Cardiomyopathy
- Myocarditis (often viral)
- Severe anemia
- Sepsis
- Dysrhythmias
- Rheumatic heart disease
Expected Findings
Impaired myocardial function:
- Tachycardia, weak peripheral pulses
- Hypotension (late)
- Cool extremities, pallor, mottling
- ↓ urine output
- Fatigue
- Cardiomegaly
- Gallop rhythm (S3)
Pulmonary congestion (left-sided HF):
- Tachypnea, dyspnea, retractions, grunting
- Crackles, wheezing
- Cough
- Orthopnea
- Cyanosis
Systemic venous congestion (right-sided HF):
- Hepatomegaly
- Peripheral and periorbital edema
- Weight gain
- Ascites (severe)
- Distended jugular veins
Infants:
- Poor feeding, prolonged feeds (> 30 min)
- Diaphoresis with feeds
- Tachypnea with feeds
- Failure to thrive
Laboratory Tests
- ↑ BNP (or NT-proBNP) — sensitive marker
- Electrolytes (hyponatremia common — dilutional)
- BUN/creatinine
- LFTs (congestion)
- ABG if respiratory distress
- CBC (rule out anemia, infection)
Diagnostic Procedures
- Echocardiogram — gold standard
- Chest X-ray: cardiomegaly, pulmonary edema
- ECG: hypertrophy, arrhythmias
- Cardiac MRI
- Cardiac catheterization
Safety Considerations
- Continuous cardiac monitoring
- O₂ as needed (cautious with shunt lesions — can ↑ pulmonary flow)
- Fluid restriction
- Strict I&O
- Position semi-Fowler's
Complications
- Pulmonary edema
- Cardiogenic shock
- Failure to thrive
- Cardiac arrest
- Multiorgan failure
- Death
Nursing Care
- Cardiopulmonary monitoring
- Strict I&O, daily weight
- Fluid restriction per order
- Position semi-Fowler's, head elevated
- Cluster care, allow rest
- High-calorie nutrition; small frequent feeds
- NG feeding if unable to PO (high caloric burn with breathing)
- O₂ as ordered
- Monitor electrolytes (diuretic-induced K loss)
- Skin care (edema)
Medications
Inotropes:
- Digoxin — improves contractility, slows HR; narrow therapeutic window; apical pulse 1 minute before dose
- Milrinone (acute), dopamine, dobutamine, epinephrine (acute decompensation)
Diuretics:
- Furosemide (Lasix) — first-line; monitor K, Na
- Spironolactone (K-sparing)
Afterload reduction:
- ACE inhibitors (captopril, enalapril)
- Hydralazine
Other:
- Beta-blockers (chronic CHF, cardiomyopathy)
- Potassium supplements (with non-K-sparing diuretics)
Therapeutic Procedures
- Treat underlying cause (surgical repair of CHD)
- Heart transplant (refractory disease)
- Ventricular assist device
- Cardiac rehabilitation
Client Education
- Medication regimen — give as scheduled, no skipping
- How to count apical pulse before digoxin
- Signs of digoxin toxicity (nausea, vomiting, anorexia, bradycardia, vision changes)
- Daily weight, recognize fluid overload (rapid weight gain)
- Sodium-restricted diet
- Fluid restriction
- Frequent small meals; supplemental calories
- Recognize worsening: tachypnea, fatigue, edema, decreased UO
- Importance of follow-up appointments
Interprofessional Care
- Pediatric cardiology
- Cardiothoracic surgery
- Cardiac ICU
- Dietitian (FTT, sodium restriction)
- Pharmacy (med management)
- Heart transplant team if applicable
Alterations in Health (Diagnosis)
Neural tube defect (NTD) — failure of neural tube to close during first 4 weeks of gestation. Three types: spina bifida occulta (vertebrae fail to close, no protrusion), meningocele (meninges herniate through defect, no neural tissue), myelomeningocele (meninges AND spinal cord herniate; most severe, causes neurologic deficits).
Pathophysiology Related to Client Problem
Failure of neural tube closure → spinal cord and meninges may protrude through unfused vertebrae. Most commonly at lumbar/sacral level. Severity of neurologic deficit correlates with location of defect (higher = worse).
Health Promotion and Disease Prevention
- Folic acid supplementation 400 mcg/day for all women of childbearing age — most important prevention
- 4 mg/day if prior pregnancy with NTD
- Take BEFORE conception (neural tube closes by week 4)
- Avoid teratogens (valproic acid, retinoids)
- Manage maternal diabetes
- Prenatal screening (AFP, ultrasound)
Risk Factors
- Folic acid deficiency
- Family history of NTD
- Maternal diabetes
- Maternal obesity
- Anti-epileptic medications (valproic acid, carbamazepine)
- Hyperthermia in first trimester
- Lower socioeconomic status
Expected Findings
Spina bifida occulta:
- Dimple, tuft of hair, hemangioma, or lipoma at spine
- Often asymptomatic
Myelomeningocele (most concerning):
- Visible saclike protrusion on back (usually lumbosacral) at birth
- Sac may be intact or ruptured (CSF leakage)
- Below-level paralysis (varies by level)
- Bowel and bladder incontinence (neurogenic)
- Lower extremity weakness, contractures, club feet
- Hydrocephalus (80%, often with Arnold-Chiari II malformation)
- Latex allergy (60% — multiple exposures)
Laboratory Tests
- Prenatal: ↑ AFP in maternal serum
- Neonatal: routine labs
Diagnostic Procedures
- Prenatal ultrasound, amniocentesis
- Newborn: visible defect
- MRI/CT spine for level of lesion
- Renal ultrasound (neurogenic bladder)
- Hip and lower extremity X-rays
- VCUG for bladder evaluation
Safety Considerations
CRITICAL pre-op safety:
- Position prone or side-lying — NEVER on back
- Cover defect with sterile saline-soaked nonadherent dressing
- NO DIAPER over defect (contamination risk)
- Maintain warm environment (heat loss from exposed defect)
- Prevent stool/urine from contaminating defect
- LATEX PRECAUTIONS from birth onward
Complications
- Hydrocephalus → VP shunt needed in 80%
- Meningitis if sac ruptures
- Neurogenic bowel and bladder → UTIs, renal damage
- Lower extremity paralysis, contractures, scoliosis
- Latex allergy (life-threatening if exposed)
- Sexual dysfunction
- Cognitive issues (especially with hydrocephalus)
- Skin breakdown from pressure
Nursing Care
Pre-op (immediate newborn care):
- Prone or side-lying position
- Sterile saline-soaked nonadherent dressing over defect; change frequently
- NO diaper; small protective barrier between defect and anus
- Measure head circumference daily
- Monitor for ↑ ICP (hydrocephalus)
- Maintain temperature (radiant warmer)
- Strict I&O
- Latex precautions
Post-op:
- Prone or side-lying still
- Monitor incision and shunt sites
- Continue latex precautions
- Bladder management (Credé maneuver, intermittent catheterization)
- Bowel program
- Skin care, prevent pressure injuries
- ROM exercises
- Family education and support
Medications
- IV antibiotics (preoperative and postoperative)
- Anticholinergics (oxybutynin) for neurogenic bladder
- Stool softeners for neurogenic bowel
- Pain management (post-op)
Therapeutic Procedures
- Surgical closure within 24–48 hours of birth (prevents infection, further damage)
- VP shunt for hydrocephalus (usually placed early)
- Orthopedic surgeries (clubfoot, hip dislocation, scoliosis)
- Urologic procedures (vesicostomy, augmentation cystoplasty)
- Intermittent catheterization program
- Physical and occupational therapy
- Tethered cord release if needed
Client Education
- Strict latex precautions for life
- Bladder management (intermittent self-catheterization usually starts age 6)
- Bowel program
- Skin care, pressure injury prevention
- Recognize signs of UTI
- Recognize shunt malfunction (vomiting, headache, lethargy, fever)
- Promote independence and mobility
- Special education and IEP rights
- Sexual health education at appropriate age
- Genetic counseling for future pregnancies (folic acid)
Interprofessional Care
- Pediatric neurosurgery (immediate closure, shunt)
- Pediatric urology (bladder management)
- Pediatric orthopedics
- Physical and occupational therapy
- Developmental pediatrician
- Special education
- Spina bifida support groups
- Geneticist for family planning
Alterations in Health (Diagnosis)
Backflow of gastric contents into the esophagus from incompetent lower esophageal sphincter (LES) or transient relaxation. Physiologic reflux (spitting up) is normal in infants; GERD involves complications/distress.
Pathophysiology Related to Client Problem
Inappropriate LES relaxation → gastric contents (acidic) reflux into esophagus → mucosal damage, inflammation, scarring, possible strictures. May progress to Barrett esophagus, esophageal adenocarcinoma (long-term, rare in pediatrics).
Health Promotion and Disease Prevention
- Breastfeeding (less GER than formula)
- Upright positioning after feeds
- Smaller, more frequent feeds
- Avoid overfeeding
Risk Factors
- Premature infants (50% have reflux)
- Cerebral palsy, neurologic impairment
- Hiatal hernia
- Down syndrome
- Cystic fibrosis
- Obesity
- Tracheoesophageal fistula history
- Family history
- Asthma
Expected Findings
Infants:
- Frequent spitting up, vomiting (effortless, non-projectile)
- Poor weight gain, FTT
- Irritability, crying with feeds
- Arching back during/after feeds (Sandifer syndrome)
- Respiratory symptoms: wheezing, chronic cough, recurrent pneumonia, apnea, ALTE
Children:
- Heartburn, epigastric pain
- Regurgitation
- Nausea
- Dysphagia
- Sore throat, hoarseness
- Chronic cough, asthma exacerbation
- Dental erosion (acid)
Laboratory Tests
- Generally not needed
- CBC if anemia from chronic blood loss suspected
- Stool guaiac
Diagnostic Procedures
- Upper GI series (rule out anatomic abnormality)
- 24-hour pH probe (gold standard — measures acid exposure)
- Endoscopy with biopsy (if severe, complications, atypical presentation)
- Multichannel intraluminal impedance (newer)
- Diagnosis often clinical based on symptoms
Safety Considerations
- Position upright during and after feeds (30 minutes for infants)
- Avoid prone positioning for sleep (SIDS risk despite reflux benefit)
- Aspiration precautions
- Avoid placing infant supine immediately after feeds
Complications
- Failure to thrive
- Esophagitis, esophageal strictures
- Aspiration pneumonia
- ALTE (apparent life-threatening event)
- Reactive airway disease/asthma exacerbation
- Dental enamel erosion
- Anemia from chronic blood loss
- Barrett esophagus (long-term)
- Sandifer syndrome (back arching with reflux)
Nursing Care
Infants:
- Small, frequent feeds
- Burp frequently during feeds
- Position upright (30°) during and 30 min after feeds
- Thicken feeds with rice cereal (1 tbsp per oz of formula) — provider order
- Avoid bouncing/active play after feeds
- Track intake, output, weight gain
- Daily weights
- Trial of hypoallergenic formula if cow milk protein allergy suspected
Children:
- Smaller, more frequent meals
- Avoid trigger foods (acidic, spicy, fatty, chocolate, caffeine)
- Avoid eating 2–3 hours before bed
- Elevate HOB during sleep (use wedge, not pillows for infants)
- Weight loss if overweight
- Avoid tight clothing
Medications
H2 receptor blockers:
- Famotidine (Pepcid), ranitidine (recalled), nizatidine
Proton pump inhibitors (PPIs):
- Omeprazole, lansoprazole, esomeprazole
- Give 30 min before meals
- Most effective for moderate-severe GERD
Other:
- Metoclopramide (Reglan) — prokinetic; rarely used due to EPS risk in children
- Antacids (older children) — short-term symptom relief
Therapeutic Procedures
- Most cases resolve by 12–18 months in infants
- Nissen fundoplication — surgical wrap of fundus around lower esophagus; for severe refractory cases, neurologic impairment, complications
- Often done with G-tube placement
Client Education
Infant feeding:
- Smaller, more frequent feedings
- Hold upright during and 30 min after feeds
- Burp frequently
- Thickened formula if recommended
- Use slow-flow nipple
Older children:
- Avoid trigger foods (chocolate, mint, citrus, caffeine, spicy/fatty foods)
- Smaller, more frequent meals
- Don't eat 2–3 hours before bed
- Elevate HOB
- Weight management if needed
- Avoid smoking, alcohol (adolescents)
- Medication compliance
Report: persistent vomiting, weight loss, blood in vomit, severe pain, respiratory symptoms.
Interprofessional Care
- Pediatric GI
- Pediatric surgery (if Nissen needed)
- Dietitian
- Speech therapist (feeding therapy)
- Pulmonology (if respiratory involvement)
Alterations in Health (Diagnosis)
Autoimmune disorder triggered by ingestion of gluten (protein found in wheat, barley, rye) in genetically susceptible individuals. Causes inflammation and damage to the small intestine mucosa → malabsorption. Lifelong condition managed by strict gluten avoidance.
Pathophysiology Related to Client Problem
Gluten exposure → immune response in genetically predisposed (HLA-DQ2/DQ8) → antibodies attack small intestinal villi → villous atrophy and crypt hyperplasia → malabsorption of nutrients, especially fat-soluble vitamins, iron, calcium.
Health Promotion and Disease Prevention
- Delay introducing gluten until 4–6 months (not after 7 mo or before 4 mo)
- Continue breastfeeding while introducing gluten
- Screen high-risk children (family history, T1DM, Down syndrome)
- Identify early to prevent complications
Risk Factors
- Family history of celiac (1st degree relative — 10% risk)
- Type 1 diabetes
- Down syndrome
- Turner syndrome
- Williams syndrome
- Other autoimmune disorders (thyroid, rheumatoid arthritis)
- IgA deficiency
- Caucasian descent
Expected Findings
Infants/young children:
- Chronic diarrhea (may also have constipation)
- Steatorrhea (foul, bulky, greasy stools)
- Failure to thrive
- Abdominal distension
- Irritability
- Vomiting
- Wasting muscles
- Anorexia
Older children:
- GI: abdominal pain, bloating, diarrhea/constipation, nausea
- Extra-intestinal: short stature, delayed puberty, weight loss, fatigue, irritability
- Anemia (iron deficiency)
- Dental enamel defects
- Dermatitis herpetiformis (itchy, blistering skin rash on extensor surfaces)
- Headache, joint pain
Celiac crisis (rare): severe diarrhea, dehydration, electrolyte imbalance, shock
Laboratory Tests
Serologic tests (while on gluten-containing diet):
- Tissue transglutaminase IgA (tTG-IgA) — best initial test
- Total IgA (rule out IgA deficiency — false negatives)
- Anti-endomysial antibody (EMA-IgA)
- Deamidated gliadin peptide (DGP)
- Genetic: HLA-DQ2, HLA-DQ8 (negative rules out)
Other:
- ↓ Hgb (iron deficiency anemia)
- ↓ albumin, calcium, vitamin D
- ↓ vitamin B12, folate
- Stool fat ↑ (steatorrhea)
Diagnostic Procedures
- Serologic testing (above)
- Definitive diagnosis: small bowel biopsy (EGD with duodenal biopsy) — villous atrophy, intraepithelial lymphocytes
- Patient MUST be on gluten-containing diet for accurate results
Safety Considerations
- Strict gluten avoidance (lifelong)
- Read all labels — gluten hidden in many products
- Avoid cross-contamination
- Monitor for nutritional deficiencies
- Watch for complications, growth issues
Complications
- Nutritional deficiencies (iron, calcium, vitamin D, B12, folate)
- Osteoporosis
- Growth failure, delayed puberty
- Infertility
- Anemia
- Lactose intolerance (often transient)
- Other autoimmune disorders (thyroid, diabetes)
- Intestinal lymphoma (increased risk if untreated)
- Dermatitis herpetiformis
- Celiac crisis (rare)
Nursing Care
- Confirm diagnosis (biopsy on gluten diet)
- Education on strict gluten-free diet
- Refer to dietitian
- Monitor growth and development
- Address nutritional deficiencies
- Monitor weight, height
- Periodic labs to monitor compliance and complications
- Psychosocial support — lifelong dietary changes
Medications
- No medication treats celiac — diet is the treatment
- Iron supplements for anemia
- Calcium and vitamin D supplements
- Multivitamin
- B12 supplementation
- Topical steroids for dermatitis herpetiformis
Therapeutic Procedures
- Strict, lifelong gluten-free diet — only effective treatment
- Annual celiac follow-up
- Bone density scans (osteopenia/osteoporosis risk)
- Periodic serology to confirm compliance
Client Education
Gluten-free diet:
- AVOID: wheat, barley, rye (also bulgur, couscous, semolina, spelt, kamut, triticale, malt)
- SAFE: rice, corn, potato, quinoa, gluten-free oats, fresh fruits, vegetables, meats, dairy, eggs
- Read ALL labels — look for "certified gluten-free"
- Hidden sources: sauces, gravies, soups, processed meats, candy, medications
- Avoid cross-contamination: separate utensils, cutting boards, toaster
- Communicate at restaurants, schools, friends' houses
Other education:
- Improvement should be seen in 1–2 weeks on diet; full mucosal recovery 6–12 months
- Even tiny amounts of gluten can damage intestine
- Even if asymptomatic, must continue diet
- Importance of follow-up
- Recognize signs of accidental ingestion
- Support groups, resources (Celiac Disease Foundation)
- Genetic counseling for siblings (screening recommended)
Interprofessional Care
- Pediatric GI
- Pediatric dietitian (specialized in celiac)
- School nurse
- Pediatric endocrinologist (if associated diabetes, thyroid disease)
- Genetic counselor (for family)
Alterations in Health (Diagnosis)
UTI: bacterial infection of any part of urinary tract (bladder = cystitis; kidney = pyelonephritis). Second most common bacterial infection in children. Diagnosis confirmed by urine culture.
Vesicoureteral reflux (VUR): retrograde flow of urine from bladder to ureters (and kidneys). Often associated with UTIs in children; major risk factor for renal scarring (reflux nephropathy).
Pathophysiology Related to Client Problem
UTI: bacteria ascend urethra → bladder; if VUR present, can ascend ureters to kidneys (pyelonephritis). E. coli causes 80% of UTIs.
VUR: incompetent ureterovesical junction (UVJ) → urine refluxes from bladder up ureters. Graded I–V (I mildest, V most severe with hydronephrosis).
Health Promotion and Disease Prevention
- Adequate fluid intake
- Proper hygiene (wipe front to back in females)
- Avoid bubble baths (irritants)
- Cotton underwear
- Frequent voiding (every 2–3 hours)
- Complete bladder emptying
- Cranberry juice/products (evidence mixed)
- Probiotics (some benefit)
Risk Factors
UTI:
- Female (short urethra)
- Uncircumcised males (especially < 1 year)
- VUR
- Urinary stasis (incomplete emptying, constipation)
- Bubble baths, scented soaps
- Sexual activity (adolescents)
- Catheterization
- Anatomic abnormalities
- Recent antibiotic use (altered flora)
VUR:
- Family history (genetic predisposition)
- Female predominance
- Other GU anomalies
- Recurrent UTIs
Expected Findings
UTI varies by age:
Infants:
- Fever (often only symptom)
- Poor feeding, FTT
- Vomiting
- Irritability, lethargy
- Jaundice (newborn)
- Foul-smelling urine
Older children:
- Dysuria, urgency, frequency
- Suprapubic or abdominal pain
- Hematuria
- Cloudy, foul-smelling urine
- Enuresis (new onset)
- Fever
Pyelonephritis:
- High fever, chills
- Flank pain
- CVA tenderness
- Nausea, vomiting
- Toxic appearance
Laboratory Tests
Urinalysis:
- ↑ leukocyte esterase
- ↑ nitrites (suggests gram-neg bacteria)
- WBC casts (pyelonephritis)
- Bacteria, pyuria, hematuria
Urine culture (definitive):
- Catheterized specimen: ≥ 50,000 CFU/mL
- Suprapubic aspirate: any growth
- Clean catch: ≥ 100,000 CFU/mL of single organism
- Bag specimen: only useful if negative (many false positives)
Other:
- CBC: elevated WBC (pyelonephritis)
- BUN/creatinine (renal function)
- Blood cultures if septic appearance
Diagnostic Procedures
- Renal/bladder ultrasound after first UTI in young children (rule out anatomic abnormality)
- Voiding cystourethrogram (VCUG) — gold standard for VUR; bladder filled with contrast, X-rays during voiding
- DMSA scan (renal scarring)
- Urodynamic studies (older children with voiding dysfunction)
Safety Considerations
- Adequate hydration
- Prompt treatment of fever in infants (UTI workup)
- Complete antibiotic course
- Recognize signs of pyelonephritis or sepsis
- Long-term follow-up to monitor for renal scarring
Complications
- Recurrent UTIs
- Pyelonephritis
- Sepsis (especially infants)
- Renal scarring → hypertension, chronic kidney disease, ESRD
- Hypertension
- Pregnancy complications (later in life)
Nursing Care
- Obtain proper urine specimen (catheterized or clean catch)
- Administer antibiotics promptly
- Encourage adequate fluid intake
- Monitor temperature, intake/output
- Educate on perineal hygiene
- Pain management (analgesics, warm baths — without bubble bath)
- Address constipation (often coexists)
- Schedule follow-up imaging
- For VUR: education on prophylactic antibiotics, follow-up imaging
Medications
Antibiotics:
- Empiric (until culture results): cephalexin, amoxicillin-clavulanate, TMP-SMX
- IV for severe/pyelonephritis: ceftriaxone, ampicillin + gentamicin
- Duration: 7–14 days (longer for pyelonephritis)
- Adjust based on sensitivities
VUR — prophylaxis:
- Low-dose nightly antibiotic prophylaxis: TMP-SMX, nitrofurantoin, cephalexin
- Continued until VUR resolves or surgical correction
Symptom relief:
- Acetaminophen, ibuprofen
- Phenazopyridine (older children — bladder analgesic; turns urine orange)
Therapeutic Procedures
- Most VUR resolves spontaneously with growth (especially low grade)
- Surgical correction (ureteral reimplantation) for severe VUR or breakthrough UTIs
- Endoscopic injection (Deflux) — newer treatment
- Treat coexisting constipation aggressively
Client Education
- Complete entire antibiotic course even if feeling better
- Adequate hydration
- Hygiene: wipe front to back (females); clean uncircumcised foreskin without forcible retraction
- Avoid bubble baths, scented soaps
- Cotton underwear
- Encourage frequent voiding (every 2–3 hr while awake)
- Complete bladder emptying ("double void")
- Treat constipation
- Recognize UTI symptoms — early treatment
- Follow-up appointments and imaging as scheduled
- For VUR: importance of prophylactic antibiotics, daily routine
- Family genetic counseling if VUR (siblings at increased risk)
Interprofessional Care
- Pediatric urology (VUR, recurrent UTI)
- Pediatric nephrology (renal scarring)
- Pediatric infectious disease (if complex)
- Continence/voiding dysfunction specialist
Alterations in Health (Diagnosis)
Spectrum of conditions affecting hip joint development — from mild laxity to complete dislocation. The femoral head and acetabulum do not develop normally. Early detection and treatment essential — outcomes much better when treated < 6 months of age.
Pathophysiology Related to Client Problem
Abnormal development of the hip joint → femoral head may be loose in acetabulum (subluxation), can be dislocated (with maneuvers), or completely dislocated. Untreated → permanent hip deformity, gait abnormality, early arthritis.
Health Promotion and Disease Prevention
- Newborn hip examination at every well-child visit until walking (Barlow and Ortolani maneuvers)
- Ultrasound screening for high-risk infants
- Avoid swaddling that holds hips in extension/adduction
- Hip-safe swaddling (allows flexion and abduction)
- Family education
Risk Factors
- Female sex (4–6× greater risk)
- Family history of DDH
- First-born
- Breech presentation
- Oligohydramnios
- Large for gestational age
- Twin pregnancy
- Native American descent (highest), Caucasian
- Tight swaddling with hips extended
Expected Findings
Newborn/infant exam:
- Positive Ortolani sign — palpable "clunk" as dislocated hip RELOCATES with abduction
- Positive Barlow sign — palpable "clunk" as hip DISLOCATES with adduction and pressure posteriorly
- Limited abduction (less than 60–80°)
- Asymmetric thigh and gluteal folds
- Positive Galeazzi (or Allis) sign — apparent shortening of femur (knees uneven when hips and knees flexed at 90°)
- Audible hip click (not specific)
Older infants/children (after walking):
- Trendelenburg gait (waddling)
- Hip pain, limp
- Limited hip ROM
- Leg length discrepancy
Laboratory Tests
- No specific labs
Diagnostic Procedures
- Physical examination (Ortolani, Barlow, Galeazzi)
- Hip ultrasound (preferred for infants < 4 months — femoral head not yet ossified)
- Hip X-ray (preferred ≥ 4–6 months)
Safety Considerations
- Proper Pavlik harness application
- No tight swaddling of hips
- Skin care under harness/brace
- Don't adjust harness without provider
Complications
- Avascular necrosis of femoral head (especially with treatment delays or improper bracing)
- Permanent hip deformity
- Leg length discrepancy
- Gait abnormalities
- Early hip arthritis
- Need for repeated surgeries
Nursing Care
Newborn screening:
- Perform Ortolani, Barlow at every newborn exam and well-child visit
- Assess for risk factors
- Refer suspected cases promptly
Pavlik harness care (infant < 6 months):
- Most common treatment for infants < 6 months
- Holds hips flexed and abducted
- Worn 23 hours/day for several weeks to months
- Check skin under harness daily
- Apply lotion to skin (not harness/straps)
- Dress with onesie or shirt under harness
- Diaper UNDER straps
- Don't adjust straps without provider
- Mark with marker for proper placement
- Continue tummy time (with harness)
Spica cast (older infants, post-surgical):
- Skin care, especially perineum
- Use waterproof tape ("petaling") at edges
- Plastic wrap or diaper to keep urine/stool from cast
- Position changes q2h
- Neurovascular checks of legs
- Adequate nutrition for healing
- Special car seat (Hippo car seat or similar)
Medications
- No specific medications for DDH itself
- Acetaminophen/ibuprofen for post-operative pain
- Pre-operative antibiotics
Therapeutic Procedures
- < 6 months: Pavlik harness — soft harness that maintains hip flexion and abduction
- 6–18 months: closed reduction under anesthesia + spica cast for 3–6 months
- > 18 months or failed closed reduction: open reduction + spica cast
- Older children may need femoral or pelvic osteotomy
- Follow-up imaging (ultrasound or X-ray) every 1–4 weeks initially
Client Education
- Importance of compliance with treatment
- Pavlik harness: care, application, skin checks
- Don't adjust harness or remove without provider approval
- Recognize complications: avascular necrosis (pain, decreased motion)
- Hip-safe swaddling for newborns
- Avoid swaddling tightly with legs extended
- Carry baby with legs straddling caregiver (hip-flexed position)
- Long-term follow-up needed
- Spica cast care if applicable
- Encourage age-appropriate activities even with harness/cast
- Genetic counseling for siblings (5× risk)
Interprofessional Care
- Pediatric orthopedic surgeon
- Physical therapy
- Child life specialist (for older children with cast)
- Early intervention services if delays
- Special car seat consultant
Alterations in Health (Diagnosis)
Lateral curvature of the spine ≥ 10° with rotation of vertebrae. Idiopathic (unknown cause) accounts for 80% of cases; typically discovered during adolescence (adolescent idiopathic scoliosis — AIS). Curvature measured by Cobb angle on X-ray.
Pathophysiology Related to Client Problem
Three-dimensional spinal deformity with lateral curvature AND vertebral rotation. Etiology unknown in idiopathic form; multifactorial (genetic, growth-related). Progression most common during adolescent growth spurt.
Health Promotion and Disease Prevention
- Routine screening at well-child visits (during growth spurts)
- School-based screening (some states)
- Adam's forward bend test annually for adolescents
- Early identification and referral
Risk Factors
- Adolescent girls (4× greater risk for progression requiring treatment)
- Family history
- Onset during growth spurt
- Connective tissue disorders (Marfan, Ehlers-Danlos)
- Neuromuscular conditions (CP, muscular dystrophy)
- Skeletal dysplasias
- Some genetic syndromes
Expected Findings
- Often asymptomatic in adolescent idiopathic scoliosis
- Unequal shoulder height
- Asymmetric scapulae (one shoulder blade prominent)
- Asymmetric waist (uneven hips)
- Rib hump on forward bending (Adam's forward bend test) — most reliable physical sign
- Unequal leg length
- Trunk shifted off-center
- Back pain (uncommon in idiopathic — if present, look for other cause)
- Possible respiratory compromise with severe curves
Laboratory Tests
- No specific labs for idiopathic scoliosis
Diagnostic Procedures
- Adam's forward bend test — screening
- Scoliometer measurement of trunk rotation
- Standing PA and lateral spine X-rays — confirm and measure
- Cobb angle measurement:
- < 10°: not scoliosis (postural)
- 10–25°: mild
- 26–40°: moderate
- > 40–45°: severe
- Risser scale (0–5) — assesses skeletal maturity from iliac crest ossification; higher = less remaining growth = less risk of progression
- MRI if atypical (pain, neurologic findings)
Safety Considerations
- Proper brace wear (compliance critical)
- Skin care under brace
- Avoid contact sports immediately post-fusion surgery
- Post-op: log roll for spinal precautions
Complications
- Progressive deformity
- Cardiopulmonary compromise (severe thoracic curves > 70°)
- Chronic back pain in adulthood
- Body image disturbance, psychosocial impact
- Post-op: blood loss, infection, neurologic injury (rare), pseudoarthrosis
Nursing Care
Screening:
- Adam's forward bend test at well visits
- Refer if asymmetric
Bracing:
- Education on brace wear schedule (typically 16–23 hours/day)
- Compliance critical — non-compliance leads to progression
- Skin care: check skin daily; wear cotton T-shirt under brace
- Reinforcement and emotional support — body image issues
- Continue activities — can play most sports out of brace
Post-operative (spinal fusion):
- Log roll for position changes
- Pain management (often PCA)
- Neurovascular checks of lower extremities (frequent)
- Monitor for hemorrhage (significant blood loss)
- Antibiotics
- Strict I&O
- NG decompression initially
- Early ambulation (24–48 hours)
- Avoid bending, lifting, twisting × 6 months
Medications
- NSAIDs for mild discomfort
- Pre-operative antibiotics (surgical prophylaxis)
- Post-operative analgesics (often PCA initially)
- Stool softeners (immobility, opioids)
Therapeutic Procedures
Treatment by Cobb angle:
- < 25°: observation — repeat X-rays every 3–6 months during growth
- 25–40° (skeletally immature): bracing (Boston, TLSO, Milwaukee) — worn 16–23 hours/day until skeletal maturity
- > 45–50°: surgery — posterior spinal fusion with instrumentation (Harrington or pedicle screw constructs)
- Vertebral body tethering (VBT) — newer, motion-preserving option for some adolescents
- Physical therapy (Schroth method)
Client Education
Bracing:
- Wear schedule (16–23 hours/day typical)
- Compliance critical — affects outcome
- Wear cotton T-shirt under to protect skin
- Check skin daily for redness or breakdown
- Can engage in most activities (out of brace for sports)
- Body image: many braces are now low-profile
- Skip brace appointments if not getting taller (no growth = no progression)
Post-surgical:
- Activity restrictions: no bending, lifting > 10 lb, twisting × 6 months
- No contact sports × 1 year
- Log roll movement initially
- Pain management
- Wound care
- Return to school 4–6 weeks (modified)
- Recognize complications: increasing pain, fever, drainage, neurologic changes
General:
- Continue normal activities
- Self-image support — peer groups, counseling if needed
- Long-term follow-up
- Genetic counseling (familial cases)
Interprofessional Care
- Pediatric orthopedic spine surgeon
- Orthotist (brace fitting)
- Physical therapy
- Psychology (body image)
- School nurse
- School (PE accommodations)
Alterations in Health (Diagnosis)
Chronic, relapsing inflammatory skin disorder characterized by intense pruritus and characteristic rash. Most common chronic skin disease in children. Part of the atopic triad (eczema, asthma, allergic rhinitis).
Pathophysiology Related to Client Problem
Combination of genetic skin barrier dysfunction (filaggrin gene mutations), immune dysregulation, and environmental triggers → impaired skin barrier → ↑ transepidermal water loss, ↑ allergen/irritant penetration → inflammation, intense itching, characteristic rash.
Health Promotion and Disease Prevention
- Family history is risk factor — atopic march (eczema → food allergies → asthma → allergic rhinitis)
- Daily moisturization to maintain skin barrier
- Identify and avoid triggers
- Gentle skin care from infancy in high-risk infants
Risk Factors
- Family history of atopic conditions (eczema, asthma, allergies)
- Filaggrin gene mutations
- Personal history of allergies or asthma
- Urban environment
- Higher socioeconomic status (interestingly)
Expected Findings
Infants (2–6 mo onset typical):
- Red, weepy, crusted rash on cheeks, scalp, extensor surfaces
- Spares diaper area typically
- Severe pruritus → irritability, sleep disturbance
Older children:
- Rash on flexural surfaces (antecubital, popliteal, neck, wrists)
- Dry, scaly, lichenified skin (thickened from chronic scratching)
- Pruritus, often severe
- Excoriations, scabs
- Sleep disturbance
- Hyperpigmented or hypopigmented patches (post-inflammatory)
Other features:
- Dry skin (xerosis) overall
- Keratosis pilaris (rough bumps on arms)
- Dennie-Morgan lines (creases under eyes)
- Allergic shiners (dark circles under eyes)
Laboratory Tests
- No specific labs for diagnosis
- ↑ IgE may be present
- Allergy testing if specific triggers suspected
Diagnostic Procedures
- Clinical diagnosis based on appearance, distribution, history
- Skin biopsy rarely needed
- Allergy testing (food, environmental) in selected cases
Safety Considerations
- Keep nails short to minimize damage from scratching
- Cotton mittens for infants
- Watch for secondary bacterial infection
- Avoid trigger exposure
Complications
- Secondary bacterial infection (impetiginization) — S. aureus most common (golden crusting)
- Eczema herpeticum (HSV infection) — emergency
- Molluscum contagiosum infection
- Sleep disturbance → behavioral, academic issues
- Psychological impact, social embarrassment
- Asthma, allergic rhinitis development (atopic march)
- Food allergies
- Permanent skin changes (lichenification, hyperpigmentation)
Nursing Care
- Assess skin thoroughly (distribution, severity, signs of infection)
- Educate on skin care regimen
- Help identify triggers
- Support family — chronic condition can be exhausting
- Pain/itch management
- Sleep environment (cool, humidified, comfortable bedding)
Medications
Topical:
- Topical corticosteroids (TCS) — cornerstone for flares; potency varies (low for face/groin, high for thick skin); thin layer; short courses
- Topical calcineurin inhibitors (tacrolimus, pimecrolimus) — steroid-sparing; FDA warning for malignancy (limited evidence in practice)
- Crisaborole (Eucrisa) — PDE4 inhibitor
- Moisturizers (emollients) — multiple times daily, ESPECIALLY after bathing (within 3 minutes)
Systemic (severe):
- Oral antihistamines (sedating ones like hydroxyzine, diphenhydramine — especially nighttime for sleep)
- Dupilumab (Dupixent) — biologic injection; for moderate-severe
- Oral corticosteroids (short course for severe flare — rarely used)
- Antibiotics if secondary infection
- Cyclosporine, methotrexate, azathioprine (severe refractory cases)
Therapeutic Procedures
- Wet wrap therapy (severe flares)
- Phototherapy (older children with severe disease)
- Allergy testing and avoidance
Client Education
Bathing:
- Soak and seal: daily lukewarm bath 5–10 min, gentle cleanser, pat dry, apply moisturizer within 3 minutes (locks in hydration)
- Avoid hot water (irritating)
- No harsh soaps, bubble baths
- Bleach baths (1/4 cup bleach in tub) 2–3× weekly for some patients (kills bacteria)
Skin care:
- Apply moisturizer 2–3× daily (creams or ointments better than lotions)
- Use fragrance-free, hypoallergenic products
- Avoid wool, rough fabrics
- Cotton clothing
- Cool temperatures (overheating triggers itching)
- Keep fingernails short
- Cotton mittens for infants if needed
Trigger identification:
- Food allergies (consider testing if severe — common: milk, egg, peanut, wheat)
- Environmental: dust mites, pet dander, pollen
- Contact: detergents, fragrances, soaps
- Sweating, heat
- Stress
Medications:
- Apply topical steroids ONLY to affected areas
- Use prescribed potency (don't apply face steroids to body)
- Apply BEFORE moisturizer
- Don't skip steroids when prescribed (under-treatment common)
- Recognize signs of infection: increased redness, weeping, golden crusts, fever, pain
Interprofessional Care
- Pediatric dermatology
- Pediatric allergy/immunology
- Pediatric pulmonology if asthma develops
- Mental health/counseling if psychosocial impact
- Eczema support groups
Alterations in Health (Diagnosis)
Most common childhood cancer; cancer of lymphoid precursors in bone marrow. Uncontrolled proliferation of immature lymphoblasts → bone marrow failure → pancytopenia → infection, bleeding, anemia. Excellent prognosis: ~90% 5-year survival with current treatment.
Pathophysiology Related to Client Problem
Malignant transformation of lymphoid progenitor cell → clonal expansion of leukemic lymphoblasts in bone marrow → crowds out normal hematopoiesis → ↓ RBCs (anemia), ↓ platelets (bleeding), ↓ functional WBCs (infection risk). Lymphoblasts spill into blood, lymph nodes, spleen, liver, CNS, testes.
Health Promotion and Disease Prevention
- No specific prevention
- Family history slightly increases risk (sibling: 4× general population)
- Genetic syndromes screening (Down syndrome, NF1)
- Avoid prenatal radiation, certain chemicals
Risk Factors
- Age 2–5 years (peak)
- Boys > girls (slightly)
- Down syndrome (10–20× increased risk)
- Other genetic syndromes (NF1, ataxia-telangiectasia, Bloom syndrome, Fanconi anemia)
- Sibling with leukemia (especially twin)
- Prenatal radiation exposure
- Maternal age > 35
- Some chromosomal translocations
Expected Findings
Bone marrow failure:
- Anemia: pallor, fatigue, tachycardia, dyspnea on exertion
- Thrombocytopenia: petechiae, purpura, bruising, mucosal bleeding, epistaxis
- Neutropenia: fever, recurrent infections, mouth sores
Extramedullary disease:
- Lymphadenopathy (painless)
- Hepatosplenomegaly
- Bone pain (especially long bones), refusal to walk
- Arthralgia, joint swelling
- Testicular enlargement (males)
- CNS involvement: headache, vomiting, cranial nerve palsies
- Mediastinal mass (T-cell ALL) — may cause SVC syndrome, respiratory compromise
Constitutional:
- Fever (often persistent)
- Weight loss, anorexia
- Fatigue
- Night sweats
Laboratory Tests
CBC:
- ↓ Hgb (anemia)
- ↓ platelets
- WBC variable: ↑↑ (with blasts), normal, or ↓
- Blasts on peripheral smear (immature lymphoblasts)
Other:
- ↑ uric acid, K, phosphorus, LDH (tumor lysis risk)
- ↓ calcium
- ↑ BUN, creatinine (TLS)
- ↑ liver enzymes
- Coagulation studies (DIC possible)
Diagnostic Procedures
- Bone marrow aspiration and biopsy (definitive) — ≥ 20% lymphoblasts confirms diagnosis
- Flow cytometry (immunophenotyping — distinguishes B-cell vs T-cell)
- Cytogenetics (chromosome analysis for prognostic markers — Philadelphia chromosome, MLL rearrangements)
- Lumbar puncture — CNS involvement assessment; also for intrathecal chemotherapy
- Chest X-ray (mediastinal mass — T-cell ALL)
- Testicular exam
- Echocardiogram (baseline before cardiotoxic chemo)
Safety Considerations
- Neutropenic precautions when ANC < 500
- Bleeding precautions (avoid aspirin, contact sports, IM injections)
- Tumor lysis syndrome prevention/monitoring
- Strict aseptic technique with central lines
- Hand hygiene
- Avoid live vaccines during chemotherapy
- Vaccinate siblings (avoid flumist — live virus)
- Avoid sick contacts
Complications
- Tumor lysis syndrome (TLS) — within 12–48 hr of starting chemo; ↑K, ↑P, ↑uric acid, ↓Ca; can cause renal failure, arrhythmias, seizures
- Febrile neutropenia — emergency; ANC < 500 + fever; immediate broad-spectrum antibiotics
- Sepsis
- Bleeding (severe thrombocytopenia)
- Anemia requiring transfusions
- Chemo-related: cardiotoxicity, infertility, secondary malignancies
- CNS involvement
- Relapse
- Long-term effects: growth disturbance, neurocognitive deficits, late cardiac toxicity, secondary cancers
Nursing Care
Initial:
- Comprehensive assessment, vital signs
- IV access (often central line placement early)
- Frequent labs
- Hydration (TLS prevention)
- Pain management
- Emotional support
During chemotherapy:
- Neutropenic precautions when indicated (private room, no fresh flowers/plants, low microbial diet)
- Bleeding precautions
- Mouth care (chlorhexidine, soft toothbrush) — prevent mucositis
- Nutrition support (often poor appetite, nausea)
- Strict I&O
- Daily weights
- Skin care (chemo extravasation prevention)
- Antiemetics before chemo
- Frequent assessment for infection
- Recognize TLS signs (urine output, labs)
- Central line care
- Family support — psychological strain
- Child life specialist involvement
- School coordination during treatment
Medications
Chemotherapy phases:
- Induction (~4 weeks): achieve remission; vincristine, prednisone/dexamethasone, asparaginase, anthracycline (high-risk)
- CNS prophylaxis: intrathecal methotrexate (sometimes cytarabine, hydrocortisone)
- Consolidation: deepen remission; additional agents
- Maintenance (2–3 years total): oral 6-mercaptopurine + methotrexate + periodic IV agents and steroid pulses
Supportive medications:
- Allopurinol or rasburicase — TLS prevention
- Antiemetics (ondansetron, granisetron)
- Antibiotics for febrile neutropenia (broad-spectrum: cefepime, vancomycin)
- Antifungals (fluconazole)
- PCP prophylaxis (TMP-SMX 3 days/week)
- G-CSF (filgrastim) for neutropenia
- Blood products (PRBCs, platelets)
Therapeutic Procedures
- Multi-modal chemotherapy (2–3 year regimen)
- Cranial radiation (only high-risk; mostly replaced by intensified intrathecal chemo)
- Hematopoietic stem cell transplant (relapsed or very high-risk disease)
- CAR-T cell therapy (tisagenlecleucel) for refractory/relapsed B-cell ALL
- Targeted therapy (e.g., imatinib for Ph+ ALL)
- Bone marrow aspirations, LPs throughout
Client Education
- Treatment duration: 2–3 years total
- Prognosis: excellent (~90% 5-year survival)
- Side effects expected: hair loss, nausea, fatigue, mouth sores, weight changes
- Fever ≥ 38.3°C (101°F) is a MEDICAL EMERGENCY during neutropenia — call oncology, do not wait
- Neutropenic precautions:
- Avoid sick contacts, large crowds
- No raw/undercooked foods (especially meat, eggs)
- Wash all fruits/vegetables thoroughly
- No live vaccines
- Frequent hand hygiene
- No rectal temperatures or suppositories
- Bleeding precautions:
- No contact sports
- Soft toothbrush, electric razor
- No NSAIDs or aspirin
- School coordination, IEP/504 plan, returning to school
- Nutrition: small frequent meals, high-calorie
- Recognize signs of TLS, infection, bleeding
- Long-term follow-up for late effects
- Survivorship clinic involvement
- Support groups, social services
Interprofessional Care
- Pediatric oncology/hematology
- Pediatric oncology nurse practitioners
- Radiation oncology (some cases)
- BMT team (some cases)
- Child life specialist
- Social work, chaplain
- School liaison
- Survivorship clinic
- Mental health
- Family support groups
Alterations in Health (Diagnosis)
Acute, life-threatening inflammatory bowel disease primarily affecting premature infants. Characterized by ischemic necrosis of the intestinal mucosa with possible progression to full-thickness bowel necrosis, perforation, and peritonitis. Most common GI emergency in NICU.
Pathophysiology Related to Client Problem
Multifactorial: combination of immature gut, intestinal ischemia, abnormal bacterial colonization, and feeding (especially formula). Leads to mucosal injury → bacterial translocation → inflammation → necrosis → possible perforation.
Health Promotion and Disease Prevention
- Breast milk feeding (significantly reduces NEC risk vs formula)
- Slow advancement of feeds in preterm infants
- Donor milk if mother's milk unavailable
- Avoid early/aggressive feeding advancement
- Standardized feeding protocols
- Probiotics (some evidence)
- Antenatal corticosteroids
Risk Factors
- Prematurity (most significant risk factor) — incidence inversely related to gestational age
- Very low birth weight (< 1500 g)
- Formula feeding (vs breast milk)
- Rapid advancement of enteral feeds
- Birth asphyxia, hypoxic-ischemic injury
- Patent ductus arteriosus
- Sepsis
- Polycythemia, anemia
- Cocaine exposure in utero
- Congenital heart disease
- Indomethacin therapy
Expected Findings
Early/non-specific (Bell stage I):
- Feeding intolerance: ↑ gastric residuals, vomiting
- Abdominal distention
- Heme-positive stools
- Lethargy, temperature instability
- Apnea, bradycardia
Definite NEC (Bell stage II):
- More pronounced abdominal distention
- Bloody stools
- Bilious gastric residuals/vomiting
- Abdominal tenderness, discoloration (bluish hue, dusky skin)
- Decreased bowel sounds
- Worsening systemic signs
Advanced NEC (Bell stage III) — bowel perforation:
- Severely ill: shock, DIC
- Severe abdominal distention, pneumoperitoneum on X-ray
- Hypotension, bradycardia, acidosis
- Disseminated intravascular coagulation
Laboratory Tests
- CBC: ↓ platelets, ↑ or ↓ WBC, anemia
- ↑ CRP
- Metabolic acidosis (lactate, base deficit)
- Electrolyte imbalances: hyponatremia, hypokalemia
- ↑ BUN, creatinine
- Coagulation: PT/PTT prolonged in advanced disease
- Blood cultures (sepsis common)
- Heme-positive stools
Diagnostic Procedures
- Abdominal X-ray (key diagnostic):
- Pneumatosis intestinalis — gas within bowel wall (HALLMARK)
- Dilated bowel loops
- Portal venous gas
- Pneumoperitoneum — free air → perforation, surgical emergency
- "Fixed loop" sign — persistent dilated loop
- Abdominal ultrasound (some centers)
Safety Considerations
- NPO at first sign of NEC
- NG decompression
- Avoid abdominal palpation if severe (perforation risk)
- Monitor for sepsis, DIC, shock
- Aseptic technique with all lines/equipment
- Daily abdominal X-rays during acute phase
Complications
- Bowel perforation with peritonitis, sepsis
- Sepsis, septic shock
- DIC
- Acute renal failure
- Short bowel syndrome (after extensive resection)
- Intestinal strictures (post-NEC, weeks-months later)
- Failure to thrive
- Cholestasis (TPN-related)
- Neurodevelopmental delays
- Death (mortality 15–30% overall, higher in surgical NEC)
Nursing Care
Immediate management:
- Stop all enteral feeds (NPO)
- NG tube to suction (decompress stomach)
- IV access (often need central line)
- IV antibiotics
- Hemodynamic monitoring
- Daily abdominal X-rays (q6h initially)
- Daily abdominal girth measurements
- Monitor for signs of perforation (sudden deterioration, severe distention)
- TPN (parenteral nutrition) for several weeks
- Strict I&O
- Stool cultures, blood cultures
- Monitor labs frequently
- Pain management
- Maintain warmth and oxygenation
- Family support
Post-surgical (if perforation):
- Stoma care (often ostomy created)
- Wound care
- Continue TPN
- Slow advancement of feeds (often weeks) once recovered
- Monitor for late strictures
Medications
- Broad-spectrum IV antibiotics: ampicillin + gentamicin + metronidazole or clindamycin (covers gram-positive, gram-negative, anaerobes)
- Antifungal if at risk (long-term TPN)
- IV fluids, electrolyte replacement
- Vasopressors if hypotension (dopamine)
- Blood products: PRBCs, platelets, FFP as needed
- Analgesics
- Acid suppression
- TPN (lipids, amino acids, dextrose)
Therapeutic Procedures
- NPO + bowel rest for 7–14 days
- NG decompression
- IV antibiotics 7–14 days
- TPN
- Surgery for perforation, peritonitis, clinical deterioration:
- Exploratory laparotomy
- Resection of necrotic bowel
- Ostomy creation (often temporary)
- Later: ostomy reversal, bowel anastomosis
- Peritoneal drainage (some VLBW infants)
Client Education
For NICU parents:
- NEC is a serious illness — understand severity
- Treatment involves stopping feeds, IV nutrition
- Surgery may be needed for severe cases
- Recovery is gradual — weeks to months
- Long-term: most who survive recover but some have ongoing issues
- Risk of strictures weeks-months after recovery (watch for symptoms)
- Importance of breast milk for prevention in future preemies
- Genetic counseling not typically needed (no clear hereditary pattern)
Long-term follow-up:
- Growth monitoring
- Nutrition (may need specialized formulas)
- Developmental assessments
- If ostomy: ostomy care, reversal surgery
- Watch for stricture symptoms (poor feeding, vomiting, distention)
Interprofessional Care
- Neonatology
- Pediatric surgery
- NICU nursing team
- Pediatric GI
- Pediatric nutrition
- Pediatric infectious disease
- Wound/ostomy specialist
- Developmental pediatrician (follow-up)
- Social work, family support
Alterations in Health (Diagnosis)
Group of conditions resulting from withdrawal in a newborn after intrauterine exposure to substances (primarily opioids, but also other substances). Manifestations begin within hours to days after birth depending on substance.
Pathophysiology Related to Client Problem
Maternal substance use during pregnancy → substance crosses placenta → fetal exposure and physiologic dependence → after birth, abrupt cessation of supply → withdrawal symptoms in newborn.
Health Promotion and Disease Prevention
- Prenatal screening for substance use (universal preferred)
- Maternal substance use treatment programs
- Methadone or buprenorphine maintenance for opioid-dependent mothers (decreases obstetric complications)
- Avoid abrupt cessation of substances during pregnancy (worsens NAS)
- Birth at facility with NICU capabilities
- Encourage prenatal care
Risk Factors
- Maternal opioid use (heroin, prescription opioids, methadone, buprenorphine)
- Other substances: benzodiazepines, alcohol, barbiturates, cocaine, methamphetamine, SSRIs, nicotine, marijuana
- Polysubstance use
- Inadequate prenatal care
- Mental health disorders
- Lower socioeconomic status
- Hepatitis C, HIV (often associated)
Expected Findings
Timing of onset:
- Heroin: within 24 hours
- Methadone: 24–72 hours (may be delayed up to 4 weeks)
- Buprenorphine: 12–48 hours
- SSRIs: 1–2 days
- Alcohol: 24–72 hours
CNS findings:
- High-pitched cry, irritability
- Tremors
- Hyperactive reflexes (Moro)
- Increased muscle tone
- Sleep disturbance
- Yawning, sneezing
- Seizures (severe)
Autonomic/Vasomotor:
- Fever, tachypnea
- Sweating
- Mottling, sneezing
GI:
- Poor feeding, uncoordinated suck
- Vomiting, diarrhea
- Excessive sucking
- Failure to thrive
- Dehydration
Other:
- Skin excoriation
- Stuffy nose
- Frequent yawning
Laboratory Tests
- Maternal urine drug screen (with consent)
- Neonatal meconium toxicology — most accurate (detects exposure during 2nd-3rd trimester)
- Neonatal urine drug screen (recent exposure only — last few days)
- Umbilical cord tissue testing (newer, accurate)
- Blood glucose monitoring
- CBC, blood gases if symptomatic
Diagnostic Procedures
- History of maternal substance use
- Clinical findings
- Toxicology testing
- Standardized scoring: Finnegan Neonatal Abstinence Scoring System — most widely used
- Score q3–4 hours after feeding; medication intervention typically with scores ≥ 8 on three consecutive scores or score ≥ 12
- Eat-Sleep-Console (ESC) — newer approach focusing on functional assessment
Safety Considerations
- Quiet environment
- Swaddling, low stimulation
- Skin protection (frequent diarrhea, restlessness)
- Monitor for seizures
- Aspiration precautions (poor feeding coordination)
- Monitor for sepsis (similar presentation)
- Mandatory reporting of substance exposure (varies by state)
Complications
- Seizures
- Failure to thrive, dehydration
- Skin breakdown from restlessness
- Sleep disturbance
- Increased risk of SIDS
- Long-term neurodevelopmental delays
- Behavioral issues (ADHD, learning disabilities)
- Foster care placement
- Family disruption
Nursing Care
Non-pharmacologic (first-line):
- Quiet, dim environment
- Swaddle tightly, position on side or prone for soothing (with monitoring)
- Skin-to-skin contact
- Rooming-in with mother when possible (and safe)
- Breastfeeding encouraged if mother in treatment program and not actively using illicit substances (some exceptions apply)
- Pacifier for non-nutritive sucking
- Small frequent feeds, high-calorie formula if needed
- Gentle handling, cluster care
- Music, gentle rocking
- Decreased stimulation (sound, light, handling)
Other:
- Frequent diaper changes (loose, frequent stools)
- Skin care (diaper area, knees, elbows from rubbing)
- Daily weights
- Strict I&O
- Finnegan scoring or ESC approach
- IV fluids if dehydrated
- Avoid abrupt loud noises
- Maternal involvement, support, and education
- Mandatory reporting per state law
- Social work referral
Medications
Used when non-pharmacologic measures inadequate (typically Finnegan score ≥ 8 × 3 or ≥ 12):
- Morphine (oral) — first-line for opioid withdrawal; weaned over days to weeks
- Methadone — alternative
- Buprenorphine — newer alternative, less hospital stay
- Phenobarbital — adjunct for severe symptoms or non-opioid (alcohol, benzo, polysubstance) withdrawal
- Clonidine — adjunct, sometimes first-line
- Wean medication slowly when symptoms controlled
Therapeutic Procedures
- Non-pharmacologic measures (first-line)
- Pharmacologic when severe symptoms (typically for opioid withdrawal)
- Length of stay: 5 days to several weeks
- Discharge when off medications and weight gain established
Client Education
Family/caregiver:
- Continue non-pharmacologic strategies at home (swaddling, quiet environment)
- Feeding techniques (small frequent feeds)
- Skin care
- Recognize feeding difficulties, dehydration
- Importance of follow-up appointments
- Long-term development monitoring
- Recognize signs of ongoing irritability, sleep issues
- Resources: early intervention, parenting support
- Treatment for maternal substance use (continuing essential)
- Safe sleep (back to sleep — important for high SIDS risk group)
- If breastfeeding mother is on methadone/buprenorphine, it is often supported (consult specialist)
- Mandatory reporting and social work involvement
- Resources for ongoing recovery support
Interprofessional Care
- Neonatology
- NICU nursing
- Social work
- Pediatric addiction specialist
- Lactation consultant
- Early intervention services
- Maternal addiction treatment programs
- Foster care/CPS if indicated
- Mental health (mother and family)
- Pediatric primary care follow-up
Alterations in Health (Diagnosis)
Neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity that interferes with functioning and development. Most common neurobehavioral disorder of childhood. Three subtypes: predominantly inattentive, predominantly hyperactive-impulsive, and combined.
Pathophysiology Related to Client Problem
Multifactorial neurobiological condition with genetic, environmental, and neurochemical components. Dysfunction in dopamine and norepinephrine pathways in prefrontal cortex → impaired executive function (attention, working memory, impulse control).
Health Promotion and Disease Prevention
- Avoid prenatal exposures (alcohol, tobacco, lead)
- Adequate prenatal care
- Healthy diet, sleep, exercise
- Structured environments
- Early identification and intervention
- Family education and support
Risk Factors
- Family history (strong genetic component — 80% heritability)
- Boys > girls (2–4× higher diagnosis rate)
- Prenatal exposure to alcohol, tobacco, lead
- Premature birth, low birth weight
- Maternal stress during pregnancy
- Brain injury, infection
- Coexisting conditions: learning disabilities, anxiety, depression, oppositional defiant disorder
Expected Findings
Diagnostic criteria (DSM-5): ≥ 6 symptoms in children < 17 years; symptoms persist ≥ 6 months; present before age 12; in 2+ settings (home AND school); impairing function.
Inattention:
- Fails to give close attention to details, makes careless mistakes
- Difficulty sustaining attention
- Does not seem to listen when spoken to
- Fails to follow through on instructions
- Difficulty organizing tasks
- Avoids tasks requiring sustained mental effort
- Loses things needed for tasks
- Easily distracted
- Forgetful in daily activities
Hyperactivity/Impulsivity:
- Fidgets, squirms
- Leaves seat when expected to remain seated
- Runs/climbs in inappropriate situations
- Difficulty playing quietly
- "On the go" / driven by motor
- Talks excessively
- Blurts out answers before questions completed
- Difficulty waiting their turn
- Interrupts or intrudes
Laboratory Tests
- No specific lab
- Rule out other conditions: thyroid panel (hyperthyroidism mimics), lead level, CBC
Diagnostic Procedures
- Clinical diagnosis based on DSM-5 criteria
- Vanderbilt ADHD Diagnostic Rating Scale (parent and teacher)
- Conners Rating Scale
- Comprehensive evaluation: history, physical, behavioral observation
- Information from multiple sources (parent, teacher)
- Educational testing (rule out learning disability)
- Hearing and vision screening (rule out sensory issues)
- Cardiac assessment before stimulant therapy (HR, BP, family history)
Safety Considerations
- Cardiovascular screening before stimulants
- Monitor growth (stimulants may suppress)
- Mental health monitoring (anxiety, depression, suicidality)
- Medication safety: secure storage (controlled substance, abuse potential)
- Avoid medication misuse (school, sharing)
- Injury risk from impulsivity
Complications
- Academic underachievement
- Social difficulties, poor peer relationships
- Family conflict
- Comorbid mental health: anxiety, depression, ODD, conduct disorder, mood disorders
- Substance use disorders (untreated ADHD higher risk)
- Self-esteem issues
- Injury (impulsivity)
- Driving accidents (adolescents)
- Failure to thrive (medication side effect)
- Cardiovascular events (rare with stimulants if screened)
- Sleep disturbance
Nursing Care
- Comprehensive assessment
- Coordinate with school for evaluation and IEP/504 plan
- Educate family about diagnosis
- Monitor medication response and side effects
- Track growth, BP, HR (with stimulants)
- Coordinate behavioral interventions
- Support family through challenges
- Monitor for comorbid mental health conditions
- Encourage positive parenting strategies
Medications
Stimulants (first-line, most effective):
- Methylphenidate: Ritalin (IR), Concerta (LA), Daytrana (patch), Focalin
- Amphetamines: Adderall (IR or XR), Vyvanse, Dexedrine
- Schedule II controlled substances
- Side effects: appetite suppression, insomnia, tachycardia, jitteriness, growth slowing
- Monitor: HR, BP, growth, mental status
Non-stimulants:
- Atomoxetine (Strattera) — SNRI; less abuse potential; suicide warning
- Guanfacine (Intuniv), Clonidine (Kapvay) — alpha-2 agonists; help with hyperactivity and sleep
Therapeutic Procedures
- Multimodal approach: medication + behavioral therapy
- Behavioral parent training
- Cognitive-behavioral therapy
- Social skills training
- School-based interventions (IEP/504 plan)
- Sleep hygiene
- Exercise
- Diet modifications (limited evidence)
- Family therapy
Client Education
Family:
- ADHD is a brain-based condition, NOT poor parenting or child's "choice"
- Treatment is multimodal: medication + behavioral strategies
- Structure, routine, clear expectations
- Positive reinforcement for desired behaviors
- Brief, clear instructions (one at a time)
- Reduce distractions during homework
- Regular schedule (sleep, meals, activities)
- Adequate sleep crucial
- Exercise daily
- Limit screen time
- Avoid label/shame language
Medication management:
- Take stimulants in morning (avoid late doses → insomnia)
- Give with breakfast (helps with appetite)
- Encourage adequate intake (snacks at school, dinner after med wears off)
- Monitor growth (height, weight at every visit)
- Watch for side effects: appetite loss, insomnia, mood changes
- Some plan "drug holidays" on weekends/summer (controversial)
- Don't stop abruptly; coordinate with provider
- Secure storage — abuse potential, theft
- Cardiac symptoms (chest pain, palpitations) → call provider
School:
- 504 plan or IEP eligibility
- Accommodations: extra time, preferential seating, breaks, organizational support
- Inform school of medication administration
- Regular communication with teachers
Interprofessional Care
- Pediatrician
- Pediatric psychiatrist (medication, complex cases)
- Psychologist (assessment, therapy)
- Behavioral therapist
- School counselor
- Special education team
- Family therapist
- Educational consultant
Alterations in Health (Diagnosis)
Tissue injury from heat, chemicals, electricity, or radiation. Children have proportionally larger heads and thinner skin, leading to deeper injuries and greater fluid requirements per kg. Burns classified by depth, extent (TBSA), and cause.
Pathophysiology Related to Client Problem
Heat denatures cellular proteins → coagulative necrosis. Three zones: coagulation (necrotic center), stasis (potentially salvageable), hyperemia (heals). Systemic effects (capillary leak, ↑ metabolism, immune suppression) seen in burns > 15–20% TBSA.
Health Promotion and Disease Prevention
- Smoke detectors, fire extinguishers in home
- Family escape plan
- Set water heater < 120°F (49°C) — scald prevention
- Test bath water temperature
- Keep hot foods/liquids out of reach
- Use back burners; turn pot handles away
- Cabinet locks for chemicals
- Outlet covers; replace damaged cords
- Sun protection
- Fire-safe sleepwear
- Educate about fire/burn safety
Risk Factors
- Ages 1–4 years (highest risk — exploring, walking but uncoordinated)
- Boys > girls
- Lower socioeconomic status
- Crowded living conditions
- Unsafe heating sources (space heaters)
- Smoking in home
- Inadequate supervision
- Cooking accidents (scald — most common)
- Older children: flame burns, electrical, chemical, sun
- Adolescents: fire-setting, work-related
- Suspicious patterns: glove/stocking distribution, symmetric burns, cigarette burns — abuse
Expected Findings
Depth of burns:
- Superficial (1st-degree): epidermis only; red, dry, painful, no blister (e.g., sunburn); heals in days
- Superficial partial-thickness (2nd-degree, superficial): epidermis + upper dermis; blisters, weepy, very painful; heals 7–14 days
- Deep partial-thickness (2nd-degree, deep): deeper dermis; pale, dry, less pain (some nerve damage); heals 2–6 weeks with scarring
- Full-thickness (3rd-degree): entire skin; white, leathery, dry, painless (nerves destroyed); requires grafting
- 4th-degree: extends to muscle, bone
Extent (TBSA):
- Lund-Browder chart — gold standard pediatrics (accounts for proportional body differences)
- Modified rule of 9s (pediatric): head 18% (vs 9% adult), each arm 9%, anterior trunk 18%, posterior trunk 18%, each leg 14% (vs 18%), perineum 1%
- Palmar method: child's palm (incl fingers) ~ 1% TBSA — for irregular burns
Major emergencies to recognize:
- Airway: inhalation injury (hoarseness, singed nasal hairs, soot in mouth/nose, carbonaceous sputum)
- Burn shock (capillary leak)
- Hypothermia
- Infection
Laboratory Tests
- ABG with co-oximetry (suspect carbon monoxide poisoning)
- CBC (hemoconcentration initially → anemia later)
- Electrolytes
- BUN/creatinine
- Glucose
- Albumin, total protein
- Type and crossmatch
- Coagulation studies
- Urinalysis (myoglobinuria — electrical burns)
- Lactate
Diagnostic Procedures
- Detailed history (mechanism, time, exposure, accelerants)
- Physical exam (assess depth, TBSA, associated injuries, signs of abuse)
- Chest X-ray, bronchoscopy if inhalation suspected
- ECG (especially electrical burns)
- Photographs of burn (medical record)
Safety Considerations
- ABC priority — airway compromise from inhalation injury possible
- 100% O₂ for carbon monoxide
- Stop the burning process; remove clothing, jewelry
- Cool burn briefly with room-temperature water (NOT ice)
- Cover with clean dry sheet
- Maintain warmth (hypothermia risk)
- Strict aseptic technique to prevent infection
- Reverse isolation for severe burns
- Mandatory reporting if abuse suspected
Complications
- Burn shock (hypovolemic) — capillary leak → massive fluid shift
- Inhalation injury, airway compromise
- Carbon monoxide poisoning
- Infection, sepsis
- Compartment syndrome (circumferential burns) — may need escharotomy
- Acute kidney injury (myoglobinuria, hypoperfusion)
- Hypothermia
- Hypermetabolism, weight loss
- Curling ulcer (stress ulcer)
- Paralytic ileus (initial)
- Scarring, contractures
- Psychological trauma
- Hypertrophic scars, keloids
- Heterotopic ossification
Nursing Care
Emergency/Acute care:
- ABC (airway, breathing, circulation)
- 100% humidified O₂; intubate if airway compromise (early!)
- Parkland formula for fluid resuscitation: 4 mL × kg × % TBSA of LR over first 24 hr
- Half in first 8 hr (from time of injury, not arrival), half over next 16 hr
- Foley catheter for I&O monitoring; goal 1 mL/kg/hr urine output
- NG decompression (ileus initial)
- Maintain temperature
- Tetanus prophylaxis
- Pain management (opioids — typically IV for severe)
- Wound care per protocol
- Strict aseptic technique
- Hourly vital signs initially
- Daily weights
Wound care:
- Hydrotherapy (gentle cleaning)
- Topical antimicrobials (silver sulfadiazine, mafenide acetate, silver-impregnated dressings)
- Debridement as needed
- Dressing changes (often painful — pre-medicate)
- Grafting for deep burns
Nutrition:
- Hypermetabolic state — caloric needs ↑↑
- NG or J-tube feeds if unable to PO
- High-calorie, high-protein
- Vitamin supplementation
Rehabilitation:
- Position to prevent contractures
- PT/OT early
- Compression garments for hypertrophic scars
- Psychological support
Medications
- Pain: IV opioids (morphine, fentanyl); PCA when age-appropriate; pre-medicate before dressing changes
- Topical antimicrobials: silver sulfadiazine (Silvadene), mafenide acetate (Sulfamylon — for ears/joints, penetrates eschar), bacitracin, silver-impregnated dressings (Acticoat, Mepilex Ag)
- Tetanus prophylaxis
- Systemic antibiotics for established infection (not prophylactic)
- H2 blockers or PPI (Curling ulcer prevention)
- Anxiolytics for procedural sedation
- Stool softeners (opioid-induced constipation)
Therapeutic Procedures
- Fluid resuscitation (Parkland formula)
- Wound care, dressing changes
- Hydrotherapy
- Escharotomy (circumferential full-thickness burns → compartment syndrome)
- Surgical debridement
- Skin grafting (autograft, allograft, xenograft, cultured epithelial autografts)
- Pressure garments, splinting (long-term)
- Physical and occupational therapy
- Psychological support
- Plastic surgery for reconstruction
Client Education
Burn unit/hospital:
- Treatment plan and expected course
- Pain management plan
- Wound care if going home
- Importance of nutrition
- Possible scarring, reconstruction
- Activity restrictions
Wound care at home:
- Hand hygiene
- Dressing change technique
- Topical medication application
- Signs of infection: fever, increased pain, redness, drainage, foul odor
- Pressure garment care (wear 23 hr/day for up to 1–2 years)
- Sun protection (burned skin sensitive to sun for life)
- Moisturize healed skin
Long-term:
- PT/OT exercises at home
- Recognize contractures, scarring
- Psychological support for child and family
- School reintegration plan
- Recognize PTSD
- Burn camps and peer support
- Multiple surgeries may be needed
Interprofessional Care
- Pediatric burn center (if severe)
- Pediatric burn surgery
- Pediatric ICU/burn ICU
- Plastic surgery
- Anesthesia (frequent procedures)
- Physical and occupational therapy
- Dietitian
- Child life specialist
- Social work, psychology
- School coordination
- CPS if abuse suspected
- Pain specialist
Alterations in Health (Diagnosis)
Immune complex disease following infection with nephritogenic strain of group A beta-hemolytic streptococcus (GABHS). Typically occurs 1–3 weeks after strep throat or 3–6 weeks after impetigo.
Pathophysiology Related to Client Problem
Strep infection → antibodies form against bacterial antigens → antigen-antibody complexes deposit in glomerular basement membrane → inflammation → ↓ glomerular filtration → fluid retention, hematuria, proteinuria, hypertension.
Health Promotion and Disease Prevention
- Prompt treatment of strep throat and skin infections
- Complete full antibiotic course
- Hand hygiene
- Avoid sharing personal items
- Treat household contacts if needed
Risk Factors
- Age 5–12 years (peak)
- Boys > girls (2:1)
- Recent strep throat (pharyngitis) or strep skin infection (impetigo)
- Untreated or inadequately treated strep
- Crowded living conditions
- Fall/winter (pharyngitis); summer (impetigo)
Expected Findings
- Onset 1–3 weeks after strep (later for skin)
- Tea-colored, cola-colored, or smoky brown urine (gross hematuria)
- Periorbital edema (especially morning) — moves to peripheral edema during day
- Hypertension (key finding)
- ↓ urine output (oliguria)
- Weight gain (fluid retention)
- Fatigue, malaise
- Headache
- Pallor, anorexia, abdominal pain
- Mild fever
- Encephalopathy (severe — confusion, seizures from hypertension)
Laboratory Tests
- Urinalysis: hematuria (gross/microscopic), RBC casts, proteinuria (mild-moderate), specific gravity high
- ↑ ASO titer (antistreptolysin O) — confirms recent strep infection
- ↑ anti-DNase B (more reliable for skin infections)
- ↓ C3 complement (returns to normal 6–8 weeks — important marker)
- ↑ BUN, creatinine (renal impairment)
- Hyperkalemia, hyperphosphatemia
- Throat or skin culture (may be negative by time of nephritis)
Diagnostic Procedures
- Clinical findings + lab markers
- Renal ultrasound (usually normal-sized kidneys)
- Renal biopsy only if atypical or no improvement
Safety Considerations
- Monitor BP closely — hypertensive encephalopathy risk
- Seizure precautions if severe HTN
- Strict I&O, daily weights
- Sodium and fluid restrictions
- Watch for fluid overload, HF
Complications
- Hypertensive encephalopathy
- Acute kidney injury
- Pulmonary edema, heart failure
- Seizures (from HTN)
- Most resolve completely; ~5% chronic glomerulonephritis
- Recurrent infections (different)
Nursing Care
- Strict I&O, daily weight (same time, scale)
- BP q4h or more frequently if elevated
- Monitor for HTN encephalopathy: headache, vision changes, altered mental status, seizures
- Restrict sodium and fluid (per order)
- Bed rest during acute phase
- Diet: ↓ Na, ↓ K (if hyperkalemic), ↓ phosphorus
- Skin care (edema)
- Test urine for protein, blood
- Monitor labs (BUN, Cr, K, C3)
- Pediatric-friendly environment, age-appropriate distractions
Medications
- Antibiotics: penicillin or erythromycin (eradicate strep if still present); does NOT alter course of glomerulonephritis
- Antihypertensives: calcium channel blockers (nifedipine, amlodipine), ACE inhibitors, hydralazine
- Diuretics: furosemide for fluid overload
- Potassium binders if hyperkalemic (sodium polystyrene)
- NOT typically used: corticosteroids (unlike nephrotic syndrome)
Therapeutic Procedures
- Supportive care
- Diet modification
- Fluid/sodium restriction
- Rarely: dialysis if severe
Client Education
- Most children recover fully within 1–2 weeks (symptoms); some lab abnormalities persist months
- Sodium-restricted diet during acute phase
- Importance of completing antibiotics
- Recognize HTN warning signs (headache, vision changes)
- Daily weights
- Monitor BP at home if possible
- Recognize fluid overload: shortness of breath, increasing edema
- Recurrence rare (immunity to nephritogenic strain)
- Long-term follow-up with renal function
- Family members may need throat culture/treatment if recent strep exposure
- Prompt treatment of future strep infections
Interprofessional Care
- Pediatric nephrology
- Pediatric dietitian
- Pediatrician/primary care
- Infection control (siblings, school)
Alterations in Health (Diagnosis)
Most common acquired bleeding disorder in children. Autoimmune destruction of platelets by antibodies → severe thrombocytopenia (platelets < 100,000, often < 20,000). Often follows viral illness 1–4 weeks before onset.
Pathophysiology Related to Client Problem
Autoantibodies (IgG) coat platelets → splenic macrophages destroy platelet-antibody complexes → ↓↓ platelet count → bleeding manifestations. Acute (children, post-viral, self-limited) vs chronic (> 6–12 months, more in older children/adolescents).
Health Promotion and Disease Prevention
- No specific prevention
- Education on bleeding precautions if known ITP
Risk Factors
- Age 2–10 years (acute form most common)
- Recent viral illness (rubella, varicella, EBV, CMV) — 1–4 weeks before
- Recent immunization (MMR, varicella)
- Family history of autoimmune disease (chronic ITP)
Expected Findings
- Sudden onset of bleeding/bruising in previously healthy child
- Petechiae (tiny pinpoint red/purple spots) — typically on extremities, trunk
- Purpura (larger bruises)
- Easy bruising, often with minor or no trauma
- Mucosal bleeding: epistaxis, gingival bleeding, oral blood blisters
- Hematuria, GI bleeding (less common)
- Heavy menses (menorrhagia) in adolescents
- Intracranial hemorrhage — rare but most feared
- NOT typical: fever, lymphadenopathy, hepatosplenomegaly (suggests other diagnosis)
Laboratory Tests
- ↓ platelets (often < 20,000)
- Normal Hgb, Hct (unless significant bleeding)
- Normal WBC and differential
- Normal coagulation: PT, aPTT
- Peripheral smear: large platelets, otherwise normal cells
- Bone marrow (if done): normal or ↑ megakaryocytes (NOT diagnostic for ITP, but rules out malignancy)
Diagnostic Procedures
- Diagnosis of exclusion: ↓ platelets in otherwise healthy child after exclusion of other causes
- CBC with differential
- Peripheral blood smear
- Bone marrow only if atypical features (other cell lines affected, no response to treatment, planning steroids)
Safety Considerations
Bleeding precautions:
- NO contact sports, rough play
- NO IM injections, rectal medications/temperatures
- NO aspirin, NSAIDs
- Soft toothbrush; no flossing during severe thrombocytopenia
- Electric razor (older children)
- Padded environment for active toddlers
- Helmet for at-risk activities
- Avoid Valsalva (constipation prevention)
Complications
- Intracranial hemorrhage (rare, < 1%, but most concerning) — risk highest with platelets < 10,000
- Severe GI bleeding
- Hematuria, blood loss anemia
- Chronic ITP (~20% become chronic)
- Splenectomy complications (if needed)
- Steroid side effects with treatment
- Heavy menses in adolescent females
Nursing Care
- Comprehensive bleeding assessment (skin, mucous membranes, stool, urine)
- Frequent neuro checks (intracranial hemorrhage)
- Strict bleeding precautions
- Avoid IM injections (use SQ or IV)
- Apply firm pressure to venipuncture sites for 5+ min
- Pad bed rails, soft environment
- Soft toothbrush
- Stool softener (avoid Valsalva)
- Monitor for occult bleeding (urine, stool)
- Encourage age-appropriate quiet activities
- Emotional support — sudden illness is frightening
Medications
- Many children require NO treatment if platelets > 20,000–30,000 and no significant bleeding — observation
- IVIG (Intravenous Immunoglobulin) — rapid platelet increase; first-line for severe bleeding
- Corticosteroids (prednisone or IV methylprednisolone) — first-line; tapered course
- Anti-D immunoglobulin (WinRho) — Rh-positive patients with intact spleen
- Platelet transfusion — ONLY for life-threatening bleeding (consumed quickly by antibodies)
- Rituximab, eltrombopag, romiplostim — chronic/refractory ITP
- NO aspirin/NSAIDs
Therapeutic Procedures
- Observation alone if mild
- Medications above
- Splenectomy for chronic refractory ITP
- Most children (acute ITP) recover spontaneously within 6 months
Client Education
- Most children recover completely from acute ITP within 6 months
- Bleeding precautions until platelets normalize:
- No contact sports, rough play, bicycle (with helmet if allowed)
- No aspirin or NSAIDs (Tylenol OK)
- Soft toothbrush, gentle oral hygiene
- Use electric razor
- Avoid IM injections
- Avoid suppositories, rectal temperatures
- Padded environment for toddlers
- Helmet for activities
- School: notify, restrict PE/contact activities until platelets recover
- Recognize warning signs: severe headache, neurologic changes, severe bleeding, persistent vomiting → ER immediately
- Daily skin checks for new bruising/petechiae
- Monitor for menstrual changes in adolescents (heavy bleeding)
- Recurrence possible; recognize early
- Follow-up CBC appointments
Interprofessional Care
- Pediatric hematology/oncology
- School nurse
- Gynecology (heavy menstrual bleeding in adolescents)
- Mental health support if chronic
Alterations in Health (Diagnosis)
Triad of: microangiopathic hemolytic anemia + thrombocytopenia + acute kidney injury. Most common cause of acute kidney injury in young children. Typically follows GI infection with Shiga toxin-producing E. coli (especially O157:H7).
Pathophysiology Related to Client Problem
Shiga toxin damages vascular endothelium (especially in kidney) → platelet aggregation, fibrin deposition → microthrombi → RBCs destroyed (schistocytes), platelets consumed, glomerular damage → AKI.
Health Promotion and Disease Prevention
- Cook ground beef thoroughly (especially burgers) — internal temp 160°F
- Wash hands and surfaces after handling raw meat
- Avoid unpasteurized milk and juices
- Wash fruits and vegetables
- Avoid public swimming pools/lakes if recent diarrheal illness
- Hand hygiene
- Avoid contact with farm animals and petting zoo precautions
Risk Factors
- Age < 5 years (peak)
- Summer months
- Consumption of undercooked ground beef, unpasteurized dairy
- Contact with cattle or farm animals
- Recent E. coli O157:H7 or Shigella infection
- Daycare exposure
- Recent diarrheal illness (especially bloody)
- Genetic factors (atypical HUS)
Expected Findings
Prodromal phase (5–10 days before HUS):
- Gastroenteritis with bloody diarrhea
- Vomiting
- Abdominal cramping
HUS onset (days after diarrhea):
- Pallor (hemolytic anemia)
- Petechiae, purpura, bruising
- Decreased urine output, oliguria/anuria
- Edema
- Hypertension
- Lethargy, irritability
- Possible seizures, altered LOC
- Jaundice (hemolysis)
- Hepatosplenomegaly
- Possible bleeding
Laboratory Tests
Hemolytic anemia:
- ↓ Hgb, Hct
- Schistocytes (fragmented RBCs) on peripheral smear
- ↑ LDH
- ↑ indirect (unconjugated) bilirubin
- ↓ haptoglobin
- Reticulocytosis
Thrombocytopenia:
- ↓ platelets (< 150,000)
AKI:
- ↑ BUN, ↑ creatinine
- ↑ K, ↑ phosphorus
- ↓ Na (sometimes)
- Metabolic acidosis
- Hematuria, proteinuria
- Cola-colored urine
Etiology:
- Stool culture for E. coli O157:H7
- Shiga toxin assay (PCR)
Diagnostic Procedures
- Clinical diagnosis based on triad
- Stool culture and Shiga toxin testing
- Renal ultrasound
- Rarely: renal biopsy (atypical HUS workup)
Safety Considerations
- Strict contact isolation for E. coli
- Fluid management: avoid overload, monitor I&O carefully
- Seizure precautions
- Hypertension management
- Bleeding precautions
- AVOID antibiotics, antimotility agents, opioids for the diarrhea (worsens HUS by ↑ toxin release)
Complications
- Acute kidney failure requiring dialysis (50% need dialysis)
- Severe hypertension
- CNS involvement: seizures, stroke, encephalopathy
- Pancreatitis
- Cardiac involvement
- Death (~3–5% acute mortality)
- Long-term renal sequelae: chronic kidney disease, hypertension (30%)
- End-stage renal disease (rare but possible)
Nursing Care
- Frequent vital signs, especially BP
- Strict I&O, daily weights
- Continuous cardiac monitoring
- Neurologic checks q4h (more if symptoms)
- Frequent monitoring of labs
- Manage fluid balance carefully (overload AND dehydration both risks)
- Prepare for possible dialysis
- Strict contact isolation
- Manage hyperkalemia
- Monitor for transfusion needs
- Manage hypertension
- Nutrition: small frequent feeds, restrict K and P if elevated
- Skin care (immobility, edema)
- Family education and support
Medications
- Supportive treatment (no specific cure)
- Antihypertensives: calcium channel blockers, ACE inhibitors
- Diuretics (furosemide) — if not anuric
- Antiemetics
- Anticonvulsants if seizures
- Phosphate binders
- Sodium polystyrene for hyperkalemia
- AVOID antibiotics for the diarrhea (can worsen HUS by lysing bacteria and releasing more toxin)
- AVOID antimotility/antidiarrheal agents (Loperamide)
- Eculizumab — for atypical HUS
- Pre-transfusion prep
Therapeutic Procedures
- Supportive care (cornerstone)
- Dialysis (peritoneal or hemodialysis) — about half require it
- RBC transfusion for severe anemia
- Platelet transfusion only if active bleeding
- Plasma exchange (for some atypical HUS)
Client Education
Prevention:
- Cook ground beef thoroughly
- Wash hands after handling raw meat
- Avoid unpasteurized dairy/juice
- Wash fruits/vegetables
- Hand hygiene
- Avoid swimming if diarrhea
- Petting zoo precautions
Recovery:
- Most children fully recover
- Long-term follow-up for kidney function
- Some develop CKD, hypertension years later
- Recognize signs of recurrent kidney problems
- Importance of follow-up labs and BP monitoring
- Annual urinalysis, BP, creatinine for years
Active illness:
- Recognize warning signs of recurrence
- Diet restrictions during recovery
- Vaccinations remain important
Interprofessional Care
- Pediatric nephrology
- PICU/critical care
- Infectious disease
- Hematology
- Public health (reportable disease)
- Dietitian
- Dialysis team if needed
Alterations in Health (Diagnosis)
Congenital deformity in which the foot is twisted out of position. Three components: foot pointing DOWN (equinus), foot turned INWARD (varus), and arch raised (cavus). Affects one or both feet. Most common pediatric foot deformity.
Pathophysiology Related to Client Problem
Idiopathic in 80% — multifactorial (genetic + intrauterine factors). Foot positioning during fetal development → contractures of muscles, tendons, and ligaments on medial side of foot. Without treatment, walking is severely impaired and painful.
Health Promotion and Disease Prevention
- Adequate folic acid before conception
- Genetic counseling if family history
- Avoid teratogens during pregnancy
- Early identification and treatment (within first 1–2 weeks of life ideal)
Risk Factors
- Boys > girls (2:1)
- Family history
- Bilateral in 50%
- Associated with: spina bifida, myelomeningocele, arthrogryposis, cerebral palsy, Edward syndrome
- Oligohydramnios
- Breech presentation
- Maternal smoking, illicit drugs
Expected Findings
- Visible deformity at birth
- Foot pointed downward (equinus — heel held UP)
- Foot turned inward (varus)
- Sole faces inward
- High arch (cavus)
- Inability to passively correct deformity
- Calf muscle atrophy (especially in older child)
- One foot may be smaller than other (unilateral)
- Hip dysplasia association (check for DDH)
Laboratory Tests
- No specific labs
- Karyotype if multiple anomalies suspected
Diagnostic Procedures
- Physical examination at birth (visible deformity)
- Prenatal ultrasound (sometimes detected)
- X-ray of feet (severity assessment)
- Hip ultrasound (check for DDH)
- Differentiate from positional clubfoot (mild, correctable with manipulation — does NOT need extensive treatment)
Safety Considerations
- Cast care, neurovascular checks
- Skin care under brace/cast
- Brace compliance (essential to prevent relapse)
- Watch for circulation issues
Complications
- Recurrence/relapse (especially if non-compliant with brace)
- Skin breakdown from cast or brace
- Joint stiffness
- Permanent deformity if untreated
- Pain, limp, calluses
- Difficulty with footwear
- Surgical complications (rare)
- Long-term effects on knee, hip from gait abnormality
Nursing Care
Ponseti method (most common):
- Weekly serial manipulation and long-leg casting
- 5–6 casts total over weeks
- Achilles tenotomy (small percutaneous procedure) at end if needed
- Then bracing (foot abduction brace) for years
Cast care:
- Neurovascular checks (color, warmth, capillary refill, sensation, movement)
- Elevate foot
- Keep cast dry
- Watch for swelling, drainage, foul odor
- Skin care at cast edges
- Position changes
- Petaling cast edges for comfort
Brace care:
- Foot abduction brace (Denis-Browne bar with shoes) initially worn 23 hr/day × 3 months, then nighttime + naps until age 4 years
- Compliance is essential — non-compliance leads to relapse
- Daily skin checks
- Cotton socks under brace
- Recognize pressure injuries
- Continue normal play activities outside brace time
Medications
- Acetaminophen, ibuprofen for discomfort
- Pre-operative antibiotics if surgical intervention
- Post-operative analgesics
Therapeutic Procedures
Ponseti method (gold standard, 90%+ success):
- Serial manipulation and casting weekly × 5–6 weeks
- Percutaneous Achilles tenotomy (most need this)
- Final cast × 3 weeks
- Foot abduction brace (Denis-Browne) 23 hr/day × 3 months
- Brace at night and naps until age 4 years
French method (less common): daily PT, stretching, taping
Surgery (reserved for resistant cases):
- Comprehensive soft tissue release
- Often results in stiffness
- Increasingly avoided with Ponseti approach
Client Education
- Early treatment (within first weeks of life) gives best outcomes
- Treatment is generally well-tolerated
- Casts need to stay on, dry, and clean
- Recognize signs of circulation problem under cast (color, temperature changes, swelling, severe pain)
- Brace compliance is essential — relapse rate high if not worn as directed
- Initial brace wear: 23 hours/day for 3 months
- Then: nights and naps until age 4 (15+ hours/day)
- Daily skin checks under brace
- Use cotton socks (not too thick)
- Most children walk and run normally after treatment
- Continue normal play and activity outside brace time
- Long-term follow-up with orthopedist
- Genetic counseling for families (familial risk)
Interprofessional Care
- Pediatric orthopedic surgeon (Ponseti-trained)
- Orthotist
- Physical therapy (some centers)
- Pediatric primary care (long-term follow-up)
- Family support groups
Alterations in Health (Diagnosis)
Most common chronic rheumatologic disease of childhood. Persistent joint inflammation lasting ≥ 6 weeks in a child < 16 years. Multiple subtypes; previously called juvenile rheumatoid arthritis (JRA).
Pathophysiology Related to Client Problem
Autoimmune disease — immune dysregulation → chronic synovial inflammation → joint damage, cartilage destruction, growth disturbance. Genetic predisposition + environmental trigger (possibly infection). Different subtypes have different presentations and prognoses.
Health Promotion and Disease Prevention
- No known prevention
- Early diagnosis essential to prevent joint damage
- Regular eye exams (uveitis risk)
- Adequate vitamin D, calcium
Risk Factors
- Family history of autoimmune disease
- Girls > boys (most subtypes)
- Age < 16 years (by definition)
- HLA associations
- Possible infectious triggers
Expected Findings
Subtypes and findings:
- Oligoarticular (most common, 50%): 1–4 joints, large joints (knees, ankles), girls, peak 2–4 yr; highest uveitis risk
- Polyarticular: 5+ joints, symmetric, small joints involved, more like adult RA
- Systemic (Still disease): high spiking fevers, salmon-colored rash, hepatosplenomegaly, lymphadenopathy
Joint symptoms:
- Morning stiffness (key feature) improving with activity
- Joint swelling, warmth, ↓ ROM
- Joint pain (may not always be present in young children — they may just refuse to walk)
- Limp
- Refusal to use affected limb
Systemic features:
- Fatigue
- Low-grade fever (or high spiking in systemic JIA)
- Poor growth, weight loss
- Anemia
- Rash
Complications:
- Uveitis (especially ANA+, young girls with oligoarticular) — often asymptomatic; can cause blindness
- Growth retardation
- Leg length discrepancy
Laboratory Tests
- ESR ↑, CRP ↑ (active inflammation)
- CBC: anemia of chronic disease, ↑ platelets, ↑ WBC (systemic)
- ANA: positive in oligoarticular subtype (especially with uveitis)
- Rheumatoid factor (RF) — most are negative; positive subtype has worse prognosis
- Anti-CCP antibody (similar to RF subtype)
- HLA-B27 (enthesitis-related subtype)
- Ferritin very high in systemic JIA (and MAS)
Diagnostic Procedures
- Clinical diagnosis — diagnosis of exclusion
- ≥ 6 weeks of arthritis
- Exclude other causes (infection, malignancy, other autoimmune)
- Joint aspiration if monoarticular (rule out septic arthritis)
- X-ray of joints
- MRI for active synovitis
- Slit-lamp exam by ophthalmology every 3–6 months (uveitis screening — silent disease)
Safety Considerations
- Routine eye exams (uveitis can be silent until blindness)
- Medication side effect monitoring
- Joint protection during flares
- Infection prevention with immunosuppressants
- Live vaccine avoidance with biologics
- Watch for MAS (macrophage activation syndrome) in systemic JIA
Complications
- Uveitis with possible blindness if not detected
- Joint deformity, contractures
- Growth retardation (overall and local — leg length discrepancy)
- Osteoporosis
- Functional disability
- Macrophage activation syndrome (MAS) — life-threatening, systemic JIA
- Medication side effects (immunosuppression, infection, malignancy)
- Psychosocial impact
Nursing Care
- Assess pain, joint function, ROM daily
- Monitor for AM stiffness
- Warm baths/showers in morning (relieve stiffness)
- Encourage activity (swimming excellent — joint-friendly)
- Avoid prolonged immobility (worsens stiffness)
- PT/OT exercises
- Joint protection (avoid jamming, hyperextension)
- Adequate sleep
- Nutritious diet (calcium, vitamin D)
- Monitor weight, growth
- Encourage normal school and social activities
- Medication compliance education
- Infection precautions if immunosuppressed
- Psychosocial support — chronic illness
Medications
NSAIDs (first-line for symptom relief):
- Naproxen, ibuprofen, celecoxib
- Anti-inflammatory + pain relief
- NOT disease-modifying alone
DMARDs (disease-modifying):
- Methotrexate (most common, weekly)
- Sulfasalazine
- Leflunomide
- Folic acid supplementation with methotrexate
Biologics:
- TNF inhibitors: etanercept, adalimumab, infliximab
- IL-1 inhibitors: anakinra, canakinumab (for systemic JIA)
- IL-6 inhibitor: tocilizumab (systemic JIA)
- Abatacept (T-cell costimulation modulator)
Corticosteroids:
- Oral prednisone (short courses or systemic JIA flares)
- IV methylprednisolone (severe flares)
- Intra-articular injections
Therapeutic Procedures
- Multimodal: medications + PT/OT
- Intra-articular steroid injections
- Splinting
- Joint replacement (rarely, severe damage in adulthood)
- Eye care (uveitis)
Client Education
- Chronic condition requiring long-term management
- Importance of medication compliance even when feeling well
- Exercise IS encouraged — improves outcomes
- Swimming, biking joint-friendly
- Adequate rest balance
- Heat (warm bath in morning) helps stiffness
- Cold for acute flares
- Recognize medication side effects
- Methotrexate teaching: weekly, NO daily, with folic acid; avoid alcohol; sun protection; consistent monitoring of LFTs and CBC
- Biologics: injection technique, storage, infection precautions, no live vaccines
- REGULAR EYE EXAMS every 3–6 months — even when feeling well
- Recognize uveitis: red eye, photophobia, vision changes
- School support: 504 plan if needed; absences for appointments
- Psychosocial support
- Support groups
- Vaccination strategy (some adjustments)
Interprofessional Care
- Pediatric rheumatology
- Pediatric ophthalmology (uveitis screening)
- Physical and occupational therapy
- Dietitian
- School nurse
- Pediatric primary care
- Psychology (chronic disease)
- JIA support groups
Alterations in Health (Diagnosis)
Most common and most severe form of muscular dystrophy. X-linked recessive disorder affecting boys. Progressive muscle weakness and degeneration starting in early childhood, leading to loss of ambulation, respiratory failure, and cardiomyopathy.
Pathophysiology Related to Client Problem
Mutation in the dystrophin gene on X chromosome → absent or non-functional dystrophin protein → muscle membrane instability → cycles of muscle injury and incomplete repair → muscle fibers replaced with fat and connective tissue → progressive weakness. Cardiac and respiratory muscles eventually affected.
Health Promotion and Disease Prevention
- Genetic testing/counseling for at-risk families
- Carrier testing for female relatives
- Prenatal testing available
- Early identification for early intervention
Risk Factors
- Male sex (X-linked recessive)
- Family history (mother carrier)
- ~30% spontaneous mutations (no family history)
- Female "carriers" usually mild or no symptoms
Expected Findings
Early (ages 2–5):
- Delayed motor milestones (walking, running)
- Toe walking
- Waddling gait
- Difficulty running, jumping, climbing stairs
- Frequent falls
- Gower's sign — child uses hands to "walk up" thighs to stand from floor (proximal weakness)
- Calf pseudohypertrophy (enlarged but weakened calves due to fat infiltration)
- Lumbar lordosis when standing
Progressive (ages 6–12):
- Loss of ability to walk (wheelchair by age 9–12)
- Scoliosis
- Joint contractures
- Worsening proximal weakness
- Learning disabilities (1/3 of patients — average IQ slightly below average)
Late (adolescence/young adult):
- Respiratory muscle weakness — ventilatory support eventually needed
- Cardiomyopathy
- Severe scoliosis
- Death typically in early adulthood (20s–30s) from respiratory or cardiac failure
Laboratory Tests
- Markedly elevated creatine kinase (CK) — 10–100× normal at diagnosis
- Elevated AST, ALT (muscle origin)
- Elevated LDH, aldolase
Diagnostic Procedures
- Genetic testing for dystrophin gene mutation (definitive)
- Muscle biopsy: absence of dystrophin staining
- ECG, echocardiogram (cardiac involvement)
- Pulmonary function tests (annually)
- EMG (rarely needed)
Safety Considerations
- Fall prevention
- Adaptive equipment safety
- Cardiac and respiratory monitoring
- Anesthesia precautions (malignant hyperthermia-like reaction risk)
- Pneumonia prevention
- Skin care (immobility)
Complications
- Respiratory failure
- Cardiomyopathy, heart failure, arrhythmias
- Pneumonia, atelectasis
- Severe scoliosis
- Joint contractures
- Osteoporosis, fractures (especially with chronic steroids)
- Aspiration as swallowing weakens
- Constipation, GI hypomotility
- Anesthetic reactions (rhabdomyolysis, hyperkalemia)
- Psychosocial impact
- Premature death (typically 20s–30s)
Nursing Care
- Maximize function, maintain independence as long as possible
- PT/OT to maintain ROM, prevent contractures
- Encourage age-appropriate activities
- Stretching, splinting (especially night splints)
- Monitor for scoliosis
- Adequate nutrition (avoid obesity worsening function)
- Skin care, position changes
- Respiratory care: incentive spirometry, manual cough assist, BiPAP eventually
- Cardiac monitoring (annual echo, ECG)
- Pneumonia prevention (annual flu, pneumococcal vaccines)
- Educational support, IEP
- Power wheelchair adaptation
- Communication devices
- Family support — terminal illness
- Palliative care coordination
Medications
- Corticosteroids (prednisone or deflazacort) — slow disease progression, prolong ambulation by 2–4 years; long-term side effects (weight gain, osteoporosis, growth slowing)
- Exon-skipping therapies (eteplirsen, golodirsen, casimersen, viltolarsen) — for specific dystrophin mutations
- Gene therapy (delandistrogene moxeparvovec — Elevidys) — newest treatment
- ACE inhibitors and beta-blockers (cardiac protection)
- Vitamin D and calcium (bone health on steroids)
- Stool softeners
- Pneumococcal, influenza vaccines
Therapeutic Procedures
- PT/OT (lifelong)
- Stretching, splinting
- Spinal fusion for scoliosis
- Tendon release surgeries
- Power wheelchair
- Non-invasive ventilation (BiPAP)
- Cough assist devices
- Tracheostomy (advanced disease)
- Cardiac care (medications, possible heart transplant)
- Palliative care
Client Education
- Chronic progressive disease without cure
- Treatment slows but does not stop progression
- Maximize independence and quality of life
- Importance of exercise (gentle, avoid exhaustion)
- Stretching and night splints to prevent contractures
- Educational support, IEP services
- Genetic counseling for family (carrier siblings, family planning)
- Vaccinations critical (pneumococcal, influenza)
- Adaptive equipment usage
- Recognize respiratory and cardiac warning signs
- Anesthesia precautions — inform all providers of DMD
- Steroid education: side effects, slow tapering, never abrupt stop
- Avoid weight gain
- Anticipatory guidance for disease progression
- Psychological support, support groups (Muscular Dystrophy Association)
- Advanced care planning
- Palliative care discussions
Interprofessional Care
- Pediatric neurology (neuromuscular specialist)
- Pediatric cardiology
- Pediatric pulmonology
- Pediatric orthopedics
- Pediatric PT/OT/speech
- Geneticist, genetic counselor
- Dietitian
- School special education
- Palliative care
- Social work, psychology
- MDA clinics
Alterations in Health (Diagnosis)
Lung disease primarily of premature infants caused by surfactant deficiency. Most common cause of respiratory failure in premature newborns. Severity inversely related to gestational age.
Pathophysiology Related to Client Problem
Premature lungs lack adequate surfactant (produced by Type II alveolar cells starting ~24 weeks gestation, mature by ~34–36 weeks) → ↓ surfactant → ↑ alveolar surface tension → alveolar collapse (atelectasis) → ↓ ventilation, ↓ oxygenation → respiratory failure.
Health Promotion and Disease Prevention
- Antenatal corticosteroids for mothers in preterm labor < 34 weeks (betamethasone or dexamethasone) — stimulates fetal lung maturation
- Tocolytics to delay preterm delivery (when appropriate)
- Adequate prenatal care
- Avoid elective deliveries before 39 weeks
- Manage diabetes in pregnancy
Risk Factors
- Prematurity (most significant — inverse relationship to gestational age)
- Born < 28 weeks: ~80% develop RDS
- Born 34–36 weeks: ~5% develop RDS
- Male sex (slightly higher risk)
- Maternal diabetes (delays surfactant production)
- C-section without labor
- Multiple gestation
- Asphyxia at birth
- Cold stress
- Sepsis
- Family history
Expected Findings
Onset within minutes to hours of birth:
- Tachypnea (RR > 60)
- Nasal flaring
- Grunting (attempts to keep alveoli open with positive pressure)
- Retractions (intercostal, subcostal, suprasternal)
- Cyanosis
- Decreased breath sounds, fine crackles
- Apnea
- ↓ Oxygen saturation
- Hypothermia
- Hypotension
- Worsens over first 24–72 hours, then improves if treated
Laboratory Tests
- ABG: respiratory acidosis, hypoxemia, hypercapnia
- ↑ PaCO₂, ↓ PaO₂
- Electrolytes
- Glucose monitoring
- Blood culture (rule out sepsis — similar presentation)
- L/S ratio (prenatal — lecithin/sphingomyelin) > 2:1 indicates mature lungs
Diagnostic Procedures
- Chest X-ray: diffuse "ground-glass" appearance, low lung volumes, air bronchograms
- Clinical findings
- ABG
Safety Considerations
- Maintain thermoregulation (radiant warmer, isolette)
- Aseptic technique with airway management
- Minimal handling, cluster care
- Pulse oximetry continuously
- Cardiorespiratory monitoring
- Watch for complications: pneumothorax, IVH
Complications
- Respiratory failure, death
- Pneumothorax (ventilator-associated)
- Pulmonary interstitial emphysema
- Bronchopulmonary dysplasia (BPD) — chronic lung disease from prolonged O₂ and ventilator use
- Intraventricular hemorrhage (IVH)
- Retinopathy of prematurity (ROP) — from O₂ toxicity
- Patent ductus arteriosus (PDA)
- Necrotizing enterocolitis
- Sepsis
- Long-term: neurodevelopmental delays
Nursing Care
- Continuous cardiorespiratory monitoring
- Pulse oximetry (maintain SpO₂ 90–95%)
- Maintain warmth (neutral thermal environment)
- Position prone or supine with head turn (some institutions)
- Gentle suctioning (only when needed)
- Cluster care to minimize stimulation
- Strict I&O
- Monitor for complications (pneumothorax, PDA, IVH)
- IV fluids, parenteral nutrition initially
- Frequent ABGs
- Maintain head midline (reduce IVH risk)
- Skin care (delicate skin, frequent leads)
- Family support — frightening situation
- Encourage parental bonding (kangaroo care when stable)
Medications
Surfactant replacement therapy:
- Beractant (Survanta), poractant (Curosurf), calfactant
- Administered via ETT
- Within first hours of life (prophylactic for very premature) or rescue treatment for established RDS
- Dramatically improves oxygenation
- May be repeated doses
Other:
- Caffeine citrate — stimulates respirations, prevents apnea of prematurity
- Antibiotics empirically (rule out sepsis)
- Indomethacin or ibuprofen — close PDA if persistent
- Diuretics (furosemide) — fluid overload
Therapeutic Procedures
- Surfactant replacement therapy
- Oxygen therapy (nasal cannula, CPAP, mechanical ventilation)
- Continuous positive airway pressure (CPAP) — first choice for stable RDS
- Mechanical ventilation (synchronized intermittent mandatory ventilation, high-frequency)
- ECMO — severe refractory cases
- Inhaled nitric oxide (some cases)
- Nutrition: parenteral initially, then trophic enteral feeds (preferably breast milk)
Client Education
- RDS is common in premature infants and treatable
- Length of treatment: days to weeks depending on severity
- Importance of NICU equipment and monitoring
- Parental involvement encouraged (kangaroo care when stable)
- Long-term: many recover well; risk of BPD, developmental delays
- Follow-up needed in pulmonology, developmental clinic, ophthalmology (ROP)
- Vaccinations on adjusted schedule based on gestational age
- Synagis (palivizumab) for RSV prevention
- Future pregnancies: history of preterm delivery, antenatal steroids if recurrent preterm labor
- Smoking cessation, household precautions
- Family support and bonding strategies
Interprofessional Care
- Neonatology
- NICU team (nursing, respiratory therapy)
- Pediatric pulmonology (if BPD)
- Pediatric ophthalmology (ROP screening)
- Developmental pediatrician
- Early intervention services
- Lactation consultant
- Social work, family support
Alterations in Health (Diagnosis)
Sudden, unexplained death of an apparently healthy infant < 1 year of age that remains unexplained after thorough investigation including autopsy, death scene investigation, and review of clinical history. Diagnosis of EXCLUSION.
Pathophysiology Related to Client Problem
Multifactorial; specific cause unknown. Current understanding involves the "triple risk model": vulnerable infant + critical developmental period + exogenous stressor. Likely involves brainstem abnormality affecting arousal/respiratory/cardiac control during sleep.
Health Promotion and Disease Prevention
SAFE TO SLEEP (formerly "Back to Sleep") campaign:
- BACK SLEEP — always place infant supine for sleep (even naps)
- FIRM SLEEP SURFACE — flat, firm mattress; safety-approved crib
- NO loose bedding, pillows, bumpers, soft toys, sleep positioners
- Room-share without bed-share — infant's sleep area in parents' room for first 6 months (ideally 1 year)
- Avoid overheating — sleep sack or one-piece sleeper rather than blanket
- NO smoking during pregnancy or around infant
- Breastfeed if possible (protective)
- Pacifier at sleep time (after breastfeeding established) — protective
- Avoid alcohol and drugs during pregnancy and breastfeeding
- Routine prenatal care
- Routine immunizations
- Tummy time when awake and supervised (prevents plagiocephaly, develops muscles)
- Avoid commercial products marketed as reducing SIDS (wedges, positioners — not safe)
- Don't sleep on couches/sofas/armchairs with infant
Risk Factors
Infant factors:
- Age 1–4 months (peak)
- Premature, low birth weight
- Male sex
- Multiple gestation
- Black or American Indian/Alaska Native ethnicity (higher rates)
- Sibling who died of SIDS
Modifiable factors:
- Prone or side-sleeping — strongest modifiable risk factor
- Soft bedding, sleeping surface
- Bed-sharing (especially with smokers, drug/alcohol use, exhausted parent)
- Overheating
- Smoke exposure (maternal smoking, secondhand smoke)
- Lack of breastfeeding
- No pacifier use
Maternal factors:
- Young maternal age
- Smoking, drug/alcohol use in pregnancy
- Inadequate prenatal care
- Short interpregnancy interval
Expected Findings
- Found unresponsive in crib, typically after sleep period
- No prior signs of distress
- No identifiable cause on history, exam, or autopsy
- Often discovered by parent in the morning
- May have frothy oronasal secretions
- Pallor or mottling
- Time between last known well and discovery often hours
Laboratory Tests
- Postmortem investigation including toxicology, metabolic studies, genetic testing in some cases
- Workup may rule out other causes
Diagnostic Procedures
- Diagnosis of exclusion AFTER:
- Complete autopsy
- Death scene investigation
- Review of clinical history
- Rule out: child abuse, accidental suffocation, infection, metabolic, cardiac causes
Safety Considerations
- This is a prevention-focused condition
- All safe sleep practices (see promotion above)
- Education at every well-child visit
- Public health campaigns
Complications
- Death of infant
- Devastating family impact: grief, guilt, depression, PTSD
- Subsequent pregnancy anxiety
- Sibling grief reactions
Nursing Care
Prevention focus (well infant care):
- Education at every well-child visit (multiple times)
- Model safe sleep in hospital (back-sleeping, alone, on back)
- Educate ALL caregivers (grandparents, daycare, babysitters)
- Provide written materials
- Address barriers to safe sleep (lack of crib, etc.)
If SIDS occurs:
- Compassionate response, no blame
- Allow family time with infant
- Acknowledge devastating loss
- Refer to bereavement resources, counseling
- Support throughout investigation (legally required investigation may feel intrusive to grieving family)
- Consider needs of siblings
- Long-term follow-up support
- Help family communicate with friends/family
- Reassure that they could not have predicted or prevented in many cases
Medications
- No medications for prevention or treatment
- Sedatives, antidepressants for family if grief becomes complicated
Therapeutic Procedures
- No specific therapeutic procedures — primarily prevention
- Grief counseling for family
- Bereavement support services
- Subsequent pregnancy: consider apnea monitors (limited evidence; reassurance more than prevention)
Client Education
ALL CAREGIVERS:
- ABC of safe sleep: Alone, Back, Crib
- Back to sleep — every nap, every night
- Alone in own sleep space (room-share but not bed-share for first year)
- Crib or bassinet meeting safety standards
- Firm mattress with fitted sheet only
- Nothing else in crib: no pillows, blankets, bumpers, stuffed animals, sleep positioners
- Avoid overheating: light clothing, no hats indoors, room temperature for adult comfort
- Pacifier at sleep time (after breastfeeding established)
- Breastfeed if possible
- NO smoking during pregnancy or around infant
- Routine immunizations (protective)
- Tummy time when awake and supervised
- Educate all who care for infant (grandparents, daycare, babysitters)
For grieving families:
- Grief is normal and individual
- Connect with SIDS support organizations
- Validate emotions (guilt, anger, depression are common)
- Future pregnancies need not be delayed but discussion with provider helpful
- Mental health support recommended
Interprofessional Care
- Public health (SIDS prevention)
- Pediatric primary care
- Family medicine/OB (prenatal education)
- NICU/well-baby nursery (modeling and teaching)
- Daycare educators
- Bereavement services
- Mental health (post-loss)
- Grief support groups (First Candle, SIDS Alliance)
- Medical examiner/coroner (investigation)
Alterations in Health (Diagnosis)
Sudden, involuntary, abnormal electrical activity in the brain causing changes in motor activity, sensation, behavior, or LOC. Types include febrile (most common pediatric), generalized (tonic-clonic, absence, myoclonic, atonic), and focal (simple/complex partial). Status epilepticus = seizure ≥ 5 min or recurrent seizures without recovery of consciousness.
Pathophysiology Related to Client Problem
Abnormal, excessive, synchronous neuronal firing. Febrile seizures: rapid rise in temperature in genetically susceptible children 6 mo – 5 yr; benign. Epilepsy: chronic recurrent unprovoked seizures from various causes (idiopathic, structural, metabolic, genetic).
Health Promotion and Disease Prevention
- Adequate seizure control with consistent medication
- Identify and avoid triggers (sleep deprivation, fever, flashing lights, missed doses)
- Antipyretic management for febrile children
- Helmet for high-risk activities; bath safety
- Medical alert ID
- Genetic counseling if hereditary
Risk Factors
- Febrile: age 6 mo–5 yr, fever ≥ 38°C, family history
- Epilepsy: family history, head trauma, CNS infection, perinatal injury, structural brain abnormality, metabolic disorders, genetic syndromes
- Sleep deprivation
- Photosensitivity
- Stress, hormonal changes
Expected Findings
Tonic-clonic (grand mal):
- Aura (premonitory sensation) — sometimes
- Tonic phase (10–30 sec): LOC, stiffening, apnea, cyanosis, eyes roll up
- Clonic phase (30 sec – 2 min): rhythmic jerking, possible tongue-biting, incontinence, frothy saliva
- Postictal: confusion, lethargy, headache, muscle soreness, sleep (minutes to hours)
Absence (petit mal):
- Brief (5–10 sec) staring, blinking, lip-smacking
- No postictal state
- May happen many times daily
- Often mistaken for inattention
Febrile:
- Generalized tonic-clonic with fever ≥ 38°C
- < 15 min duration (simple)
- Doesn't recur within 24 hr
Focal/partial:
- Localized motor (one limb), sensory, autonomic, or psychological symptoms
- May or may not have impaired consciousness
Laboratory Tests
- Glucose (rule out hypoglycemia)
- Electrolytes (Na, Ca, Mg)
- BUN/Cr
- CBC, blood culture (if febrile/infection suspected)
- Drug levels (if on AEDs, for compliance or toxicity)
- Toxicology screen (older children)
- Ammonia, lactate (metabolic disorders)
- LP if meningitis suspected
Diagnostic Procedures
- EEG (key test) — captures abnormal activity; may be normal between seizures
- Video-EEG monitoring
- MRI (preferred) or CT brain — structural causes
- Detailed history of seizure semiology
- Eyewitness video helpful
Safety Considerations
During seizure (DO):
- Protect from injury — pad/clear surroundings
- Side-lying position when possible (prevents aspiration)
- Loosen restrictive clothing
- Time the seizure
- Note characteristics for description
During seizure (DON'T):
- Do NOT put anything in mouth
- Do NOT restrain patient
- Do NOT move unless in danger
Status epilepticus = EMERGENCY — call code, IV access, benzodiazepine
Complications
- Injury during seizure (falls, bites)
- Aspiration
- Status epilepticus → brain injury, death
- Sudden Unexpected Death in Epilepsy (SUDEP)
- Learning/behavioral issues
- Medication side effects, toxicity
- Psychosocial impact, stigma
- Restrictions: driving, swimming alone
Nursing Care
During seizure:
- Stay with patient; call for help
- Time seizure; observe characteristics
- Protect from injury (clear area, pad rails, lower to floor if needed)
- Side-lying position
- Do NOT restrain; do NOT put anything in mouth
- Suction available; oxygen ready
- IV access if status
Postictal:
- Reorient gently; allow rest
- Assess injuries
- Document: time, duration, semiology, postictal state, triggers
- Reassess after fully alert
Ongoing care:
- Educate family on home seizure management
- Medication compliance critical
- Identify triggers
- Seizure diary
- Safety planning
- School coordination, seizure action plan
- Psychosocial support
Medications
Acute/Status epilepticus (first-line):
- IV/IM/IN lorazepam (Ativan) or midazolam (Versed); PR diazepam (Diastat)
- If continues: levetiracetam, fosphenytoin, or valproate IV
- Refractory: phenobarbital, propofol, midazolam infusion
Maintenance AEDs:
- Levetiracetam (Keppra) — broad-spectrum, well-tolerated; behavioral side effects
- Phenytoin (Dilantin) — gingival hyperplasia, hirsutism, narrow therapeutic range (10–20 mcg/mL)
- Valproate — hepatotoxicity, pancreatitis, teratogenic; check LFTs, ammonia, platelets
- Carbamazepine — neutropenia, SJS (HLA-B*1502 testing), hyponatremia
- Ethosuximide — drug of choice for absence seizures
- Topiramate, lamotrigine, oxcarbazepine, others
Febrile seizures:
- Antipyretics (does NOT prevent seizures but treats fever)
- Routine prophylactic AEDs NOT recommended
- Rescue benzodiazepine for prolonged
Therapeutic Procedures
- Ketogenic diet (high-fat, low-carb) — refractory epilepsy
- Vagal nerve stimulator (VNS)
- Epilepsy surgery (resection)
- Responsive neurostimulation
- Corpus callosotomy (drop attacks)
Client Education
For caregivers — seizure first aid:
- Stay calm; time the seizure
- Move objects out of the way; lower to floor
- Side-lying position
- Do NOT put anything in mouth or restrain
- Loosen tight clothing
- Stay with child until fully alert
- Call 911 if: seizure > 5 minutes, multiple seizures without recovery, first-ever seizure, breathing problems, injury occurs, drowning/water
- Use rescue medication (rectal diazepam, intranasal midazolam) per plan
Medication:
- Take EXACTLY as prescribed; never skip or stop abruptly
- Specific side effects per drug
- Drug interactions (many AEDs)
- Avoid alcohol (adolescents)
- Photosensitivity, sleep, stress as triggers
- Maintain regular sleep schedule
- Adequate hydration
Safety:
- Helmet for high-risk activities
- Shower instead of bath (drowning risk in tub)
- Swimming only with direct supervision
- Avoid heights, climbing alone
- Driving restrictions per state (typically seizure-free 6–12 months)
- Medical alert ID
- School seizure action plan
- Inform teachers, coaches, friends
Febrile seizures:
- Most children outgrow by 5 years
- Risk of epilepsy slightly increased but most do NOT develop epilepsy
- Treat fever promptly but seizures may still occur
- Future fevers: comfort, antipyretics
Interprofessional Care
- Pediatric neurology
- EEG technologist
- Pediatric pharmacy
- School nurse
- Dietitian (ketogenic diet)
- Mental health
- Social work
- Genetic counselor (familial)
- Epilepsy Foundation
Alterations in Health (Diagnosis)
Most common pediatric infection. Acute otitis media (AOM): rapid-onset middle ear infection with effusion and inflammation. Otitis media with effusion (OME): fluid in middle ear without acute signs of infection. Eustachian tube dysfunction is central.
Pathophysiology Related to Client Problem
Eustachian tube in children: shorter, wider, more horizontal → poor drainage → fluid accumulation → bacterial colonization → infection. Common pathogens: Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis. Viral URI often precedes.
Health Promotion and Disease Prevention
- Breastfeeding ≥ 6 months (protective)
- Avoid bottle propping; feed upright
- No pacifier after 6 months (some evidence)
- Pneumococcal vaccine (PCV) and influenza vaccine
- Avoid secondhand smoke
- Limit daycare exposure when possible
- Hand hygiene
Risk Factors
- Age 6 mo – 2 yr (peak)
- Daycare attendance
- Bottle feeding (vs breastfeeding)
- Bottle propping, feeding supine
- Pacifier use after 6 mo
- Family history
- Cleft palate, Down syndrome, craniofacial abnormalities
- Secondhand smoke exposure
- Allergies
- Native American, Alaska Native (higher rates)
- Male sex (slight)
- Winter months
Expected Findings
AOM:
- Ear pain (otalgia); infant pulls/tugs at ear
- Fever
- Irritability, fussiness
- Sleep disturbance
- Decreased appetite
- Vomiting, diarrhea
- Possible drainage if TM perforated (purulent otorrhea — pain often relieves)
- URI symptoms often precede
- Hearing loss (conductive, often unnoticed)
OME:
- Often asymptomatic
- Mild hearing loss
- Sensation of fullness in ear
- Balance problems (rare)
Otoscopic findings:
- AOM: red, bulging tympanic membrane; ↓ mobility on insufflation; loss of bony landmarks; purulent fluid
- OME: amber/dull TM; air-fluid level or bubbles; ↓ mobility; retracted in chronic
Laboratory Tests
- Generally not needed
- Tympanocentesis culture if recurrent, severe, immunocompromised
Diagnostic Procedures
- Otoscopy (pneumatic preferred) — TM appearance and mobility
- Tympanometry — measures TM mobility
- Audiometry — hearing assessment if recurrent
- Clinical diagnosis
Safety Considerations
- Pain management
- Recognize TM rupture (sudden pain relief + drainage)
- Watch for complications (mastoiditis, meningitis — rare)
- Hearing assessment with recurrent OM
- Speech-language assessment if hearing impaired
Complications
- Tympanic membrane perforation
- Chronic OM with effusion
- Hearing loss (usually conductive, reversible) — speech delay if persistent
- Speech and language delay (chronic OM)
- Mastoiditis
- Meningitis (rare)
- Cholesteatoma
- Recurrent OM
- Tympanosclerosis
Nursing Care
- Pain assessment and management (often the primary concern)
- Position upright/sitting (reduces pressure)
- Warm compress to affected ear
- Antibiotic education (compliance critical)
- Antipyretics
- Monitor for hearing/speech development
- Follow-up assessment of TM healing
- Educate parents about preventive measures
Medications
AOM antibiotic (when indicated):
- Amoxicillin (high-dose 80–90 mg/kg/day) — first-line
- Amoxicillin-clavulanate if recent antibiotic use, severe illness, treatment failure, concurrent purulent conjunctivitis
- Cefdinir, cefuroxime, cefpodoxime (cephalosporins) — if penicillin allergy (non-anaphylactic)
- Azithromycin, clarithromycin — true penicillin allergy
- Duration: 10 days < 2 yr or severe; 5–7 days for older children
Observation (watchful waiting):
- Recommended for > 6 months without severe symptoms, otherwise healthy
- Provider may give SNAP (safety net antibiotic prescription) to fill if not improving in 48–72 hours
Pain management:
- Acetaminophen, ibuprofen
- Topical benzocaine drops (older children, intact TM)
NOT recommended:
- Decongestants, antihistamines (no proven benefit)
- Topical antibiotics (unless TM ruptured)
Therapeutic Procedures
- Myringotomy with tympanostomy tubes (PE tubes) — recurrent AOM (3 in 6 months or 4 in 12 months) or chronic OME > 3 months with hearing loss
- Adenoidectomy (sometimes with second set of tubes)
- Hearing evaluation if recurrent
Client Education
- Complete entire antibiotic course even if feeling better
- Pain may take 24–72 hours to fully resolve with antibiotics
- Pain management around-the-clock first 1–2 days
- Follow-up appointment if no improvement in 48–72 hours
- Recognize TM rupture: sudden pain relief + drainage (call provider)
- Preventive measures:
- Breastfeed if possible
- Don't prop bottles; feed upright
- Avoid secondhand smoke
- Hand hygiene
- Stay current with vaccinations (PCV13/PCV15, flu)
- Avoid pacifier after age 6 mo
- If PE tubes: keep water out of ears (custom earplugs for swimming; avoid head dunking in soapy bathwater); tubes usually fall out in 6–12 months
- Monitor speech/hearing development
- Recurrent infections may warrant ENT referral
Interprofessional Care
- Pediatrician/family medicine
- Otolaryngology (ENT) for recurrent/chronic
- Audiology
- Speech-language pathology if delayed
- School/preschool monitoring
Alterations in Health (Diagnosis)
Inflammation of lung parenchyma resulting from infection. Bacterial, viral, or atypical (mycoplasma). Leading cause of death in children worldwide.
Pathophysiology Related to Client Problem
Pathogens reach lower respiratory tract → inflammation, exudate in alveoli → impaired gas exchange. Viral most common in younger children (RSV, influenza, adenovirus). Bacterial: Streptococcus pneumoniae (most common bacterial), Staph aureus, H. influenzae. Atypical: Mycoplasma pneumoniae (school-age and adolescents — "walking pneumonia").
Health Promotion and Disease Prevention
- Routine vaccinations: PCV15/PCV20, Hib, varicella, pertussis, measles, influenza (annual), COVID-19
- Breastfeeding (protective)
- Hand hygiene
- Avoid secondhand smoke
- Adequate nutrition
- Limit exposure to sick contacts
Risk Factors
- Age < 5 years (highest risk)
- Prematurity, low birth weight
- Chronic lung disease (BPD, CF, asthma)
- Congenital heart disease
- Immunodeficiency
- Daycare attendance
- Secondhand smoke
- Crowded living conditions
- Aspiration risk (neurologic impairment)
- Incomplete immunizations
- Winter months
Expected Findings
General:
- Fever (often high in bacterial)
- Cough (productive or non-productive)
- Tachypnea (most sensitive sign in children)
- Increased work of breathing: retractions, nasal flaring, grunting
- Crackles, decreased breath sounds, bronchial breath sounds
- Dullness to percussion
- Egophony, bronchophony
- Decreased oxygen saturation
- Cyanosis (severe)
Infants:
- Poor feeding
- Vomiting, diarrhea
- Apnea
- Irritability or lethargy
Older children:
- Chest pain, abdominal pain (referred)
- Headache
- Malaise
Bacterial vs viral:
- Bacterial: higher fever, more toxic appearance, lobar consolidation
- Viral: gradual onset, wheezing, diffuse
- Mycoplasma: persistent dry cough, headache, sore throat, low-grade fever
Laboratory Tests
- CBC: ↑ WBC with left shift (bacterial); often normal/lymphocytic (viral)
- ↑ CRP, procalcitonin (bacterial)
- Blood culture (if hospitalized, severe)
- Respiratory viral PCR (RSV, flu, COVID)
- Mycoplasma testing (PCR or IgM) for school-age
- Sputum culture (if obtainable, older children)
- ABG if severe
- Pulse oximetry
Diagnostic Procedures
- Chest X-ray (not always needed for outpatient):
- Bacterial: lobar consolidation, air bronchograms
- Viral: bilateral interstitial infiltrates, hyperinflation
- Mycoplasma: patchy infiltrates
- Empyema, effusion may be seen
- Clinical diagnosis often sufficient
Safety Considerations
- Continuous pulse oximetry if hospitalized
- Aspiration precautions
- Standard or droplet precautions per organism
- Recognize respiratory failure signs
- Adequate hydration without overload
Complications
- Respiratory failure
- Pleural effusion, empyema
- Bacteremia, sepsis
- Lung abscess
- Necrotizing pneumonia
- Pneumothorax
- Bronchiectasis (chronic)
- Hyponatremia (SIADH)
- Hemolytic anemia (mycoplasma)
- Dehydration
- Death (especially in low-resource settings)
Nursing Care
- Frequent respiratory assessment
- Continuous pulse ox
- Position upright (semi-Fowler's) for comfort
- Oxygen therapy as needed (maintain SpO₂ ≥ 92%)
- Humidified air
- Encourage hydration (IV if not tolerating PO)
- Caution NOT to overload with fluids (SIADH risk)
- Antipyretics
- Cluster care; promote rest
- Encourage cough (older children)
- Chest physiotherapy NOT routine but case-by-case
- Monitor labs, X-ray follow-up
- Strict I&O
- Nutrition support
- Family education
Medications
Outpatient bacterial (presumed):
- Amoxicillin (high-dose) — first-line for typical bacterial in fully immunized children
- Amoxicillin-clavulanate (if recent antibiotic use)
- Azithromycin or doxycycline (atypical/mycoplasma, school-age)
- Cephalosporins (alternative)
- Penicillin allergy: macrolides, cefdinir
Inpatient:
- Ampicillin IV (typical)
- Ceftriaxone IV (more severe or not fully immunized)
- Vancomycin if MRSA suspected
- Add macrolide if atypical possible
Antiviral (if applicable):
- Oseltamivir (Tamiflu) for influenza
- Remdesivir for severe COVID-19
Supportive:
- Acetaminophen, ibuprofen for fever/pain
- Bronchodilators if wheezing
- Cough suppressants generally NOT recommended in children
- Antibiotics generally NOT for purely viral pneumonia
Therapeutic Procedures
- Oxygen therapy
- Suctioning (clear airway)
- IV hydration
- Thoracentesis (large effusion)
- Chest tube (empyema)
- Mechanical ventilation (respiratory failure)
- Bronchoscopy (foreign body or refractory)
Client Education
Home care:
- Complete entire antibiotic course
- Adequate hydration
- Rest
- Antipyretics for comfort
- Use humidifier (cool mist)
- Avoid smoke exposure
- Position upright for comfort
- Encourage cough — productive cough is helpful
- Small frequent meals
- Follow-up appointment
- Return if: ↑ work of breathing, ↑ fever, persistent vomiting, lethargy, dehydration, cyanosis, ↓ saturation
- Most fully recover in 1–2 weeks
- Cough may persist 2–4 weeks
Prevention:
- Stay current with vaccinations (PCV, Hib, flu)
- Hand hygiene
- Avoid sick contacts
- Don't smoke around child
- Adequate nutrition
Interprofessional Care
- Pediatric primary care
- Pediatric pulmonology (severe, recurrent)
- Pediatric infectious disease
- Respiratory therapy
- Public health (reportable cases)
Alterations in Health (Diagnosis)
Group of acute infectious diseases primarily affecting children. Most are now vaccine-preventable. Includes measles, mumps, rubella, varicella (chickenpox), erythema infectiosum (fifth disease), roseola, hand-foot-mouth, and scarlet fever.
Pathophysiology Related to Client Problem
Each caused by specific pathogen with characteristic transmission, incubation, prodrome, and rash. Most spread by respiratory droplets or contact; high contagiousness.
Health Promotion and Disease Prevention
- Vaccinations (most are now vaccine-preventable):
- MMR at 12–15 mo and 4–6 yr
- Varicella at 12–15 mo and 4–6 yr
- Hand hygiene
- Cover cough/sneeze
- Stay home when ill
- Identify and isolate cases
- Notify school, daycare
- Reportable to public health
Risk Factors
- Unvaccinated or under-vaccinated
- Daycare, school exposure
- Crowded living
- Pregnancy (rubella → congenital rubella)
- Immunocompromised
- International travel
Expected Findings
Measles (rubeola):
- Incubation 8–12 days
- Prodrome: 3 C's — cough, coryza, conjunctivitis; high fever
- Koplik spots (white spots on buccal mucosa) — pathognomonic, appear before rash
- Maculopapular rash starts at hairline, spreads down (cephalocaudal), confluent on face
- Photophobia
- Complications: pneumonia, encephalitis, otitis
Mumps:
- Incubation 16–18 days
- Fever, headache, malaise
- Parotid swelling (usually bilateral)
- Pain with chewing
- Complications: orchitis (post-pubertal males, sterility risk), meningitis, deafness
Rubella (German measles):
- Incubation 14–21 days
- Mild fever
- Postauricular and occipital lymphadenopathy
- Pink maculopapular rash starting on face, spreading
- Forchheimer spots on soft palate
- Pregnancy danger: congenital rubella syndrome (deafness, cataracts, heart defects)
Varicella (chickenpox):
- Incubation 14–16 days
- Fever, malaise
- Pruritic vesicular rash in successive crops — macule → papule → vesicle → crust ("dewdrop on rose petal")
- Different stages at same time
- Mucous membranes affected
- Contagious 1–2 days before rash until all crusted
- Complications: skin infections, encephalitis, Reye syndrome (with aspirin), shingles later in life
Fifth disease (erythema infectiosum, parvovirus B19):
- Incubation 4–14 days
- Mild fever, malaise (prodrome — most contagious phase)
- "Slapped cheek" rash on face
- Lacy/reticular rash on trunk and extremities
- Once rash appears, NOT contagious
- Pregnancy concern: fetal hydrops
Roseola (HHV-6, exanthem subitum):
- Children 6 mo – 2 yr typically
- High fever (3–5 days)
- Rash appears AS FEVER BREAKS (rose-pink macules on trunk)
- Febrile seizures possible
Scarlet fever (group A strep):
- Strep pharyngitis + rash
- "Sandpaper" rash
- Strawberry tongue
- Pastia's lines (skin folds)
- Circumoral pallor
- Treatment: penicillin
Hand-foot-mouth (Coxsackie):
- Ulcers in mouth + vesicles on hands/feet/buttocks
- Fever, sore throat
- Self-limited
Laboratory Tests
- Often clinical diagnosis
- Serology (IgM, IgG) for specific virus
- PCR available for some
- Streptococcus rapid test, culture (scarlet fever)
- CBC: lymphocytosis common (viral)
Diagnostic Procedures
- Clinical based on classic findings
- Serology to confirm
- Public health notification required
Safety Considerations
- Isolation:
- Measles, varicella: airborne + contact
- Rubella, mumps, pertussis: droplet
- Scarlet fever: contact until 24 hours of antibiotics
- HFM, fifth disease, roseola: standard precautions (less contagious after rash)
- Pregnant healthcare workers should AVOID rubella, fifth disease, varicella patients
- Aspirin contraindicated with varicella, influenza (Reye syndrome)
Complications
- Measles: pneumonia, otitis, encephalitis, SSPE (rare, fatal)
- Mumps: orchitis, deafness, meningitis, pancreatitis
- Rubella: congenital rubella syndrome (devastating in pregnancy)
- Varicella: bacterial superinfection, encephalitis, pneumonia, Reye syndrome (aspirin), shingles later
- Fifth disease: fetal hydrops, aplastic crisis in SCD
- Scarlet fever: rheumatic fever, glomerulonephritis if untreated
Nursing Care
- Implement appropriate isolation immediately
- Comfort measures: cool sponge baths, calamine lotion (NOT for chickenpox blisters specifically — debated)
- Antipyretics (NO ASPIRIN — Reye syndrome)
- Adequate hydration
- Oral hygiene (HFM mouth ulcers)
- Quiet, dim environment (measles photophobia)
- Keep fingernails short (varicella scratching)
- Mittens for infants
- Notify exposed contacts
- Report to public health
- Identify and vaccinate susceptible contacts when applicable
Medications
- Most are SUPPORTIVE care
- Acetaminophen, ibuprofen for fever (NOT aspirin)
- Varicella: acyclovir for severe disease, immunocompromised, adolescents
- Scarlet fever: penicillin V or amoxicillin × 10 days
- Measles: vitamin A supplementation (decreases mortality), ribavirin in severe cases
- Antipruritics: diphenhydramine, hydroxyzine (varicella)
- Topical calamine for itching
- Post-exposure prophylaxis: immunoglobulin (measles, varicella) or vaccine for susceptible contacts
Therapeutic Procedures
- Supportive care
- Hydration
- Hospitalization if severe
- Public health surveillance
Client Education
- Stay home from school/daycare until non-contagious
- Hand hygiene
- Antipyretics (NOT aspirin)
- Comfort measures specific to disease
- Adequate fluid intake
- Recognize complications and call provider
- Importance of vaccinations to prevent
- Notify school, exposed contacts
- Don't expose pregnant women (especially rubella, fifth disease, varicella)
- Don't expose immunocompromised
- Disease-specific:
- Varicella: keep nails short, prevent scratching/scarring, don't use aspirin
- Measles: dim lights for comfort
- Scarlet fever: complete antibiotic course (prevent rheumatic fever)
Interprofessional Care
- Pediatric primary care
- Public health (reportable)
- Infection prevention
- School/daycare coordination
- Pediatric infectious disease if complicated
- Obstetrics for exposed pregnant patients
Alterations in Health (Diagnosis)
Common pediatric skin conditions caused by bacteria, fungi, or parasites. Most are highly contagious, treatable, and often acquired in school or daycare settings.
Pathophysiology Related to Client Problem
Impetigo: superficial bacterial (Staph aureus, Group A strep) infection of skin. Tinea (ringworm): dermatophyte fungal infection. Pediculosis (lice): obligate parasite, head, body, or pubic. Scabies: Sarcoptes scabiei mite burrows into skin, lays eggs.
Health Promotion and Disease Prevention
- Hand hygiene
- Don't share combs, hats, towels, bedding
- Treat cuts, scrapes promptly
- Check children regularly for lice (especially after sleepovers, camp)
- Hot water wash for fomites
- Identify and treat contacts
Risk Factors
- School-age children
- Close contact with infected person
- Daycare, school, summer camp
- Crowded living
- Sharing personal items
- Warm humid climates (fungal)
- Sports (especially wrestlers — tinea, MRSA)
- Poor hygiene (some)
- Atopic dermatitis (impetigo)
Expected Findings
Impetigo:
- Initially red macule → vesicle → ruptures
- "Honey-colored crust" (pathognomonic)
- Typically on face (around mouth, nose), extremities
- Pruritic
- Lymphadenopathy possible
- Bullous form: large flaccid blisters (mostly newborns/infants)
Tinea (ringworm):
- Tinea capitis (scalp): patchy hair loss, scaly, kerion (boggy mass), occipital lymphadenopathy
- Tinea corporis (body): annular (ring-shaped) lesions with raised border, central clearing
- Tinea pedis (athlete's foot): itching, scaling between toes
- Tinea cruris (jock itch): groin, inner thighs
- Pruritus, may have hair loss (scalp)
Pediculosis (head lice):
- Pruritus of scalp (especially nape, behind ears)
- Nits (eggs) attached to hair shafts (white/translucent, ~1/4 inch from scalp)
- Adult lice (less common to see — fast movers)
- Excoriation, possible bacterial superinfection
Scabies:
- Intense pruritus, especially at night
- Burrows (linear) — webs of fingers, wrists, axillae, waistband, genitalia
- In children: face, head, soles, palms also
- Vesicles, papules, excoriations
- Pruritus continues weeks AFTER successful treatment (immune response to dead mites)
Laboratory Tests
- Generally clinical diagnosis
- Bacterial culture (impetigo if doesn't respond, MRSA suspected)
- KOH prep of skin scraping (tinea)
- Wood's lamp (some tinea — fluoresces)
- Microscopy of nits or mites
Diagnostic Procedures
- Visual inspection
- Specific tests as above
Safety Considerations
- Standard precautions
- Contact precautions for impetigo (until 24 hr antibiotics) and scabies
- Identify and treat contacts/household
- Disinfect environment for lice and scabies
- Watch for bacterial superinfection from scratching
Complications
- Bacterial superinfection (scratching)
- Cellulitis
- Post-streptococcal glomerulonephritis (impetigo)
- Permanent hair loss (severe tinea capitis)
- MRSA (some impetigo)
- Crusted (Norwegian) scabies in immunocompromised — very contagious
- Psychosocial: stigma, school exclusion
- Allergic reactions to treatments
- Resistance to treatment
Nursing Care
- Educate family on specific treatment
- Hand hygiene
- Trim fingernails short (prevent further inoculation)
- Keep affected areas clean and dry
- Treatment compliance crucial
- Avoid sharing personal items
- Wash bedding, clothing, towels in hot water
- Vacuum carpets, upholstery
- Inspect contacts
- School/daycare communication
- Monitor for complications
Medications
Impetigo:
- Mild: topical mupirocin or retapamulin
- Extensive or systemic: oral cephalexin, dicloxacillin, or clindamycin (covers MRSA if needed)
- 10-day course
- May return to school after 24 hours of antibiotics
Tinea:
- Topical antifungals (clotrimazole, terbinafine, miconazole) for body, foot, groin — 2–4 weeks
- Tinea capitis requires ORAL antifungal: griseofulvin or terbinafine × 6–8 weeks (topical alone won't work)
- Selenium sulfide shampoo (reduces spore shedding)
Pediculosis:
- First-line: permethrin 1% (Nix) or pyrethrin (RID) — applied to dry hair, leave 10 min, rinse
- Repeat in 7–10 days to kill newly hatched nits
- Resistance increasing — alternatives: malathion, ivermectin (topical or oral), spinosad
- Wet combing with fine-tooth (nit) comb
- Manual nit removal
Scabies:
- Permethrin 5% cream — apply neck to soles of feet, leave 8–14 hours, wash off
- Treat ALL household members and close contacts simultaneously
- Repeat in 1 week
- Alternative: ivermectin (oral)
- Symptoms (itching) persist 2–4 weeks AFTER successful treatment (not treatment failure)
- Antihistamines (diphenhydramine) for pruritus
- Topical steroids (hydrocortisone) for pruritus
Therapeutic Procedures
- Cleansing affected areas
- Crust removal (impetigo) — gentle, with warm water
- Avoid scratching
- Environmental cleaning
Client Education
Impetigo:
- Highly contagious; cover lesions if exposed to others
- Hand hygiene critical
- May return to school 24 hours after starting antibiotics
- Wash with soap and water before applying topical
- Don't share towels, washcloths
- Cut fingernails short
Tinea:
- Tinea capitis is contagious — don't share combs, hats, bedding
- Topical or oral as prescribed; complete full course
- Pets can transmit (especially cats — tinea corporis)
- Treat athletes' foot to prevent jock itch (use separate towel for feet)
Lice:
- Lice do NOT transmit disease and do NOT indicate poor hygiene
- Apply pediculicide per directions; repeat in 7–10 days
- Wet comb with nit comb daily
- Wash bedding, hats, brushes in hot water (130°F)
- Items that can't be washed: seal in plastic bag for 2 weeks or dry clean
- Vacuum carpets, furniture
- No "no-nit" policies in most schools now (CDC, AAP)
- Check siblings, contacts
Scabies:
- HIGHLY contagious — treat all household contacts simultaneously
- Apply cream neck to feet (and head/face in young children)
- Leave on 8–14 hours
- Wash bedding, towels, clothes (within 72 hours) in hot water; dry on hot
- Items that can't be washed: seal in plastic bag for at least 72 hours
- Vacuum mattress, upholstery
- Itching may persist 2–4 weeks after treatment — NOT treatment failure
- Use antihistamines and steroids for itching
Interprofessional Care
- Pediatric primary care
- School nurse
- Public health (some require reporting)
- Dermatology (refractory)
- Family/contacts evaluation
Alterations in Health (Diagnosis)
Highly contagious respiratory infection caused by Bordetella pertussis. Characterized by severe paroxysmal coughing followed by inspiratory "whoop." Most severe and life-threatening in infants < 6 months who haven't been fully vaccinated.
Pathophysiology Related to Client Problem
B. pertussis attaches to ciliated respiratory epithelium → toxin production → ciliary damage and inflammation → impaired clearance of secretions → paroxysmal cough as body attempts to expel.
Health Promotion and Disease Prevention
- DTaP vaccine: 2, 4, 6, 15–18 months, 4–6 years
- Tdap booster at 11–12 years, then every 10 years
- Tdap during EACH pregnancy (27–36 weeks) — protects newborn until first vaccine
- Tdap for family members and caregivers of newborns ("cocooning")
- Identify and isolate cases
- Antibiotic prophylaxis for close contacts
- Hand hygiene, droplet precautions
Risk Factors
- Infants < 6 months (not yet fully vaccinated) — highest mortality
- Unvaccinated children
- Adolescents/adults with waning immunity
- Healthcare workers
- Daycare attendance
- Close contact with infected person
- Crowded conditions
Expected Findings
Three stages (over 6+ weeks):
- Catarrhal (1–2 weeks): URI symptoms — rhinorrhea, mild cough, low-grade fever, sneezing; most contagious phase
- Paroxysmal (2–6 weeks): hallmark phase
- Severe paroxysms of coughing — repeated rapid coughs in single exhalation
- Followed by inspiratory "whoop" (older children — high-pitched gasp)
- Cyanosis, post-tussive vomiting
- Bulging eyes, drooling, tongue protrusion
- Exhausted between paroxysms
- Infants may NOT have whoop — instead present with apnea, gasping, cyanosis
- Severe paroxysms more frequent at night
- Triggers: feeding, crying, activity, smoke
- Convalescent (weeks to months): gradual recovery; "100-day cough"
Laboratory Tests
- Nasopharyngeal swab: PCR (preferred — sensitive in first 3 weeks)
- Nasopharyngeal culture (specific but slow, lower sensitivity)
- Serology (for diagnosis later in illness)
- CBC: marked lymphocytosis (WBC ↑, especially in infants — can resemble leukemia)
- Chest X-ray (rule out pneumonia)
Diagnostic Procedures
- Clinical suspicion + lab confirmation
- NP swab for PCR (preferred test)
- Mandatory reportable disease (public health)
Safety Considerations
- Droplet precautions until 5 days of effective antibiotics (or 21 days untreated)
- Apnea, cyanosis monitoring (especially infants)
- Hospital admission for infants < 6 months or severe cases
- Continuous pulse oximetry, cardiorespiratory monitoring
- Resuscitation equipment available
Complications
- Apnea (especially infants < 6 months) — most serious
- Pneumonia (secondary bacterial)
- Seizures
- Encephalopathy (cerebral hypoxia)
- Death (especially infants)
- Subconjunctival hemorrhage
- Rib fractures from coughing
- Hernias (umbilical, inguinal)
- Rectal prolapse
- Urinary incontinence
- Sleep disturbance
- Bronchiectasis
- Weight loss (poor feeding, post-tussive vomiting)
Nursing Care
Hospital care (especially infants):
- Droplet precautions
- Continuous cardiorespiratory monitoring
- Pulse oximetry
- Apnea monitoring
- Have suction, oxygen, intubation supplies available
- Minimize triggers (crying, suctioning) when possible
- Position to optimize comfort
- Small frequent feeds (avoid post-tussive vomiting)
- NG/IV fluids if feeding compromised
- Document cough episodes (frequency, severity, post-cough symptoms)
Outpatient:
- Antibiotic compliance education
- Comfort measures
- Encourage rest, hydration
- Avoid triggers (smoke, allergens)
- Family/contacts treatment and prophylaxis
- Cool mist humidifier
Medications
Antibiotics (most effective in catarrhal phase; minimal effect on cough once paroxysmal but reduces transmission):
- Azithromycin (first-line for all ages, especially infants < 1 month)
- Clarithromycin or erythromycin (alternative; erythromycin associated with pyloric stenosis in infants < 1 month)
- TMP-SMX if macrolide allergic (NOT for < 2 months)
Post-exposure prophylaxis (PEP):
- Macrolide for ALL household contacts and close contacts, regardless of vaccination status
- Within 21 days of exposure
Supportive:
- Cough suppressants and sedatives NOT effective
- Bronchodilators of unclear benefit
- Corticosteroids occasionally for severe cases
- Acetaminophen for fever/discomfort
Therapeutic Procedures
- Supportive care
- Hospitalization for infants and severe cases
- Oxygen, mechanical ventilation as needed
- Tube feeding if poor PO
- ECMO in rare extreme cases
Client Education
Family:
- Highly contagious — strict droplet precautions, isolation
- 5 days of antibiotics before returning to school/daycare
- All household contacts need prophylactic antibiotics
- Complete antibiotic course
- Cough may persist for weeks ("100-day cough") even after treatment
- Avoid triggers: smoke, allergens, activity, crying when possible
- Small frequent feeds; sitting upright
- Keep humidifier (cool mist)
- Adequate hydration
- Recognize warning signs: apnea, cyanosis, severe vomiting, dehydration, seizures → ER immediately
Prevention:
- Vaccinate per schedule (DTaP, Tdap)
- Tdap during EACH pregnancy
- "Cocoon" infants: ensure all caregivers, family, and visitors are vaccinated
- Adolescents/adults need Tdap booster (immunity wanes)
- Reportable disease — public health will investigate
Interprofessional Care
- Pediatric infectious disease
- Pediatric pulmonology (severe)
- PICU for infants requiring intensive care
- Public health (reportable, contact tracing)
- Obstetrics (Tdap in pregnancy)
- Daycare/school coordination
Alterations in Health (Diagnosis)
Most common solid tumors in children; second most common pediatric cancer overall (after leukemia). Most pediatric brain tumors are infratentorial (below tentorium — cerebellum and brainstem), unlike adults. Includes medulloblastoma, astrocytoma, brainstem glioma, ependymoma, craniopharyngioma.
Pathophysiology Related to Client Problem
Abnormal proliferation of cells within the brain. Tumors cause symptoms by: ↑ ICP from mass effect or hydrocephalus, infiltration of brain tissue, displacement of structures, hormonal effects (pituitary), seizure activity. Etiology mostly unknown; some genetic syndromes increase risk.
Health Promotion and Disease Prevention
- No specific primary prevention
- Genetic counseling for at-risk families (NF1, NF2, Li-Fraumeni, tuberous sclerosis)
- Avoid unnecessary radiation in children
- Early recognition of symptoms
Risk Factors
- Age: bimodal (peak 5–10 yr and adolescence)
- Slight male predominance
- Genetic syndromes: neurofibromatosis (NF1, NF2), tuberous sclerosis, Li-Fraumeni, von Hippel-Lindau
- Prior cranial radiation
- Family history (some cases)
Expected Findings
↑ Intracranial pressure (most common presentation):
- Headache — often morning, worsens with cough/Valsalva, may wake child from sleep
- Vomiting — often morning, projectile, without nausea
- Vision changes: diplopia, blurry vision, papilledema
- Lethargy, irritability
- Behavioral changes
- ↓ school performance
Cerebellar (most common location — infratentorial):
- Ataxia, clumsy gait
- Nystagmus
- Dysmetria
- Head tilt
- Loss of fine motor skills
Brainstem:
- Cranial nerve deficits (facial weakness, dysphagia, diplopia)
- Hemiparesis
- Ataxia
Supratentorial:
- Seizures
- Focal motor weakness
- Speech difficulties
- Personality changes
- Visual field deficits
Other:
- Endocrine: short stature, delayed/precocious puberty, polyuria (pituitary/hypothalamic tumors)
- Infants: macrocephaly, bulging fontanel, irritability, lethargy, FTT, "setting sun" eyes
- School-age: declining grades, fatigue, headaches
Laboratory Tests
- CBC, electrolytes, LFTs
- Tumor markers if specific type suspected (AFP, beta-HCG — germ cell)
- CSF analysis (sometimes for staging)
Diagnostic Procedures
- MRI of brain with contrast (gold standard)
- CT head (initial if ↑ ICP suspected)
- MRI of entire spine (some tumors metastasize)
- Biopsy (tissue diagnosis essential)
- Ophthalmology exam (papilledema)
- Endocrine evaluation (suprasellar tumors)
- Neuropsychological testing
Safety Considerations
- Recognize ↑ ICP — emergency
- Seizure precautions
- Fall prevention (ataxia)
- Pre-operative preparation
- Post-craniotomy care
- Risk of hydrocephalus → shunt
- Watch for endocrine crises
- Aspiration precautions if cranial nerve involvement
Complications
- ↑ ICP, herniation, death
- Hydrocephalus (obstruction of CSF flow)
- Permanent neurologic deficits
- Seizures
- Endocrine dysfunction (DI, growth hormone deficiency, hypothyroidism)
- Vision loss
- Cognitive impairment (tumor + treatment effects)
- Surgical complications
- Radiation effects: leukoencephalopathy, secondary tumors, growth issues
- Chemotherapy side effects
- Tumor recurrence
Nursing Care
Pre-operative:
- Neurologic baseline
- Monitor ↑ ICP signs
- Manage seizures
- Pain management
- Emotional support to child and family
- Pre-op teaching
Post-operative (craniotomy):
- HOB elevation (30°) and midline head positioning to facilitate drainage
- Neurologic checks frequently
- Monitor for ↑ ICP (especially first 72 hours)
- Strict I&O (DI possible)
- Pain management (opioids cautiously — don't mask neuro changes)
- Antiemetics
- Seizure precautions
- Wound care
- Watch for CSF leak
- Monitor temperature (post-op fever common, but rule out infection)
- Encourage child life involvement
During chemotherapy/radiation:
- Neutropenic precautions
- Bleeding precautions
- Nutrition support
- Anti-emetics
- Skin care (radiation)
- Cognitive assessment
Medications
- Dexamethasone (Decadron) — reduces cerebral edema
- Anticonvulsants (levetiracetam, phenytoin) if seizures
- Mannitol — acute ↑ ICP
- Chemotherapy agents (varies by tumor type): vincristine, cisplatin, carboplatin, cyclophosphamide, temozolomide, lomustine
- Hormone replacement (post-op endocrine deficits): hydrocortisone, levothyroxine, DDAVP, growth hormone
- Pain medications
- Antiemetics (ondansetron)
- Stool softeners
Therapeutic Procedures
- Surgery (gross total resection preferred when possible)
- VP shunt or ETV for hydrocephalus
- Radiation therapy (varies by tumor type and age — avoided < 3 yr)
- Chemotherapy
- Stem cell transplant (some tumors)
- Proton beam therapy (newer, more targeted)
- Targeted therapies (NTRK, BRAF inhibitors)
- Palliative care
Client Education
- Diagnosis and treatment plan (multidisciplinary)
- Treatment course often lengthy (months to years)
- Side effects expected and how to manage
- Hospitalization for surgery, possibly chemo cycles
- School coordination (IEP, modified schedule)
- Long-term follow-up needed
- Late effects: cognitive, endocrine, vision, hearing
- Recognize warning signs: severe headache, vomiting, behavioral change, vision change, seizure → urgent eval
- Vaccinations (some restrictions during chemo)
- Genetic counseling if syndromic
- Survivorship clinic for long-term follow-up
- Psychosocial support — family, sibling support
- Realistic expectations (varies by tumor type and grade)
Interprofessional Care
- Pediatric neuro-oncology
- Pediatric neurosurgery
- Pediatric oncology
- Pediatric radiation oncology
- Pediatric neurology
- Pediatric endocrinology
- Pediatric ophthalmology
- Neuropsychology
- Rehabilitation (PT, OT, speech)
- Child life specialist
- Social work, chaplain
- Genetic counselor
- Survivorship clinic
- Palliative care
Alterations in Health (Diagnosis)
Malignancy of the lymphatic system characterized by presence of Reed-Sternberg cells (multinucleated giant cells). Most common cancer in adolescents (15–19 yr). Excellent prognosis with treatment (> 90% cure rate).
Pathophysiology Related to Client Problem
Originates in B lymphocytes; transformed cells (Reed-Sternberg cells) and inflammatory cells in lymph nodes → lymphadenopathy → spread to other nodes, spleen, marrow, organs in advanced disease. Possible EBV association.
Health Promotion and Disease Prevention
- No specific prevention
- Early recognition of persistent lymphadenopathy
- EBV vaccination not yet available
Risk Factors
- Adolescents and young adults (peak 15–35 yr)
- Male sex (slight)
- EBV infection (mononucleosis)
- Immunodeficiency (HIV, immunosuppression)
- Family history
- Higher socioeconomic status (interestingly)
Expected Findings
- Painless, firm, rubbery, enlarged lymph nodes — typically cervical or supraclavicular
- Often unilateral, slowly progressive
- Mediastinal mass on CXR (common) — may cause cough, dyspnea, SVC syndrome
- Splenomegaly, hepatomegaly (advanced)
"B" symptoms (denotes worse prognosis):
- Fever > 38°C (unexplained)
- Drenching night sweats
- Unexplained weight loss > 10% over 6 months
Other:
- Pruritus (especially after alcohol — classic, rare)
- Fatigue, anorexia, malaise
- Pain in nodes with alcohol consumption (rare but classic)
- Generalized lymphadenopathy (advanced)
Laboratory Tests
- CBC (anemia, thrombocytopenia in advanced)
- ESR, CRP (often ↑)
- LDH (↑ in disease activity)
- LFTs
- BUN/creatinine
- HIV testing
- EBV serology
- Pregnancy test (adolescent female)
Diagnostic Procedures
- Excisional lymph node biopsy (definitive) — Reed-Sternberg cells
- Bone marrow biopsy (staging)
- Imaging: PET-CT (functional staging — gold standard now)
- CT chest/abdomen/pelvis
- MRI (some cases)
- Echocardiogram (baseline before cardiotoxic chemo)
- Pulmonary function tests (baseline before bleomycin)
- Fertility preservation consultation (treatment can affect fertility)
Staging (Ann Arbor):
- Stage I: single node region
- Stage II: multiple regions, same side of diaphragm
- Stage III: both sides of diaphragm
- Stage IV: extranodal disease
- A = no B symptoms; B = with B symptoms
Safety Considerations
- Mediastinal mass: monitor for airway compromise (especially with anesthesia)
- Neutropenic precautions during chemo
- Bleeding precautions
- Fertility preservation discussion
- Avoid live vaccines during treatment
- Long-term cardiac and pulmonary monitoring
Complications
- SVC syndrome from mediastinal mass
- Tumor lysis syndrome (with chemo)
- Infection during neutropenia
- Chemotherapy side effects
- Long-term effects of treatment:
- Secondary malignancies (breast cancer, leukemia, lung — especially with mediastinal radiation)
- Cardiomyopathy (anthracyclines, radiation)
- Pulmonary fibrosis (bleomycin, radiation)
- Thyroid dysfunction (radiation)
- Infertility
- Growth issues
- Avascular necrosis
- Cognitive late effects
Nursing Care
- Assess lymphadenopathy, B symptoms
- Pre-treatment baseline assessments (organ function)
- Central line care (typically port placed)
- Manage chemo side effects: nausea, mucositis, alopecia, fatigue
- Neutropenic precautions during nadirs
- Frequent assessment of body systems
- Skin care during radiation
- Nutritional support
- Psychosocial support — diagnosis devastating
- Education on treatment course
- Coordinate fertility preservation if desired (sperm banking, oocyte cryopreservation)
- School coordination, IEP/504
- Adolescent-specific support (body image, peers, dating)
- Family support
- Long-term follow-up planning (survivorship clinic)
Medications
Chemotherapy (varies by stage and risk):
- ABVE-PC: doxorubicin (Adriamycin), bleomycin, vincristine, etoposide, prednisone, cyclophosphamide (pediatric protocols)
- BEACOPP — more intensive for advanced disease
- Brentuximab vedotin — newer, for relapsed
- Immunotherapy (checkpoint inhibitors) — relapsed/refractory
Supportive:
- Antiemetics (ondansetron, palonosetron, aprepitant)
- Hydration
- Allopurinol — TLS prevention
- G-CSF (filgrastim) — neutropenia
- Antibiotics for febrile neutropenia
- Antifungals, PCP prophylaxis (TMP-SMX)
- Vaccines (inactivated; avoid live during treatment)
Therapeutic Procedures
- Combination chemotherapy (cornerstone)
- Radiation therapy (involved-field; reduced doses now)
- Stem cell transplant (relapsed)
- Targeted therapies
- Immunotherapy
- Palliative care if needed
Client Education
- Hodgkin lymphoma is highly curable (> 90% cure rate overall)
- Treatment usually 4–6 months of chemotherapy
- Some receive radiation in addition
- Plan for school accommodation
- Recognize emergencies: fever during neutropenia (≥ 38.3°C/101°F), bleeding, severe pain, respiratory distress
- Neutropenic precautions during nadir periods
- Bleeding precautions during thrombocytopenia
- Nutrition: small frequent meals, high calorie
- Hair loss expected (regrows after treatment)
- Fertility: discuss preservation BEFORE starting treatment
- Long-term follow-up critical:
- Secondary cancer screening (especially breast cancer in females with mediastinal radiation — earlier mammograms)
- Cardiac monitoring (echo)
- Thyroid monitoring
- Pulmonary function tests
- Healthy lifestyle (no smoking — increases secondary lung cancer risk)
- Avoid live vaccines during and shortly after treatment
- Support groups, peer support important
Interprofessional Care
- Pediatric oncology/hematology
- Pediatric oncology nurse practitioners
- Radiation oncology
- Pediatric cardiology
- Pediatric pulmonology
- Pediatric endocrinology
- Reproductive medicine (fertility)
- Psychology, child life
- Social work
- School liaison
- Survivorship clinic
- Mental health
Alterations in Health (Diagnosis)
Osteosarcoma: most common primary bone tumor in children/adolescents; malignant osteoblasts produce osteoid. Peak during adolescent growth spurt. Ewing sarcoma: second most common; small round blue cell tumor; can affect bone or soft tissue.
Pathophysiology Related to Client Problem
Osteosarcoma: malignant cells produce immature bone (osteoid) in the metaphysis of long bones, especially distal femur and proximal tibia. Rapid growth period of adolescence likely contributes.
Ewing sarcoma: chromosomal translocation t(11;22) creating EWSR1-FLI1 fusion gene → small round blue cells. Diaphysis of long bones or pelvis most commonly.
Health Promotion and Disease Prevention
- No specific prevention
- Genetic counseling for at-risk families (Li-Fraumeni, retinoblastoma → ↑ osteosarcoma)
- Limit unnecessary radiation
- Awareness of warning signs in adolescents (persistent bone pain)
Risk Factors
Osteosarcoma:
- Adolescents during growth spurt (10–20 yr)
- Tall stature
- Rapid growth
- Prior radiation to bone
- Genetic syndromes: hereditary retinoblastoma, Li-Fraumeni, Rothmund-Thomson
- Paget disease (older patients)
Ewing sarcoma:
- Adolescents and young adults
- Caucasian (much higher rate than Black)
- Genetic predisposition
Expected Findings
- Localized pain, progressively worse, often worse at night, may be attributed to injury (delays diagnosis)
- Mass/swelling at site
- Decreased range of motion
- Limp if lower extremity
- Limited use of affected limb
- Possible pathologic fracture
- Warm, tender area
- Ewing-specific: may have fever, weight loss, fatigue (systemic symptoms more common; can resemble infection)
- Lymphadenopathy uncommon
Common locations:
- Osteosarcoma: distal femur, proximal tibia, proximal humerus (knee area most common)
- Ewing: pelvis, femur, tibia, fibula, humerus
Laboratory Tests
- ↑ alkaline phosphatase (especially osteosarcoma)
- ↑ LDH
- CBC, ESR, CRP
- Genetic testing (Ewing fusion gene)
Diagnostic Procedures
- X-ray: osteosarcoma — "sunburst" pattern, Codman triangle; Ewing — "onion-skin" periosteal reaction, "moth-eaten" lytic lesion
- MRI of primary tumor (extent assessment)
- CT chest (most common metastasis site for both)
- Bone scan or PET-CT (skeletal metastases)
- Biopsy (definitive — open or core needle) — must be done by orthopedic oncology to preserve future limb salvage
- Bone marrow biopsy (Ewing — staging)
Safety Considerations
- Pain management
- Limb protection — risk of pathologic fracture
- Avoid weight-bearing if instructed
- Crutches, wheelchair
- Neutropenic precautions during chemo
- Surgical complications
- Phantom limb pain (post-amputation)
Complications
- Pathologic fracture
- Metastasis (lung most common, also bone for both)
- Limb loss (amputation in some cases)
- Functional impairment
- Chemotherapy side effects: cardiotoxicity, nephrotoxicity, ototoxicity, infertility
- Surgical complications
- Limb-length discrepancy (growth disturbance)
- Secondary malignancies
- Psychosocial: body image, loss of physical function
- Recurrence
- Death (with metastatic disease)
Nursing Care
- Pain assessment and management
- Mobility assistance (crutches, wheelchair, walker)
- Pre-operative preparation
- Post-amputation or limb salvage care
- Phantom limb pain awareness
- Wound care
- Range of motion exercises
- Physical and occupational therapy
- Chemo administration and monitoring
- Antiemetics
- Neutropenic and bleeding precautions
- Body image support
- School coordination, return to school plan
- Adolescent-specific support: body image, dating, friends
- Prosthetic adaptation
- Long-term follow-up
Medications
Osteosarcoma chemotherapy (MAP regimen):
- Methotrexate (high-dose; requires leucovorin rescue, hydration, urine alkalinization)
- Doxorubicin (Adriamycin) — cardiotoxic
- Cisplatin — ototoxic, nephrotoxic
- ± Ifosfamide, etoposide
Ewing chemotherapy:
- VDC alternating with IE: vincristine, doxorubicin, cyclophosphamide / ifosfamide, etoposide
Supportive:
- Pain medications (opioids often needed)
- Antiemetics
- Hydration
- Leucovorin rescue (methotrexate)
- Mesna (cyclophosphamide, ifosfamide — bladder protection)
- G-CSF
- Antibiotics for febrile neutropenia
- Iron, transfusions if anemic
Therapeutic Procedures
Surgical:
- Limb salvage surgery (preferred) — wide resection + endoprosthetic or allograft reconstruction
- Amputation (some cases)
- Rotationplasty (creative limb-sparing technique in young children)
Other:
- Neoadjuvant chemotherapy (shrinks tumor before surgery)
- Adjuvant chemotherapy (after surgery)
- Radiation therapy (Ewing — sensitive; osteosarcoma — less responsive)
- Stem cell transplant (recurrent Ewing)
- Targeted therapies (some)
- Resection of pulmonary metastases (curative intent)
Client Education
- Diagnosis and treatment plan (multidisciplinary)
- Treatment course: chemotherapy (~10 months), surgery, post-op chemotherapy
- Total treatment ~1 year
- 5-year survival: localized disease 65–75%; metastatic worse
- Surgical options discussed in detail (limb salvage vs amputation)
- Adjusting to amputation or prosthesis (physical and emotional)
- Phantom limb pain may occur
- Importance of physical therapy
- Fertility preservation before chemo
- Long-term effects: cardiac, kidney, hearing monitoring
- School modification
- Adolescent issues: body image, peers, dating
- Recognize warning signs of recurrence: pain, swelling, dysfunction
- Lifelong follow-up
- Support groups for amputees, cancer survivors
- Psychological support encouraged
- Most maintain functional and rewarding lives
Interprofessional Care
- Pediatric oncology
- Pediatric orthopedic oncology surgery
- Pediatric radiology
- Pathology
- Radiation oncology (Ewing)
- Physical and occupational therapy
- Prosthetics specialist
- Pain management
- Reproductive specialist (fertility)
- Psychology
- Social work
- School coordinator
- Survivorship clinic
Alterations in Health (Diagnosis)
Psychiatric disorders involving disturbed eating behaviors and body image distortion. Anorexia nervosa (AN): intentional weight loss, restrictive eating, intense fear of weight gain, body image distortion. Bulimia nervosa (BN): recurrent binge eating with compensatory behaviors (vomiting, laxatives, exercise) to prevent weight gain; typically normal or above-normal weight.
Other eating disorders: binge eating disorder, avoidant-restrictive food intake disorder (ARFID), other specified feeding and eating disorders.
Pathophysiology Related to Client Problem
Complex interaction of biological (genetics, neurochemistry), psychological (perfectionism, anxiety, depression), and sociocultural (thin-ideal, family dynamics) factors. Severe nutritional deficiency leads to multi-organ effects.
Health Promotion and Disease Prevention
- Promote healthy body image
- Avoid diet talk and weight-shaming
- Family meals
- Education about media literacy
- Address bullying about weight
- Early identification and intervention
- Screen at well-child visits (adolescents)
- Education about healthy eating, not diets
- Address comorbid mental health
- Avoid focus on weight in healthcare visits
Risk Factors
- Female sex (10× more common, though males increasing)
- Adolescents and young adults
- Genetic predisposition (family history of eating disorders, anxiety, depression)
- Personality traits: perfectionism, anxiety, OCD traits, low self-esteem
- Family dysfunction
- History of trauma, abuse
- Sports/activities emphasizing thinness: dance, gymnastics, wrestling (cutting weight), running, modeling
- Type 1 diabetes (insulin restriction for weight loss — "diabulimia")
- Social media/peer influence
- Cultural pressure
- Bullying about weight
- Higher in LGBTQ+ youth
Expected Findings
Anorexia nervosa:
- Restrictive eating, low caloric intake
- Significantly low weight (BMI < 5th percentile for age in adolescents)
- Intense fear of weight gain
- Body image distortion (sees self as fat despite emaciation)
- Amenorrhea (post-menarche; primary amenorrhea pre-menarche)
- Bradycardia, hypotension, hypothermia
- Cold intolerance
- Dry skin, brittle hair, hair loss
- Lanugo (fine, downy body hair)
- Russell's sign (knuckle calluses from self-induced vomiting — also in BN)
- Constipation
- Fatigue
- Excessive exercise
- Food rituals, hiding food
- Wearing baggy clothes (hide body or stay warm)
- Depression, anxiety, social withdrawal
- Two subtypes: restrictive vs binge/purge
Bulimia nervosa:
- Binge eating (large amounts, sense of loss of control)
- Compensatory behaviors:
- Self-induced vomiting (Russell's sign on knuckles)
- Laxative, diuretic abuse
- Diet pills
- Excessive exercise
- Fasting
- Usually normal or slightly above-normal weight
- Frequent bathroom trips after meals
- Dental erosion (vomiting — esp. lingual surfaces of upper teeth)
- Parotid gland swelling ("chipmunk cheeks")
- Esophagitis, throat pain
- Electrolyte imbalances
- Menstrual irregularities
- Depression, shame, impulsivity
Laboratory Tests
- CBC: leukopenia, anemia, thrombocytopenia (severe AN)
- Electrolytes: hypokalemia, hyponatremia, hypochloremia, metabolic alkalosis (from vomiting or laxative abuse)
- ↓ glucose
- ↓ phosphorus (refeeding syndrome risk)
- BUN/creatinine (often ↑ in dehydration)
- Albumin, prealbumin (nutritional status)
- ↓ LH, FSH, estradiol, testosterone (hypogonadism)
- Thyroid: low T3, normal TSH (euthyroid sick)
- ↑ cortisol
- LFTs (sometimes ↑)
- EKG (bradycardia, QT prolongation, U waves)
- DEXA scan (osteoporosis screening if prolonged)
- Urine specific gravity, pregnancy test
Diagnostic Procedures
- Clinical diagnosis (DSM-5 criteria)
- Comprehensive medical and psychiatric evaluation
- Screening tools: SCOFF, EAT-26, EDE-Q
- Vital signs, weight, height, BMI percentile
- EKG
- Labs (above)
- DEXA (bone density)
Safety Considerations
- Refeeding syndrome — life-threatening shift of fluid/electrolytes (especially phosphorus, magnesium, potassium) when refeeding malnourished patient; must refeed SLOWLY
- Cardiac monitoring (arrhythmias, bradycardia)
- Suicide risk assessment
- Hospitalization criteria: severe malnutrition, electrolyte abnormalities, bradycardia < 50 bpm awake / 45 asleep, hypotension, hypothermia, cardiac arrhythmia, refeeding syndrome, suicide risk
- Supervised meals and bathroom breaks
- No purging access
- Weight monitoring (often blind weight — child doesn't see)
- Therapy required
Complications
- Cardiac: bradycardia, hypotension, arrhythmias, sudden cardiac death
- Refeeding syndrome — major risk during nutritional rehabilitation
- Osteoporosis, stress fractures
- Growth retardation (children)
- Amenorrhea, infertility
- Hypoglycemia
- Anemia, leukopenia
- GI: gastric rupture, esophageal tears (Mallory-Weiss), gastroparesis
- Renal: stones, failure
- Dental damage (BN)
- Comorbid psychiatric: depression, anxiety, OCD, self-harm, suicide
- Substance abuse
- Death (highest mortality rate of any psychiatric illness, especially AN)
Nursing Care
Inpatient/initial:
- Daily vital signs, especially HR, BP, temperature
- Daily weight (blind weight typically) — same time, scale, clothing, post-void
- Cardiac monitoring
- Supervised meals, observation 1 hour after
- No access to bathroom for 1 hour after eating
- Calorie counts
- Strict I&O
- Slow refeeding to avoid syndrome (start ~1000–1200 kcal/day, advance slowly)
- Monitor for refeeding syndrome: edema, ↓ phosphorus, ↓ magnesium, ↓ potassium, ↑ glucose, heart failure
- Therapeutic milieu
- Family-based therapy
- Establish trusting therapeutic relationship
- Don't comment on appearance, weight, food
- Set firm limits with empathy
- Education on nutrition (without shaming)
Outpatient:
- Weekly weighing
- Vital signs each visit
- Continued therapy (individual, family)
- Nutritional counseling
- School coordination
Medications
No FDA-approved medications for anorexia specifically
Bulimia: SSRIs (especially fluoxetine — FDA-approved)
Comorbid conditions:
- SSRIs for depression, anxiety (once weight restored — antidepressants less effective when malnourished)
- Anti-anxiety meds (short-term, carefully)
- Olanzapine — sometimes used off-label for AN (some weight gain effect)
- Caution with QT-prolonging medications
Refeeding support:
- Phosphorus, potassium, magnesium supplementation
- Thiamine (vitamin B1)
- Multivitamin
- Calcium and vitamin D (bone health)
Therapeutic Procedures
- Multidisciplinary treatment: medical, psychiatric, nutritional
- Family-Based Treatment (Maudsley) — gold standard for adolescents with AN; parents take charge of refeeding initially
- CBT, especially for BN
- Nutritional rehabilitation
- Treat comorbid conditions
- Levels of care: outpatient, IOP, PHP, residential, inpatient, ICU (medical stabilization)
- NG feeding if refusing to eat
Client Education
Family:
- Eating disorders are SERIOUS mental illnesses, NOT a choice or phase
- NOT caused by family but family is part of recovery
- Highest mortality rate of psychiatric illness
- Long-term recovery possible with treatment
- Treatment is multidisciplinary and long-term
- Don't focus on weight, food, appearance directly
- Don't engage in negotiations about food
- Take charge of meals (parents) for adolescents
- Patience — recovery takes time
- Self-care for family (caregiver burnout common)
- Watch for warning signs of relapse
- Don't comment on weight/appearance (positive or negative)
- Avoid diet talk in home
Patient:
- Recovery is possible
- Following the meal plan is essential
- Therapy attendance
- Long-term medical follow-up needed
- Recognize warning signs of relapse
- Connect with peer support (carefully — avoid pro-ana communities)
- Address comorbid conditions
- Recovery involves more than weight restoration — addresses underlying issues
Interprofessional Care
- Pediatric adolescent medicine
- Pediatric psychiatry
- Therapist (individual)
- Family therapist
- Registered dietitian (eating disorder specialized)
- Pediatric primary care
- Pediatric cardiology
- Pediatric endocrinology
- Pediatric gastroenterology
- Dental care
- School counselor
- Support resources: National Alliance for Eating Disorders (note: NEDA helpline has been discontinued)
- Inpatient/residential programs
Alterations in Health (Diagnosis)
Neurodevelopmental disorder characterized by persistent deficits in social communication and interaction, and restricted, repetitive patterns of behavior, interests, or activities. Wide spectrum of severity. Onset in early childhood; symptoms must impair function.
Pathophysiology Related to Client Problem
Multifactorial neurobiological condition with strong genetic component (heritability ~80%). Differences in brain connectivity and development. No single cause identified; not caused by vaccines or parenting.
Health Promotion and Disease Prevention
- Early identification crucial (intervention < age 3 most effective)
- Universal developmental screening at 9, 18, 24, 30 months
- Specific ASD screening at 18 and 24 months (M-CHAT-R/F)
- Address parental concerns promptly
- Genetic counseling if family history
- Adequate prenatal care
Risk Factors
- Male sex (4× more common than females)
- Family history (sibling with ASD — 10–20% recurrence; identical twin — 70–90%)
- Older parental age
- Genetic syndromes: fragile X, tuberous sclerosis, Rett syndrome, Down syndrome
- Prematurity, low birth weight
- Prenatal exposure: valproate, thalidomide
- Maternal infections, autoimmune conditions in pregnancy
- Vaccines DO NOT cause autism — extensively studied and debunked
Expected Findings
Social communication deficits:
- Poor eye contact
- Limited or absent social smile
- Doesn't respond to name
- Reduced joint attention (not pointing, sharing interest)
- Difficulty interpreting facial expressions, body language
- Lack of pretend play
- Difficulty making/maintaining friendships
- Language delays (some don't speak, others have advanced vocabulary but poor pragmatic use)
- Echolalia (repeating words/phrases)
- Difficulty with reciprocal conversation
- Literal interpretation (no understanding sarcasm, idioms)
Restricted/Repetitive behaviors:
- Stereotyped movements: hand-flapping, rocking, spinning, finger-flicking
- Insistence on sameness, distress with changes
- Rigid routines, rituals
- Restricted, intense interests (memorizing facts about specific topics)
- Lining up toys
- Sensory sensitivities (hyper- or hypo-reactive)
- Unusual reactions to sensory input (textures, sounds, lights)
Early signs (red flags):
- No babbling by 12 months
- No pointing or waving by 12 months
- No single words by 16 months
- No 2-word phrases (not echolalic) by 24 months
- Loss of any language or social skill at any age
- Limited eye contact, lack of social smile
- Doesn't respond to name
Often comorbid:
- Intellectual disability (~30%)
- ADHD
- Anxiety, depression
- Sleep disorders
- Seizures (20–25%)
- GI issues
- Feeding/eating issues
Laboratory Tests
- Hearing test (rule out deafness as cause of language delay)
- Lead level
- Genetic testing: chromosomal microarray, fragile X testing
- Metabolic studies if indicated
- EEG if seizures
Diagnostic Procedures
- Clinical diagnosis based on DSM-5 criteria
- M-CHAT-R/F screening at 18 and 24 months
- ADOS (Autism Diagnostic Observation Schedule) — gold standard observational tool
- ADI-R (Autism Diagnostic Interview—Revised) — parent interview
- Comprehensive evaluation by multidisciplinary team (developmental pediatrician, psychologist, speech-language pathologist)
- Cognitive assessment
- Adaptive functioning assessment
- Hearing and vision screening
Safety Considerations
- Elopement (wandering) — common in ASD; secure home, ID, GPS
- Drowning is leading cause of death in children with ASD who wander
- Self-injurious behaviors (head-banging, hitting)
- Aggression (often related to sensory overload or communication frustration)
- Pica (eating non-food items)
- Bullying victimization
- Difficulty communicating pain → may underrecognize illness
- Sensory considerations in healthcare
Complications
- Educational and adaptive functioning challenges
- Mental health comorbidities (anxiety, depression)
- Self-injurious behavior
- Family stress, burnout
- Social isolation
- Bullying, exploitation
- Difficulty with transitions (school changes, adolescence, adulthood)
- Employment, independent living difficulties
- Premature death (especially from drowning, seizures, accidents)
Nursing Care
Healthcare visits:
- Schedule appointments at less busy times
- Quiet environment, reduce stimuli
- Allow extra time
- Prepare child with visual schedule, social story
- Speak directly to child (with parent guidance on level)
- Use literal language
- Predict steps, explain what you'll do
- Demonstrate on doll or parent
- Use distraction, sensory tools
- Allow comfort items
- Sensory considerations: lighting, sounds, smells, touch
- Be patient with delayed responses
- Use AAC (augmentative and alternative communication) if applicable
- Respect routines
- Pain assessment may be difficult — observe behavior
General care:
- Maintain routines
- Visual supports (picture schedules, social stories)
- Communication strategies based on individual needs
- Sensory accommodations
- Anticipate transitions
- Reinforce desired behaviors
- Family support and education
- Sibling support
- Coordinate care across settings
- School communication (IEP, BIP)
Medications
No medication treats core ASD symptoms
Used for specific symptoms/comorbidities:
- Risperidone (Risperdal) — FDA-approved for irritability in ASD ages 5–16
- Aripiprazole (Abilify) — FDA-approved for irritability in ASD ages 6–17
- Stimulants for comorbid ADHD (may worsen irritability in some)
- SSRIs for anxiety, depression (caution — may have unusual effects)
- Melatonin for sleep disturbances
- Anticonvulsants if seizures
- Alpha-agonists (clonidine, guanfacine) for sleep, irritability
Therapeutic Procedures
Early intervention essential (before age 3):
- Applied Behavior Analysis (ABA) — most evidence-based behavioral intervention
- Speech-language therapy
- Occupational therapy (sensory integration)
- Physical therapy
- Special education (IEP)
- Social skills training
- Cognitive behavioral therapy (older children)
- Picture Exchange Communication System (PECS), AAC devices
- Floortime/DIR
- Social stories
- Family-based interventions
Client Education
Family:
- ASD is a lifelong condition but EARLY INTERVENTION significantly improves outcomes
- Spectrum varies widely — each individual unique
- NOT caused by vaccines, parenting, or any single factor
- Genetic component — siblings at increased risk
- Multidisciplinary treatment
- School services through IEP (start as young as 3)
- Early intervention services 0–3 (Part C of IDEA)
- Special education services 3–21 (Part B)
- Therapies as recommended (ABA, OT, ST)
- Routines and predictability help reduce anxiety
- Use visual supports (schedules, social stories)
- Sensory accommodations
- Safety: secure home, ID, GPS tracking, swim lessons (drowning is leading cause of death)
- Address comorbidities
- Family respite, support groups
- Sibling support
- Transition planning starting early adolescence (school to adult life, employment, housing)
- Guardianship/supported decision-making considerations
- Caregiver mental health critical
- Resources: Autism Society, Autism Speaks (controversial in some communities), ASAN (Autistic Self Advocacy Network)
- Neurodiversity perspective: ASD as natural variation, not solely deficit
Interprofessional Care
- Developmental pediatrician
- Pediatric psychiatrist
- Pediatric psychologist
- Speech-language pathologist
- Occupational therapist
- ABA therapist (BCBA)
- Special education team (IEP)
- School nurse
- Pediatric neurologist (if seizures)
- Pediatric primary care
- Pediatric GI (if GI issues)
- Social work, case manager
- Family therapist
- Disability services agency
- Vocational rehab (adolescents)
Alterations in Health (Diagnosis)
Spectrum from mild concussion to severe traumatic brain injury (TBI). Concussion: mild TBI from blow/jolt causing transient functional disturbance. Contusion: bruising of brain. Hematoma: epidural (arterial bleed under skull, "lucid interval"), subdural (venous bleed between dura and brain), intracerebral. Head injury is leading cause of pediatric death from trauma.
Pathophysiology Related to Client Problem
Mechanism: blunt or penetrating trauma → primary injury (immediate damage) + secondary injury (hypoxia, edema, hemorrhage, ↑ ICP). Children at unique risk due to: larger head-to-body ratio, weak neck muscles, thinner skull, less myelination, more water content in brain.
Health Promotion and Disease Prevention
- Helmets: bike, scooter, skateboard, sports, motorcycle
- Car seats and seatbelts
- Window guards, stair gates
- Adult supervision
- Safe play environments
- Concussion education for athletes and parents
- Return-to-play protocols
- Childproof firearms
- Address shaken baby syndrome
Risk Factors
- Falls (most common in young children)
- Motor vehicle crashes (#1 in older children)
- Sports injuries (especially contact sports — football, hockey, soccer)
- Bicycle, scooter accidents without helmet
- Physical abuse (consider in infants with head injury)
- Penetrating injuries (gunshot, sharp objects)
- Male sex
- Adolescent risk-taking
- Previous concussion (↑ risk of second)
Expected Findings
Concussion:
- Brief LOC (or none)
- Confusion, disorientation
- Headache
- Dizziness, balance issues
- Nausea/vomiting (single episode)
- Visual disturbances, light/sound sensitivity
- Difficulty concentrating, memory issues
- Sleep disturbances
- Emotional changes, irritability
- Amnesia (retrograde/anterograde)
↑ ICP / severe TBI:
- Cushing's triad (late sign): hypertension, bradycardia, irregular respirations
- Altered LOC (use Glasgow Coma Scale — pediatric version)
- Pupillary changes (unequal, dilated, sluggish/non-reactive)
- Focal neurologic deficits
- Posturing (decorticate, decerebrate)
- Seizures
- Persistent vomiting
- Worsening headache
Infants (specific signs):
- Bulging fontanel
- ↑ head circumference
- High-pitched cry
- Irritability or lethargy
- Poor feeding
- Setting-sun eyes
- Seizures
Skull fracture signs:
- Battle's sign — bruising behind ear (basilar)
- Raccoon eyes — periorbital bruising (basilar)
- CSF leak from nose (rhinorrhea) or ears (otorrhea) — "halo sign" on cloth
- Hemotympanum
Laboratory Tests
- CBC
- Coagulation studies (if surgery anticipated)
- Type and screen
- Glucose, electrolytes
- Toxicology (older children)
- ABG if respiratory compromise
Diagnostic Procedures
- CT head (without contrast) — first-line imaging for acute injury
- MRI for subtle injuries or follow-up
- X-ray cervical spine (rule out C-spine injury)
- Glasgow Coma Scale (pediatric) — eye, verbal, motor (3-15)
- Neuro exam: pupils, motor, sensory, reflexes, cranial nerves
- PECARN criteria — when to image (avoids unnecessary radiation in low-risk)
- Neuropsychological testing (post-concussion)
- Balance Error Scoring System (BESS) — sports concussion
- SCAT5 — sports concussion assessment
- ImPACT testing (baseline and post-injury)
Safety Considerations
- C-spine precautions until cleared (especially in trauma)
- HOB elevation 30° (if no spinal injury) to ↓ ICP
- Maintain head midline
- Avoid neck flexion (may compromise infant airway)
- Strict bedrest initially in severe injury
- Seizure precautions
- Frequent neuro assessment (q1h initially in severe)
- Suspect non-accidental trauma in infants with significant injury
- Pain management without masking neuro changes
- Anticoagulation reversal if on blood thinners
- Avoid hypoxia, hypotension, hyperthermia, hyperglycemia (worsen secondary injury)
Complications
- ↑ ICP, herniation
- Cerebral edema
- Hemorrhage (epidural, subdural, subarachnoid, intracerebral)
- Skull fracture
- Cervical spine injury
- Seizures (acute and post-traumatic epilepsy)
- SIADH or DI
- Second impact syndrome (catastrophic brain swelling from repeat concussion before first heals)
- Chronic traumatic encephalopathy (CTE) — long-term from repeated concussions
- Cognitive impairment
- Learning, behavioral, emotional changes
- Post-concussion syndrome (persistent symptoms)
- Hydrocephalus
- Hearing or vision loss
- Cranial nerve deficits
- Coma, death
Nursing Care
Acute:
- ABCs first
- C-spine immobilization
- Frequent vital signs and neurologic checks (GCS, pupils, motor)
- HOB 30° (if no spinal injury)
- Head/neck midline
- Pulse oximetry, oxygen as needed
- IV access
- Strict I&O (DI/SIADH risk)
- Monitor for ↑ ICP signs
- Seizure precautions
- Pain management (avoid sedation that masks neuro changes)
- Antiemetics
- Cluster care to allow rest
- Quiet, dim environment
- Document trends
Concussion / Post-acute:
- Physical rest initially — no sports, screen time, school
- Cognitive rest — limited screens, reading, schoolwork
- Gradual return to activity
- Follow concussion protocol (5 stages — symptom-limited progression)
- School coordination — academic accommodations
- Sleep, hydration, nutrition
- Avoid second injury until completely cleared
- Education about post-concussion symptoms
- Monitor for delayed symptoms
Medications
- Acetaminophen for pain (avoid NSAIDs initially due to bleeding risk)
- Antiemetics (ondansetron)
- Anticonvulsants (levetiracetam) — prevent seizures in severe TBI
- Hyperosmolar therapy: 3% hypertonic saline or mannitol — acute ↑ ICP
- Sedatives, analgesics in ICU (titrate carefully)
- Antibiotics if open fracture, CSF leak
- Tetanus prophylaxis if indicated
- Stool softeners (avoid Valsalva)
- Reversal agents for anticoagulants if applicable
Therapeutic Procedures
- ICP monitoring (severe TBI)
- Mechanical ventilation
- Hypertonic saline or mannitol
- Decompressive craniectomy
- Hematoma evacuation (epidural, subdural)
- External ventricular drain
- Burr holes (emergent)
- Therapeutic hypothermia (controversial)
- Rehabilitation (PT, OT, speech, neuropsychology)
Client Education
Caregivers (after discharge):
- Wake child every 2 hours x 1 night to assess
- Watch for warning signs:
- Worsening or severe headache
- Repeated vomiting (more than 1-2 times)
- Difficulty waking or excessive sleepiness
- Confusion, slurred speech
- Weakness, numbness, balance issues
- Seizures
- Unequal pupils
- CSF leak from nose/ears
- Behavior changes
- Return to ED if any of these occur
- Activity restrictions per provider
- No sports until cleared
- Concussion can take days to weeks to fully resolve
Return to Play (5-stage progression):
- Symptom-limited activity
- Light aerobic exercise
- Sport-specific exercise
- Non-contact training drills
- Full contact practice → return to game
Each stage 24 hours minimum; if symptoms return, drop back. Total minimum: 5 days; often longer in pediatrics.
Return to School:
- Initial: rest, limited screen time
- Then: half days, frequent breaks
- Accommodations: extended test time, reduced workload
- Coordinate with school nurse/counselor
- 504 plan if persistent
Prevention:
- Helmets for all wheeled sports, contact sports
- Car seats per guidelines
- Safe play environments
- Window guards, stair gates
- Address bullying
Interprofessional Care
- Pediatric trauma team
- Pediatric neurosurgery
- Pediatric neurology
- Pediatric ICU
- Sports medicine
- Neuropsychology
- Rehabilitation (PT, OT, speech)
- Social work
- School coordinator
- Athletic trainer
- Mental health
- Concussion clinic
Alterations in Health (Diagnosis)
Inflammation of stomach and intestines causing diarrhea, vomiting, abdominal pain, and dehydration. Most common cause of acute illness in children. Viral (most common — rotavirus, norovirus, adenovirus, astrovirus), bacterial (Salmonella, Campylobacter, Shigella, E. coli, C. difficile), parasitic (Giardia, Cryptosporidium).
Pathophysiology Related to Client Problem
Pathogen reaches GI tract → inflammation → ↓ absorption + ↑ secretion → diarrhea ± vomiting → fluid/electrolyte losses → dehydration. Some bacterial cause invasive disease with bloody stools.
Health Promotion and Disease Prevention
- Rotavirus vaccine at 2, 4, 6 months (live oral)
- Hand hygiene (especially after diaper changes, toileting)
- Safe food handling, cooking
- Clean water
- Breastfeeding (protective)
- Avoid contact with sick contacts
- Stay home from daycare when symptomatic
- Clean contaminated surfaces (bleach)
Risk Factors
- Age < 5 years (highest risk for severe dehydration)
- Daycare attendance
- Crowded living
- Poor sanitation
- Contaminated food/water
- International travel
- Immunocompromised
- Recent antibiotic use (C. diff)
- Untreated water exposure (Giardia)
- Petting zoo/farm exposure (E. coli)
- Winter (rotavirus, norovirus)
- Cruise ships, schools (norovirus outbreaks)
Expected Findings
Diarrhea:
- Watery (most viral, some bacterial)
- Bloody/mucousy (invasive — Shigella, Salmonella, E. coli O157, C. diff, Campylobacter)
- Pale, foul-smelling, fatty (Giardia)
- Frequency varies; may be many times daily
Other:
- Vomiting (often precedes diarrhea in viral)
- Fever (varies)
- Abdominal pain, cramping
- Anorexia
- Malaise
- Sometimes headache, myalgia
Dehydration (severity):
| Severity | Signs |
|---|---|
| Mild (3-5%) | Slightly dry mucous membranes, slightly ↓ urine, normal vitals, no skin tenting |
| Moderate (6-9%) | Dry mucous membranes, sunken eyes/fontanel, decreased skin turgor, decreased urine, tachycardia, irritable, no tears |
| Severe (≥10%) | Very dry, very sunken fontanel/eyes, marked skin tenting, very ↓ urine, lethargic/obtunded, tachycardia, hypotension, prolonged cap refill, COLD MOTTLED extremities, SHOCK |
Laboratory Tests
- Often NOT needed for routine viral GE
- Electrolytes (Na, K, Cl, HCO3) if moderate-severe dehydration — hyponatremic, hypernatremic, or isotonic dehydration
- BUN/creatinine
- Glucose
- CBC (if bloody diarrhea or severe illness)
- Stool studies if: bloody, high fever, dysentery, prolonged, immunocompromised, recent antibiotics, daycare outbreak, travel
- Stool culture, ova/parasites, C. diff toxin, viral PCR
- Lactate (severe dehydration/shock)
Diagnostic Procedures
- Clinical assessment (most cases)
- Daily weights (best dehydration assessment)
- Strict I&O
- Skin turgor, mucous membranes, fontanel, capillary refill
- Vital signs
- Urinalysis (specific gravity)
- Imaging only if surgical abdomen suspected
Safety Considerations
- Standard + contact precautions (especially diapered/incontinent)
- Hand hygiene CRITICAL
- C. diff — soap and water (alcohol gel doesn't kill spores)
- Recognize dehydration severity
- Severe dehydration → shock → emergency
- Hyponatremia/hypernatremia correction must be SLOW
- NOT antimotility agents (Lomotil, Imodium) in children — can prolong illness and worsen invasive bacterial
- Identify outbreak situations and report
Complications
- Dehydration, shock
- Electrolyte imbalances (hypo/hypernatremia, hypokalemia, metabolic acidosis)
- Acute kidney injury
- Hypovolemic shock
- Hemolytic uremic syndrome (HUS) — especially E. coli O157:H7 — bloody diarrhea, AKI, hemolytic anemia, thrombocytopenia
- Sepsis (Salmonella in infants)
- Reactive arthritis
- Guillain-Barré (post-Campylobacter)
- Carrier state (Salmonella)
- Toxic megacolon (severe C. diff)
- Failure to thrive (prolonged)
- Lactose intolerance (transient post-illness)
- Death (in severe untreated cases, especially infants)
Nursing Care
- Assess hydration status frequently
- Daily weights (most accurate)
- Strict I&O (count diarrheal stools, urine output)
- Urine output: ≥1 mL/kg/hr in children
- Oral Rehydration Solution (ORS) — first-line for mild/moderate
- Small frequent sips (5-15 mL every 5-10 min)
- Advance to age-appropriate diet quickly once hydrated (within 24 hours) — NO prolonged BRAT diet (outdated)
- Breastfeeding/formula should continue
- IV fluids if: severe dehydration, vomiting precludes oral, altered mental status
- Bolus 20 mL/kg NS (or LR) for shock
- Maintenance + replacement fluids
- Correct electrolyte abnormalities (especially hyponatremia, hypokalemia — carefully)
- Antiemetic if needed (ondansetron — has good evidence in pediatric GE)
- Skin care — frequent diaper changes, barrier cream
- Comfort measures
- Contact precautions
- Educate family
Medications
Most viral GE: supportive only
Antiemetic:
- Ondansetron (Zofran) — single dose has evidence in pediatric GE; can prevent need for IV fluids
Antimicrobials (only if specific indication):
- Bacterial dysentery (Shigella): azithromycin, ciprofloxacin
- Severe Salmonella in infants < 3 months or immunocompromised: ceftriaxone, azithromycin
- Giardia: metronidazole, tinidazole, nitazoxanide
- C. difficile: oral vancomycin or fidaxomicin (no longer metronidazole as first-line)
- Do NOT treat E. coli O157:H7 with antibiotics — ↑ HUS risk
NOT recommended in children:
- Antimotility agents (loperamide, diphenoxylate) — can worsen invasive disease, mask severity
- Bismuth subsalicylate (salicylate concern — Reye syndrome)
- Probiotics — variable evidence
Therapeutic Procedures
- Oral rehydration therapy (preferred when possible)
- IV fluid resuscitation if severe
- Hospitalization if: severe dehydration, intractable vomiting, electrolyte abnormalities, altered LOC, hemodynamic instability, failure of outpatient management
- NG rehydration sometimes used
Client Education
Family:
- Hand hygiene is most important prevention
- ORS preferred over plain water, juice, or sports drinks (wrong electrolyte balance for severe diarrhea)
- Small frequent sips — sips every 5-10 min, gradually increasing
- Continue breastfeeding/formula
- Resume regular diet quickly (within 24 hours)
- Bland foods are fine, but BRAT diet not necessary or recommended exclusively
- Probiotics may help shorten viral illness
- Stay home from daycare/school until 24 hours symptom-free
- Disinfect surfaces (bleach for norovirus, C. diff)
- Watch for dehydration signs (decreased urine, dry mouth, no tears, lethargy)
- Return to ED if: signs of severe dehydration, bloody/black stools, high fever, persistent vomiting, abdominal pain, lethargy
- Keep child home from daycare until 24 hours after diarrhea resolves
- Stress prevention (rotavirus vaccine!)
Interprofessional Care
- Pediatric primary care
- Pediatric GI (severe or chronic)
- Pediatric infectious disease
- Public health (reportable diseases — Salmonella, Shigella, E. coli O157, etc.)
- School/daycare
- Nephrology (if HUS)
Alterations in Health (Diagnosis)
Disruption in continuity of bone. Pediatric bones are more porous, flexible, and have growth plates (physes) — leading to unique fracture patterns and healing characteristics not seen in adults.
Pathophysiology Related to Client Problem
Pediatric features: thick periosteum (heals faster), open growth plates (vulnerable but allow remodeling), and softer bone (greenstick patterns). Salter-Harris classification for growth plate fractures (Type I-V). Healing typically 1/2 the time of adults (4-6 weeks pediatric vs 6-12 weeks adult for similar fractures).
Health Promotion and Disease Prevention
- Helmets, protective gear for sports
- Safe play environments
- Car seats, seatbelts
- Childproofing (gates on stairs, window guards)
- Calcium and vitamin D intake
- Weight-bearing exercise
- Address bone health in chronic illness (CF, anorexia, steroid use)
- Anticipatory guidance about age-appropriate activities
- Address abuse risk factors
Risk Factors
- Age (toddlers — falls; school-age — sports/play; adolescents — sports/MVCs)
- Male sex
- Sports participation (especially contact)
- Falls from heights
- Inadequate supervision
- Unsafe environment
- Osteogenesis imperfecta
- Bone disease (rickets, vitamin D deficiency)
- Steroid use (chronic)
- Malnutrition, anorexia
- Cerebral palsy
- Previous fracture
- Trauma (MVC, abuse)
- NAT (non-accidental trauma) — especially in infants pre-walking, multiple fractures in different healing stages
Expected Findings
- Pain at site (worse with movement)
- Swelling, bruising
- Deformity (visible or palpable)
- Crepitus
- Limited or guarding range of motion
- Refusal to bear weight or use limb
- Limp
- Tenderness on palpation
- Neurovascular compromise (severe)
- Open fracture: bone protruding through skin
Unique pediatric fracture types:
- Greenstick: incomplete fracture; one side breaks, other bends
- Torus/buckle: compression of bone (typically wrist after fall on outstretched hand) — heals well
- Plastic deformation/bowing: bone bent but not fractured
- Salter-Harris (growth plate) Type I-V — affect physis
- Spiral: twisting force; concerning for abuse if in non-ambulatory infant
- Toddler's fracture: spiral fracture of tibia, common in toddlers
- Supracondylar humerus: most common pediatric elbow fracture — neurovascular risk
Laboratory Tests
- CBC (if significant blood loss)
- Type and screen (if surgery)
- Coagulation
- If suspected abuse: skeletal survey, head CT, retinal exam, social work consult
- If suspected bone disease: calcium, phosphorus, ALP, vitamin D, parathyroid
Diagnostic Procedures
- X-ray — first-line; compare to opposite side if uncertain
- Multiple views (AP, lateral)
- X-ray of joint above and below
- CT for complex fractures
- MRI for occult fractures, soft tissue, growth plate
- Bone scan for occult/stress fractures
- Ultrasound (sometimes for sternum, ribs)
- Skeletal survey if abuse suspected (children < 2 years)
Safety Considerations
- Assess neurovascular status distal to fracture (6 Ps)
- Immobilize before transport
- NPO until cleared for procedure/surgery
- C-spine precautions for trauma until cleared
- Pain management
- Watch for compartment syndrome (early sign: pain out of proportion to injury, severe pain on passive stretch)
- Open fracture: cover with sterile dressing, antibiotics, tetanus, urgent surgery
- Recognize signs of abuse (history doesn't match, multiple injuries, different healing stages, suspicious patterns)
- Mandated reporting if abuse suspected
Complications
- Compartment syndrome — limb-threatening emergency
- Neurovascular injury
- Growth disturbance (Salter-Harris injuries)
- Limb length discrepancy
- Angular deformity, malunion
- Nonunion (rare in children)
- Avascular necrosis
- Infection (open fractures)
- Fat embolism (long bone, rare in children)
- Refracture
- Joint stiffness, contractures
- Pulmonary embolism (rare in pediatrics)
- Pain, prolonged immobilization
- Psychosocial impact (loss of activity, school)
Nursing Care
Acute:
- Trauma assessment (ABC)
- Assess for other injuries
- Pain assessment and management
- Immobilize injured area (splint, sling)
- Apply ice (20 min on/off)
- Elevate limb if possible
- Neurovascular checks frequently (pulse, color, warmth, capillary refill, movement, sensation distal to injury)
- NPO if surgery anticipated
- IV access
- Tetanus if open fracture
- Prepare for reduction (closed or open)
- Procedural sedation as needed
Post-reduction/cast:
- Continue NV checks
- Elevate cast first 24-48 hours
- Ice over cast (in plastic bag)
- Watch for compartment syndrome
- Pain control
- Educate cast care
- Activity restrictions
- Crutch training
- Follow-up X-rays
Medications
- Pain management:
- Acetaminophen, ibuprofen (NSAIDs caution — may delay bone healing in some studies, controversial)
- Opioids (short-term for severe pain, monitor)
- Local anesthetic (lidocaine for reduction)
- Procedural sedation (ketamine common for reduction)
- Other:
- Tetanus toxoid if not current and open fracture
- Antibiotics for open fractures (cefazolin, gentamicin)
- Antiemetic
- DVT prophylaxis (older adolescents in prolonged immobility)
Therapeutic Procedures
- Closed reduction: manipulating bone back into alignment without surgery
- Open reduction internal fixation (ORIF): surgical realignment + plates/screws/pins
- Casting: plaster or fiberglass
- Splinting: initial or non-displaced
- Traction — skeletal or skin (rare currently)
- External fixation — complex/open
- Sling, brace
- Procedural sedation for reduction
- PT/OT for rehab
Client Education
Cast care:
- Keep cast dry (use plastic bag in shower/bath)
- Don't put anything inside cast for itch (no rulers, hangers, etc.)
- Cool dry air for itch (hair dryer on cool setting)
- Don't cut or alter cast
- Watch for warning signs:
- Severe pain not relieved by medication
- Numbness, tingling
- Coolness, color change of fingers/toes
- Drainage, foul odor
- Cast becomes loose or breaks
- Fever
- Return to ED if any warning signs
Activity:
- Elevate limb first 24-48 hours
- Ice (in plastic bag) over cast 20 min on/off
- Bear weight only as instructed
- Use crutches/wheelchair as prescribed
- Wiggle fingers/toes frequently
- Avoid contact sports until cleared
- Gradual return to activity
Cast removal:
- Saw vibrates, doesn't cut skin
- Will be loud — bring headphones, distraction
- Skin will appear dry, scaly — moisturize gently
- Muscle weakness, atrophy normal — PT helps
- Take it easy initially
Prevention:
- Helmets, pads, mouthguards for sports
- Safe play environments
- Proper car seat use
- Address bone health (calcium, vitamin D, exercise)
Interprofessional Care
- Pediatric orthopedic surgery
- Pediatric ED
- Pediatric radiology
- Pediatric anesthesia (for sedation/surgery)
- Physical and occupational therapy
- Athletic trainer (sports injuries)
- Social work (especially if abuse suspected — mandated)
- Child Protective Services if NAT
- School coordinator
Alterations in Health (Diagnosis)
Severe, life-threatening, systemic hypersensitivity reaction with rapid onset, potentially fatal. Type I IgE-mediated reaction (most common) or anaphylactoid (non-IgE). EMERGENCY — requires immediate epinephrine and airway/circulatory support.
Pathophysiology Related to Client Problem
Antigen exposure → IgE-mediated mast cell and basophil degranulation → release of histamine, leukotrienes, prostaglandins, tryptase → vasodilation, ↑ vascular permeability, bronchoconstriction, ↑ secretions, GI motility changes → multi-system involvement (skin, respiratory, cardiovascular, GI) → potentially shock and death.
Health Promotion and Disease Prevention
- Identify and avoid known allergens
- Carry epinephrine auto-injectors at all times
- Medical alert ID
- Allergy testing
- School plan: action plan, EpiPen at school, trained staff
- Food allergy precautions (reading labels, cross-contamination)
- Inform restaurants, social hosts
- Annual epinephrine training
- Allergen immunotherapy (some allergens)
Risk Factors
- Previous anaphylaxis (highest predictor)
- Known severe allergies (food, medication, insect)
- Atopy (asthma, eczema, allergic rhinitis)
- Severe asthma (esp uncontrolled) — increases anaphylaxis severity
- Adolescents and young adults (highest mortality — risk-taking, delayed treatment)
- Mast cell disorders
Common triggers in children:
- Foods: peanuts, tree nuts, milk, eggs, shellfish, fish, wheat, soy, sesame
- Medications: penicillins, cephalosporins, NSAIDs, vaccines
- Insect stings/bites: bees, wasps, hornets, fire ants
- Latex (especially with spina bifida, multiple surgeries)
- Contrast media
- Exercise-induced (especially with food)
- Idiopathic
Expected Findings
Anaphylaxis typically involves ≥ 2 systems within minutes-hours of exposure:
Skin/mucosa (most common — but absent in 10-20%):
- Urticaria (hives)
- Angioedema (face, lips, tongue, throat)
- Flushing
- Pruritus
- Itchy lips, mouth
Respiratory:
- Stridor (upper airway edema)
- Wheezing (bronchospasm)
- Dyspnea
- Hoarseness
- Cough
- Throat tightness
- Drooling (severe)
- Cyanosis (late)
Cardiovascular:
- Tachycardia → late bradycardia
- Hypotension
- Shock
- Syncope, dizziness
- Cardiac arrest (severe)
GI:
- Nausea, vomiting
- Crampy abdominal pain
- Diarrhea
Neurologic:
- Anxiety, sense of impending doom
- Confusion
- LOC
- Seizures
Biphasic reaction: recurrence of symptoms hours after initial resolution (1-72 hours, typically 4-12). Why observation period needed.
Laboratory Tests
- Often clinical diagnosis — don't delay treatment for labs
- Tryptase level (within 1-2 hours of onset — supports diagnosis if elevated; not always elevated in food anaphylaxis)
- Histamine (short half-life, less useful)
- Blood gas if respiratory compromise
- Allergy testing AFTER recovery: skin prick, specific IgE blood tests, oral food challenge
Diagnostic Procedures
- Clinical diagnosis
- History of exposure
- Physical exam findings of ≥ 2 systems
- NIAID/FAAN criteria
- Allergist evaluation post-event
Safety Considerations
- EPINEPHRINE FIRST — don't delay
- Position: supine with legs elevated (unless respiratory distress — semi-Fowler's)
- Don't make patient sit/stand (can cause fatal arrhythmia from "empty heart")
- Airway management priority
- IV access x 2 large bore
- Continuous monitoring (cardiac, pulse ox, BP)
- Observation period 4-6 hours minimum (some up to 24)
- Don't use antihistamines or steroids as FIRST treatment — they don't treat acute reaction
- Two EpiPens in case repeat needed
- Watch for biphasic reaction
Complications
- Respiratory failure
- Hypoxia
- Hypotensive shock
- Cardiac arrest
- Death
- Biphasic reaction (1-72 hr after initial)
- Brain hypoxia → permanent injury
- Anxiety, PTSD post-event
- Avoidance behaviors
Nursing Care
IMMEDIATE (in order):
- Remove trigger (stop infusion, remove stinger, etc.)
- Call for help — emergency response team
- Administer EPINEPHRINE IM lateral thigh (most rapid absorption) — first-line, life-saving
- 0.01 mg/kg (1:1000) max 0.3-0.5 mg/dose; repeat every 5-15 min as needed
- EpiPen Jr (0.15 mg) for child 15-30 kg
- EpiPen (0.3 mg) for ≥ 30 kg
- Position: supine, legs elevated (or semi-Fowler's if breathing better that way)
- High-flow oxygen via mask
- IV access — fluid bolus 20 mL/kg NS
- Cardiac monitor, pulse ox, BP, continuous
- Repeat epinephrine q5-15 min as needed (up to 3 doses, then consider infusion)
- Adjunct medications AFTER epinephrine
- Be ready for intubation
- Transfer to higher level of care if needed
- Observe ≥ 4 hours after resolution (up to 24 if severe)
- Document carefully
Education before discharge:
- Trigger identification
- EpiPen technique
- Avoidance strategies
- Action plan
- Allergy referral
- Medical alert ID
Medications
FIRST-LINE — DO NOT DELAY:
- EPINEPHRINE IM 0.01 mg/kg (1:1000 solution) IM lateral thigh; max 0.3-0.5 mg; repeat q5-15 min as needed
- EpiPen Jr 0.15 mg (15-30 kg); EpiPen 0.3 mg (≥30 kg)
- Severe refractory: epinephrine IV infusion 0.1-1 mcg/kg/min
Adjunctive (after epinephrine):
- H1 antihistamine: diphenhydramine (Benadryl) 1-2 mg/kg IV/IM/PO; max 50 mg
- H2 antihistamine: famotidine IV
- Corticosteroid: methylprednisolone IV — for prevention of biphasic reaction (no acute benefit)
- Bronchodilator: nebulized albuterol for persistent bronchospasm
- Vasopressors: if refractory hypotension (epinephrine drip, norepinephrine)
- Glucagon: if patient on beta-blocker (which blocks epinephrine effect)
IV fluids:
- NS 20 mL/kg bolus; repeat as needed
Therapeutic Procedures
- Epinephrine administration
- Oxygen therapy
- IV fluid resuscitation
- Intubation if airway failure
- CPR if cardiac arrest
- ICU admission for monitoring (severe)
- Allergen immunotherapy (after — for some allergens like insect venom)
Client Education
Critical education:
- Carry 2 epinephrine auto-injectors at all times (in case 1 doesn't work or repeat dose needed)
- Check expiration dates — replace before expiration
- Store at room temperature, not in extreme heat/cold
- Use EpiPen EARLY — when in doubt, USE IT
- "Blue to the sky, orange to the thigh" (older EpiPen design)
- New designs vary — practice with trainer (no needle)
- Hold against lateral thigh, even through clothing
- Hold for 10 seconds (older) or 3 seconds (newer)
- Massage area 10 seconds
- Call 911 even if symptoms improve
- Lie down, elevate legs (unless better sitting)
- Stay with patient
- Repeat in 5-15 min if no improvement
- Go to ED for monitoring (biphasic risk)
- Action plan: written, share with school, daycare, family
- Medical alert ID (bracelet, necklace, or shoe tag)
- Schools: keep EpiPen accessible, train staff
Avoidance:
- Food allergies: read labels EVERY time (recipes change), ask at restaurants, beware cross-contamination, kitchen tools/oils, school cafeteria
- Insect: avoid bright clothes, perfumes; close drinks outdoors; check shoes
- Medications: alert all providers, pharmacists; wear medical alert
- Latex: notify providers; check products (balloons, condoms, gloves, dental dams)
Follow-up:
- Allergist evaluation
- Allergen testing
- Possible immunotherapy
- Treat comorbid asthma well (improves anaphylaxis outcomes)
- Psychological support if anxiety post-event
Interprofessional Care
- Emergency physician
- Pediatric allergist/immunologist
- Pediatric pulmonologist (asthma)
- Pediatric primary care
- School nurse
- Daycare staff
- Pharmacist
- Dietitian (food allergies)
- Mental health (anxiety)
- FARE (Food Allergy Research and Education)
Alterations in Health (Diagnosis)
Exposure to substance causing harmful effect. Toddlers most common (exploratory ingestions, "tasting"); adolescents (intentional, recreational, suicide attempts). Most pediatric poisonings are accidental and involve a single substance.
Common pediatric poisonings: acetaminophen, ibuprofen, household products, plants, medications (especially grandparent's), iron, lead, alcohol, opioids, illicit drugs.
Pathophysiology Related to Client Problem
Specific to substance: many cause local injury (caustics), systemic toxicity (CNS depression, cardiac, hepatic, renal), or both. Some require specific antidotes; many treated supportively.
Health Promotion and Disease Prevention
- Childproof containers (note: not "child-proof" — can be opened by some children)
- Store all medications and household chemicals out of reach AND sight (locked cabinets)
- Original containers — don't transfer to food/drink containers
- Don't call medicine "candy"
- Take medications when child isn't watching
- Keep purses/bags out of reach (often contain medications)
- Check grandparent's home (visits = ingestion risk)
- Poison Control number: 1-800-222-1222 — post visibly
- Lead screening per AAP/CDC
- Address adolescent substance abuse, suicide screening
Risk Factors
- Age 1-5 years (peak — exploratory ingestion)
- Adolescents (intentional)
- Curious child, peak mouthing age
- Inadequate supervision
- Medications in home (grandparents — biggest source of pediatric ingestions)
- Mental health disorders, suicide risk
- Substance abuse history
- Recent stressful events
- Older homes (lead paint — built before 1978)
- Pica
Expected Findings
Varies by substance — high index of suspicion in children with sudden symptoms:
- Altered LOC (drowsy, lethargic, agitated)
- Vomiting, diarrhea
- Tachypnea or hypoventilation
- Tachycardia, bradycardia, arrhythmia
- Hypotension or hypertension
- Pupillary changes (pinpoint — opioids/organophosphates; dilated — anticholinergics/cocaine)
- Seizures
- Skin: cyanosis, flushed, cherry-red (CO), burns (caustic)
- Hyperthermia or hypothermia
- Smells: garlic (arsenic, organophosphate), bitter almond (cyanide), fruity (DKA, isopropyl)
- Diaphoresis, salivation
- Specific syndromes: anticholinergic, cholinergic, sympathomimetic, opioid, sedative-hypnotic
Specific common pediatric:
- Acetaminophen: initially asymptomatic → 24-72 hr: nausea, vomiting, RUQ pain → 72-96 hr: hepatotoxicity, jaundice, ↑ AST/ALT
- Iron: phase 1 (vomiting, diarrhea, GI bleed) → phase 2 (apparent improvement) → phase 3 (shock, acidosis, hepatic failure, coma) → phase 4 (recovery or death)
- Lead: chronic: abdominal pain, constipation, anemia, learning/behavior issues, developmental delay; acute high-level: encephalopathy
- Opioid: classic triad — respiratory depression, miosis, ↓ LOC
- Caustic (lye, drain cleaner): oropharyngeal burns, drooling, dysphagia, esophageal injury
- Aspirin: tachypnea, hyperthermia, vomiting, tinnitus, mixed acid-base disturbance
Laboratory Tests
- Bedside glucose
- Electrolytes, anion gap
- BUN/creatinine, LFTs
- Lactate
- Osmolar gap (toxic alcohols)
- Salicylate level, acetaminophen level (always check in unknown ingestion)
- Specific drug levels per suspicion
- Lead level (if suspected)
- Iron level + TIBC
- Urine drug screen
- CBC
- Coagulation (severe)
- ABG
- EKG (TCAs, calcium channel blockers, digoxin)
- Carboxyhemoglobin (CO)
- Methemoglobin
Diagnostic Procedures
- Call Poison Control IMMEDIATELY (1-800-222-1222)
- History — what, when, how much, how, witnessed?
- Pill count of medication bottles
- Identify pills (Poison Control, pharmacy)
- Plant identification
- EKG (rule out cardiotoxicity)
- X-ray (radiopaque substances: iron, lead, batteries, body packing)
- Toxidrome identification
Safety Considerations
- ABCs always first
- Don't induce vomiting (syrup of ipecac NO LONGER recommended)
- Don't give activated charcoal in obtunded patient without airway protection
- Decontamination: irrigate eyes/skin for topical exposures
- NPO until cleared
- Cardiac monitoring, frequent VS
- Pulse ox, GCS
- Identify the substance ASAP
- Assess for suspected NAT/abuse (medication ingestion in infants)
- Suicide risk in adolescents — mental health evaluation
- Lead encephalopathy is medical emergency
Complications
- Aspiration
- Respiratory failure
- Cardiac arrhythmias, arrest
- Seizures
- Hepatotoxicity (APAP, iron)
- Renal failure
- Esophageal stricture (caustics)
- Permanent neurologic damage (lead, anoxia)
- Death
- Post-ingestion behaviors (especially adolescents)
Nursing Care
- ABCs — airway protection priority
- Call Poison Control (1-800-222-1222)
- IV access
- Continuous cardiac, pulse ox, BP monitoring
- Frequent neuro checks (GCS)
- Strict I&O
- Decontamination as appropriate:
- Topical: irrigate skin, eyes copiously
- GI: activated charcoal (1 g/kg) — within 1 hour, if alert and protecting airway, for substances that bind
- NOT for: caustics, iron, lithium, hydrocarbons, alcohols
- Gastric lavage rarely used now
- Whole bowel irrigation: iron, lead, body packers
- Antidotes per substance
- Supportive care
- Document carefully
- Mental health evaluation (adolescents)
- Social work (suspected NAT)
- Education before discharge
- Mandated reporting if applicable
Medications
Antidotes (key ones):
- Acetaminophen → N-acetylcysteine (Mucomyst, Acetadote) — start within 8 hours; check level at 4 hours, plot on Rumack-Matthew nomogram
- Opioids → Naloxone (Narcan)
- Benzodiazepines → Flumazenil (rare — risk of seizures)
- Iron → Deferoxamine (severe iron poisoning)
- Lead → EDTA, succimer (DMSA), dimercaprol (BAL) for chelation
- Organophosphates → Atropine + pralidoxime
- Beta-blockers → Glucagon, calcium
- Calcium channel blockers → Calcium, glucagon, insulin/glucose
- Digoxin → Digoxin immune Fab (Digibind)
- Cyanide → Hydroxocobalamin or amyl/sodium nitrite + sodium thiosulfate
- Methemoglobinemia → Methylene blue
- Warfarin → Vitamin K, FFP
- TCAs → Sodium bicarbonate
- Methanol/ethylene glycol → Fomepizole, ethanol, dialysis
- Sulfonylurea → Octreotide, dextrose
- Salicylates → Sodium bicarb, urinary alkalinization, dialysis
Activated charcoal: 1 g/kg PO/NG (max 50 g), within 1 hour, alert patient
Therapeutic Procedures
- Decontamination (skin, eye irrigation)
- Activated charcoal
- Whole bowel irrigation
- Hemodialysis (some drugs — salicylates, lithium, methanol, ethylene glycol)
- Specific antidotes
- Supportive care (intubation, vasopressors, etc.)
- Endoscopy (caustic ingestion)
- Surgery (body packer, intestinal perforation)
Client Education
Family (post-incident):
- Identify how ingestion occurred
- Eliminate the hazard
- Childproofing: locked cabinets, store out of reach AND sight
- Use childproof containers (effective but not foolproof)
- Keep all medications in original containers
- Don't call medicine "candy"
- Take medications when child not watching
- Keep purses/bags out of reach
- Check grandparent's house (visits are high risk)
- Save Poison Control number: 1-800-222-1222 — post visibly
- Don't induce vomiting unless directed
- If poisoning suspected: call Poison Control immediately
- Bring container/pills to ED
Prevention by age:
- Toddlers: childproofing, supervision, locked storage
- Adolescents: medication storage, mental health, substance education
Specific:
- Acetaminophen: dose carefully by weight, not by age; don't exceed maximum; check pediatric dosing
- Lead: routine screening, address home hazards, water testing, nutrition (calcium, iron, vit C reduce absorption)
- Button batteries: emergency if swallowed (esophageal burn risk) — go to ED immediately
Interprofessional Care
- Poison Control Center (consult)
- Emergency department
- Pediatric ICU
- Pediatric toxicology
- Pediatric GI (for endoscopy)
- Mental health (intentional ingestions)
- Social work
- Child Protective Services if NAT
- Public health (lead investigation)
- Substance abuse counselor (adolescents)
Alterations in Health (Diagnosis)
Aspiration of object into airway, can range from partial obstruction with stridor/wheezing to complete obstruction causing asphyxia. Peak age 1-3 years. Leading cause of accidental death in children under 1 year.
Pathophysiology Related to Client Problem
Object lodges in airway: larynx/trachea (above carina — bilateral problem, often life-threatening) or bronchus (usually right mainstem due to anatomy — unilateral). Obstruction can be partial (passes some air) or complete (no air movement, hypoxia, cardiac arrest).
Health Promotion and Disease Prevention
- Avoid choking hazards in children < 4 years:
- Whole grapes (cut lengthwise)
- Hot dogs (cut lengthwise then bites)
- Hard candy
- Popcorn
- Whole nuts, seeds
- Chunks of meat, raw carrots/celery
- Marshmallows
- Peanut butter (large amounts)
- Small toy parts (buttons, eyes, magnets, button batteries)
- Coins
- Balloons (latex)
- Sit at table while eating; don't walk/run with food in mouth
- Pediatric BLS training for parents/caregivers
- Check toys for small parts (use choke tube)
- Latex balloons highly dangerous — never deflated kept around children
Risk Factors
- Age 6 months - 4 years (peak)
- Toddlers exploring with mouth
- Lack of molars (poor chewing)
- Eating while running, playing, lying down
- Older sibling sharing food/toys
- Distracted by talking, laughing
- Special needs (developmental delay, dysphagia)
- Male sex (slight)
- Holiday/party season (more small objects, hazardous foods)
Expected Findings
Acute (witnessed aspiration):
- Sudden choking, coughing, gagging
- Stridor (high-pitched inspiratory) — upper airway
- Wheezing (lower airway)
- Dyspnea, increased work of breathing
- Cyanosis
- Drooling
- Voice change, aphonia (complete obstruction)
- Anxiety, panic
Complete obstruction:
- Cannot speak, cough, or breathe
- Universal choking sign (hands at throat)
- Cyanosis, color change
- LOC, cardiac arrest within minutes
Chronic (missed/unwitnessed):
- Persistent cough
- Unilateral wheezing
- Recurrent pneumonia (same location)
- Hemoptysis (chronic)
- Fever
- Failure to respond to antibiotics
- Decreased breath sounds on affected side
Triad: cough, wheeze, decreased breath sounds (but only 1/3 of cases have all three)
Laboratory Tests
- Pulse oximetry (often decreased)
- ABG (severe)
- CBC, CRP if chronic with infection
Diagnostic Procedures
- Chest X-ray:
- Most foreign bodies are radiolucent (not visible) — coins/metal visible
- Indirect signs: hyperinflation on affected side, atelectasis, mediastinal shift
- Inspiratory and expiratory films (or decubitus in children) — "air trapping" on affected side during exhalation
- Neck X-ray for upper airway FB
- Bronchoscopy — diagnostic AND therapeutic (rigid bronchoscopy is gold standard for removal)
- Direct laryngoscopy
- Chest CT (rare; specific cases)
Safety Considerations
- Complete obstruction = EMERGENCY
- Pediatric BLS:
- Infant: 5 back blows + 5 chest thrusts (NOT abdominal — liver injury risk)
- Child (≥ 1 year): abdominal thrusts (Heimlich)
- If LOC: CPR, look for object before rescue breaths
- If partial obstruction with effective cough: don't interfere; transport to ED
- Calm patient (anxiety worsens)
- Don't blind sweep mouth (may push deeper)
- Position to optimize breathing (often sitting up)
- Don't delay bronchoscopy for chronic case
- Suspect button battery in any unknown ingestion/aspiration — EMERGENCY (esophageal burn)
Complications
- Complete airway obstruction → asphyxia → cardiac arrest → death
- Hypoxic brain injury
- Pneumonia (especially with prolonged obstruction)
- Atelectasis
- Bronchiectasis (chronic)
- Pneumothorax
- Pneumomediastinum
- Bronchoscopy complications: laryngospasm, bleeding, perforation, infection
- Esophageal/airway burn (button battery)
- Migration of object
- Vocal cord injury
Nursing Care
Acute (partial obstruction):
- Stay calm; calm child
- Allow child to find position of comfort
- Continuous pulse ox
- Provide oxygen as needed
- NPO until bronchoscopy
- IV access
- Don't agitate child
- Prepare for emergent bronchoscopy
Complete obstruction:
- BLS algorithm immediately
- Call for help, activate code
- If LOC: begin CPR
- Direct laryngoscopy by skilled provider — may visualize and remove with Magill forceps
- Surgical airway (cricothyrotomy) if unable to ventilate
Post-bronchoscopy:
- Recovery from anesthesia
- Continuous monitoring (airway swelling possible)
- Watch for stridor, retractions
- Humidified oxygen
- Dexamethasone may be given
- Antibiotic if infection present
- NPO until alert, gag reflex returned
- Discharge education
Medications
- Dexamethasone — reduce airway edema post-procedure
- Racemic epinephrine — laryngeal edema
- Antibiotics if pneumonia/infection
- Pre-procedure: sedation, anesthesia
- Post-procedure: pain management
Therapeutic Procedures
- BLS for complete obstruction
- Rigid bronchoscopy (gold standard) — under general anesthesia
- Flexible bronchoscopy (some cases)
- Direct laryngoscopy
- Tracheostomy (rare; can't intubate)
- Thoracotomy (rare; deeply embedded, complications)
Client Education
Family:
- Pediatric BLS training — encourage all caregivers
- Recognize choking signs
- Universal choking sign (hands at neck) — older children
- Don't interfere with effective cough
- Don't do blind finger sweep
Choking management:
- Infant (< 1 yr):
- 5 back blows (head down, supported on forearm, between scapulae)
- 5 chest thrusts (turn over, head down, 2 fingers on lower sternum)
- Alternate; check mouth between
- If unresponsive: CPR (check mouth before breaths)
- Child (≥ 1 yr):
- Heimlich (abdominal thrusts) — stand behind, fist above navel, 5 thrusts inward and upward
- If unresponsive: CPR (check mouth before breaths)
- Call 911 immediately if anyone unsuccessful or LOC
Prevention:
- Cut grapes, hot dogs lengthwise then small bites
- Avoid hard candy, popcorn, whole nuts, raw carrots/celery, marshmallows in < 4 years
- Sit at table to eat; no eating while running, walking, playing
- Check toys for small parts (test with toilet paper tube — if it fits through, it's a choking hazard for < 3 years)
- Keep small objects (coins, button batteries, magnets) out of reach
- Latex balloons — never deflated near small children
- Inspect toys regularly
Interprofessional Care
- Pediatric ED
- Pediatric ICU
- Pediatric pulmonology (rigid bronchoscopy)
- Pediatric anesthesia
- Pediatric ENT
- Pediatric pulmonary rehab if chronic
- Family education / CPR training
- Public health if pattern of injuries (advocate for safer products)
Alterations in Health (Diagnosis)
Most common autosomal chromosomal disorder; caused by an extra copy of chromosome 21 (full or partial). Three types: nonjugation (95%, sporadic), translocation (4%, may be inherited), mosaicism (1%, milder). Characterized by intellectual disability, distinctive features, and increased risk of multiple medical issues.
Pathophysiology Related to Client Problem
Extra genetic material from chromosome 21 (mostly 21q22 critical region) → multi-system developmental abnormalities. Maternal age is most significant risk factor (although younger mothers have most absolute births of children with DS).
Health Promotion and Disease Prevention
- Genetic counseling for couples at risk
- Prenatal screening: maternal serum (PAPP-A, free beta-hCG, AFP, estriol, inhibin A); ultrasound (nuchal translucency); cell-free fetal DNA (highest sensitivity, 10 weeks)
- Diagnostic testing: CVS (10-13 wk) or amniocentesis (15-20 wk)
- Folic acid before/during pregnancy
- AAP Down Syndrome Health Supervision schedule for routine care
- Early intervention services starting in infancy
Risk Factors
- Advanced maternal age (esp. ≥ 35 years)
- Previous child with Down syndrome (1% recurrence)
- Translocation carrier parent (higher recurrence)
- Family history
Expected Findings
Distinctive features (varies):
- Flat facial profile
- Upward-slanting palpebral fissures
- Epicanthal folds
- Brushfield spots (white speckles on iris)
- Low-set ears
- Small/flat nasal bridge
- Protruding tongue (relative macroglossia)
- Short neck
- Single transverse palmar crease (simian)
- Short, broad hands with short 5th finger curving inward (clinodactyly)
- Wide gap between 1st and 2nd toes ("sandal gap")
- Hypotonia ("floppy baby")
- Loose joints, hyperflexibility
- Brachycephaly (flat occiput)
- Short stature
Developmental:
- Intellectual disability (mild to moderate typically)
- Speech and language delays
- Delayed motor milestones
- Friendly, social temperament typically
Associated medical conditions:
- Congenital heart disease (40-50%) — AV canal defect, VSD, ASD
- GI: duodenal atresia, Hirschsprung disease, celiac, GERD, imperforate anus
- Endocrine: hypothyroidism (common), DM
- Hematologic: leukemia (10-20× ↑ risk — ALL, AML especially under age 5)
- Atlantoaxial instability (cervical spine — sports caution)
- Hearing loss (50-70%)
- Vision: refractive errors, strabismus, cataracts (15%)
- Obstructive sleep apnea
- Immune deficiency (recurrent infections)
- Early-onset Alzheimer disease (high risk by 40s-50s)
- Obesity
- Skin issues
- Periodontal disease
Laboratory Tests
- Karyotype (confirms diagnosis)
- FISH for rapid result
- Newborn screening (TSH baseline)
- CBC at birth, 6 months, annually (leukemia screening)
- Thyroid function (TSH) at birth, 6 months, 12 months, annually
- Celiac screening (TTG IgA, total IgA) at age 2+, periodically
Diagnostic Procedures
- Clinical features at birth + karyotype confirms
- Prenatal: NIPT, CVS, amniocentesis
- Echocardiogram at birth (CHD screening)
- Hearing test (newborn, then annually)
- Eye exam (annual)
- Dental exam (every 6 months from age 2)
- Cervical spine X-rays per AAP guidelines (especially before sports — atlantoaxial instability)
- Sleep study if obstructive sleep apnea signs
- Growth charts (DS-specific growth curves)
Safety Considerations
- Cardiac evaluation early
- Hearing/vision screening (developmental impact)
- Atlantoaxial instability — neurologic signs (neck pain, weakness, ↓ activity tolerance, ↑ DTRs); MRI if symptoms; sports clearance if normal
- Aspiration precautions (hypotonia, dysphagia)
- Constipation prevention (hypotonia + GI issues)
- Watch for leukemia signs (bleeding, bruising, infection)
- Avoid neck hyperflexion in procedures (intubation, anesthesia)
- Pediatric resuscitation considerations
- Bullying, exploitation risk
Complications
- Cardiac complications (heart failure)
- Pulmonary hypertension
- Recurrent infections (especially respiratory)
- Hearing loss → speech/language delay
- Vision loss
- Leukemia
- Hypothyroidism
- Sleep apnea
- Atlantoaxial subluxation
- Obesity
- Diabetes
- Early-onset Alzheimer disease
- Premature aging
- Reduced life expectancy (improving — now 60+ years)
- Psychosocial impact on family
Nursing Care
- Family-centered care at birth — sensitive notification, support
- Encourage attachment and bonding
- Promote feeding (may need consultation — sucking weakness, tongue thrust)
- Position upright after feeds
- Cardiac assessment
- Routine screenings per schedule
- Early intervention referral
- Speech, OT, PT
- Anticipatory guidance (DS-specific milestones)
- Family resources, support groups
- Vision and hearing checks
- Dental care
- Nutrition counseling
- Exercise promotion (obesity, fitness)
- Vaccinations on schedule
- Address sleep, behavior
- School coordination, IEP
- Transition planning (adolescence)
Medications
- Treatment of comorbidities (e.g., levothyroxine if hypothyroidism, cardiac meds if CHD)
- Vaccines: routine schedule (some live vaccines may be modified if immunocompromised)
- Treatment of leukemia if it develops
- No specific medication for DS itself
Therapeutic Procedures
- Early intervention — birth to 3 years (IDEA Part C)
- Special education — IEP (Part B)
- Speech, OT, PT
- Cardiac surgery if CHD
- GI surgery if duodenal atresia, etc.
- ENT for hearing/sleep apnea
- Annual screening (cardiac, thyroid, vision, hearing, cervical spine)
- Dental care
- Vocational training/transition (adolescence)
- Augmentative communication if needed
Client Education
- Down syndrome is a CHROMOSOMAL condition — not a disease; varies in severity
- Life expectancy and quality of life have improved dramatically with appropriate care
- Early intervention significantly improves outcomes
- Encourage attachment, bonding, normal experiences
- Follow AAP Health Supervision schedule for DS
- Recognize signs of comorbidities (cardiac symptoms, hearing issues, thyroid issues, leukemia warning signs, atlantoaxial instability)
- Watch for changes that may indicate medical problems (since communication may be limited)
- Promote independence and skill development
- School: IEP, inclusive education when possible
- Address sexuality, relationships (adolescents)
- Transition planning: post-school, employment, housing, supports
- Family support, sibling support, respite
- Avoid hyperextension of neck (atlantoaxial)
- Wear medical alert ID if atlantoaxial instability or other issues
- Resources: NDSS (National Down Syndrome Society), NDSC (National Down Syndrome Congress), Local DS groups
- Person-first language: "child with Down syndrome" not "Down's child"
Interprofessional Care
- Developmental pediatrician or DS clinic
- Pediatric cardiology
- Pediatric endocrinology
- Pediatric ENT (audiology, sleep apnea)
- Pediatric ophthalmology
- Pediatric GI
- Pediatric neurology
- Pediatric hematology/oncology
- Speech-language pathologist
- Occupational therapist
- Physical therapist
- Dentist
- Nutritionist
- Special education
- Social work
- Genetic counseling
- DS support organizations
Alterations in Health (Diagnosis)
Involuntary urination in a child ≥ 5 years old (developmentally), at least 2 times per week for at least 3 months. Types: nocturnal (night, most common), diurnal (daytime), or both. Primary: never been dry for 6 consecutive months. Secondary: dry for ≥ 6 months then begins wetting again. Most children outgrow without treatment.
Pathophysiology Related to Client Problem
Multifactorial: delayed maturation of bladder control, small functional bladder capacity, ↑ urine production at night (low ADH at night), heavy sleeper (decreased arousal to bladder fullness), genetic predisposition. Secondary enuresis often has identifiable cause.
Health Promotion and Disease Prevention
- Reassurance — most children outgrow
- Avoid shaming, punishment
- Limit fluids 2 hours before bed (but not entire evening)
- Empty bladder before bed
- Treat constipation (often coexists)
- Manage stress, address psychosocial issues
- Sleep hygiene
- Don't pressure for early toilet training
Risk Factors
- Age (peak 5-7 years; decreases with age)
- Male sex (2× more common — primary enuresis)
- Family history (strong genetic component — 70% if both parents had it; 40% if one)
- Heavy sleeper
- Constipation (impacted stool affects bladder)
- UTI
- Diabetes (mellitus or insipidus)
- Stress (new sibling, divorce, school start, abuse)
- OSA (obstructive sleep apnea)
- ADHD (associated)
- Spinal cord abnormality
- Anatomic abnormalities (rare)
- Developmental delay
Expected Findings
Primary nocturnal enuresis (most common):
- Bedwetting only at night
- Otherwise normal voiding pattern
- Heavy sleeper
- No daytime symptoms
Diurnal enuresis (concerning):
- Daytime wetting
- Urinary urgency, frequency
- Holding maneuvers (squatting, leg crossing)
- Often associated with UTI or anatomic/neurologic issue
Secondary enuresis (concerning):
- Was dry for ≥ 6 months → resumed wetting
- Look for underlying cause: UTI, diabetes, abuse, stress, constipation
Red flags requiring workup:
- Diurnal symptoms
- Polyuria, polydipsia, polyphagia (diabetes)
- Painful urination
- Fever
- Constipation, soiling
- Gait abnormalities, back pain
- Snoring, sleep apnea symptoms
- Sudden behavior change (abuse possible)
Laboratory Tests
- Urinalysis (always — rule out UTI, diabetes — glucose, specific gravity)
- Urine culture if UTI suspected
- Bloodwork only if clinical suspicion (e.g., diabetes, renal disease)
Diagnostic Procedures
- Thorough history and physical (especially abdomen, back, genitalia, neurologic)
- Voiding diary (volume, frequency, urgency, wet/dry)
- Urinalysis
- Imaging usually NOT needed for typical primary nocturnal enuresis
- Ultrasound (renal/bladder) if anatomic concern, abnormal exam, or daytime symptoms
- VCUG, uroflowmetry if anatomic abnormality
- MRI spine if neurologic findings (suspect tethered cord, occult spina bifida)
- Polysomnography if OSA suspected
Safety Considerations
- Address psychosocial impact (embarrassment, social isolation, bullying)
- NEVER punish or shame
- Address coexisting constipation (very common, may be the key)
- Rule out medical causes
- Screen for abuse if sudden secondary enuresis without obvious cause
- Monitor for desmopressin side effects (hyponatremia — rare but serious)
- Watch for misuse of alarm (not used appropriately)
Complications
- Psychosocial: low self-esteem, anxiety, depression, social withdrawal, bullying
- Skin irritation, infections (chronic wetness)
- Sleep disturbance (child and family)
- Family stress, sibling teasing
- Limited social activities (can't do sleepovers, camp)
- UTI risk
- Hyponatremia (if water intoxication while on desmopressin)
Nursing Care
- Reassuring, non-judgmental approach
- Comprehensive history
- Physical exam
- Voiding diary education
- Behavioral interventions first-line
- Bladder training
- Treat constipation if present (laxatives, fiber, hydration)
- Address psychosocial impact
- Family counseling
- Reward systems (sticker charts for dry nights — focus on positive)
- Avoid punishment
- Child as active participant (responsibility helps)
- Protect bed (mattress cover, layered sheets)
- Limited fluids in evening (but not entire evening)
- Empty bladder before bed
- Daytime: regular voiding schedule
- Address triggers (stress)
Medications
First-line is BEHAVIORAL (alarm)
Desmopressin (DDAVP):
- Synthetic ADH — reduces urine production
- Oral tablet (NOT nasal spray — withdrawn for enuresis due to hyponatremia)
- Take at bedtime
- Effective for ~70%
- Often used for sleepovers/camp (short-term)
- Risk: hyponatremia (rare but can be severe — limit fluid intake at night)
- Watch for water intoxication
Imipramine (TCA):
- Less commonly used due to side effects
- Cardiac toxicity if overdose
- Effective in 50%
- Sedation, dry mouth, anxiety
Anticholinergics (oxybutynin, tolterodine):
- For overactive bladder, daytime symptoms
- Side effects: dry mouth, constipation, blurred vision
Therapeutic Procedures
- Enuresis alarm (urine alarm) — FIRST-LINE; ~70% effective; takes 8-12 weeks; long-lasting effect; requires family commitment
- Bladder training exercises
- Treat constipation
- Treat OSA if present
- Counseling for psychosocial impact
- Bell-and-pad alarm
Client Education
Family:
- Reassure — enuresis is NORMAL up to age 5-6 and common up to age 10
- Strong genetic component (often runs in families)
- NEVER punish or shame — counterproductive and harmful
- Be patient — most children outgrow without treatment
- Address embarrassment, support self-esteem
- Bedwetting is involuntary, NOT laziness
Behavioral measures:
- Limit fluids 2 hours before bed (not earlier in evening — child needs hydration)
- Avoid caffeine
- Empty bladder right before bed
- Wake child to void midnight (some find helpful)
- Regular daytime voiding (every 2-3 hours)
- Treat constipation (high fiber, fluids, stool softener if needed)
- Reward dry nights (sticker chart) — focus on positive
- Child participates in cleanup (responsibility, not punishment)
- Protective mattress cover
If using alarm:
- Takes weeks to work (8-12 weeks typical)
- Continue until 14 consecutive dry nights
- Whole family commitment
- Initially parents help child wake
- Pads or briefs may be needed during use
If using DDAVP:
- LIMIT FLUIDS at night (water intoxication risk)
- Take 1 hour before bed
- Discontinue during illness with vomiting/diarrhea
- Take periodic breaks to see if outgrown
Sleepover/camp tip:
- Talk with child openly
- Consider DDAVP for short-term use
- Bring pull-ups discreetly if needed
- Speak with adult chaperones
Interprofessional Care
- Pediatric primary care
- Pediatric urology (if anatomic concern)
- Pediatric nephrology (renal disease)
- Pediatric gastroenterology (constipation)
- Pediatric psychology (psychosocial impact)
- School nurse
- Sleep specialist (if OSA)
- Endocrinology (if diabetes)
Alterations in Health (Diagnosis)
Failure of the ductus arteriosus (fetal vessel connecting pulmonary artery to aorta) to close after birth. Normally closes within 24-72 hours of birth, completely by 2-3 weeks. Left-to-right shunt (acyanotic CHD).
Pathophysiology Related to Client Problem
In fetal circulation, ductus arteriosus bypasses lungs (which aren't used). After birth: ↑ O2, ↓ prostaglandins → ductus normally closes. If patent: L→R shunt from high-pressure aorta to lower-pressure pulmonary artery → ↑ pulmonary blood flow → pulmonary congestion, ↑ pulmonary pressures, eventual heart failure. If reverses (Eisenmenger) → cyanosis.
Health Promotion and Disease Prevention
- Adequate prenatal care
- Avoid prematurity if possible
- Avoid in utero exposures: rubella (TORCH), congenital infections
- Genetic counseling if family history
- Folic acid in pregnancy
- Routine newborn assessment for murmurs
Risk Factors
- Prematurity (very common in preterm; immature smooth muscle response)
- Female sex (2× more common)
- High altitude births
- Congenital rubella (TORCH)
- Family history of CHD
- Down syndrome and other genetic syndromes
- Maternal smoking
Expected Findings
Small PDA: often asymptomatic
Moderate-large PDA:
- Continuous "machinery" murmur at upper left sternal border — heard during systole AND diastole — pathognomonic
- Loud S2 (with pulmonary hypertension)
- Bounding peripheral pulses (wide pulse pressure)
- Hyperactive precordium
- Tachycardia
- Tachypnea
- Diaphoresis with feeds
- Poor feeding, fatigue
- Failure to thrive
- Frequent respiratory infections
- Signs of heart failure (especially in preemies): respiratory distress, hepatomegaly
In preterm infants:
- Apnea, bradycardia
- ↑ ventilator requirements
- Pulmonary hemorrhage
- Difficulty weaning from ventilator
- NEC risk increased
Laboratory Tests
- CBC
- BNP (heart failure)
- ABG
- Lactate (severe)
Diagnostic Procedures
- Echocardiogram — definitive diagnosis; shows shunt size, direction, pulmonary pressures
- Cardiac auscultation (classic continuous murmur)
- Chest X-ray: cardiomegaly, ↑ pulmonary vascularity
- EKG: LVH, sometimes biventricular hypertrophy
- Pulse oximetry: usually normal (or diff between upper and lower extremities in late presentation)
- Cardiac catheterization (rare — done with closure)
Safety Considerations
- Monitor for signs of heart failure
- Adequate caloric intake (↑ metabolic demand)
- Avoid fluid overload
- Maintain pulse oximetry
- Position for comfort, ease of breathing
- Monitor for pulmonary hypertension
- Endocarditis prophylaxis NOT routinely required (per AHA — only specific high-risk lesions)
- Avoid prostaglandin (which keeps ductus open) unless ductal-dependent lesion (different scenario)
Complications
- Heart failure
- Pulmonary hypertension
- Failure to thrive
- Recurrent respiratory infections
- Pulmonary edema, hemorrhage (especially preemies)
- NEC (preemies)
- Endocarditis (rare)
- Eisenmenger syndrome (irreversible pulmonary HTN with shunt reversal → cyanosis — late, untreated cases)
- Aneurysm of ductus
Nursing Care
Monitoring:
- Vital signs frequently
- Continuous cardiorespiratory monitoring
- Pulse oximetry
- Auscultate heart and lungs frequently
- Palpate peripheral pulses
- Assess for heart failure signs
- Daily weights
- Strict I&O
Feeding:
- Small frequent feeds
- Allow rest periods
- Concentrated formula (more calories per oz)
- NG feeds if poor oral intake
- Position upright (preemies)
Other:
- Conserve energy (cluster care)
- Promote rest
- Maintain neutral thermal environment
- Administer medications as ordered
- Pre/postoperative care
- Family support and education
Medications
Pharmacologic closure (preemies, neonates):
- Indomethacin — NSAID inhibits prostaglandin → closes ductus
- Ibuprofen — alternative
- Acetaminophen — newer option, fewer side effects
- Watch for: renal dysfunction, GI bleed, ↓ platelets, hyperbilirubinemia, NEC, decreased cerebral perfusion
Heart failure management:
- Diuretics (furosemide)
- Digoxin
- ACE inhibitors
- Fluid restriction
Endocarditis prophylaxis:
- NOT routinely needed for PDA per AHA
Therapeutic Procedures
- Watchful waiting for small asymptomatic PDA (may close spontaneously — most by age 1)
- Pharmacologic closure (preemies): indomethacin, ibuprofen, acetaminophen
- Cardiac catheterization closure (preferred when feasible) — device closure (coil or occluder) — older children and adults
- Surgical ligation (thoracotomy) — small/preterm infants or complex anatomy
- Video-assisted thoracoscopic surgery (VATS)
Client Education
- PDA is a common congenital heart condition, especially in premature infants
- Small PDAs often close on their own
- Larger PDAs require treatment to prevent heart and lung problems
- Closure options: medication (preemies), catheter-based, surgery
- Excellent long-term prognosis with successful closure
- Recognize signs of heart failure: poor feeding, sweating with feeds, fast breathing, fatigue
- Adequate nutrition important
- Routine immunizations including RSV prophylaxis (palivizumab) for preemies if eligible
- Follow up with cardiology
- Endocarditis precautions discussed (mostly not needed)
- Physical activity restrictions depend on severity (most cleared after closure)
- Genetic counseling if syndromic or recurrent in family
- Post-procedure: avoid heavy lifting, restrict activity per cardiology
Interprofessional Care
- Pediatric cardiology
- Pediatric cardiac surgery
- Neonatologist (for preterm)
- Pediatric ICU
- Interventional cardiology
- Cardiac catheterization lab
- NICU team
- Nutritionist
- Social work
- Genetic counselor (if syndromic)
Alterations in Health (Diagnosis)
Inadequate secretion of growth hormone (GH) from the anterior pituitary, resulting in short stature and delayed growth in children. Can be congenital (genetic, structural pituitary abnormalities) or acquired (tumors, radiation, trauma, infection, idiopathic). Diagnosis based on clinical features + GH stimulation testing.
Pathophysiology Related to Client Problem
Reduced GH secretion → ↓ insulin-like growth factor 1 (IGF-1) production by liver → ↓ growth of bone, cartilage, and soft tissue. May involve other pituitary hormones (panhypopituitarism). Genetic forms include GH gene mutations, GHRH receptor defects, GHRH-N defects.
Health Promotion and Disease Prevention
- Early recognition of short stature
- Track growth at well-child visits — plot on growth chart
- Investigate any child crossing percentiles downward
- Genetic counseling if family history
- Adequate nutrition
- Prompt evaluation of CNS lesions or surgery
Risk Factors
- Family history
- Congenital pituitary abnormalities (e.g., empty sella, midline defects)
- Birth trauma, breech delivery
- Brain tumors (craniopharyngioma, germinoma)
- Cranial radiation therapy
- Head trauma
- CNS infection (meningitis, encephalitis)
- Hydrocephalus
- Genetic syndromes (Turner, Prader-Willi)
- Septo-optic dysplasia
- Idiopathic (most common)
Expected Findings
- Short stature — height < 3rd percentile or < 2 SD below mean for age and sex
- Decelerating growth velocity — height crossing downward through percentiles
- Delayed bone age (X-ray of left hand/wrist)
- Normal body proportions (in isolated GHD)
- Increased subcutaneous fat (especially trunk)
- Decreased muscle mass
- Delayed dentition
- Delayed puberty
- Hypoglycemia (especially in neonates with GHD)
- Doll-like face (rounded, immature features)
- Underdeveloped facial bones, depressed nasal bridge
- High-pitched voice
- Micropenis (some)
- If acquired (tumor): headaches, vision changes, polyuria/polydipsia (DI), other pituitary deficits
Laboratory Tests
- IGF-1 and IGFBP-3 levels (screening — low in GHD)
- Random GH not helpful (pulsatile secretion)
- GH stimulation testing: arginine, insulin, clonidine, glucagon, L-DOPA → measure GH response (failure to rise indicates deficiency)
- Free T4, TSH (rule out hypothyroidism — causes short stature)
- Cortisol (rule out other pituitary deficiency)
- Karyotype (rule out Turner in girls)
- Celiac screening
- CBC, ESR (rule out chronic disease)
- BUN/Cr (rule out renal disease)
- Newborn screen for hypothyroidism, hypoglycemia
Diagnostic Procedures
- Accurate growth charts — plot serial measurements
- Bone age X-ray (hand/wrist)
- GH stimulation testing (definitive)
- MRI of brain/pituitary (rule out tumor, anatomic abnormalities)
- Detailed history and physical
- Genetic testing for syndromes
- Mid-parental height calculation
Safety Considerations
- Watch for hypoglycemia in neonates with GHD
- Address psychosocial impact of short stature
- Monitor for tumor recurrence (acquired GHD)
- Side effects of GH therapy (uncommon)
- Address bullying
- Don't treat with GH unless documented deficiency (controversies with GH for idiopathic short stature)
Complications
- Permanently short adult stature (without treatment)
- Hypoglycemia (especially neonatal)
- Psychosocial: poor self-esteem, depression, bullying, social isolation
- Decreased bone mineral density
- Cardiovascular disease (in adult with untreated GHD)
- Delayed puberty
- Side effects of GH therapy (uncommon): pseudotumor cerebri, slipped capital femoral epiphysis (SCFE), scoliosis worsening, insulin resistance, edema
- Tumor recurrence (if acquired)
- Other pituitary hormone deficiencies developing over time
Nursing Care
- Accurate measurement of height (stadiometer) and weight at each visit
- Plot on growth chart
- Calculate growth velocity
- Comprehensive history including family heights, birth history, nutrition, chronic illness
- Coordinate evaluations (endocrine, neuroimaging)
- Assist with GH stimulation testing
- Teach injection technique
- Assess and address psychosocial impact
- Monitor growth response on treatment
- Monitor for side effects
- Coordinate with school for accommodations if needed
- Support self-esteem, advocate against bullying
- Document growth response (cm/year)
Medications
Recombinant Human Growth Hormone (rhGH; somatropin):
- Subcutaneous injection daily (or weekly newer formulations)
- Continued until: epiphyseal closure, adult height attained, or growth velocity < 2 cm/year
- Rotate injection sites (abdomen, thigh, upper arm, buttock)
- Refrigerate
- Brand names: Genotropin, Humatrope, Norditropin, Saizen, Nutropin, Omnitrope, Zomacton
- Dosing: ~0.025-0.05 mg/kg/day (varies by indication)
Hormone replacement (if panhypopituitarism):
- Levothyroxine (hypothyroidism)
- Hydrocortisone (adrenal insufficiency)
- Sex hormones at appropriate age (delayed puberty)
- DDAVP (diabetes insipidus)
Therapeutic Procedures
- GH replacement therapy (daily SC injection)
- Tumor management (surgery, radiation, chemotherapy)
- Manage other pituitary deficits
- Nutrition optimization
- Psychological support
- School support
Client Education
Family:
- GH deficiency is a treatable condition
- Treatment is daily injections — can be done at home
- Treatment can continue for many years (until growth complete)
- Catch-up growth typically seen in first 1-2 years of therapy
- Maximum potential growth — won't exceed genetic potential
- Final adult height depends on duration of treatment, age at start, dose, growth potential
- Importance of adherence to daily injections
- Rotate injection sites
- Refrigerate medication; protect from light
- Don't shake vigorously
Injection technique:
- Inject into subcutaneous fat (abdomen, thigh, upper arm, buttock)
- Pen device or syringe
- Rotate sites
- Inject at bedtime (mimics natural release)
- Use sharps disposal container
Monitoring:
- Endocrine visits every 3-6 months
- Growth velocity assessment
- IGF-1 levels
- Bone age periodically
- Watch for: headaches, vision changes, hip/knee pain (SCFE), scoliosis, weight gain
- Annual eye exam (pseudotumor cerebri risk)
Psychosocial:
- Treat child age-appropriately, not height-appropriately
- Build self-esteem
- Address bullying
- School support
- Connect with support groups (Magic Foundation, Human Growth Foundation)
Interprofessional Care
- Pediatric endocrinology (primary management)
- Pediatric primary care (growth monitoring)
- Pediatric neurology (if CNS pathology)
- Pediatric neurosurgery (tumors)
- Pediatric radiation oncology
- Pediatric ophthalmology
- Nutritionist
- Psychology, social work
- School coordinator
- Genetic counselor (if syndromic)
- Support organizations
Alterations in Health (Diagnosis)
Common pilosebaceous unit disorder of adolescence (and pre-adolescence). Characterized by comedones, papules, pustules, nodules, cysts. Can cause significant psychosocial impact. Severity ranges from mild (comedonal) to severe (nodulocystic with scarring).
Pathophysiology Related to Client Problem
Four factors: 1. Increased sebum production (androgen-stimulated, esp puberty); 2. Follicular hyperkeratinization (abnormal keratin shedding → blockage → comedone); 3. Cutibacterium acnes (formerly Propionibacterium acnes — bacterial proliferation); 4. Inflammation. Open comedones (blackheads) and closed (whiteheads) can develop into inflammatory lesions.
Health Promotion and Disease Prevention
- Education about acne pathogenesis (especially myth-busting)
- Regular gentle cleansing (not over-scrubbing)
- Don't pick/squeeze (worsens, causes scarring)
- Use non-comedogenic products
- Address sun protection
- Healthy diet (some evidence for dairy, high glycemic index foods)
- Manage stress
- Encourage early treatment to prevent scarring
Risk Factors
- Adolescence (peak age)
- Family history
- Male sex (more severe, longer duration)
- Female sex (more flares around menses, PCOS link)
- Hormonal: puberty, PCOS, menstrual cycle
- Comedogenic cosmetics, hair products
- Friction/pressure (helmets, masks, backpack straps)
- Some medications (corticosteroids, lithium, anticonvulsants)
- Stress
- Dairy, high glycemic index diet (some evidence)
- Humidity, heat
- Smoking
Expected Findings
Lesion types:
- Non-inflammatory:
- Open comedones (blackheads) — open follicle, oxidized melanin
- Closed comedones (whiteheads) — closed follicle
- Inflammatory:
- Papules — small, red, raised
- Pustules — papule with visible pus ("pimples")
- Nodules — large, painful, deep
- Cysts — large, painful, pus-filled, often scar
- Post-inflammatory hyperpigmentation
- Scarring (atrophic — "ice pick," "boxcar," "rolling"; hypertrophic; keloid)
Distribution: face, upper chest, back, shoulders (areas of high sebaceous gland density)
Severity:
- Mild: mostly comedones, few papules/pustules
- Moderate: more numerous papules and pustules
- Severe: numerous nodules and cysts, scarring
Variants:
- Neonatal acne (resolves spontaneously)
- Infantile acne (rare, may need treatment)
- Acne fulminans (severe, systemic)
- Hidradenitis suppurativa (axillary, groin, inflammatory)
Laboratory Tests
- Generally NONE needed for diagnosis (clinical)
- If hormonal cause suspected (PCOS, hirsutism, irregular menses): total/free testosterone, DHEA-S, LH/FSH
- Pregnancy test before isotretinoin (iPLEDGE program)
- Baseline LFTs, lipids before isotretinoin; monthly during
- Baseline CBC for some treatments
Diagnostic Procedures
- Clinical diagnosis
- Inspect all affected areas (face, chest, back)
- Categorize lesion types
- Assess severity
- Evaluate psychosocial impact
- Consider endocrine evaluation in atypical cases
Safety Considerations
- Topical retinoids: pregnancy category C (some categorize as X)
- Isotretinoin: STRONG TERATOGEN — pregnancy category X; iPLEDGE program mandatory; 2 forms of contraception or abstinence required
- Mental health monitoring on isotretinoin (depression, suicide — controversial association)
- Photosensitivity with retinoids, doxycycline
- Liver function monitoring on isotretinoin, tetracyclines
- Combined oral contraceptives — VTE risk
- Spironolactone — hyperkalemia, monitor potassium
- Address psychosocial impact, depression, anxiety, self-esteem
- Don't use tetracyclines in children < 8 years (tooth discoloration)
Complications
- Scarring (permanent — atrophic or hypertrophic)
- Post-inflammatory hyperpigmentation
- Psychosocial: depression, anxiety, social withdrawal, low self-esteem, suicidal ideation
- Bacterial superinfection
- Adverse effects of medications
- Isotretinoin: teratogenicity, ↑ triglycerides, hepatotoxicity, dry skin/eyes/lips, IBD (controversial)
Nursing Care
- Assess severity, lesion types, distribution
- Assess psychosocial impact (very important)
- Education on pathogenesis (correct myths)
- Treatment plan based on severity
- Topical medication application techniques
- Cleansing routine
- Avoid picking, squeezing
- Use non-comedogenic, oil-free products
- Sun protection (sunscreen — especially with retinoids, doxycycline)
- Monitor treatment response (takes weeks-months)
- Monitor for side effects
- Adolescent confidentiality
- Address mental health, especially on isotretinoin
- Coordinate with iPLEDGE program if isotretinoin
- Support self-esteem
- Encourage adherence to treatment
Medications
Mild (comedonal):
- Topical retinoid: tretinoin, adapalene, tazarotene — first-line; apply at night; expect initial flare-up
- ± Benzoyl peroxide
Moderate (inflammatory):
- Topical retinoid + topical antimicrobial (benzoyl peroxide, topical antibiotic — clindamycin, erythromycin)
- Oral antibiotic (doxycycline, minocycline, sarecycline — children > 8 years)
- Combined oral contraceptive (females)
- Spironolactone (females)
Severe (nodulocystic):
- Isotretinoin (Accutane) — single most effective treatment
- 0.5-1 mg/kg/day; cumulative dose 120-150 mg/kg
- Treatment course 4-6 months
- iPLEDGE program required (REMS) — registered prescribers, pharmacies, patients
- Pregnancy test monthly (females)
- 2 forms of contraception or abstinence
- Monthly labs: CBC, LFTs, lipids
- Watch for: severe dryness (skin, eyes, lips), ↑ triglycerides, ↑ LFTs, mood changes, suicide (controversial association — monitor), IBD (controversial), photosensitivity, sun protection
- NO blood donation during and 1 month after
- NO waxing, dermabrasion during and 6 months after
- NO tetracyclines concurrent (pseudotumor cerebri)
Topical adjuvants:
- Azelaic acid, salicylic acid, dapsone gel
- Sulfur preparations
Therapeutic Procedures
- Topical and oral medications
- Comedone extraction (by professional)
- Light/laser therapy (some clinics)
- Chemical peels
- Intralesional steroid injection (for large cysts)
- Skin resurfacing for scarring (after acne controlled)
- Fillers for atrophic scars
- Microneedling
Client Education
Myth-busting:
- Acne is NOT caused by poor hygiene
- Acne is NOT caused by chocolate per se (high-glycemic diet may have role)
- Acne is NOT caused by greasy food
- Tanning does NOT cure acne (worsens hyperpigmentation, ↑ skin cancer)
- Toothpaste, witch hazel — not effective and may irritate
Skin care:
- Wash 2× daily with gentle non-medicated cleanser; don't over-scrub
- Use lukewarm water
- Pat dry (don't rub)
- Use non-comedogenic, oil-free moisturizer (yes, even acne-prone skin needs moisture)
- Non-comedogenic makeup if used
- Wash makeup off before bed
- Clean phones, pillowcases
- Don't pick, squeeze, scratch lesions (worsens, scars)
- Wash hair regularly; keep off face
- Wash after sweating
Sun protection:
- Sunscreen daily SPF 30+ (non-comedogenic)
- Especially with retinoids, tetracyclines (photosensitivity)
Medication adherence:
- Improvement takes 6-12 weeks
- Apply topicals to entire affected area, not just lesions
- Use small amount (pea-sized)
- Initial worsening may occur
- Use sunscreen with retinoids
- Take antibiotics on empty stomach (most), full glass water
- Doxycycline can cause photosensitivity — sunscreen, protective clothing
- Don't lie down for 30 min after doxycycline (esophageal irritation)
Isotretinoin specific:
- STRICT contraception (2 forms) or abstinence — life-altering teratogen
- iPLEDGE: monthly pregnancy tests, online quizzes
- Expect: dryness everywhere (lips, eyes, nose, skin)
- Lip balm constantly
- Don't donate blood
- No waxing, dermabrasion
- Take with food (fat helps absorption)
- Avoid sun, tanning
- Monthly labs
- Mental health watch — speak up about mood
- Course is 4-6 months
Psychosocial:
- Acne is real, treatable medical condition — not just cosmetic
- Significant impact on self-esteem, social life
- Don't wait to treat (prevents scarring)
- Recognize signs of depression
- Build self-esteem
Interprofessional Care
- Pediatric primary care
- Pediatric dermatology (severe or refractory)
- Adolescent medicine
- Endocrinology (if hormonal cause)
- Mental health
- Pharmacist (medication management)
- iPLEDGE coordinator (isotretinoin)
Alterations in Health (Diagnosis)
Chronic viral infection caused by Human Immunodeficiency Virus (HIV-1 most common). HIV attacks CD4 T-cells → progressive immune deficiency → opportunistic infections and malignancies (AIDS). With early antiretroviral therapy (ART), HIV is now a manageable chronic disease. Most pediatric HIV is perinatally transmitted; perinatal transmission has dropped dramatically with prevention protocols.
Pathophysiology Related to Client Problem
HIV enters CD4+ T-cells via CD4 receptor + co-receptor (CCR5 or CXCR4) → reverse transcription → integration into host DNA → viral replication → CD4 destruction → progressive immunosuppression. Without treatment: CD4 declines, opportunistic infections, AIDS, death. With ART: viral suppression, immune preservation, near-normal lifespan.
Health Promotion and Disease Prevention
- Prevent perinatal transmission: universal prenatal HIV testing; ART for HIV+ pregnant women (zidovudine + others); cesarean if viral load > 1000; avoid breastfeeding in developed countries; IV zidovudine during labor; infant ART prophylaxis 4-6 weeks
- Universal precautions in healthcare
- Safe sex education adolescents
- Needle safety; no sharing
- PrEP (pre-exposure prophylaxis) for high-risk adolescents
- PEP (post-exposure prophylaxis) within 72 hours of exposure
- Blood supply screening
- Routine HIV screening per CDC (universal in adolescents ≥13)
Risk Factors
- Perinatal: HIV+ mother (most pediatric cases)
- Adolescent: unprotected sex (especially MSM), multiple partners, STI history
- IV drug use (sharing needles)
- Blood transfusions (pre-1985)
- Sexual abuse
- Healthcare worker needlestick
- Tattoos/piercings with contaminated equipment
- Co-infection with other STIs increases risk
Expected Findings
Perinatally infected infants:
- Often asymptomatic at birth
- Symptoms typically emerge at 3-6 months
- Failure to thrive
- Recurrent infections (otitis, pneumonia, oral candidiasis)
- Lymphadenopathy, hepatosplenomegaly
- Developmental delay or regression
- Chronic diarrhea
- Recurrent fever
- Eczematous rash
- Parotitis
Older children/adolescents (acquired):
- Acute retroviral syndrome 2-4 weeks post-exposure: fever, lymphadenopathy, pharyngitis, rash, malaise (mono-like)
- Asymptomatic latent phase (years)
- Symptomatic: weight loss, fevers, night sweats, fatigue
- Opportunistic infections (when CD4 drops): PCP (Pneumocystis jirovecii), MAC, candidiasis, CMV, toxoplasmosis, cryptosporidium, TB
- Malignancies: lymphoma, Kaposi sarcoma (rare in pediatrics)
- HIV encephalopathy
- Lymphoid interstitial pneumonia (pediatric-specific)
Laboratory Tests
- Infants < 18 months: HIV DNA PCR or HIV RNA PCR (not antibody — maternal antibodies cross placenta) — test at birth, 2 weeks, 1-2 months, 4-6 months
- Children ≥ 18 months and adolescents: HIV antibody/antigen combination test; confirmation with PCR or differentiation assay
- CD4 count and percentage (immune status)
- HIV viral load (treatment monitoring)
- HIV genotype (resistance testing before ART)
- CBC (anemia, leukopenia)
- LFTs (baseline + during ART)
- Renal function
- Lipids
- STI panel (adolescents)
- TB testing
- Toxoplasma, CMV, HSV serology
- Hepatitis B and C serology
Diagnostic Procedures
- HIV testing (above)
- Comprehensive medical and psychosocial history
- Physical exam: growth parameters, lymph nodes, organomegaly, skin, oral, neurologic, developmental
- Disclosure planning (gradual, age-appropriate)
- Routine: dental, vision
- STI screening adolescents
- Cervical Pap (sexually active adolescent girls — earlier and more frequent than HIV-negative)
Safety Considerations
- Universal/standard precautions for all blood and body fluids
- No breastfeeding for HIV+ mothers (in developed countries)
- Strict ART adherence — resistance with skipped doses
- Safe sex education for adolescents
- Avoid live vaccines in symptomatic/severely immunocompromised: MMR and varicella can be given if CD4 % ≥15% and not symptomatic; LAIV nasal flu contraindicated; BCG contraindicated
- PCP prophylaxis when indicated
- Disclosure decisions sensitive (when to tell child, others)
- Mental health screening (depression common)
- Address stigma and discrimination
- Confidentiality (HIV status)
Complications
- Opportunistic infections (PCP, MAC, candidiasis, CMV, cryptosporidium, toxoplasmosis)
- Malignancies (lymphoma, Kaposi sarcoma)
- HIV encephalopathy, developmental delay
- Failure to thrive
- Lymphoid interstitial pneumonia
- Cardiomyopathy
- Nephropathy
- Wasting syndrome
- ART side effects (mitochondrial toxicity, lipodystrophy, ↑ lipids, insulin resistance, bone disease)
- Drug resistance
- Psychosocial: stigma, depression, disclosure stress, adherence challenges
- Co-infections (HBV, HCV, TB, syphilis)
- Transmission to others
Nursing Care
- Confidentiality (sensitive)
- Family-centered, multidisciplinary care
- Education about HIV, transmission, treatment
- Growth and development monitoring
- ART adherence support (the most important predictor of outcome)
- Routine vaccinations (modified for live vaccines)
- Opportunistic infection prophylaxis
- Pre-op screening for medication interactions
- Nutrition support
- Psychosocial assessment and support
- Disclosure planning (gradual, age-appropriate)
- School coordination (don't need to inform; child's right to privacy)
- Address bullying, stigma
- Adolescent transition to adult care
- Sexual health education
- Mental health
- Universal precautions
Medications
Antiretroviral Therapy (ART) — combination of ≥3 drugs from different classes:
- NRTIs (Nucleoside Reverse Transcriptase Inhibitors): zidovudine, lamivudine, abacavir, emtricitabine, tenofovir
- NNRTIs (Non-nucleoside RTIs): efavirenz, nevirapine, etravirine, rilpivirine
- Protease Inhibitors: lopinavir/ritonavir, atazanavir, darunavir
- Integrase Inhibitors: dolutegravir, raltegravir, bictegravir
- Entry Inhibitors: maraviroc, enfuvirtide
- Newer single-tablet regimens (better adherence)
- Long-acting injectable (cabotegravir/rilpivirine) for adolescents
Opportunistic infection prophylaxis:
- PCP: TMP-SMX (Bactrim) starting at 4-6 weeks if perinatally exposed; continue until HIV ruled out; for HIV+ based on CD4
- MAC: azithromycin if CD4 very low
- TB: INH if PPD positive
- Antifungal: fluconazole prophylaxis if recurrent
Vaccines per ACIP HIV guidelines (modified live vaccine recommendations based on immune status)
Therapeutic Procedures
- Combination ART (cornerstone)
- Adherence support: pill organizers, reminders, family/peer support
- OI treatment when occurs
- Mental health counseling, support groups
- Nutritional support
- Developmental intervention (if delays)
- Adolescent transition program to adult care
- Pregnancy planning for HIV+ adolescents
Client Education
Family:
- HIV is now a manageable chronic disease with appropriate treatment
- Near-normal life expectancy with consistent ART
- ART must be taken every day, at the same time, lifelong
- Skipping doses → drug resistance → fewer options
- U=U: Undetectable = Untransmittable (sexual transmission)
- Use universal precautions for body fluids; can't catch HIV from casual contact, sharing food, hugging
- HIV testing of all sexual partners, condom use
- Don't share toothbrushes, razors
- Notify dentists, providers
- Confidentiality protected by law
- School: doesn't need to know unless family chooses
- Stigma is real but combatable; support groups
Disclosure:
- Gradual disclosure as child grows (typically school-age)
- Age-appropriate language
- Adolescents need their diagnosis disclosed to participate in care
- Family decision when/how to disclose to others
Adolescents:
- Sexual health education
- Discuss disclosure to partners (legal obligation in many states)
- Contraception
- Mental health
- Substance use prevention
- Transition to adult care
Prevention (for HIV-negative family):
- PrEP if high-risk
- Condom use
- Universal precautions
Interprofessional Care
- Pediatric infectious disease (primary)
- Pediatric primary care
- Adolescent medicine
- Maternal-fetal medicine (perinatal)
- Pharmacy (drug interactions)
- Dietitian
- Mental health
- Social work
- Developmental pediatrics
- HIV/AIDS support organizations
- School coordinator (if disclosed)
- Public health
- Adult HIV clinic (transition)
Alterations in Health (Diagnosis)
UROLOGIC EMERGENCY. Spermatic cord twists, cutting off blood supply to testis. Testicular salvage rate decreases dramatically over time: ~90% if detorsed within 6 hours, ~50% at 12 hours, <10% beyond 24 hours. Peak incidence: neonates and adolescents (10-20 years).
Pathophysiology Related to Client Problem
Abnormal mobility of testis within tunica vaginalis ("bell-clapper deformity") allows twisting of spermatic cord → venous obstruction → edema → arterial occlusion → ischemia → infarction → testicular necrosis.
Health Promotion and Disease Prevention
- Education about scrotal pain — seek immediate care
- Annual physical exam — testicular self-exam (adolescents)
- Orchiopexy for one side often done bilateral (prophylactic)
- Awareness during sports/activity
Risk Factors
- Age (peak): neonates and adolescents 12-18 yr
- Bell-clapper deformity (anatomic predisposition; often bilateral)
- Trauma to scrotum
- Vigorous activity, sports
- Cold exposure
- Family history
- Cryptorchidism (undescended testis)
- Previous torsion (contralateral side higher risk)
Expected Findings
- Sudden severe scrotal pain (often awakens from sleep)
- Pain may radiate to lower abdomen, groin, flank
- Nausea, vomiting
- Affected testis: swollen, tender, high-riding, transverse lie
- Absent cremasteric reflex (stroking inner thigh doesn't elevate testis on affected side) — highly suggestive
- Negative Prehn sign (elevation does NOT relieve pain — vs. epididymitis where it does)
- Scrotal skin may be red, warm
- Walking with widened stance
- Refusal to walk (young child)
- Anxiety
Neonatal torsion:
- Often painless
- Hard mass in scrotum
- Discoloration (blue/black)
- Often already necrotic at presentation
Laboratory Tests
- Usually clinical diagnosis — don't delay surgery for labs
- UA (rule out UTI)
- CBC if needed
Diagnostic Procedures
- Clinical diagnosis — urgent surgical evaluation
- Doppler ultrasound with color flow: ↓ or absent blood flow to affected testis (gold standard for confirmation)
- BUT — don't delay surgery for imaging if clinical picture clear
- TWIST score (Testicular Workup for Ischemia and Suspected Torsion) — helps risk-stratify
- Surgical exploration is definitive
Safety Considerations
- TIME IS TESTICLE — surgical detorsion within 6 hours optimal
- NPO immediately
- IV access
- Notify urology STAT
- Pain management
- Antiemetics
- Avoid pressure on scrotum
- Manual detorsion (twist outward — "opening a book") can be attempted by trained provider while awaiting surgery (may relieve pain temporarily)
Complications
- Testicular necrosis → orchiectomy (loss of testis)
- Infertility risk (some)
- Hormone production (usually preserved with one testis)
- Future torsion of contralateral testis (~10% lifetime risk)
- Atrophy of affected testis even if salvaged
- Cosmetic concerns (testicular prosthesis option)
- Psychological impact
- Surgical complications
Nursing Care
- RAPID assessment — recognize emergency
- NPO status
- IV access, fluids
- Pain assessment and management
- Notify urology STAT
- Prepare for emergent OR
- Pre-op teaching (brief, child and family)
- Address anxiety
- Post-op: wound care, pain management, scrotal support, ice for first 24-48 hours, activity restriction
- Education on signs of recurrence
- Psychological support (adolescent — body image)
- Follow-up
Medications
- IV analgesics: morphine, fentanyl
- Antiemetics: ondansetron
- Pre-op antibiotics
- Post-op pain medication (acetaminophen, ibuprofen, opioid short-term)
- Stool softeners
Therapeutic Procedures
- Emergent surgical detorsion within 6 hours (within 4-6 hr ideally)
- If salvageable: orchiopexy (fix testis to scrotal wall to prevent recurrence)
- Bilateral orchiopexy (prophylactic on contralateral side — bell-clapper often bilateral)
- If necrotic: orchiectomy (testicular removal)
- Testicular prosthesis option (later)
- Manual detorsion only as temporizing measure by trained provider
Client Education
- Testicular torsion is a TRUE EMERGENCY — every minute counts
- ANY sudden severe testicular pain → ER immediately
- Don't wait to see if it gets better
- Don't apply heat
- Don't take pain medication that might delay seeking care
- Time to surgery determines testicular salvage
- Lifetime risk of contralateral torsion exists (often prophylactically pinned at same time)
- If testis lost: hormonal function generally preserved with one testis; fertility usually preserved; prosthesis available
- Self-exam education for adolescent males
- Return immediately if: severe pain, swelling, fever, drainage, can't urinate
- Post-op: scrotal support; ice 20 min on/off for 24-48 hours; no strenuous activity for 2-4 weeks; no contact sports for 4-6 weeks
- Follow-up appointments
- Counseling if psychological impact
Interprofessional Care
- Pediatric/adolescent urology (primary)
- Emergency department
- Pediatric anesthesia
- Pediatric primary care
- Mental health (if needed)
- Endocrinology (if hormonal concerns)
- Reproductive specialist (if fertility concerns later)
Alterations in Health (Diagnosis)
Acute, life-threatening syndrome of inadequate tissue perfusion → cellular hypoxia → multi-organ dysfunction. Children compensate well initially, then crash quickly — early recognition is key. Hypotension is a LATE finding; recognition before hypotension dramatically improves outcomes.
Types: hypovolemic (most common — dehydration, hemorrhage, burns), distributive (septic, anaphylactic, neurogenic), cardiogenic (heart failure), obstructive (PE, tension pneumothorax, cardiac tamponade).
Pathophysiology Related to Client Problem
Mismatch between O2 delivery and tissue demand → anaerobic metabolism → lactic acidosis → cell dysfunction/death → multi-organ failure. Initially compensated by: ↑ HR, ↑ SVR (vasoconstriction), ↑ contractility. When compensation fails → decompensated shock → hypotension → cardiac arrest.
Health Promotion and Disease Prevention
- Sepsis prevention: vaccines (PCV, Hib, meningococcal, flu, COVID)
- Recognize early warning signs and treat sepsis early ("Sepsis bundle")
- Trauma prevention
- Fluid management for dehydration
- Allergen avoidance, EpiPens
- Cardiac follow-up for known CHD
- Pediatric Early Warning Score (PEWS) monitoring
Risk Factors
- Infants/neonates highest risk for septic shock
- Immunocompromise
- Chronic illness (CHD, lung disease, cancer, immunodeficiency)
- Indwelling devices (central lines, foley, VP shunt)
- Recent surgery
- Trauma
- Severe burns
- Severe dehydration (gastroenteritis)
- Hemorrhage
- Known allergies (anaphylaxis)
- Splenectomy (encapsulated organisms)
- Sickle cell disease
Expected Findings
Compensated shock (BP normal!):
- Tachycardia (earliest, most sensitive)
- Tachypnea
- Cool, mottled, or pale extremities
- Delayed capillary refill (> 2 seconds)
- Weak peripheral pulses
- ↓ urine output (< 1 mL/kg/hr in children, < 2 mL/kg/hr in infants)
- Altered mental status (irritability, confusion, lethargy)
- Compensated shock may have NORMAL BP
Decompensated shock (BP drops — LATE):
- Hypotension
- Profound tachycardia → bradycardia (terminal)
- Severe altered mental status
- Cold, mottled, central cyanosis
- Anuria
- Respiratory failure
Specific types:
- Septic: fever or hypothermia, mottling, "warm shock" (vasodilated, bounding pulses) early OR "cold shock" (vasoconstricted) — children more often cold
- Hypovolemic: dehydration signs, sunken eyes/fontanel, dry mucosa, hemorrhage
- Anaphylactic: hives, angioedema, bronchospasm, exposure
- Cardiogenic: hepatomegaly, gallop, edema, JVD (older children)
- Obstructive: JVD, decreased breath sounds (pneumothorax), distant heart sounds (tamponade)
Laboratory Tests
- Lactate (elevated — tissue hypoxia)
- ABG: metabolic acidosis
- CBC: ↑ or ↓ WBC, thrombocytopenia (sepsis), anemia (hemorrhage)
- Electrolytes
- BUN/Cr (AKI common)
- LFTs (shock liver)
- Coagulation (DIC in sepsis)
- Glucose (hypo or hyper)
- Blood cultures (sepsis)
- UA, urine culture
- CSF (if meningitis suspected)
- Procalcitonin, CRP
- Type and screen
- Troponin if cardiac
- BNP if cardiogenic
Diagnostic Procedures
- Clinical assessment — recognize early
- Capillary refill, pulse quality, mental status, urine output
- Heart rate trend
- Vital signs (BP last)
- Imaging based on cause: CXR (heart, lungs), echo (cardiogenic, tamponade), CT (trauma)
- Cultures (if sepsis)
Safety Considerations
- RECOGNIZE EARLY — before hypotension
- "Pediatric Sepsis Hour" — antibiotics, fluids, vasoactives within first hour for septic shock
- IV access — large bore × 2 (IO if peripheral fails)
- Continuous monitoring (ECG, SpO₂, BP, ETCO2 if possible)
- Frequent reassessment after each intervention
- Glucose check (children prone to hypoglycemia)
- Temperature management
- Universal precautions
- Anticipate decompensation
Complications
- Multi-organ dysfunction syndrome (MODS)
- Acute kidney injury
- ARDS
- DIC
- Cerebral hypoxia, brain injury
- Cardiac dysfunction
- Hepatic dysfunction
- Coagulopathy
- Cardiac arrest
- Death
- Long-term: PTSD, cognitive impairment, developmental delay
Nursing Care
- RAPID recognition
- Activate response team / pediatric code
- ABCs
- Oxygen (100% non-rebreather; intubation if needed)
- IV access × 2 large bore; IO if needed
- 20 mL/kg NS or LR bolus over 5-10 min; reassess; repeat up to 60 mL/kg in first hour for septic/hypovolemic
- For cardiogenic: cautious fluids (5-10 mL/kg) — may worsen
- Vasoactives if fluid-refractory: epinephrine (most common pediatric), norepinephrine
- Antibiotics within 1 hour if sepsis (broad-spectrum)
- Cultures BEFORE antibiotics (don't delay though)
- Glucose monitoring/treatment
- Continuous vitals, urine output
- Strict I&O
- Foley catheter
- Source control (drain abscess, surgery if needed)
- Family support
- PICU transfer
Medications
Antibiotics for sepsis (within 1 hour):
- Empiric broad-spectrum based on age and source:
- Neonate: ampicillin + gentamicin or cefotaxime
- Older infant/child: ceftriaxone + vancomycin (if MRSA risk)
- Add metronidazole if abdominal source
- Narrow once cultures back
Vasoactives:
- Epinephrine — first-line in pediatric septic shock (cold) and anaphylactic shock
- Norepinephrine — warm septic shock
- Dopamine (less commonly used now)
- Milrinone — cardiogenic
- Vasopressin (adjunctive)
Other:
- Hydrocortisone — adrenal insufficiency, refractory shock
- Inotropic agents
- Diuretics — cardiogenic with overload
- Blood products: PRBCs (hemorrhage), FFP (coagulopathy), platelets, cryoprecipitate
- Calcium
- Glucose for hypoglycemia
- Insulin for hyperglycemia
- Bicarbonate (controversial)
Therapeutic Procedures
- Fluid resuscitation (cornerstone — most types)
- Vasoactive drugs
- Mechanical ventilation
- Source control: surgery (perforation, abscess), drainage
- ECMO (refractory cases)
- CRRT/dialysis if AKI
- Blood products
- Pericardiocentesis (tamponade)
- Needle decompression/chest tube (tension pneumothorax)
- PICU admission
Client Education
- Recognize warning signs (especially family of high-risk children):
- Fever, lethargy, poor feeding, poor color, fast/labored breathing, ↓ urine output, mottled extremities, altered mental status
- Call provider/ER promptly
- Sepsis is a medical emergency — early treatment saves lives
- Vaccinations to prevent severe infections
- Hand hygiene
- Identify allergens; carry EpiPen if anaphylaxis risk
- Adequate hydration during illness
- Long-term follow-up after PICU admission
- Watch for late effects: developmental, cognitive, emotional (PTSD)
- Family support during long ICU stay
- Survivorship issues
Interprofessional Care
- Pediatric ICU (primary)
- Pediatric ED
- Pediatric infectious disease (sepsis)
- Pediatric cardiology (cardiogenic)
- Pediatric surgery (source control)
- Pediatric pharmacy
- Pediatric respiratory therapy
- Social work
- Chaplain
- Mental health (post-discharge)
- Rehabilitation
- Family support
Alterations in Health (Diagnosis)
AKI: sudden decline in kidney function (hours-days) with ↑ creatinine, ↓ urine output, electrolyte/fluid disturbances. CKD: progressive irreversible decline in GFR over months-years; can progress to end-stage renal disease (ESRD) requiring dialysis or transplant. AKI may resolve or progress to CKD.
Pathophysiology Related to Client Problem
AKI categories: Pre-renal (decreased perfusion — dehydration, shock, hemorrhage), Intrinsic (renal tissue damage — ATN, glomerulonephritis, HUS, drugs), Post-renal (obstruction — stones, tumors, posterior urethral valves). CKD pathophys: progressive nephron loss → adaptive hyperfiltration → glomerulosclerosis → further nephron loss → uremia.
Health Promotion and Disease Prevention
- Treat infections promptly (prevent post-streptococcal GN)
- Hydration during illness
- Address risk factors: DM, HTN
- Avoid nephrotoxic drugs when possible (NSAIDs, aminoglycosides)
- Address congenital anomalies (CAKUT — Congenital Anomalies of Kidney and Urinary Tract)
- Genetic counseling for hereditary kidney disease
- Prevent dehydration
- Monitor renal function with nephrotoxic drugs
Risk Factors
AKI risk factors:
- Critical illness
- Severe dehydration
- Sepsis
- Trauma, blood loss
- Burns
- Heart failure
- Cardiac surgery
- Nephrotoxic drugs (NSAIDs, aminoglycosides, contrast, chemo)
- HUS
- Glomerulonephritis
- Obstruction
CKD causes (pediatric):
- CAKUT (most common pediatric cause): VUR, renal dysplasia, posterior urethral valves
- Hereditary: polycystic kidney disease, Alport syndrome
- Glomerulonephritis
- Diabetes (T1DM in adolescents)
- HUS
- Hypertension
- Nephrotic syndrome (some)
Expected Findings
AKI:
- ↓ urine output (oliguria < 0.5 mL/kg/hr children, < 1 mL/kg/hr infants; anuria < 0.3 mL/kg/hr)
- Fluid overload: edema, weight gain, HTN, JVD, pulmonary edema
- Electrolyte disturbances: hyperkalemia, hyperphosphatemia, hypocalcemia, hyponatremia, acidosis
- Lethargy, confusion (uremia)
- Nausea, vomiting
- Some have polyuria phase
CKD:
- Often insidious; may present with:
- Poor growth, FTT (key pediatric finding)
- Anemia (↓ erythropoietin) — pallor, fatigue
- Bone disease (renal osteodystrophy) — bone pain, fractures, deformities
- HTN
- Edema
- Polyuria, nocturia, enuresis
- Anorexia, nausea
- Pruritus, dry skin
- Foul breath (uremic fetor)
- Developmental delay
- Late: oliguria, anuria, uremia, encephalopathy
- Cardiovascular disease (#1 mortality in CKD)
Laboratory Tests
- ↑ BUN, creatinine
- ↓ GFR (use Schwartz formula or new equations in children)
- Electrolytes: ↑ K, ↑ phosphorus, ↓ Ca, metabolic acidosis (low HCO3), variable Na
- CBC: anemia (CKD), thrombocytopenia (some)
- UA: proteinuria, hematuria, casts
- Urinary protein/creatinine ratio, microalbumin
- ↑ PTH (CKD — secondary hyperparathyroidism)
- ↓ Vitamin D (CKD)
- Lipids ↑ (CKD)
- Fractional excretion of sodium (FENa): <1% pre-renal, >2% intrinsic
- Specific tests per etiology: ANA, ANCA, complement, ASO, anti-DNase B, hepatitis serology
- Iron studies, ferritin
Diagnostic Procedures
- Comprehensive history and physical
- Strict I&O, daily weights
- Urinalysis
- Renal ultrasound (size, structure, hydronephrosis)
- VCUG (VUR)
- Renal scan (function, anatomy)
- CT/MRI as needed
- Renal biopsy (often needed for diagnosis of intrinsic disease)
- Genetic testing (hereditary causes)
- BP monitoring (ambulatory if indicated)
- Echocardiogram (LVH, function)
- Bone X-rays (renal osteodystrophy)
- DEXA scan
- Eye exam (Alport syndrome)
Safety Considerations
- Strict I&O, daily weights
- Watch for hyperkalemia → arrhythmias (peaked T waves, prolonged PR, wide QRS, sine wave)
- Watch for fluid overload → pulmonary edema, hypertension
- Adjust medications for renal function (dose adjustments, avoid nephrotoxins)
- Avoid IV contrast when possible; if needed → hydration, N-acetylcysteine
- Avoid NSAIDs
- Vaccination status (all immunizations including HBV — important for hemodialysis/transplant)
- NO live vaccines if on immunosuppression (post-transplant)
- Dialysis access protection (no BP/blood draws/IV in fistula arm)
- Recognize peritonitis (PD): cloudy fluid, abdominal pain, fever — emergency
- Address growth delay
Complications
- Fluid overload, pulmonary edema
- Hyperkalemia → arrhythmias
- Metabolic acidosis
- Uremic encephalopathy
- Pericarditis
- Severe hypertension, encephalopathy, stroke
- Anemia
- Renal osteodystrophy, fractures
- Growth failure (key in pediatrics)
- Cardiovascular disease (#1 cause of death in CKD)
- Sepsis
- Bleeding (uremic platelets)
- Progression to ESRD (CKD)
- Death
- Dialysis complications: access infections, peritonitis, electrolyte shifts, hypotension
- Transplant complications: rejection, infections, malignancy, recurrent disease
- Psychosocial: chronic illness burden, school disruption
Nursing Care
- Strict I&O (every hour in AKI)
- Daily weights (same scale, time, clothing)
- Vital signs frequently (especially BP)
- Monitor for fluid overload
- ECG monitoring (hyperkalemia risk)
- Fluid restriction (often) — strict count
- Dietary management: protein restriction (modest), potassium, phosphorus, sodium restriction
- Avoid nephrotoxic drugs
- Adjust dosing for GFR
- Monitor labs frequently
- Skin care (pruritus, edema)
- Bone health
- Anemia management
- Hypertension management
- Growth monitoring (recombinant growth hormone if indicated)
- Dialysis care: access, pre/post-dialysis weight, complications
- Transplant: immunosuppression compliance, infection prevention
- School coordination
- Psychosocial support
- Transition to adult care (adolescents)
Medications
AKI management:
- Fluids (carefully — based on volume status)
- Diuretics (furosemide) — fluid overload
- Hyperkalemia: calcium gluconate (cardiac protection), insulin + D50, albuterol, bicarb, sodium polystyrene sulfonate (Kayexalate), patiromer; dialysis if severe
- Sodium bicarbonate (acidosis)
- Phosphate binders
- Stop nephrotoxic drugs
CKD management:
- ACE inhibitors / ARBs — reduce proteinuria, BP
- Other antihypertensives
- Phosphate binders (calcium carbonate, sevelamer)
- Active vitamin D (calcitriol)
- Calcimimetics (cinacalcet)
- Erythropoietin-stimulating agents (epoetin, darbepoetin) for anemia
- IV/oral iron for iron deficiency
- Recombinant growth hormone for growth failure
- Sodium bicarbonate (acidosis)
- Diuretics
- Bone meds
Post-transplant immunosuppression:
- Tacrolimus or cyclosporine
- Mycophenolate mofetil
- Prednisone (taper)
- Induction: basiliximab, ATG
- Prophylaxis: TMP-SMX (PCP), valganciclovir (CMV), nystatin (candida)
Therapeutic Procedures
- Fluid management
- Renal replacement therapy:
- Hemodialysis (HD) — typically 3-4 hours, 3× weekly; AV fistula, graft, or CVC
- Peritoneal dialysis (PD) — daily; continuous (CAPD) or cycler (APD); often preferred in young children
- CRRT (continuous renal replacement therapy) — ICU setting, AKI
- Kidney transplantation (best long-term outcome)
- Source control of underlying cause
- Bone health management
- Growth hormone
- Nutrition support, gastrostomy if needed
- School modifications
Client Education
Family:
- AKI may resolve completely if cause is treated
- CKD progresses without intervention; treatment slows progression and treats complications
- Multidisciplinary care
- Dietary modifications (work with renal dietitian):
- Protein: moderate restriction
- Potassium restriction: limit bananas, oranges, potatoes, tomatoes, melons
- Phosphorus restriction: limit dairy, cola, processed foods
- Sodium restriction
- Fluid restriction (calculated)
- Take phosphate binders with meals
- Medications and adherence critical
- Avoid OTC NSAIDs
- Stay up-to-date with vaccinations (especially HBV before dialysis/transplant)
- Recognize signs of complications:
- Edema, weight gain, decreased urine output
- Headache, vision changes (HTN)
- Bleeding
- Fever (infection)
Dialysis education:
- Access care: no BP, IV, or blood draws in fistula arm; daily thrill/bruit check; protect access
- PD: meticulous sterile technique; recognize peritonitis (cloudy fluid, abdominal pain) → emergency
- Diet and fluid restrictions stricter on dialysis days
Transplant education:
- Lifelong immunosuppression
- Strict medication adherence
- Sun protection (↑ skin cancer)
- Avoid live vaccines
- Infection prevention
- Watch for rejection signs: ↑ BP, fever, ↓ urine, weight gain, edema, pain at site, ↑ Cr
- Routine labs and clinic visits
- Address adolescent non-adherence proactively
Growth and development:
- Growth hormone therapy if growth failure
- Nutrition support critical (NG, G-tube common in CKD infants)
- School modifications
- Cognitive monitoring
- Adolescent: transition to adult care planning
Interprofessional Care
- Pediatric nephrology (primary)
- Renal dietitian
- Renal social worker
- Transplant team
- Dialysis nursing
- Pediatric urology (CAKUT)
- Pediatric endocrinology (growth, bone)
- Pediatric cardiology
- Pediatric infectious disease
- Pharmacy
- School coordinator, IEP
- Child life
- Mental health
- Genetic counseling
- Palliative care (ESRD)
Alterations in Health (Diagnosis)
Chronic lung disease primarily of premature infants who required prolonged oxygen and/or mechanical ventilation in the neonatal period. Defined as oxygen requirement at 36 weeks corrected gestational age. Most common chronic lung disease in infancy.
Pathophysiology Related to Client Problem
Multifactorial injury to developing lungs from: prematurity (immature lung development), oxygen toxicity (free radicals), mechanical ventilation (barotrauma, volutrauma), inflammation, infection → impaired alveolar and vascular development → chronic lung dysfunction with airway inflammation, smooth muscle hypertrophy, and impaired gas exchange.
Health Promotion and Disease Prevention
- Prevent preterm birth (prenatal care, treat infections, cervical insufficiency management)
- Antenatal corticosteroids for women in preterm labor 24-34 weeks (matures fetal lungs)
- Gentle ventilation strategies in NICU
- Minimize oxygen exposure (target SpO₂ 90-95%, not higher)
- Surfactant therapy when indicated
- Prevent infection (sepsis, pneumonia)
- Optimal nutrition
- Patent ductus arteriosus management
- Caffeine therapy (for apnea — reduces BPD)
- Avoid in utero smoke exposure
- Vitamin A supplementation (some studies)
Risk Factors
- Prematurity (especially < 32 weeks, < 1500 g)
- RDS in neonatal period
- Prolonged mechanical ventilation
- High oxygen exposure
- Sepsis, infection
- Chorioamnionitis (in utero)
- PDA
- Pulmonary hemorrhage
- Male sex
- White race
- Family history of atopy
- In utero smoke exposure
- Nutritional deficits
- Genetic predisposition
Expected Findings
Acute (NICU):
- Persistent oxygen dependence beyond 28 days
- ↑ work of breathing
- Retractions, tachypnea
- Crackles, wheezing
- Slow weight gain
- Feeding difficulties, GERD
Chronic (post-NICU):
- Chronic oxygen dependence (varies)
- Tachypnea, retractions
- Wheezing, cough
- Frequent respiratory infections
- Growth failure
- Feeding intolerance, oral aversion
- Recurrent hospitalizations (especially RSV season)
- Pulmonary hypertension (severe BPD)
- Developmental delay
- Hearing/vision deficits (from prematurity)
- Hyperactive airway (asthma-like)
- Cyanosis with feeds, crying
Laboratory Tests
- ABG: chronic respiratory acidosis (compensated), hypoxemia
- Continuous pulse ox
- CBC, electrolytes
- Hemoglobin (chronic hypoxia may cause polycythemia or anemia)
- BNP if pulmonary HTN suspected
Diagnostic Procedures
- Clinical diagnosis: oxygen requirement at 36 weeks corrected age (mild/moderate/severe based on FiO2)
- Chest X-ray: hyperinflation, lung opacities, atelectasis, cystic changes
- Pulmonary function tests (older children)
- Echocardiogram (pulmonary HTN screening)
- Polysomnography (sleep-disordered breathing)
- Bronchoscopy (some)
- HRCT chest (severe)
- Developmental assessments
- Hearing, vision screening
Safety Considerations
- Maintain SpO₂ goals (typically 92-95% — not too high)
- Aspiration precautions if GERD/feeding issues
- RSV prophylaxis (palivizumab) in eligible infants
- Avoid respiratory irritants (smoke, dust)
- Strict infection precautions
- Recognize respiratory decompensation
- Vaccination on schedule (especially flu, COVID, RSV)
- Monitor for pulmonary HTN
- Cardiopulmonary monitoring at home if applicable
- Emergency plan for caregivers
Complications
- Recurrent respiratory infections (RSV, etc.)
- Asthma/reactive airway disease
- Pulmonary hypertension
- Cor pulmonale (right heart failure)
- Failure to thrive, growth delay
- Developmental delay
- Neurosensory disabilities
- Recurrent hospitalizations
- Tracheostomy (severe)
- Feeding difficulties, G-tube
- Long-term lung function deficits (extending into adulthood)
- Adult-onset COPD risk
- Mortality in severe BPD
Nursing Care
NICU:
- Gentle ventilation
- Minimize oxygen and pressure
- Cluster care
- Position changes
- Suctioning as needed
- Nutrition: high calorie (~120-150 cal/kg/day), often fortified
- Fluid balance (avoid overload)
- Family support, kangaroo care
- Developmental care
Post-NICU/outpatient:
- Home oxygen if needed
- Apnea/pulse ox monitoring
- Frequent feedings, high calorie
- NG/G-tube feeds if needed
- RSV season precautions
- Vaccinations (especially palivizumab)
- Daily weight, growth tracking
- Bronchodilators, steroids as ordered
- Diuretics if fluid overload
- Avoid smoke exposure
- Educate family on assessment, equipment, emergencies
- Coordinate multidisciplinary care
- Watch for pulmonary HTN signs
Medications
- Caffeine — apnea of prematurity, ↓ BPD risk
- Diuretics (furosemide, chlorothiazide, spironolactone) — fluid overload, improve lung mechanics
- Bronchodilators (albuterol) — wheezing episodes
- Inhaled corticosteroids — chronic airway inflammation (severe cases)
- Systemic steroids (dexamethasone, hydrocortisone) — controversial; may aid weaning from ventilator but neurodevelopmental concerns; balance carefully
- Vitamin A — early in NICU (controversial)
- Palivizumab (Synagis) — RSV prophylaxis (monthly during RSV season)
- Routine vaccinations on schedule
- Influenza vaccine yearly > 6 months
- Anti-reflux meds (PPI, H2 blocker) for GERD
- Pulmonary HTN medications (sildenafil, bosentan) if applicable
Therapeutic Procedures
- Oxygen therapy (titrate to SpO₂ goals)
- Mechanical ventilation (initial; wean as tolerated)
- CPAP, HFNC (heated high-flow)
- Tracheostomy (severe, prolonged)
- Nutritional support: high-calorie formula, fortification, NG/G-tube
- Chest physiotherapy (selective)
- Pulmonary rehab
- Cardiac care for pulmonary HTN
- RSV prophylaxis
- Early intervention (developmental)
- PT, OT, speech
- Eventual lung transplant (rare, severe)
Client Education
Family:
- BPD often improves over years as new lung tissue grows
- Most children outgrow oxygen dependence by 1-2 years
- Watch for respiratory infections — quickly worsen
- RSV especially dangerous — prophylaxis, isolation during season
- Avoid smoke exposure (most preventable risk for lung worsening)
- Avoid sick contacts when possible
- Hand hygiene
- Vaccinations on schedule (especially flu, palivizumab if eligible)
- Recognize warning signs: ↑ work of breathing, retractions, ↓ oxygen sat (home pulse ox), wheezing, cyanosis, decreased feeding, fever, lethargy
- Emergency action plan: when to give bronchodilator, when to call provider, when to go to ER
Care of home equipment:
- Oxygen setup, safety (no smoking, flames near O2)
- Pulse ox at home
- Apnea monitor if prescribed
- Tube feeding
- Suction
- Tracheostomy care if applicable
Feeding:
- Small frequent meals (don't overwhelm respiratory effort)
- High-calorie diet
- NG/G-tube feeding may be needed
- GERD management
- Oral feeding skills (oral aversion possible)
- Don't force-feed
Development:
- Early intervention crucial
- PT, OT, speech
- Use adjusted age (corrected for prematurity)
- Encourage developmental milestones
- Hearing, vision testing
Long-term:
- Lung function gradually improves but deficits may persist
- ↑ risk of asthma, recurrent respiratory illness
- Adult lung function may be reduced
- Encourage healthy lifestyle (no smoking)
- Stay current with respiratory vaccines
Interprofessional Care
- Neonatology (NICU)
- Pediatric pulmonology (primary outpatient)
- Pediatric cardiology (pulmonary HTN)
- Developmental pediatrics
- Pediatric GI (feeding, GERD)
- PT, OT, speech therapy
- Dietitian (high calorie)
- Respiratory therapy (home O2)
- Home health nursing
- Social work
- Early intervention
- School coordinator
- Genetic counseling (familial)
- Palliative care (severe)
Alterations in Health (Diagnosis)
Major Depressive Disorder (MDD): persistent depressed mood or anhedonia + multiple cognitive/somatic symptoms ≥ 2 weeks. Suicidal ideation/behavior: thoughts, plans, or actions intended to end one's life. Suicide is the 2nd-3rd leading cause of death in adolescents. Depression and suicide risk significantly increased post-pandemic. Vital to screen all adolescents.
Pathophysiology Related to Client Problem
Multifactorial: neurobiologic (serotonin, dopamine, norepinephrine dysregulation), genetic (heritability ~40-50%), environmental (trauma, abuse, loss, bullying, social media), and developmental factors. Adolescent brain especially vulnerable (prefrontal cortex still developing).
Health Promotion and Disease Prevention
- Universal screening at age 12+ at well visits (PHQ-9, PHQ-A, Columbia Suicide Severity Rating Scale)
- Reduce access to lethal means (firearms locked, medication safety)
- Address bullying, discrimination
- Promote connectedness (family meals, school engagement)
- Mental health literacy in schools
- Substance use prevention
- Identify and address LGBTQ+ youth at increased risk
- Treat parental mental illness
- Crisis hotlines: 988 Suicide and Crisis Lifeline
- Treat depression EARLY
- Adequate sleep, exercise, nutrition
- Limit social media use
- Address trauma promptly
- Stop stigma (don't use "committed suicide" — use "died by suicide")
Risk Factors
Depression risk factors:
- Family history depression
- Personal history mental illness
- Trauma, abuse, neglect
- Loss (death, divorce)
- Chronic illness
- Substance use
- Bullying (in-person, cyber)
- LGBTQ+ youth (especially without family support)
- Social isolation
- Sleep deprivation
- Academic pressure
- Female sex (depression — incidence twice that of males)
- Hormonal changes
Suicide risk factors (SAD PERSONS, etc.):
- Previous attempt (strongest predictor)
- Depression, bipolar, anxiety
- Substance use
- Family history of suicide
- Sexual orientation/gender identity issues (especially without support)
- Childhood maltreatment
- Recent loss
- Access to firearms (most lethal means)
- Bullying
- Adolescent boys (higher completion rate)
- Native American/Alaska Native youth (highest rates)
- Recent psychiatric hospitalization
Expected Findings
Major Depressive Disorder (≥ 5 symptoms ≥ 2 weeks):
- Depressed mood (children may appear irritable instead)
- Anhedonia (loss of interest)
- Weight/appetite changes
- Sleep disturbance (insomnia or hypersomnia)
- Psychomotor agitation or retardation
- Fatigue, low energy
- Feelings of worthlessness, excessive guilt
- Concentration/decision-making problems
- Recurrent thoughts of death, suicidal ideation
Pediatric/adolescent presentations:
- Irritability prominent (children, adolescents)
- Somatic complaints (headaches, abdominal pain)
- School decline, refusal
- Social withdrawal
- Risky behaviors
- Substance use
- Self-harm (cutting, burning)
- Sleep changes
- Appetite changes
Warning signs of suicide:
- Talking/writing about wanting to die
- Researching methods
- Saying goodbye, giving away possessions
- Sudden calmness after depression (may indicate decision made)
- ↑ substance use
- Reckless behavior
- Social withdrawal
- Rage, agitation
- Feeling trapped, hopeless
- Mood swings
- Posts on social media
Laboratory Tests
- Mostly to rule out medical causes:
- CBC (anemia)
- TSH (hypothyroidism)
- Vitamin D, B12
- Toxicology (if substance use suspected)
- Pregnancy test (females)
- If suicide attempt: tox screen, acetaminophen/salicylate levels
Diagnostic Procedures
- Screening: PHQ-9 (or PHQ-A for adolescents), Columbia Suicide Severity Rating Scale (C-SSRS), Ask Suicide-Screening Questions (ASQ)
- HEEADSSS interview
- Mental status exam
- Risk assessment: ideation, plan, intent, means, access
- Safety assessment of home environment
- Comprehensive psychiatric evaluation
- Trauma history
- Substance use screen (CRAFFT)
- School, social functioning assessment
- Family history
- Suicide attempt: medical evaluation, psychiatric admission decision
Safety Considerations
- ASK directly about suicidal thoughts — does NOT increase risk
- "Are you having thoughts of suicide or wanting to hurt yourself?"
- Mandated to report some situations (varies)
- Lethal means counseling:
- Lock up firearms (or remove from home)
- Lock up medications
- Limit acetaminophen/aspirin access
- Sharp objects
- Safety planning (Stanley-Brown Safety Plan): warning signs, internal coping, social distractions, social support, professional resources, environment safety
- 1:1 observation in hospital (if active suicidality)
- Continuous observation
- Remove sharps, cords, anything potentially used for self-harm
- Psychiatric admission if: active suicidal ideation with plan/intent, recent attempt, can't maintain safety, severe symptoms, lack of supports
- Don't leave alone
- Crisis resources: 988 (call or text), Crisis Text Line (text HOME to 741741)
Complications
- Suicide attempt
- Completed suicide
- Self-harm (cutting, burning, etc.)
- Substance use disorder
- Academic decline, dropout
- Social isolation
- Risky behaviors (unprotected sex, accidents)
- Comorbid anxiety, eating disorders
- Sleep disorders
- Chronic depression (untreated)
- Family disruption
- Survivors of suicide: complicated grief, PTSD, ↑ risk of suicide
Nursing Care
Acute (post-attempt or active SI):
- Medical stabilization first (treat overdose, injuries)
- 1:1 observation
- Suicide precautions (remove sharps, cords, drawstrings, anything potentially harmful)
- Safe environment (often inpatient psychiatric unit)
- Calm, non-judgmental approach
- Listen without interruption
- Don't minimize feelings
- Comprehensive evaluation
- Family involvement (lethal means counseling)
- Discharge planning with safety plan
- Follow-up appointment within 7 days
- Document carefully
Ongoing care:
- Medication management (SSRI as ordered)
- Therapy (CBT, DBT, IPT)
- School coordination
- Family therapy
- Group therapy/support groups
- Substance use treatment if comorbid
- Trauma-focused therapy if applicable
- Skills building: coping, distress tolerance, problem-solving
- Connection to community resources
- Regular follow-up
- Address comorbid conditions
- Identify triggers
- Sleep hygiene
- Physical activity
Medications
SSRIs are first-line for adolescent depression:
- Fluoxetine (Prozac) — FDA-approved for depression age ≥ 8, OCD age ≥ 7
- Escitalopram (Lexapro) — FDA-approved for depression age ≥ 12
- Sertraline (Zoloft), citalopram — off-label but used
Black Box Warning: Antidepressants ↑ suicidal thoughts in children, adolescents, young adults. Monitor closely especially first 4 weeks. Benefits outweigh risks for most.
Key teaching:
- Effects take 4-6 weeks
- Don't stop abruptly (discontinuation syndrome)
- Side effects: nausea, headache, sleep changes, sexual dysfunction (older adolescents)
- Avoid alcohol
- Drug interactions (especially other serotonergic agents — serotonin syndrome)
- Pregnancy considerations
Other:
- Bupropion (Wellbutrin)
- Mirtazapine
- SNRIs (less commonly used in adolescents)
- Atypical antipsychotic augmentation (refractory)
- Ketamine (esketamine intranasal) for refractory in older adolescents (newer)
Therapeutic Procedures
- Psychotherapy (often first-line for mild-moderate):
- Cognitive Behavioral Therapy (CBT) — most evidence
- Interpersonal therapy
- Dialectical Behavior Therapy (DBT) — self-harm, suicide risk
- Family therapy
- Trauma-focused CBT (if trauma history)
- Group therapy
- Combination therapy + medication often most effective
- Crisis stabilization unit
- Inpatient psychiatric hospitalization
- Partial hospitalization, intensive outpatient programs
- ECT (severe, refractory, rare in adolescents)
- TMS (transcranial magnetic stimulation)
- Lifestyle: exercise, sleep, sunlight
- Social support
- School accommodations
Client Education
Family:
- Depression is a MEDICAL condition, NOT weakness or character flaw
- Suicide is preventable
- ASK directly about suicidal thoughts — asking does NOT increase risk
- Take ALL suicidal statements seriously
- Lethal means counseling — REMOVE/LOCK firearms and medications
- Don't leave child alone if active suicidality
- Recognize warning signs
- Don't minimize feelings
- Listen non-judgmentally
- Encourage treatment compliance
- Medication takes 4-6 weeks for full effect
- Monitor for side effects, suicidal thoughts
- Don't stop medications abruptly
- Crisis resources: 988 Suicide and Crisis Lifeline (call or text); Crisis Text Line: text HOME to 741741
- Make safety plan together
- Address bullying with school
- Promote healthy lifestyle
- Limit social media if contributing
- Family meals, time together
- Family therapy can help
- Self-care for caregivers
Adolescent:
- Confidentiality (with exceptions for safety)
- HEEADSSS interview without parent
- Take medications as prescribed
- Therapy attendance important
- Healthy coping strategies
- Identify triggers
- Build support network
- Reach out when struggling — call/text 988
- Avoid alcohol and substances
- Adequate sleep
- Physical activity
- Address bullying
- It gets better — recovery is possible
Interprofessional Care
- Pediatric/adolescent mental health (primary)
- Pediatric primary care
- Psychiatric NP/psychiatrist
- Therapist (CBT, DBT)
- School counselor
- Social worker
- Substance use counselor (if comorbid)
- Crisis services
- Inpatient psychiatric facility
- Family therapist
- Trevor Project (LGBTQ+ youth)
- 988 Suicide and Crisis Lifeline
- Survivors of Suicide Loss groups
- Trauma specialist
Alterations in Health (Diagnosis)
Inflammation of the vermiform appendix. Most common surgical emergency in children. Peak age 9-12 years; uncommon < 2 years but high perforation rate when occurs (atypical presentation). Untreated appendicitis → perforation → peritonitis.
Pathophysiology Related to Client Problem
Obstruction of appendiceal lumen (fecalith, lymphoid hyperplasia, foreign body, tumor) → ↑ intraluminal pressure → ↓ venous drainage → ischemia → bacterial overgrowth → inflammation → if untreated: gangrene → perforation → peritonitis or abscess.
Health Promotion and Disease Prevention
- No specific prevention
- Early recognition of abdominal pain
- High fiber diet (some evidence — possibly protective)
- Prompt medical evaluation for unexplained abdominal pain in children
Risk Factors
- Age 9-12 years (peak)
- Male sex (slight predominance)
- Family history
- Cystic fibrosis (mucus obstruction)
- Constipation (some evidence)
Expected Findings
Classic progression:
- Periumbilical pain → migrates to RLQ (McBurney point)
- Anorexia (almost always — important)
- Nausea, vomiting (after pain begins)
- Low-grade fever (high suggests perforation)
- Pain with movement (children walk slowly, may limp on right side)
Exam findings:
- McBurney point tenderness (RLQ)
- Rovsing sign (LLQ palpation → RLQ pain)
- Psoas sign (pain with right hip extension)
- Obturator sign (pain with right hip internal rotation)
- Rebound tenderness (peritoneal irritation)
- Guarding, rigidity (peritonitis)
- Decreased bowel sounds (late)
Perforation signs:
- Sudden relief of pain (rupture)
- Then worsening diffuse pain (peritonitis)
- High fever
- Toxic appearance
- Distention, rigid abdomen
- Tachycardia, tachypnea
Atypical presentation (young children):
- Vague symptoms
- Diarrhea or constipation
- Difficult diagnosis
- Higher perforation rate
Laboratory Tests
- CBC: ↑ WBC (10-18K), left shift
- ↑ CRP
- UA: rule out UTI; mild pyuria possible (appendix near ureter)
- Pregnancy test (older girls)
- BMP if dehydration
Diagnostic Procedures
- Ultrasound (first-line in children — no radiation): enlarged, non-compressible appendix > 6mm, periappendiceal fluid
- CT abdomen/pelvis with contrast if ultrasound non-diagnostic (more sensitive but radiation)
- MRI (some centers, especially pregnant patients)
- Clinical scoring: Pediatric Appendicitis Score (PAS), Alvarado score
- Surgical consult
Safety Considerations
- NPO
- IV access, fluid resuscitation
- Pain management (does NOT mask diagnosis — give analgesics)
- Avoid laxatives, enemas (perforation risk)
- Don't apply heat to abdomen
- Monitor for perforation signs
- Pre-op antibiotics
- Surgical urgency
Complications
- Perforation (high in children, especially < 5 years — up to 80%)
- Peritonitis
- Abscess formation
- Sepsis
- Wound infection
- Ileus
- Small bowel obstruction (adhesions — long term)
- Infertility (girls, from pelvic adhesions)
- Stump appendicitis (rare)
- Death (rare)
Nursing Care
Pre-op:
- NPO, IV access, fluids
- Pain assessment (often FLACC or numeric)
- Pain management (IV opioids, acetaminophen)
- Antiemetics
- Pre-op antibiotics (broad-spectrum)
- Vital signs frequently
- Monitor for peritonitis
- Family education and support
Post-op:
- Vital signs, pain
- Wound assessment
- Bowel sounds, ambulation, flatus
- Diet advancement (clear → regular as tolerated)
- Pain management
- Antibiotics continuation (depends on whether perforated)
- Drain care if perforated
- Activity restrictions
- Discharge teaching
Medications
- Pre-op IV antibiotics (cefoxitin, piperacillin-tazobactam, or ampicillin/gentamicin/metronidazole)
- Pain: IV morphine, fentanyl; transition to acetaminophen, NSAIDs, oral opioids short-term
- Antiemetics: ondansetron
- IV fluids
- Post-op antibiotics if perforated (continue for several days)
- Antibiotic only treatment (non-operative) — newer approach for uncomplicated; controversial in pediatrics
Therapeutic Procedures
- Laparoscopic appendectomy (preferred — smaller incisions, faster recovery)
- Open appendectomy (if complicated or surgeon preference)
- If perforated with abscess: percutaneous drainage + IV antibiotics, then interval appendectomy 6-8 weeks later
- NG tube if ileus, peritonitis
- IV antibiotics
Client Education
Family:
- Appendectomy is curative
- Most uncomplicated cases — same-day or overnight stay
- Perforated requires longer hospitalization (5-7 days)
- Pain management at home (typically 1-2 weeks)
- Wound care: keep clean and dry; report redness, drainage, fever
- Activity restriction: no contact sports/heavy lifting × 2-4 weeks; ambulation encouraged
- Return to school in 1-2 weeks
- Diet: advance as tolerated
- Constipation common post-op (opioids) — stool softeners, fiber
- Return to ED for: fever > 38.5°C, severe pain, vomiting, abdominal distention, wound drainage
- Follow-up appointment in 2-4 weeks
Interprofessional Care
- Pediatric surgery (primary)
- Pediatric ED
- Pediatric anesthesia
- Pediatric radiology
- Infection control if perforated
- Child life specialist
- School coordinator
Alterations in Health (Diagnosis)
Hypospadias: congenital malformation where urethral meatus opens on the ventral (underside) of penis (rather than tip); 1 in 200-300 male births. Epispadias: rarer; meatus opens on dorsal (top) surface; often associated with bladder exstrophy.
Pathophysiology Related to Client Problem
Failure of urethral folds to fuse during fetal development (8-14 weeks gestation). Hypospadias often associated with: chordee (ventral curvature of penis), abnormal foreskin (dorsal hood, ventral deficiency), and rarely undescended testis.
Health Promotion and Disease Prevention
- Adequate prenatal care
- Folic acid before/during pregnancy
- Avoid in utero exposures (some endocrine disruptors, maternal smoking, some medications)
- Genetic counseling if family history
Risk Factors
- Family history
- Genetic predisposition
- In utero exposure: maternal smoking, alcohol, environmental endocrine disruptors
- Premature birth
- Low birth weight
- Advanced maternal age
- Subfertility, IVF
- Maternal hypertension
- Some genetic syndromes
Expected Findings
Hypospadias:
- Urethral opening on ventral surface of penis (anywhere from glans to perineum)
- Severity: glanular (most common, mild) → coronal → distal shaft → midshaft → penoscrotal → scrotal/perineal (severe)
- Chordee (ventral curvature, especially with erection)
- Dorsal hooded foreskin (foreskin deficient ventrally)
- Abnormal urinary stream — sprays, deflects downward
- May have to sit to urinate (severe)
Epispadias:
- Urethral opening on dorsal surface
- Often associated with bladder exstrophy
- Incontinence (urethral sphincter dysfunction)
- Penis may be short, broad
- Pubic diastasis
Laboratory Tests
- Generally clinical diagnosis
- Karyotype if ambiguous genitalia (DSD — disorders of sex development)
- Renal function
Diagnostic Procedures
- Physical examination at birth
- Renal ultrasound (rule out other anomalies — VUR, hydronephrosis)
- VCUG sometimes
- Evaluation for cryptorchidism (more common in hypospadias)
- Genetic evaluation if severe or ambiguous
- Preoperative imaging
Safety Considerations
- DO NOT CIRCUMCISE — foreskin needed for surgical repair
- Alert all providers, OB, pediatrician
- Document clearly in chart
- Inform parents at birth
- Sign at bedside if newborn
- Stent/catheter care post-op
- Activity restrictions post-op
- Avoid trauma to area
Complications
- Surgical complications: fistula formation (most common), meatal stenosis, urethral stricture, dehiscence
- Recurrence of chordee
- Cosmetic dissatisfaction
- Need for additional surgeries
- Psychosocial: body image, gender concerns
- Sexual function issues (potential, depends on severity)
- Fertility (usually preserved in mild cases)
- UTI
- Untreated: voiding issues, psychosocial
Nursing Care
Newborn period:
- Recognize at birth — alert team, prevent circumcision
- Family education and emotional support
- Referral to pediatric urology
- Routine newborn care
Pre-op:
- Pre-op teaching
- NPO per protocol
- Address parental anxiety
Post-op:
- Pain management
- Care of urinary stent/catheter (may remain for 1-2 weeks)
- Double diapering technique to protect surgical site
- Strict I&O
- Watch for bleeding, infection
- Activity restriction (no straddle toys, riding, sand play for weeks)
- Wound care
- Antispasmodic for bladder spasms
- Follow-up visits
Medications
- Pre-op: routine
- Post-op pain: acetaminophen, ibuprofen, oral opioids short-term
- Antispasmodic: oxybutynin (bladder spasms)
- Antibiotics prophylaxis if stent
- Stool softeners
- Anticholinergics if needed
Therapeutic Procedures
- Surgical repair (urethroplasty) — typically 6-18 months of age
- Goals: functional urethra, straighten penis, normal appearance
- Foreskin used in repair (NEVER circumcise hypospadias before repair)
- Tubularized incised plate (TIP) repair most common
- Severe cases may need staged procedures
- Stent placement (1-2 weeks post-op)
- Bladder exstrophy repair (epispadias) — complex, multiple stages
Client Education
- NO CIRCUMCISION before repair — repeat to all family and providers
- Surgery typically between 6-18 months
- Multiple stages may be needed for severe cases
- Foreskin used in repair
- Most boys have good functional and cosmetic outcomes
- Long-term follow-up for late complications
Post-op home care:
- Double diapering (inner for stool, outer for urine and stent)
- Avoid straddle activities: no Walker, riding toys, tricycles, swimming for 2-6 weeks
- Tub baths NOT until cleared (then short ones)
- Sponge bathing only initially
- Pain medication around the clock first few days
- Antibiotic prophylaxis
- Avoid constipation (stool softeners, fluids)
- Recognize complications: bleeding, swelling, fever, drainage, stent/catheter blockage → contact provider
- Avoid forced retraction of foreskin if present
- Follow-up appointments important
Long-term:
- Late complications can occur years later
- Lifetime urology follow-up
- Sexual function/fertility usually normal (mild cases)
- Psychosocial support — body image as adolescent
- Reassure that adolescent boys with repaired hypospadias usually have normal sexual function
Interprofessional Care
- Pediatric urology (primary)
- Pediatric anesthesia
- Pediatric primary care
- Newborn nursery / pediatrician
- Genetics if syndromic or ambiguous
- Endocrinology (DSD evaluation)
- Mental health (adolescent body image)
Alterations in Health (Diagnosis)
Most common extracranial solid tumor in children; arises from neural crest cells of sympathetic nervous system. Median age at diagnosis: 17 months (one of few cancers in young infants). Tumor most commonly in adrenal medulla but can occur anywhere along sympathetic chain (paraspinal, neck, chest, pelvis). Highly variable behavior — can spontaneously regress in infants (stage 4S) or aggressively metastasize.
Pathophysiology Related to Client Problem
Originates from primitive sympathetic ganglion cells (neuroblasts). Tumors classified by location, age, stage, MYCN amplification, histology, DNA ploidy. High-risk features: age > 18 months, MYCN amplification, unfavorable histology, advanced stage.
Health Promotion and Disease Prevention
- No specific prevention
- Genetic counseling for at-risk families (familial neuroblastoma rare — ALK, PHOX2B mutations)
- Early recognition of abdominal mass
Risk Factors
- Age < 5 years (90% of cases)
- Median age 17 months
- Family history (rare — < 2%)
- Genetic syndromes: neurofibromatosis, Hirschsprung, Beckwith-Wiedemann
- Maternal opioid use during pregnancy (some evidence)
Expected Findings
Symptoms depend on location:
- Abdominal mass (most common — adrenal) — firm, irregular, often crosses midline (unlike Wilms which usually doesn't)
- Abdominal pain, fullness
- Bowel/bladder dysfunction (large mass)
- Hypertension (catecholamine secretion)
- Diarrhea (VIP secretion)
Thoracic:
- Respiratory distress
- Horner syndrome (ptosis, miosis, anhydrosis — cervical/upper thoracic tumor compressing sympathetic)
- SVC syndrome
Paraspinal:
- "Dumbbell" tumor with intraspinal extension
- Back pain, weakness, paraplegia, bowel/bladder issues
Metastatic signs:
- "Raccoon eyes" (periorbital ecchymosis — bone marrow metastasis to skull)
- Bone pain, limping
- Pallor, fatigue (marrow involvement)
- Failure to thrive
- Fever, weight loss
- "Blueberry muffin" subcutaneous nodules (infants)
- Opsoclonus-myoclonus syndrome ("dancing eyes, dancing feet") — paraneoplastic, may be presenting feature
Laboratory Tests
- Urine catecholamine metabolites: ↑ VMA (vanillylmandelic acid) and HVA (homovanillic acid) — present in > 90%
- CBC: anemia, thrombocytopenia (marrow involvement)
- LDH
- Ferritin
- BUN/Cr, LFTs
- Coagulation studies
Diagnostic Procedures
- Tumor markers: urine VMA and HVA
- Imaging: ultrasound (initial), CT/MRI of primary site, MRI spine if paraspinal
- MIBG scan (meta-iodobenzylguanidine) — taken up by neuroblastoma cells (functional imaging)
- Bone scan
- Bilateral bone marrow biopsies
- Tumor biopsy: histology, MYCN amplification, ploidy, segmental chromosomal aberrations
- Staging: INSS (International Neuroblastoma Staging System), INRG (newer)
Safety Considerations
- Hypertension management (catecholamine excess) — careful BP control before surgery
- Tumor lysis syndrome prevention
- Neutropenic precautions during chemo
- Bleeding precautions
- Bone pain management
- Cord compression — emergency if paraspinal tumor
- Watch for catecholamine crisis (rare)
Complications
- Local complications: mass effect, hypertension
- Cord compression, paralysis
- Metastatic disease: bone, marrow, liver, skin, lymph nodes
- Chemo-related: cardiotoxicity, neurotoxicity, secondary cancers
- Stem cell transplant complications
- Long-term: growth, endocrine, hearing, cognitive issues
- Death (advanced disease, high-risk)
- Tumor lysis syndrome
- Recurrence
Nursing Care
- Comprehensive assessment
- Pain management (often significant)
- BP monitoring (catecholamine-driven HTN)
- Pre-op preparation
- Surgical care
- Chemo administration and monitoring
- Manage side effects: nausea, alopecia, mucositis, fatigue
- Neutropenic precautions during nadir
- Bleeding precautions
- Nutrition support
- Family education and support
- Coordinate complex multi-modal care
- Bone marrow transplant care
- Address developmental concerns (young children)
- Survivorship planning
Medications
- Chemotherapy: cisplatin, etoposide, doxorubicin, cyclophosphamide, vincristine
- Targeted/immunotherapy:
- Dinutuximab (anti-GD2 antibody) — high-risk maintenance
- Iodine-131 MIBG (targeted radiation)
- ALK inhibitors (some)
- Retinoic acid (differentiation therapy — maintenance)
- GM-CSF
- IL-2
- Supportive: antiemetics, hydration, allopurinol (TLS), G-CSF, antibiotics, transfusions
- Antihypertensives if needed
Therapeutic Procedures
Treatment based on risk stratification:
- Low risk: observation or surgery alone
- Intermediate risk: chemotherapy + surgery
- High risk: intensive multi-modal therapy:
- - Induction chemo
- - Surgery
- - High-dose chemo with autologous stem cell transplant
- - Radiation therapy
- - Immunotherapy (dinutuximab) + retinoic acid maintenance
- Stage 4S (infants): often spontaneously regresses; minimal therapy
- Survivorship clinic
Client Education
- Neuroblastoma has wide spectrum of behavior — varies from spontaneous regression to aggressive metastatic disease
- Treatment intensity matches risk
- High-risk: 1-2 years of intensive treatment
- Excellent prognosis in low-risk (90%+ survival) vs. challenging in high-risk (~50% survival)
- Side effects of chemo/radiation discussed
- Recognize warning signs: fever (especially during neutropenia → ER), bleeding, severe pain
- Bone pain may persist
- Long-term follow-up for late effects
- Hearing (cisplatin), cardiac (doxorubicin), growth, endocrine, cognitive monitoring
- Second cancer risk monitored
- School support
- Family/sibling support
- Connect with support organizations
Interprofessional Care
- Pediatric hematology/oncology (primary)
- Pediatric surgery
- Pediatric radiation oncology
- Pediatric stem cell transplant
- Pediatric anesthesia
- Pediatric cardiology (anthracyclines)
- Pediatric endocrinology
- Pediatric audiology (cisplatin)
- Rehabilitation services
- Nutrition
- Psychology, child life
- Social work
- Survivorship clinic
- Palliative care
- Genetic counseling (familial)
Alterations in Health (Diagnosis)
Congenital opening between right and left atria, allowing blood to shunt left-to-right (acyanotic). Types: ostium secundum (most common, 70%), ostium primum (with AV canal defects), sinus venosus. Often asymptomatic in childhood; symptoms may emerge in adulthood.
Pathophysiology Related to Client Problem
Defect in atrial septum → blood shunts from higher-pressure LA to RA → ↑ right heart volume → right atrial and right ventricular dilation → ↑ pulmonary blood flow. Long-term: pulmonary hypertension, arrhythmias, right heart failure.
Health Promotion and Disease Prevention
- Adequate prenatal care
- Genetic counseling if family history
- Avoid in utero exposures (alcohol, certain medications, rubella)
- Folic acid in pregnancy
- Routine newborn assessment
Risk Factors
- Female sex (slight)
- Family history
- Down syndrome (especially primum type with AV canal)
- Genetic syndromes (Holt-Oram, Noonan)
- Maternal rubella, alcohol, smoking
- Maternal diabetes
Expected Findings
- Often asymptomatic in childhood
- Heart murmur often the only finding:
- Fixed split S2 (classic for ASD)
- Systolic ejection murmur at upper left sternal border
- Mid-diastolic rumble at lower left sternal border (large shunt)
- Exercise intolerance, fatigue (with age)
- Frequent respiratory infections
- Slow weight gain (large ASD)
- Failure to thrive (rare)
- Adults: dyspnea on exertion, palpitations, atrial arrhythmias, embolic stroke
- Pulmonary HTN signs (late)
Laboratory Tests
- Generally clinical/imaging diagnosis
- BNP if HF suspected
Diagnostic Procedures
- Echocardiogram (definitive) — visualizes defect, direction of shunt, RV/RA dilation, pulmonary pressures
- EKG: RAD (right axis deviation), RVH, incomplete RBBB
- Chest X-ray: cardiomegaly (RA enlargement), ↑ pulmonary vascularity
- Transesophageal echo (some, especially adults)
- Cardiac MRI
- Cardiac catheterization (rarely needed for diagnosis; used for closure)
Safety Considerations
- Endocarditis prophylaxis NOT routinely required for isolated ASD per AHA
- Monitor for arrhythmias
- Pre-procedural planning if closure
- Watch for paradoxical embolism risk
Complications
- Heart failure (large ASD, with age)
- Atrial arrhythmias (atrial fibrillation, atrial flutter) — adults
- Pulmonary hypertension
- Right heart failure
- Paradoxical embolism (stroke)
- Eisenmenger syndrome (rare, late)
- Endocarditis (very rare)
- Closure-related: device migration, erosion, residual shunt
Nursing Care
- Assessment — cardiac, respiratory
- Monitor growth
- Identify symptoms suggesting need for closure
- Pre-procedure preparation
- Post-procedure monitoring: cardiac rhythm, bleeding from access site, neuro
- Education on activity restrictions
- Long-term follow-up coordination
- Cardiology referral and routine visits
- Recognize new symptoms
Medications
- Many small ASDs need no medication
- If HF: diuretics, ACE inhibitors, digoxin
- Antiarrhythmics if needed
- Post-closure: aspirin × 6 months (prevent clot on device)
- Endocarditis prophylaxis only if specific high-risk lesions or during 6 months post-device
Therapeutic Procedures
- Small ASD (< 5mm): may close spontaneously; observation
- Larger ASD or symptomatic: closure typically between ages 2-5
- Cardiac catheterization closure (preferred — Amplatzer occluder, Helex device) — for secundum ASD with adequate rims
- Surgical closure: open heart surgery with cardiopulmonary bypass; primary closure or patch (Dacron, pericardium)
- Required for: primum, sinus venosus, large secundum without adequate rims
- Lifelong cardiology follow-up
Client Education
- ASD is one of most common congenital heart defects
- Small ASDs often close on their own
- Larger ASDs need closure to prevent long-term problems (HF, arrhythmias, stroke)
- Excellent prognosis with closure
- Closure options: device closure (catheter — less invasive) or surgery
- Most children active and asymptomatic after closure
- Activity restrictions: typically 1-2 weeks for device, 4-6 weeks for surgery; gradual return to full activity
- Lifelong cardiology follow-up to monitor for: residual shunt, arrhythmias, pulmonary HTN
- Pregnancy considered safe after closure (with cardiology follow-up)
- Routine immunizations
- Endocarditis prophylaxis usually NOT needed
Interprofessional Care
- Pediatric cardiology
- Pediatric cardiothoracic surgery
- Interventional cardiology
- Pediatric anesthesia
- Pediatric ICU
- Genetics
- Adult congenital heart disease team (transition)
Alterations in Health (Diagnosis)
Cyanotic congenital heart defect. Aorta arises from right ventricle and pulmonary artery arises from left ventricle — creating parallel circulations instead of normal series. Without mixing (via PDA, ASD, or VSD), incompatible with life. Cardiac emergency in newborn period — requires PGE1 to keep PDA open, then surgical correction.
Pathophysiology Related to Client Problem
Embryologic abnormality of conotruncal development → great arteries arise from wrong ventricles. Deoxygenated systemic blood returns to RA → RV → AORTA (back to body) — never gets oxygenated. Oxygenated pulmonary venous return goes to LA → LV → PA → lungs again. Survival depends on shunt between two circulations (PDA, ASD, VSD).
Health Promotion and Disease Prevention
- Adequate prenatal care, fetal echo
- Avoid in utero exposures (maternal diabetes ↑ risk)
- Folic acid
- Genetic counseling
- Prenatal diagnosis allows delivery at specialized cardiac center
Risk Factors
- Male sex
- Maternal diabetes
- Maternal age > 40
- Genetic syndromes (rare; isolated more common)
- In utero retinoic acid exposure
- Family history
Expected Findings
Newborn presentation:
- Profound cyanosis within hours of birth (worsens as ductus closes)
- Cyanosis NOT improved with oxygen ("hyperoxia test")
- Tachypnea
- Single loud S2 (aorta anterior)
- Murmur usually absent (or VSD murmur if present)
- Hepatomegaly
- Sometimes appears well at birth — deteriorates as ductus closes
- Metabolic acidosis if circulation inadequate
- Without intervention: cardiovascular collapse, death within days
Laboratory Tests
- ABG: ↓ PaO₂ (does NOT improve with 100% O2 — characteristic)
- Metabolic acidosis
- Glucose (hypoglycemia common in distressed newborn)
- CBC, electrolytes
Diagnostic Procedures
- Fetal echocardiogram (prenatal diagnosis allows planned delivery at cardiac center)
- Echocardiogram (definitive postnatal)
- EKG: RVH
- Chest X-ray: classic "egg on a string" appearance (narrow mediastinum), ↑ pulmonary vascularity
- Hyperoxia test (100% O2 → ABG): no improvement in PaO₂ → cyanotic CHD
- Cardiac MRI, CT angiography (some)
- Cardiac catheterization (often combined with balloon atrial septostomy)
Safety Considerations
- PGE1 (prostaglandin E1) IV infusion IMMEDIATELY to keep PDA open (don't close ductus!)
- Watch PGE1 side effects: apnea (intubation often needed), fever, hypotension
- Don't give high O2 (closes ductus)
- Balloon atrial septostomy (Rashkind procedure) emergent if inadequate mixing
- Maintain neutral thermal environment
- NPO until surgery
- Avoid stress (cluster care)
- Continuous monitoring
- Transfer to pediatric cardiac surgery center ASAP
Complications
- Pre-surgical: cardiovascular collapse, death without intervention
- Surgical complications: arrhythmias, bleeding, infection, low cardiac output
- Coronary insufficiency (coronary reimplantation issue)
- Neurologic injury (CPB, stroke)
- Long-term: pulmonary valve stenosis (if pulmonary autograft used in Ross), neoaortic insufficiency, coronary issues, ventricular dysfunction
- Need for reoperation
- Developmental delays
- Arrhythmias
Nursing Care
Pre-op (newborn):
- Maintain PGE1 infusion at all costs (don't interrupt!)
- Intubation often needed (PGE1 → apnea)
- Continuous cardiorespiratory monitoring, pulse ox
- IV access
- NPO
- Maintain neutral thermal environment
- Cluster care
- Address family anxiety
- Transfer to pediatric cardiac center
Post-op (arterial switch):
- PICU care
- Mechanical ventilation
- Inotropic support
- Chest tubes
- Strict I&O
- Hemodynamic monitoring
- Pain management
- Feeding advancement
- Family support during prolonged stay
Medications
- PGE1 (alprostadil) infusion — maintains ductus open
- Inotropes post-op: epinephrine, milrinone
- Diuretics: furosemide
- Sedation, pain control
- Antibiotics
- Anti-arrhythmics if needed
- Long-term: ACE inhibitors, beta-blockers if dysfunction
- No routine endocarditis prophylaxis (after repair)
Therapeutic Procedures
- Emergency: PGE1 + balloon atrial septostomy (Rashkind)
- Definitive: Arterial Switch Operation (Jatene procedure) — typically within first 1-2 weeks of life: switch great arteries back to anatomic positions, reimplant coronary arteries
- Senning or Mustard (older atrial switch procedures, rarely done now)
- Rastelli procedure for TGA with VSD and pulmonary stenosis
- ECMO if needed
- Lifelong cardiology follow-up
Client Education
- TGA is a serious heart defect requiring early surgery
- Without surgery: not survivable
- With surgery: excellent long-term outcomes (90%+ survival)
- Surgery typically in first 1-2 weeks of life
- Prolonged hospitalization (weeks)
- Most children grow normally and have good quality of life after repair
- Lifelong cardiology follow-up needed
- Watch for: signs of heart failure, exercise intolerance, arrhythmias, chest pain
- Routine activity allowed (with cardiology clearance)
- Avoid contact sports (some) — depends on cardiac function
- Encourage normal childhood activities
- Pregnancy planning for adult women (specialized care)
- Genetic counseling for family planning
Interprofessional Care
- Maternal-fetal medicine (prenatal)
- Pediatric cardiology
- Pediatric cardiothoracic surgery
- NICU/Pediatric cardiac ICU
- Pediatric anesthesia
- Perfusionist
- Cardiac rehabilitation
- Genetic counseling
- Developmental specialists
- Family support, social work
- Adult congenital heart disease (transition)
Alterations in Health (Diagnosis)
Severe congenital heart defect: underdeveloped left side of heart (mitral and aortic valves, left ventricle, ascending aorta). Without intervention, uniformly fatal in newborn period. Requires staged surgical reconstruction or heart transplant.
Pathophysiology Related to Client Problem
Underdeveloped left ventricle cannot pump blood to systemic circulation. Systemic blood flow depends on: RV pumping blood through PDA to aorta (retrograde). Pulmonary venous return goes through ASD to right heart. As ductus closes → systemic perfusion fails → shock and death.
Health Promotion and Disease Prevention
- Adequate prenatal care
- Fetal echocardiogram (allows planned delivery at cardiac center)
- Genetic counseling if family history
- Folic acid in pregnancy
- Avoid in utero exposures
Risk Factors
- Male sex
- Family history of CHD
- Genetic syndromes: Turner, trisomy 13, 18; chromosomal abnormalities
- Maternal diabetes
- Recurrence risk in siblings ↑
Expected Findings
- May appear normal at birth (especially with patent ductus)
- Within hours-days: as ductus closes:
- Pallor, mottling, ashen color
- Tachypnea, retractions
- Weak/absent pulses (especially femoral)
- Cool extremities
- ↓ urine output
- Hepatomegaly
- Metabolic acidosis (poor perfusion)
- Cyanosis (variable — depends on mixing)
- Single S2
- No specific murmur typically (or soft systolic)
- Lethargy
- Shock and cardiovascular collapse
- Death within days without intervention
Laboratory Tests
- ABG: severe metabolic acidosis
- Lactate elevated
- Hypoglycemia
- ↑ LFTs, ↑ creatinine (hypoperfusion)
- BNP elevated
Diagnostic Procedures
- Prenatal echo (~80% diagnosed prenatally now)
- Postnatal echocardiogram (definitive)
- Chest X-ray: cardiomegaly, ↑ pulmonary vascularity
- EKG: RVH
- Hyperoxia test (no improvement)
- Pulse oximetry: pre-ductal (right hand) vs post-ductal (foot) — may be similar in HLHS
- Cardiac MRI
Safety Considerations
- PGE1 infusion IMMEDIATELY
- Maintain balance of systemic and pulmonary circulations (Qp:Qs ratio)
- DON'T give high oxygen (decreases PVR, increases pulmonary blood flow at expense of systemic)
- Target SpO₂ 75-85% (not "normal" — would mean too much pulmonary flow)
- NPO, gastric decompression
- Avoid stress
- Watch for cardiovascular collapse
- Transfer to specialized center
- Family discussion of treatment options (surgery vs comfort care vs transplant)
Complications
- Without intervention: 100% mortality
- Surgical mortality: 10-20% per stage
- Long-term: ventricular dysfunction, arrhythmias, protein-losing enteropathy, plastic bronchitis
- Need for heart transplant (some)
- Neurodevelopmental issues
- Failure to thrive
- Cyanosis
- Exercise intolerance (lifelong)
- Surgical complications
- Post-Fontan: late complications (liver disease, etc.)
Nursing Care
Pre-op:
- PGE1 infusion (don't interrupt)
- Intubation often needed
- Continuous monitoring
- Maintain target SpO₂ 75-85%
- Adjust FiO2 to balance Qp:Qs
- Inotropic support
- Correct acidosis
- NPO, gastric tube
- IV access
- Family support — devastating diagnosis
Post-Stage 1 (Norwood):
- PICU care, often weeks
- Mechanical ventilation
- Inotropes
- Strict I&O
- Watch for "interstage" complications (between Stage 1 and 2)
- Home monitoring program (daily weights, SpO₂)
- Feeding challenges (often G-tube)
- Avoid dehydration, illness
Medications
- PGE1 infusion
- Diuretics: furosemide
- ACE inhibitors
- Aspirin (post-Glenn/Fontan — prevents shunt thrombosis)
- Anticoagulation
- Inotropes
- Sildenafil (pulmonary HTN)
- Beta-blockers (sometimes)
- Antibiotics for endocarditis prophylaxis (after staged repair)
- Post-transplant: immunosuppression
Therapeutic Procedures
Three-stage Norwood reconstruction:
- Stage 1 — Norwood (first 1-2 weeks): reconstruct aorta from pulmonary artery, BT shunt or Sano shunt for pulmonary flow, atrial septectomy
- Stage 2 — Bidirectional Glenn (4-6 months): SVC connected directly to pulmonary arteries
- Stage 3 — Fontan (2-4 years): IVC also connected to pulmonary arteries (single ventricle physiology)
- Alternative: Heart transplant (limited donor availability)
- Comfort care option discussed with families
- ECMO bridge if needed
Client Education
Family:
- HLHS is a serious heart defect requiring multiple surgeries
- Three-stage reconstruction over first few years
- Or heart transplant alternative
- Some families choose comfort care — supported decision
- Long hospital stays expected
- Survival to adulthood now possible (was uniformly fatal before 1980s)
- 5-year survival now ~70%
- "Single ventricle" physiology — lifelong cardiac monitoring
- Interstage monitoring (home pulse ox, daily weights)
- Feeding challenges common — G-tube often needed
- Watch for: cyanosis, ↓ feeds, vomiting, lethargy, ↑ work of breathing → contact provider
- Avoid dehydration during illness
- Activity restrictions per cardiology
- Routine vaccinations (especially RSV, flu, COVID)
- School coordination
- Address developmental delays
- Adolescent transition to adult congenital heart team
- Family-decision pregnancy planning (genetic recurrence)
- Family support resources (Mended Little Hearts, etc.)
- Mental health support (for parents, sibling, and patient)
Interprofessional Care
- Maternal-fetal medicine (prenatal)
- Pediatric cardiology
- Pediatric cardiothoracic surgery
- Pediatric cardiac ICU
- Pediatric heart transplant team
- Pediatric anesthesia
- Pediatric pulmonology
- Pediatric GI (feeding)
- Pediatric developmental specialists
- PT, OT, speech
- Genetics
- Social work
- Chaplain
- Mental health
- Palliative care
- Adult congenital heart team (transition)
- Family support groups
Alterations in Health (Diagnosis)
Congenital malformation where esophagus does not connect normally to stomach (atresia) and/or there is abnormal connection to trachea (fistula). Most common type: EA with distal TEF (~85%) — proximal esophageal pouch, distal esophagus connects to trachea. Surgical emergency in newborn period.
Pathophysiology Related to Client Problem
Failure of normal embryonic separation of foregut into esophagus and trachea (4-6 weeks gestation). Multiple types (Gross classification A-E). Associated anomalies common: VACTERL (Vertebral, Anal, Cardiac, TE, Renal, Limb).
Health Promotion and Disease Prevention
- Adequate prenatal care
- Avoid in utero exposures
- Folic acid in pregnancy
- Genetic counseling if syndromic
- Fetal screening — polyhydramnios may suggest TEF
Risk Factors
- Maternal: diabetes, advanced age
- Prematurity
- Family history (rare)
- Genetic syndromes: VACTERL association, CHARGE, trisomy 18, 13, 21
- Maternal exposures (some)
Expected Findings
Newborn (immediately apparent):
- Excessive drooling, frothy saliva
- Choking, coughing, cyanosis with first feeding
- Inability to pass oral/nasogastric tube past 10-15 cm (classic test)
- Respiratory distress
- Abdominal distension (if distal TEF allows air into stomach)
- Scaphoid abdomen (if no distal TEF — pure atresia)
- Aspiration with feeds
- Recurrent pneumonia (if missed)
Prenatal:
- Polyhydramnios (mother unable to swallow)
- Absent or small stomach bubble on prenatal ultrasound
H-type TEF (no atresia):
- May present later
- Recurrent pneumonia
- Coughing/choking with feeds
- Abdominal distension
Laboratory Tests
- CBC, electrolytes
- Type and screen
- ABG
- Echo (cardiac anomalies common — VACTERL)
Diagnostic Procedures
- Inability to pass OG/NG tube past 10-15 cm
- Chest X-ray: coiled feeding tube in proximal pouch; pattern of air in stomach (distal TEF) or absence (pure atresia)
- NO contrast study unless absolutely needed (aspiration risk)
- Evaluate for VACTERL: spine X-ray, anus exam, echo, renal ultrasound, limb evaluation
- Bronchoscopy (H-type or before surgery)
- Esophagoscopy
Safety Considerations
- NPO immediately
- Continuous suction of proximal esophageal pouch (Replogle tube) — prevents aspiration of saliva
- HOB elevated 30°
- Prone or supine — depends on protocol (some prefer prone with head elevated to drain saliva)
- NPO
- IV access, fluids
- Antibiotics if pneumonia
- Maintain airway
- Watch for respiratory distress
- Avoid bag-mask ventilation if distal TEF (gastric distension)
- Transfer to pediatric surgical center
Complications
- Aspiration pneumonia (pre-op)
- Surgical complications: anastomotic leak (5-20%), anastomotic stricture (most common — needs dilation), recurrent fistula
- GERD (very common post-op)
- Tracheomalacia
- Esophageal dysmotility
- Dysphagia
- Failure to thrive
- Recurrent respiratory infections
- Barrett esophagus (long-term)
- Esophageal cancer (rare, very long-term)
- Death (especially with associated anomalies)
Nursing Care
Pre-op:
- NPO
- Continuous low-intermittent suction of proximal pouch (Replogle)
- HOB elevated
- Position to minimize aspiration
- NPO, IV fluids
- Respiratory monitoring
- Pulse ox, suction available
- Parental teaching (devastating diagnosis)
- Evaluate for VACTERL anomalies
- Pre-op teaching
Post-op:
- NICU/PICU care
- Mechanical ventilation may continue
- Chest tube management
- NPO initially
- Gastrostomy tube feeds may start
- Strict I&O
- Pain management
- Watch for anastomotic leak (drainage, fever, ↑ WBC)
- Suctioning with marked catheter (don't advance past anastomosis)
- Position to prevent stretch on anastomosis
- Gradual feeding advancement
- Esophagoscopy follow-up
- Long-term: dilation for strictures, GERD management
- Feeding therapy
Medications
- IV antibiotics (pneumonia, prophylaxis)
- IV fluids
- Pain management: opioids, acetaminophen
- Sedation as needed
- PPI for GERD (almost always)
- Antifungals if needed
- Antiemetics
Therapeutic Procedures
- Surgical repair — primary anastomosis (TEF ligation + esophageal anastomosis), typically within first few days of life
- Thoracoscopic approach increasingly common
- Long-gap atresia: staged repair (delayed primary, esophageal replacement)
- Gastrostomy tube for feeding
- Dilation for strictures (often multiple)
- Fundoplication for severe GERD
- Speech and feeding therapy
- Long-term follow-up: pediatric surgery, GI, pulmonology
Client Education
Family:
- TEF/EA is a complex congenital malformation requiring surgery
- Surgery typically within first few days of life
- Long hospitalization (weeks-months)
- Most children grow up with normal-functioning esophagus, but complications common
- Lifelong feeding considerations
Post-op home care:
- Feeding: small frequent feeds, upright position, slow pace
- GERD management critical: PPI, upright after meals
- Watch for stricture: choking, regurgitation, food sticking — may need dilation
- Avoid hard foods initially
- G-tube care if applicable
Watch for problems:
- Difficulty feeding, food refusal
- Recurrent respiratory infections
- Persistent cough
- Vomiting, regurgitation
- Failure to gain weight
- Choking episodes
Long-term:
- Feeding therapy
- Speech therapy
- Repeated endoscopy/dilations
- Periodic surveillance for Barrett
- Address developmental delays (if associated anomalies)
- Family support
- Surgery follow-up
- Connect with TEF/EA support groups
Interprofessional Care
- Pediatric surgery (primary)
- NICU/Pediatric ICU
- Pediatric pulmonology
- Pediatric GI (feeding, GERD)
- Pediatric cardiology (cardiac anomalies)
- Pediatric urology (renal anomalies)
- Pediatric orthopedics (limb anomalies)
- Speech-language pathology
- Feeding therapy
- Nutritionist
- Genetics
- Social work, family support
Alterations in Health (Diagnosis)
Chronic immune-mediated GI inflammation. Two main types: Ulcerative colitis (UC) — continuous inflammation limited to colon mucosa/submucosa. Crohn's disease — transmural inflammation, "skip lesions," any part of GI tract (mouth to anus, most common terminal ileum). 25% of IBD presents in childhood/adolescence.
Pathophysiology Related to Client Problem
Multifactorial: genetic predisposition + environmental triggers + dysregulated immune response to gut microbiome → chronic inflammation. Children often have more severe disease at presentation than adults.
Health Promotion and Disease Prevention
- No specific prevention
- Family screening if family history (not for active screening, but recognize symptoms)
- Address growth and nutrition
- Breastfeeding (some evidence — protective)
- Avoid frequent early antibiotics (some evidence)
Risk Factors
- Family history (strongest)
- Genetic syndromes (e.g., NOD2 mutations Crohn's)
- Caucasian, Ashkenazi Jewish ancestry
- Smoking (Crohn's risk; protective for UC)
- Diet: low fiber, high processed foods
- NSAIDs (may trigger flares)
- Early childhood infections, antibiotics (some evidence)
Expected Findings
Crohn's disease:
- Abdominal pain (often RLQ, post-prandial)
- Diarrhea (may not be bloody)
- Weight loss, failure to thrive
- Growth delay (in children — sometimes only sign)
- Delayed puberty
- Fever
- Fatigue
- Perianal disease (fistulas, abscesses, skin tags) — characteristic
- Oral ulcers, aphthous stomatitis
- Anorexia
- Bowel obstruction signs (strictures)
Ulcerative colitis:
- Bloody diarrhea (characteristic)
- Mucus, pus in stool
- Tenesmus, urgency
- Abdominal cramping (lower)
- Fever (severe)
- Weight loss
- Anemia
- Toxic megacolon (severe)
Extraintestinal manifestations (both):
- Arthralgia, arthritis (most common)
- Erythema nodosum, pyoderma gangrenosum
- Uveitis, episcleritis
- Primary sclerosing cholangitis (UC especially)
- Aphthous ulcers
- Renal stones (Crohn's)
- Gallstones (Crohn's with terminal ileum disease)
- Osteoporosis
- Iron deficiency, B12 deficiency, vitamin D deficiency
- Anemia
- Growth failure
Laboratory Tests
- CBC: anemia (chronic disease, iron deficiency), thrombocytosis
- ↑ ESR, CRP (inflammation)
- ↓ albumin (malabsorption, inflammation)
- Electrolytes, BUN/Cr
- LFTs (PSC)
- Iron studies, ferritin, B12, folate, vit D
- Stool studies: rule out infection (C. diff, ova/parasites, viral); fecal calprotectin (inflammation marker)
- Antibodies: pANCA (UC), ASCA (Crohn's) — not diagnostic alone
Diagnostic Procedures
- Colonoscopy with biopsy — definitive diagnostic
- Upper endoscopy (Crohn's)
- Capsule endoscopy or MR enterography (small bowel — Crohn's)
- Histology: UC — continuous, mucosal/submucosal; Crohn's — transmural, skip lesions, granulomas
- CT abdomen/pelvis (acute or complications)
- Plain X-ray (toxic megacolon screen)
- Bone density (osteoporosis)
- Growth chart, Tanner staging
Safety Considerations
- Address malnutrition, dehydration
- Watch for toxic megacolon (severe UC) — surgical emergency
- Watch for bowel obstruction (Crohn's strictures)
- Watch for perforation
- Monitor growth and pubertal development
- Live vaccines BEFORE starting immunosuppression
- Cancer surveillance (colon cancer ↑ in long-standing colitis — colonoscopy every 1-2 yr after 8-10 yr of disease)
- Infection risk on immunosuppression
- Mental health screening (chronic illness)
- Adherence support
Complications
- Growth failure, delayed puberty
- Malnutrition, vitamin deficiencies
- Anemia
- Strictures, bowel obstruction (Crohn's)
- Fistulas, abscesses (Crohn's)
- Toxic megacolon (UC)
- Perforation
- Massive hemorrhage
- Colon cancer (long-standing colitis)
- Osteoporosis
- Extraintestinal disease
- Psychosocial: depression, anxiety, school disruption
- Medication side effects
- Need for surgery
- Recurrence post-surgery (Crohn's)
Nursing Care
- Comprehensive history and physical
- Growth charts (each visit)
- Nutrition assessment
- Monitor for flares
- Educate about disease, medications
- Adherence support (compliance challenges in adolescents)
- Side effect monitoring
- Vaccinations before immunosuppression (especially live)
- Psychosocial support
- School coordination (504/IEP)
- Address body image, bathroom access
- Transition to adult care
- Cancer surveillance scheduling
- Bone health
- Pain management
- Stool tracking
Medications
Mild-moderate:
- 5-ASA (mesalamine) — UC primarily; less effective Crohn's
- Sulfasalazine
- Topical (enemas, suppositories) for distal UC
Moderate-severe / Induction:
- Corticosteroids (prednisone, budesonide) — short-term induction; NOT for maintenance (side effects)
- Enteral nutrition (formula only) — induction in pediatric Crohn's (first-line in many centers)
Maintenance / Immunomodulators:
- Azathioprine, 6-mercaptopurine
- Methotrexate
- Watch: bone marrow suppression, hepatotoxicity, pancreatitis, lymphoma risk
Biologics:
- Anti-TNF: infliximab (Remicade), adalimumab (Humira)
- Anti-integrin: vedolizumab
- Anti-IL-12/23: ustekinumab, risankizumab
- JAK inhibitors: tofacitinib, upadacitinib (UC adolescents)
- Watch: TB screening before, infection risk, infusion reactions, lupus-like
Supportive:
- Iron (oral or IV)
- B12, vitamin D supplementation
- Calcium
- Antibiotics (perianal Crohn's, abscess, pouchitis)
- Probiotics (some evidence UC)
- Antidiarrheals — CAREFUL (toxic megacolon risk)
Therapeutic Procedures
Crohn's:
- Surgery NOT curative (recurs)
- Indications: strictures, fistulas, abscesses, perforation, refractory disease
- Resection, stricturoplasty
- Perianal: seton, drainage
UC:
- Total colectomy CURATIVE
- Indications: refractory, toxic megacolon, dysplasia, cancer
- Total proctocolectomy with ileal pouch-anal anastomosis (IPAA — "J pouch") or end ileostomy
- Stoma care education
Other:
- Nutritional support (enteral preferred)
- TPN if severe
- Psychological support
- Cancer surveillance
Client Education
Family:
- IBD is a CHRONIC condition — flares and remissions
- NOT caused by stress or diet (though may exacerbate)
- Lifelong management for most
- Goal: induce and maintain remission
- Long-term medications usually needed
- Treatment success depends on adherence
Medications:
- Take exactly as prescribed
- Don't stop steroids abruptly
- Vaccinations before immunosuppression (live especially)
- Monitor for side effects
- Bring all meds to appointments
- Don't take NSAIDs (may trigger flares)
Diet:
- No specific "IBD diet"
- Identify personal triggers (varies)
- Adequate calories, protein
- Vitamin/mineral supplementation
- Low-residue during flares
- Avoid: high fiber, dairy if lactose intolerant, spicy, high-fat during flare
- Enteral nutrition (formula only) — option for Crohn's induction
Lifestyle:
- Don't smoke (especially Crohn's)
- Manage stress (doesn't cause but may worsen)
- Stay active (within tolerance)
- Adequate sleep
- Mental health support
Watch for flares/complications:
- Increased frequency/blood in stools
- Severe pain
- Fever
- Weight loss
- Vomiting (obstruction)
- Abdominal distension
- Notify provider
Long-term:
- Routine follow-up
- Colonoscopy surveillance for cancer
- Bone density monitoring
- Address growth, puberty
- School support — bathroom access plan
- 504 plan for accommodations
- Body image, dating support (adolescents)
- Transition to adult GI
- CCFA (Crohn's and Colitis Foundation) resources, support groups
- Family planning (medications, pregnancy)
Interprofessional Care
- Pediatric GI (primary)
- Pediatric surgery
- Pediatric dietitian (IBD-specialized)
- Pediatric infectious disease
- Rheumatology (extraintestinal)
- Pediatric ophthalmology (uveitis)
- Endocrinology (growth, bone)
- Mental health
- Social work
- School coordinator
- Stoma nurse (post-op UC)
- Adult GI (transition)
- Support organizations (CCFA)
- Genetic counseling (familial)
Alterations in Health (Diagnosis)
Most common soft tissue sarcoma in children. Arises from primitive mesenchymal cells (skeletal muscle precursors). Can occur anywhere in body — head/neck (orbit), GU tract, extremities most common locations. Two main histologic types: embryonal (younger children, better prognosis) and alveolar (older, worse).
Pathophysiology Related to Client Problem
Malignant transformation of embryonic skeletal muscle precursor cells. Tumor may compress, invade, or metastasize. Embryonal subtype includes botryoid variant ("grape-like" appearance — vaginal, bladder).
Health Promotion and Disease Prevention
- No specific prevention
- Genetic counseling for at-risk families (Li-Fraumeni syndrome, neurofibromatosis-1, Beckwith-Wiedemann)
- Early recognition of mass
Risk Factors
- Age < 10 years (most common)
- Male slight predominance
- Genetic syndromes: Li-Fraumeni, neurofibromatosis-1, Beckwith-Wiedemann, Costello, DICER1
- In utero exposure to certain agents
- Prior radiation (rare)
Expected Findings
Depends on location:
- Head and neck (40%):
- Orbital: proptosis, eyelid swelling, vision changes
- Parameningeal: nasal/sinus obstruction, ear pain, cranial nerve palsies, headache, vomiting
- Nonparameningeal: painless mass
- GU tract (25%):
- Bladder/prostate: hematuria, urinary obstruction, dribbling
- Vagina: vaginal mass/bleeding, "botryoid" grape-like mass
- Paratesticular: scrotal mass
- Extremities (20%):
- Painful or painless mass
- Often mistaken for trauma initially
- Pain, swelling
- Trunk/retroperitoneum: mass, organ displacement
- Metastatic disease:
- Bone pain
- Pallor (marrow involvement)
- Respiratory symptoms (lung mets)
- Lymphadenopathy
Laboratory Tests
- CBC, CMP
- LDH (elevated)
- Coagulation
- UA
- LFTs
Diagnostic Procedures
- Imaging: CT/MRI of primary site
- Biopsy: histology, molecular markers, FOXO1 fusion (alveolar)
- Staging workup: chest CT, bone scan, PET-CT, bone marrow biopsies (bilateral)
- LP if parameningeal
- Risk stratification: low/intermediate/high based on histology, location, stage, age, fusion status
Safety Considerations
- Cancer-specific safety (neutropenic precautions, bleeding precautions)
- Pre-op evaluation
- Radiation safety
- Tumor lysis syndrome prevention
- Pain management
- Long-term effects monitoring
Complications
- Local invasion (varies by location)
- Metastatic disease (lung, bone, bone marrow, lymph nodes)
- Treatment-related: cardiotoxicity (doxorubicin), nephrotoxicity (cisplatin), infertility, secondary cancers, growth issues
- Cosmetic/functional issues (after surgery, radiation)
- Vision issues (orbital)
- Cognitive (parameningeal radiation)
- Recurrence
- Death (high-risk)
Nursing Care
- Comprehensive assessment
- Tumor-location-specific care
- Pre-op preparation
- Chemotherapy administration
- Manage side effects
- Neutropenic precautions
- Pain management
- Nutrition support
- Address developmental needs
- Family support
- Coordinate multidisciplinary care
- Survivorship planning
Medications
- Chemotherapy (VAC regimen): vincristine, dactinomycin, cyclophosphamide
- Add: doxorubicin, ifosfamide, etoposide, irinotecan (some)
- Supportive: antiemetics, hydration, mesna (cyclophosphamide), G-CSF, antibiotics
- Pain medications
Therapeutic Procedures
- Multimodal therapy: chemo + surgery + radiation
- Chemotherapy (all patients)
- Surgical resection (when possible without unacceptable morbidity)
- Radiation therapy (most patients)
- Treatment duration ~12 months
- Reconstruction (cosmetic, functional) — secondary
Client Education
- Rhabdomyosarcoma is treatable, often curable
- 5-year survival: 70-80% overall (varies by risk group)
- Multi-year follow-up
- Side effects of chemo, radiation discussed
- Fertility preservation discussion (older children/adolescents)
- Late effects monitoring lifelong
- Cardiac (anthracyclines), kidney, hearing, growth, endocrine
- Secondary cancer risk
- Functional/cosmetic concerns after treatment
- School support during treatment
- Psychological support
- Family/sibling support
- Connection to support organizations
Interprofessional Care
- Pediatric hematology/oncology
- Pediatric surgery
- Pediatric radiation oncology
- Location-specific specialists (ENT, GU, ortho, ophth)
- Pediatric cardiology
- Pediatric endocrinology
- Fertility specialist (older children)
- Audiology
- Rehabilitation
- Nutrition
- Child life, psychology
- Social work, school
- Genetic counseling
- Survivorship clinic
Alterations in Health (Diagnosis)
Inadequate growth in young children — weight (and sometimes height) falls below expected for age. Defined as weight < 5th percentile, or crossing 2+ major percentiles downward, or weight-for-height < 5th percentile. Now often called "faltering growth" (less pejorative). Causes: organic (medical), nonorganic (environmental, psychosocial), or mixed (most common).
Pathophysiology Related to Client Problem
Inadequate calorie intake, malabsorption, increased calorie expenditure, or combination → energy deficit → impaired growth → potential developmental, cognitive, immune effects.
Health Promotion and Disease Prevention
- Adequate nutrition counseling
- Breastfeeding support
- Routine growth monitoring well-child visits
- Early recognition of feeding difficulties
- Social support for at-risk families
- WIC participation
- Maternal nutrition (prenatal)
- Treat maternal mental health
- Address food insecurity
Risk Factors
Organic causes:
- Inadequate intake: cleft palate, neurologic feeding problems, poor suck
- Malabsorption: cystic fibrosis, celiac, food allergies, short gut
- Increased needs: chronic infection, congenital heart disease, BPD, hyperthyroidism
- Endocrine: hypothyroidism, growth hormone deficiency
- Genetic: chromosomal abnormalities, Turner syndrome, Russell-Silver
- Renal disease, liver disease
- GI: GERD, IBD
- Inborn errors of metabolism
Nonorganic causes:
- Poverty, food insecurity
- Inadequate breastfeeding (poor education, technique)
- Improper formula preparation (over-diluted)
- Neglect, abuse
- Maternal depression
- Parental mental illness
- Family stress
- Caregiver-child feeding mismatch
- Excessive juice/water
Expected Findings
- Weight gain less than expected (review growth chart)
- Weight < 5th percentile or crossing 2+ major percentile lines
- Weight-for-height ratio low
- Length/height eventually affected if severe
- Head circumference may eventually decline (severe)
- Decreased subcutaneous fat
- Muscle wasting
- Apathy, irritability
- Developmental delay
- Poor muscle tone
- Listlessness, lethargy
- Skin: pale, dry
- Hair sparse
- Decreased social interaction
- Poor feeding behavior
- Dental issues (older)
Laboratory Tests
- CBC (anemia)
- BMP, magnesium, phosphorus
- Albumin, prealbumin
- LFTs
- TSH
- Lead level
- Urinalysis, urine culture
- Iron studies
- Vitamin D, vitamin B12
- Celiac screen (anti-TTG IgA)
- HIV (some)
- Sweat chloride if CF suspected
- Stool studies
- Newborn screen review
Diagnostic Procedures
- Detailed history: feeding (volume, frequency, technique), formula prep, stools, urine output, developmental, social, family
- Growth chart review (compare to previous; identify when growth faltering began)
- Physical exam: nutritional assessment, dysmorphic features, organ systems
- Developmental screening
- Observe feeding
- Hospitalization sometimes needed (severe, suspected neglect)
- Imaging based on suspected cause: skeletal survey (abuse), abdominal imaging
- Endoscopy if GI
- Cardiac evaluation if heart disease suspected
- Specialized testing per cause
Safety Considerations
- Watch for refeeding syndrome in severely malnourished (initial period of refeeding)
- Monitor electrolytes (K, Mg, Phos)
- Increase calories gradually (don't overfeed too fast)
- Document all feeding observations
- Mandatory reporting if abuse/neglect suspected
- Safe sleep practices
- Address feeding aversions
- Cardiac monitoring if severely malnourished
Complications
- Stunted growth (irreversible if persistent)
- Developmental delay (cognitive, motor, social)
- Cognitive deficits (long-term)
- Behavioral problems
- Immune dysfunction
- Increased infection risk
- Death (severe, untreated)
- Refeeding syndrome (during treatment)
- Cardiac issues with severe malnutrition
- Long-term: chronic disease risk
Nursing Care
- Comprehensive feeding assessment
- Observe a feeding
- Weight on same scale, same time, same clothing daily
- Strict I&O
- Calorie count (24-hour)
- Document everything fed and refused
- Calorie-dense feedings (formulas may be concentrated)
- Frequent small feedings
- Quiet, non-distracting environment
- Skin-to-skin holding
- Don't force-feed
- Avoid power struggles
- Caregiver education (feeding technique, formula prep, cues)
- Address feeding aversions (often need feeding therapy)
- NG/G-tube if oral intake inadequate
- Coordinate multidisciplinary care
- Address psychosocial factors
- Mandatory reporting if neglect suspected
- Discharge planning with close follow-up
Medications
- Generally none specific — treat underlying cause
- Multivitamin with iron
- Iron supplementation if deficient
- Vitamin D, calcium
- Pancreatic enzymes (CF)
- PPI/H2 blocker for GERD
- Treatment of identified conditions
Therapeutic Procedures
- High-calorie diet (formula concentration, fortifier, calorie supplements)
- Feeding therapy (OT, speech)
- NG or G-tube feeding (when oral inadequate)
- Hospitalization for evaluation/severe cases
- Treatment of underlying medical condition
- Psychosocial intervention
- Family therapy
- Early intervention services
- WIC, food assistance
Client Education
Family education on feeding:
- Proper formula preparation (don't over-dilute!)
- Adequate volume and frequency for age
- Avoid excessive juice, water (< 6 months: no water; toddlers: limit juice to 4 oz/day)
- Responsive feeding (respond to hunger and satiety cues)
- Avoid force-feeding
- Pleasant feeding environment
- Family meals when older
- Variety of foods
- Continue breastfeeding/formula appropriately
- Solids introduction timing (4-6 months)
- Calorie-dense foods (avocado, peanut butter, full-fat dairy)
- Limit "empty calories"
Watch for:
- Adequate wet diapers (6+ per day for infants)
- Adequate weight gain
- Developmental progress
- Behavior
Resources:
- WIC
- Food banks, SNAP
- Lactation consultants
- Feeding therapy
- Early intervention
- Parenting support
- Mental health for caregivers
- Pediatric primary care close follow-up (weekly initially)
Interprofessional Care
- Pediatric primary care (close follow-up)
- Pediatric GI (organic causes)
- Pediatric dietitian
- Feeding therapy (OT/SLP)
- Lactation consultant
- Social work (always — psychosocial assessment)
- WIC, food assistance
- Mental health (caregivers)
- Early intervention
- Child protective services (if neglect)
- Specialists per underlying cause
- Home health
Alterations in Health (Diagnosis)
Process of respiratory impairment from submersion/immersion in liquid. Outcomes range from no morbidity to death. Leading cause of unintentional injury death in children 1-4 years. New terminology: "drowning" includes survival; avoid "near-drowning" or "dry drowning" (outdated).
Pathophysiology Related to Client Problem
Submersion → breath-holding/laryngospasm → hypoxia → loss of consciousness → aspiration of water → hypoxemia, hypercarbia, acidosis → multi-organ injury (brain most vulnerable). Secondary effects: ARDS, pulmonary edema, hypothermia, electrolyte issues. Outcome largely determined by initial hypoxic insult duration and time to effective resuscitation.
Health Promotion and Disease Prevention
- Active adult supervision around water ("touch supervision" for < 5 yr)
- Pool fencing (4-sided, self-latching gates) — saves lives
- Swim lessons (≥ 1 year, with formal training)
- Coast Guard-approved life jackets (NOT water wings — false sense of security)
- Adult CPR training
- Empty buckets, bathtubs after use
- Toilet locks for toddlers
- Adult sober supervision around water
- Boating safety
- Avoid swimming alone
- Address seizure disorders
- Pool covers (when not in use)
- Avoid alcohol around water (adolescents)
Risk Factors
- Age 1-4 years (peak)
- Adolescent males (higher risk — alcohol, risk-taking)
- Inability to swim
- Lack of supervision
- Lack of barriers (pool fence)
- Seizure disorders
- Autism spectrum (elopement to water)
- Alcohol/drug use (adolescents)
- Long QT syndrome
- Cold water (longer hypoxia tolerance but also hypothermia)
- African American children (higher rate)
- Low socioeconomic status
Expected Findings
On scene:
- Unconscious, unresponsive (severe)
- Apneic or agonal breathing
- Cyanosis
- No pulse (cardiac arrest)
- Hypothermia
- Vomiting (common)
If respiratory compromise:
- Tachypnea, dyspnea
- Coughing
- Crackles, wheezing
- Hypoxia
- Altered mental status
- Cyanosis
- Hypothermia (especially cold water)
Even apparently asymptomatic:
- May develop respiratory issues 4-8 hours later (pulmonary edema)
- So 4-8 hour observation needed even for minor submersion
Laboratory Tests
- ABG: hypoxemia, hypercarbia, metabolic acidosis
- CBC
- Electrolytes (rarely deranged in fresh water)
- BUN/Cr
- Glucose
- LFTs (later)
- Coagulation (DIC severe)
- Lactate (perfusion)
- Troponin (cardiac injury)
- Tox screen (adolescent)
- Pregnancy test (females)
Diagnostic Procedures
- Continuous monitoring (vitals, SpO₂, ECG)
- CXR: pulmonary edema, aspiration, ARDS
- CT head (if neuro symptoms or trauma)
- C-spine imaging (if diving or trauma)
- EEG (if seizures, severe)
- Echo (cardiac function, especially with hypoxia)
Safety Considerations
- SAFE RESCUE: don't become a victim yourself
- C-spine precautions if diving injury or trauma suspected
- Hypothermia management (rewarm gradually)
- Aspiration precautions (suction available)
- Continuous ECG monitoring
- Long arrest with cold water → continue resuscitation (better outcomes)
- Family support — devastating event
- Mandatory reporting if neglect suspected
- Observation 4-8 hours even if appears well (delayed symptoms)
Complications
- Death
- Anoxic brain injury (most concerning long-term)
- Persistent vegetative state
- Cognitive deficits, developmental regression
- Seizures
- ARDS, pulmonary edema
- Pneumonia (especially aspiration, contaminated water)
- Bronchospasm
- Cardiac arrhythmias
- Multi-organ failure
- Hypothermia complications
- Renal failure
- DIC
- Hypoxic-ischemic encephalopathy
- PTSD (family, child)
Nursing Care
On scene / ED:
- ABCs — airway, breathing, circulation
- CPR if needed (rescue breaths first — drowning is primarily hypoxic arrest)
- 100% oxygen, intubation if needed
- C-spine immobilization if trauma suspected
- Continuous monitoring
- Two large-bore IV/IO
- Warm child (passive then active rewarming)
- Treat hypothermia carefully
- Suction PRN
- NG tube (gastric distension common)
- Glucose check
- Foley catheter
ICU:
- Mechanical ventilation
- PEEP, lung-protective settings
- Manage ARDS
- Therapeutic hypothermia (some centers — controversial)
- Treat seizures
- Neuro monitoring
- ICP management if cerebral edema
- Family support
- Chaplain, social work
If asymptomatic:
- Observation 4-8 hours
- Repeat CXR, SpO₂
- Discharge with strict return precautions if normal
Medications
- Oxygen
- Bronchodilators (wheezing)
- Antibiotics if pneumonia (especially contaminated water — broad-spectrum)
- Antiepileptics if seizures
- Sedation for ventilation
- Vasopressors if shock
- NOT routine: prophylactic steroids, prophylactic antibiotics
Therapeutic Procedures
- Aggressive resuscitation
- Mechanical ventilation
- ECMO (severe ARDS, refractory)
- Therapeutic hypothermia (some centers)
- Rehabilitation (PT, OT, speech) for survivors with brain injury
- Long-term care for severe brain injury
- Family counseling, mental health
- Palliative care discussion if severe injury
Client Education
PREVENTION is paramount:
- Active touch supervision (designated water watcher)
- Never leave child alone in/near water — even for a moment
- Pool fencing 4-sided with self-latching gates — saves lives
- Empty all standing water (buckets, kiddie pools, bathtubs)
- Toilet locks for toddlers
- Swim lessons starting age 1+
- Coast Guard-approved life jackets (NOT water wings or floats)
- Adult CPR training
- Avoid alcohol around water
- Don't swim alone
- Address risk factors (seizures)
- Boating safety
- Beach: watch for rip currents, swim near lifeguards
If incident:
- Even if appears well, seek evaluation (delayed symptoms possible)
- Watch for 4-8 hours minimum
- Return for: respiratory distress, cough, vomiting, lethargy, fever
Family support after event:
- PTSD common (parents, siblings, child)
- Mental health resources
- Support groups
- Don't blame yourself (when applicable)
- Time for healing
Interprofessional Care
- Pediatric ED
- Pediatric ICU
- Pediatric pulmonology
- Pediatric neurology (if brain injury)
- Pediatric cardiology
- Rehabilitation team
- Child life
- Social work, chaplain
- Mental health
- Palliative care (if severe)
- School coordinator (return planning)
- Public health (prevention education)
Alterations in Health (Diagnosis)
Systemic bacterial, viral, or fungal infection in newborn (< 28 days). Major cause of neonatal mortality. Early-onset (< 72 hours): transmitted from mother, often GBS or E. coli. Late-onset (3-28 days): often nosocomial, Staphylococcus, coagulase-negative staph. Neonates have non-specific presentation — high suspicion needed.
Pathophysiology Related to Client Problem
Pathogen enters bloodstream (vertical transmission, ascending infection, nosocomial, or community) → systemic inflammatory response → endothelial dysfunction → microvascular dysfunction → multi-organ failure. Immature neonatal immune system (less efficient phagocytosis, complement, antibody) → high vulnerability.
Health Promotion and Disease Prevention
- Maternal GBS screening (35-37 weeks) and intrapartum antibiotics
- Adequate prenatal care
- Treat maternal infections promptly (UTI, chorioamnionitis)
- Avoid unnecessary cesarean and procedures
- Strict hand hygiene
- Aseptic technique with all neonatal procedures
- Limited invasive devices (early removal of catheters)
- Breastfeeding (immune support)
- Immunizations as scheduled
- NICU infection control protocols
- Reduce length of stay when possible
Risk Factors
Early-onset risks:
- Maternal GBS colonization without adequate antibiotic prophylaxis
- Premature rupture of membranes > 18 hours
- Maternal chorioamnionitis (fever, fetal tachycardia)
- Maternal UTI
- Prolonged labor
- Prematurity
- Low birth weight
- Male sex (slight)
- Maternal age < 20
Late-onset risks:
- Prematurity
- Low birth weight
- Central lines, indwelling catheters
- Mechanical ventilation
- Surgery
- Hyperalimentation (TPN)
- NICU stay
- Skin breakdown
Expected Findings
Subtle, non-specific (most common):
- Temperature instability (hypothermia more common than fever in neonates)
- Poor feeding
- Lethargy or irritability
- "Just doesn't look right" to parents/staff
- Tachycardia, bradycardia
- Tachypnea, apnea, grunting
- Hypotension (late)
- Cyanosis, pallor, mottling
- Hypoglycemia or hyperglycemia
- Hypotonia
- Seizures
- Bulging fontanel (meningitis)
- Vomiting, abdominal distension
- Jaundice
- Petechiae, purpura, bleeding (DIC)
- Decreased urine output
- Hepatomegaly, splenomegaly
Laboratory Tests
- CBC with differential: ↑ or ↓ WBC, neutropenia, immature-to-total neutrophil ratio > 0.2, thrombocytopenia (concerning)
- Blood cultures × 2 (before antibiotics if possible)
- CSF (lumbar puncture): cell count, protein, glucose, culture — meningitis common
- Urine culture (catheterized, late-onset)
- Surface cultures (some, controversial)
- CRP, procalcitonin (serial)
- ABG: metabolic acidosis
- Glucose (often abnormal)
- Electrolytes
- Coagulation (DIC)
- LFTs
- BUN/Cr
- Lactate
Diagnostic Procedures
- Sepsis evaluation: cultures (blood, CSF, urine if late-onset)
- Lumbar puncture (especially if neuro symptoms or hemodynamically stable)
- CXR (pneumonia)
- Abdominal X-ray (NEC concern)
- Head ultrasound (IVH, hydrocephalus)
- Echo (cardiac function)
- HSV testing if maternal HSV or skin/mouth lesions, seizures, or sepsis-like
Safety Considerations
- Don't wait for cultures — start empiric antibiotics ASAP (within 1 hour)
- Universal precautions, contact precautions per organism
- Strict hand hygiene
- Aseptic technique
- Limit invasive procedures
- Glucose monitoring
- Watch for: hypoglycemia, hypothermia, electrolyte issues
- Cluster care (minimize stress)
- Watch for DIC
- Monitor for shock
- Track development
- Watch for sequelae (hearing, vision, developmental)
Complications
- Meningitis (very common in neonates with sepsis)
- Shock, multi-organ failure
- DIC
- Seizures
- Brain injury (hypoxic-ischemic, infectious)
- Hydrocephalus
- Hearing loss
- Vision impairment
- Cerebral palsy
- Developmental delay
- Pneumonia, respiratory failure
- NEC (sometimes complication or coexistent)
- AKI
- Death
- Long-term morbidity
Nursing Care
- Frequent vital signs (Q1-2 hours initially)
- Temperature monitoring (axillary in neonate; rectal NOT done)
- Maintain neutral thermal environment (isolette/warmer)
- Continuous SpO₂, HR monitoring
- BP frequently
- Glucose monitoring
- Strict I&O (weigh diapers)
- Daily weights
- Cluster care (minimize stress)
- Aseptic technique for all procedures
- Administer antibiotics on schedule
- Watch for adverse effects (especially aminoglycosides — peak/trough levels)
- Support respiratory needs
- Maintain hydration, glucose
- Skin care (fragile)
- Position for comfort
- Developmental care
- Family support (devastating, especially in NICU)
- Encourage parental involvement (kangaroo care when stable)
- Communicate clearly
- Follow-up: hearing, vision, developmental screening
- Discharge teaching
Medications
Empiric antibiotics (start immediately):
- Early-onset: Ampicillin + gentamicin (or cefotaxime)
- Late-onset: Vancomycin + gentamicin or cefotaxime (cover Staph, gram-negatives)
- Add acyclovir if HSV suspected
- Antifungal (fluconazole, amphotericin) if fungal sepsis
- Narrow once cultures back
- Duration: 7-21 days depending on organism and site
Supportive:
- IV fluids (NS or D10NS depending on glucose)
- Vasopressors if shock: dopamine, epinephrine
- Anticonvulsants (phenobarbital) if seizures
- Blood products if DIC, anemia
- Surfactant if respiratory failure
- Caffeine for apnea of prematurity
Therapeutic Procedures
- IV antibiotics
- Oxygen, mechanical ventilation
- Fluid resuscitation
- Vasopressors
- Phototherapy (jaundice)
- Treat seizures
- NEC management if present
- Source control if abscess
- Surgery rarely (drain, debridement)
- Early intervention services post-discharge
- PT, OT, speech follow-up
Client Education
Family during treatment:
- Why hospitalized, expected course
- Cultures take 24-72 hours
- Antibiotics started before results — better safe than sorry
- Hand hygiene critical
- Limit visitors
- Address sibling fears
- Encourage kangaroo care when stable
- Breastfeeding support (or pump)
- Skin-to-skin
- Photos, voice recordings while in NICU
Discharge teaching:
- Continue any home antibiotics as prescribed (rare)
- Watch for fever (≥ 38°C in < 3 months = ER), poor feeding, lethargy, breathing problems, color changes
- Take temperature axillary
- Hand hygiene
- Limit exposure to sick people
- Vaccinations on schedule
- Follow-up: pediatrician within 1-2 days, hearing screen, vision, developmental
- Address family stress, PTSD
- Bonding important — encourage parental involvement
- WIC, lactation, social work as needed
Interprofessional Care
- Neonatology / NICU (primary)
- Pediatric infectious disease
- Pediatric pharmacy (antibiotic dosing)
- Pediatric audiology
- Pediatric ophthalmology
- Developmental pediatrics
- PT, OT, speech
- Lactation
- Social work, chaplain
- Family support
- Early intervention services
- Pediatric primary care (follow-up)
- Maternal medicine (postpartum)
Alterations in Health (Diagnosis)
Genetic disorder of collagen type I formation → fragile bones with frequent fractures. Spectrum of severity from mild (Type I) to lethal (Type II). Most cases autosomal dominant (COL1A1 or COL1A2 gene mutations).
Pathophysiology Related to Client Problem
Defective synthesis of type I collagen (main bone protein) → abnormal bone matrix → reduced bone strength → fragility and recurrent fractures. Other tissues with type I collagen affected: skin, sclera, dentin, ligaments, tendons.
Health Promotion and Disease Prevention
- Genetic counseling for affected families
- Prenatal diagnosis available (severe types)
- Prevent injury to children with known OI
- Adequate calcium, vitamin D in pregnancy and after
- Avoid trauma
- Education to caregivers and providers
Risk Factors
- Family history (autosomal dominant — most)
- Spontaneous mutations (some)
- Rare autosomal recessive forms
- Genetic syndrome
Expected Findings
Classic features:
- Multiple fractures with minimal trauma
- Fractures may be present at birth
- Blue sclerae (thin sclera reveals choroidal vasculature) — classic but not universal
- Short stature, especially severe types
- Bone deformities (bowing, especially long bones)
- Spinal deformities (scoliosis, kyphosis)
- Joint hypermobility
- Muscle weakness
- Easy bruising
- Dentinogenesis imperfecta (yellow-brown, translucent, brittle teeth) — about 1/3
- Conductive hearing loss (adults — early onset progressive)
- Fragile skin
- Triangular face
- Wormian bones on skull X-ray
- Macrocephaly
- Respiratory issues (severe — chest wall deformity)
- Cardiovascular (aortic dilation — rare)
Types (Sillence classification):
- Type I: mildest, blue sclerae, fractures during childhood
- Type II: lethal in perinatal period
- Type III: progressive deformity, most severe survivable
- Type IV: moderate, white sclerae, dental issues
Laboratory Tests
- Generally clinical/genetic diagnosis
- Calcium, phosphorus, alkaline phosphatase (usually normal)
- Genetic testing (COL1A1, COL1A2, other genes)
- Vitamin D level
Diagnostic Procedures
- X-rays: multiple fractures at various stages of healing, wormian bones (skull), bowing, scoliosis
- DEXA scan (bone density)
- Genetic testing (definitive)
- Hearing testing
- Eye exam (sclera)
- Dental exam
- Echocardiogram (severe)
- Skin biopsy (collagen testing — research)
- Prenatal ultrasound (severe OI — short long bones, fractures)
- Differential: child abuse — must consider carefully (but OI is real diagnosis)
Safety Considerations
- HANDLE WITH EXTREME CARE — fractures with minimal trauma
- NEVER lift child by arms, ankles, or under armpits
- Support head, trunk, hips when handling infants
- Use blanket/sheet to lift
- Gentle clothing changes
- Soft surfaces (mattress, car seat liner)
- Avoid extreme positions or pulling on joints
- Educate ALL caregivers and providers
- Document carefully (don't mistake for abuse, but mandatory report still required if pattern unclear)
- Hearing screening
- Dental care
- Spinal monitoring
- Cardiac monitoring (severe)
- Pregnancy considerations (adult women with OI)
Complications
- Recurrent fractures
- Bone deformities (bowing, scoliosis, basilar invagination)
- Short stature
- Respiratory compromise (kyphoscoliosis, rib fractures)
- Hearing loss
- Dental issues
- Cardiovascular: aortic dilation, valve issues (rare)
- Surgical complications
- Pain
- Mobility issues
- Mistaken for child abuse
- Psychosocial issues
- Death (severe types — respiratory, perinatal)
Nursing Care
- GENTLE HANDLING — educate everyone
- Support head, trunk, hips
- Use blanket/sheet for lifts
- Don't pull on extremities
- Padded surfaces
- Pain management for fractures
- Casting/splinting care
- Mobility assistance
- PT/OT
- Nutritional support (calcium, vitamin D)
- Bisphosphonate infusion (if used)
- Hearing protection, monitoring
- Dental care
- Education to family on handling
- Address psychosocial
- Genetic counseling
- Educational support
- Pre-op planning (fragile bones — careful positioning)
- Post-op care
Medications
- Bisphosphonates (pamidronate, zoledronic acid) — IV infusion every few months; ↑ bone density, ↓ fractures
- Watch for bisphosphonate side effects: flu-like reaction (first infusion), hypocalcemia, GI upset
- Vitamin D supplementation
- Calcium supplementation
- Pain medications
- Newer therapies: monoclonal antibodies (some research)
Therapeutic Procedures
- Fracture management: gentle handling, casting/splinting
- Bisphosphonate infusions
- PT/OT: strengthen muscles, prevent contractures, maximize function
- Surgical interventions:
- - Intramedullary rodding (telescoping rods that grow with child)
- - Scoliosis correction
- - Spinal fusion
- Bracing
- Mobility aids (wheelchair, walker, AFOs)
- Hearing aids
- Dental care
- Genetic counseling
- Educational support, IEP
- Psychosocial support
- Adaptive equipment
Client Education
Family education:
- Genetic basis — autosomal dominant typically
- Genetic counseling for family planning
- Wide spectrum of severity
- Lifelong condition
- Treatment to improve bone strength, function
- HANDLE WITH CARE — never lift by extremities
- Use sheet/blanket for transfers
- Diaper change technique — lift hips with hand under buttocks (don't lift legs)
- Padded car seat, stroller
- Safety in home: padded surfaces, prevent falls
- School/daycare educated and supportive
- Vaccinations on schedule
- Encourage normal activities (within safety)
- Swimming excellent activity (low impact)
- Avoid contact sports
- Adequate calcium, vitamin D, protein
- Avoid smoking (lung function, bone)
Self-care (older child/adult):
- Recognize fractures (may have minor pain)
- Bisphosphonate infusion schedule
- Hearing checks regularly
- Dental care
- Bone density monitoring
- Pregnancy planning for women
- Connect with OI Foundation
- Support groups
- Body image, mental health
Interprofessional Care
- Pediatric orthopedics (primary)
- Pediatric genetics
- Pediatric endocrinology (bone health)
- PT, OT
- Pediatric dentistry
- Pediatric audiology
- Pediatric pulmonology
- Pediatric cardiology
- Pediatric anesthesia (special considerations)
- Adaptive equipment specialist
- School/IEP
- Genetic counseling
- OI Foundation
- Adult specialists (transition)
Alterations in Health (Diagnosis)
Idiopathic avascular necrosis (osteonecrosis) of the femoral head in children, usually 4-8 years old. Self-limited process over 2-5 years, but residual deformity can lead to early hip arthritis. Male:female ratio 4:1.
Pathophysiology Related to Client Problem
Disruption of blood supply to femoral head → osteonecrosis → bone resorption → reossification → potential deformity of femoral head. Stages: 1) initial necrosis, 2) fragmentation, 3) reossification, 4) remodeling/residual.
Health Promotion and Disease Prevention
- No specific prevention
- Early recognition for prompt treatment
- Address risk factors when modifiable
Risk Factors
- Age 4-8 years (peak)
- Male sex (4:1)
- Caucasian and Asian
- Family history
- Low birth weight
- Passive smoking exposure
- Short stature, delayed bone age
- Hyperactivity, ADHD (association)
- Coagulopathies (some)
- Lower socioeconomic status
Expected Findings
- Limping (painless or painful)
- Hip, groin, thigh, or knee pain (knee pain in child = check hip!)
- Pain worse with activity, relieved by rest
- Decreased range of motion of hip (especially abduction and internal rotation)
- Trendelenburg gait
- Trendelenburg sign positive
- Limb length discrepancy (later — affected side shorter)
- Muscle atrophy of thigh
- Insidious onset
- Usually unilateral (10% bilateral)
Laboratory Tests
- Usually normal
- Rule out other causes: CBC, ESR, CRP (rule out septic, JIA)
Diagnostic Procedures
- Hip X-ray (AP and frog-leg lateral): early — increased density, joint space widening; later — fragmentation, flattening
- MRI (most sensitive — early diagnosis, full extent of necrosis)
- Bone scan (early — decreased uptake)
- Differential: transient synovitis (usually resolves in 1-2 weeks), septic arthritis (acute, fever), SCFE (older child), JIA
Safety Considerations
- Activity restriction (no high-impact activity)
- Pain management
- Watch for development of severe head deformity
- Long-term follow-up
- Crutches if needed
- Treat differential dx if symptoms change (fever, etc. → septic arthritis)
Complications
- Permanent femoral head deformity
- Hip osteoarthritis (in 20s-30s) — premature
- Hip impingement
- Limb length discrepancy
- Limp, decreased ROM
- Need for total hip arthroplasty in young adulthood (severe)
- Chronic pain
- Psychosocial: missed activities, school
- If bilateral, more severe disability
Nursing Care
- Comprehensive assessment
- Pain assessment and management
- Activity restriction education
- Range of motion exercises (per PT)
- Crutch training
- Brace/cast care (if used)
- PT coordination
- Pre/post-op care (if surgery)
- Address psychosocial impact (missed activities)
- Family education
- School coordination
- Long-term follow-up
Medications
- NSAIDs (ibuprofen, naproxen) for pain and inflammation
- Acetaminophen
- Short-term opioids if needed for severe pain or post-op
Therapeutic Procedures
- Treatment principle: "containment" — keep femoral head within acetabulum during repair
- Activity restriction: avoid high-impact, contact sports
- Physical therapy: maintain ROM (especially abduction)
- Crutches, weight-bearing modifications
- Bracing (Petrie cast, Atlanta brace — less common now)
- Surgery if severe or older child (varies by center):
- - Femoral osteotomy
- - Acetabular osteotomy
- - Combined
- Goal: spherical femoral head, congruent joint
- Hip arthroplasty in adulthood (long-term, if severe)
Client Education
- Self-limited disease — heals over 2-5 years
- Outcome depends on:
- - Age at onset (younger = better)
- - Extent of femoral head involvement
- - How well-contained the femoral head remains
- Avoid high-impact activities: running, jumping, contact sports
- Allowed: swimming, biking, low-impact activities
- Use crutches if prescribed
- Physical therapy important — maintain ROM
- Follow-up X-rays/MRI to monitor progression
- Pain management as needed
- School coordination — adaptive PE, modified activities
- Address frustration with activity restrictions
- Long-term: monitor for arthritis
- Some develop hip arthritis in 30s-40s — may need total hip replacement (young age)
- Maintain healthy weight (less hip stress long-term)
Interprofessional Care
- Pediatric orthopedics (primary)
- Physical therapy
- Pediatric primary care
- School coordinator (modified PE, accommodations)
- Pain management
- Mental health (chronic illness, activity restrictions)
- Adult orthopedics (transition, hip arthroplasty later)
Alterations in Health (Diagnosis)
Acute infection caused by Epstein-Barr Virus (EBV) (~90%) or sometimes CMV. Most common in adolescents and young adults. Transmitted via saliva ("kissing disease"). Self-limited but prolonged fatigue and risk of splenic rupture.
Pathophysiology Related to Client Problem
EBV enters via oropharynx → infects B-lymphocytes → cell-mediated immune response → atypical lymphocytes (reactive T-cells) → lymphoid hyperplasia (tonsillar enlargement, lymphadenopathy, splenomegaly, hepatomegaly).
Health Promotion and Disease Prevention
- Avoid sharing drinks, utensils, kissing (during acute illness)
- Hand hygiene
- Cover cough/sneeze
- Don't return to contact sports until splenomegaly resolves (3-4 weeks minimum)
- Education for adolescents
Risk Factors
- Age 15-24 years (peak)
- Close contact with infected person
- Sharing saliva (kissing, shared drinks)
- College/dorm living
- Immunosuppression (more severe)
Expected Findings
Classic triad:
- Fever
- Pharyngitis (often severe, exudative — looks like strep)
- Lymphadenopathy (posterior cervical especially, can be generalized)
Other findings:
- Splenomegaly (~50%) — risk of rupture
- Hepatomegaly
- Severe fatigue (often most prolonged symptom)
- Headache
- Malaise
- Anorexia
- Myalgia
- Rash (~5%, often after ampicillin given for misdiagnosed strep — characteristic morbilliform rash)
- Palatal petechiae
- Periorbital edema
- Jaundice (rare)
- Duration: 2-4 weeks acute; fatigue can persist months
Laboratory Tests
- CBC: lymphocytosis, > 10% atypical lymphocytes
- ↑ LFTs (mild hepatitis in > 90%)
- Heterophile antibody test (Monospot): rapid, but false negatives in young children < 4 yr and early in illness
- EBV-specific antibodies: VCA-IgM (acute), VCA-IgG (current or past), EBNA (4-6 wk after infection — chronic)
- If Monospot negative but mono suspected → EBV serology
- Throat culture/rapid strep (rule out strep)
- Mild thrombocytopenia possible
Diagnostic Procedures
- Clinical + lab confirmation
- Physical exam: tonsillar enlargement (often impressive), posterior cervical lymphadenopathy, splenomegaly (gentle palpation), hepatomegaly
- Throat culture (rule out strep)
- Ultrasound if splenic rupture suspected
- CT if neurologic symptoms
Safety Considerations
- NO CONTACT SPORTS for at least 3-4 weeks (until splenomegaly resolves — minimum 3 weeks, longer if athlete or splenic enlargement)
- Watch for SPLENIC RUPTURE: sudden LUQ pain, left shoulder pain (Kehr sign), hypotension, signs of shock
- Avoid amoxicillin/ampicillin — causes diffuse maculopapular rash (not allergy, but unpleasant)
- Avoid contact during acute illness (saliva)
- Don't share drinks, utensils, food
- Hand hygiene
- Adequate hydration
- Watch for airway obstruction (severe tonsillar swelling)
- Recognize complications
Complications
- Splenic rupture (rare, ~0.1%, but life-threatening) — usually 2nd-3rd week
- Airway obstruction (massive tonsillar enlargement)
- Hemolytic anemia, thrombocytopenia
- Hepatitis (mild common, severe rare)
- Encephalitis, meningitis (rare)
- Guillain-Barré syndrome (rare)
- Myocarditis, pericarditis (rare)
- Chronic fatigue (may persist months)
- Secondary bacterial infection (sinusitis, otitis)
- Lymphoma association (Burkitt, Hodgkin — long-term, very rare)
- Reactivation in immunosuppression
Nursing Care
- Symptom management (supportive care)
- Fluid intake
- Adequate rest
- Activity restriction: no contact sports × 3-4 weeks minimum
- Cool fluids, popsicles for sore throat
- Saline gargles, throat lozenges (older child)
- Antipyretics
- Watch for splenic rupture signs
- Educate about transmission
- Address fatigue (often most challenging)
- School absence may be prolonged
- Mental health (long illness can be depressing)
- Follow-up to monitor splenomegaly resolution (clinical, ultrasound if needed)
Medications
- Acetaminophen, ibuprofen for fever, sore throat
- AVOID amoxicillin/ampicillin — causes rash
- Antibiotics only if confirmed bacterial superinfection
- Corticosteroids: controversial; reserved for airway obstruction, severe hemolytic anemia, severe thrombocytopenia, neurological complications
- NO routine antivirals (don't alter clinical course)
- Cough suppressants if needed
Therapeutic Procedures
- Supportive care
- Rest, hydration
- Activity restrictions
- Hospitalization rarely needed (airway, splenic rupture, severe complications)
- If splenic rupture: emergent surgery (splenectomy) or interventional radiology
- School modification
- Gradual return to activity
Client Education
Activity:
- NO contact sports or heavy lifting × 3-4 weeks minimum (longer if athlete)
- Splenic rupture risk highest weeks 2-3
- Resume only after splenomegaly resolves and provider clears
- Light activity OK (walking) when feeling better
- Rest when tired — fatigue is real
Symptoms management:
- Cold fluids, popsicles, ice cream — soothing
- Soft foods if pharyngitis severe
- Saline gargles (older children)
- Acetaminophen, ibuprofen for fever, pain
- Hydration important
- Sleep adequately
Transmission:
- Spread through saliva ("kissing disease")
- Don't share drinks, utensils, food, lip balm
- Cover mouth when coughing
- Wash hands often
- EBV can shed in saliva months after recovery
- Most adults already had EBV (asymptomatic)
Watch for emergency signs:
- Severe abdominal pain (LUQ — splenic rupture)
- Left shoulder pain (Kehr sign)
- Dizziness, fainting
- Severe sore throat with breathing difficulty (airway)
- Drooling, stridor
- Confusion
- Yellow skin (severe hepatitis)
- Severe abdominal pain → ER!
Long course:
- Acute illness 2-4 weeks
- Fatigue may persist weeks-months
- Plan for school absence
- Gradual return to activities
- Mental health support if prolonged
Interprofessional Care
- Pediatric/adolescent primary care
- Athletic trainer (return-to-play clearance)
- School nurse
- Pediatric ED (acute complications)
- Pediatric surgery (splenic rupture)
- Pediatric infectious disease (severe)
- Mental health (prolonged fatigue, depression)
Alterations in Health (Diagnosis)
Rare but potentially fatal syndrome of acute encephalopathy + fatty liver degeneration in children. Classically follows viral illness (especially varicella or influenza) and aspirin use. Now rare due to public awareness to avoid aspirin in children.
Pathophysiology Related to Client Problem
Mitochondrial dysfunction in liver and brain → impaired fatty acid metabolism, ammonia detoxification → microvesicular fatty infiltration of liver (steatosis) + cerebral edema. Etiology unclear but associated with aspirin use during viral illness.
Health Promotion and Disease Prevention
- DO NOT GIVE ASPIRIN to children for fever/illness — major preventive measure
- Use acetaminophen or ibuprofen instead
- Read labels for hidden salicylates (Pepto-Bismol contains bismuth subsalicylate — avoid in children with viral illness)
- Influenza vaccination
- Varicella vaccination
- Recognize early so treatment can begin
- Educate parents on aspirin avoidance
Risk Factors
- Recent viral illness (varicella, influenza, gastroenteritis)
- Aspirin (salicylate) use during viral illness — key risk factor
- Children < 18 years (especially 4-12 years)
- Underlying inborn errors of metabolism (genetic predisposition — may mimic Reye)
Expected Findings
Staged progression (5 stages):
- Stage 1: persistent vomiting (the classic onset, usually a few days after viral illness), lethargy, dreamlike state
- Stage 2: disorientation, combative behavior, deep tachypnea, hyperactive reflexes, sweating
- Stage 3: obtunded, coma, decorticate posturing, intact pupillary reflexes
- Stage 4: deeper coma, decerebrate posturing, large fixed pupils, loss of oculovestibular reflexes
- Stage 5: flaccid, no DTRs, no pupillary response, respiratory arrest, death
Other:
- Hepatomegaly (without jaundice)
- Hyperventilation
- Seizures
- Hypoglycemia (especially < 1 year)
- NO meningeal signs typically
Laboratory Tests
- ↑ AST, ALT (3× normal)
- ↑ Ammonia (often 1.5-3× normal — > 100 ug/dL)
- ↑ PT, PTT (coagulopathy)
- Hypoglycemia (especially < 1 year)
- ↑ Free fatty acids
- Bilirubin usually normal or slightly elevated (KEY differentiator from hepatitis)
- Metabolic acidosis or respiratory alkalosis
- BUN sometimes elevated
- CSF: usually normal (rules out meningitis); ↑ glutamine
Diagnostic Procedures
- Clinical features + lab abnormalities
- Liver biopsy (if needed): microvesicular fatty infiltration
- CT/MRI head: cerebral edema, normal early
- EEG (encephalopathy pattern)
- Rule out inborn errors of metabolism (urine organic acids, plasma amino acids, acylcarnitines)
- LP (rule out meningitis/encephalitis)
- Toxicology screen
Safety Considerations
- NEVER GIVE ASPIRIN to children with viral illness
- Read all labels for salicylates
- Recognize early symptoms
- ICP precautions (HOB ↑ 30°)
- Watch for cerebral edema
- Glucose monitoring
- Coagulopathy monitoring
- Avoid further hepatotoxic medications
- Adequate ventilation
- Cluster care to minimize ICP fluctuations
Complications
- Cerebral edema → herniation
- Brain death
- Respiratory failure
- Cardiac dysfunction
- Hepatic failure
- Coagulopathy, bleeding
- Renal failure
- Pancreatitis
- Death (mortality 20-40% historically, lower with early recognition)
- Survivors: neurological sequelae (cognitive, motor) — depends on severity
- Recurrence possible
Nursing Care
- ICU care
- Neurological assessment frequently (Q1H or more)
- ICP precautions: HOB elevated 30°, midline head position, avoid neck flexion, decrease stimuli, cluster care
- ICP monitoring (severe)
- Mechanical ventilation
- Maintain normocapnia or mild hypocapnia (PaCO2 30-35) — reduce ICP
- Strict I&O
- Hourly vital signs
- Glucose monitoring (IV dextrose maintenance)
- Replace clotting factors as needed
- Avoid sedation that masks neuro exam
- Seizure precautions
- Skin care
- Nutrition
- Family support (devastating, often previously well child)
- Long-term follow-up: developmental, cognitive
Medications
- IV fluids with dextrose (D10 or higher) — prevent hypoglycemia
- Mannitol (osmotic diuretic) — cerebral edema
- Hypertonic saline (3%) — cerebral edema
- Vitamin K (coagulopathy)
- Fresh frozen plasma, cryoprecipitate, platelets (bleeding)
- Antiepileptics for seizures (phenytoin, levetiracetam)
- Anti-emetics
- Sedation, paralysis if intubated
- NO aspirin or salicylate-containing meds
Therapeutic Procedures
- ICU supportive care
- Mechanical ventilation
- ICP management
- Treat hypoglycemia, coagulopathy
- Liver transplant rare (poor prognosis when needed)
- Address inborn errors of metabolism if discovered
- Rehabilitation for survivors with sequelae
Client Education
Primary message — PREVENTION:
- NEVER give aspirin to children for fever or viral illness
- Use acetaminophen or ibuprofen (in children > 6 months)
- Read all OTC medication labels (look for: aspirin, acetylsalicylic acid, ASA, salicylate, bismuth subsalicylate — Pepto-Bismol)
- Avoid aspirin-containing combination products in children
- Educate babysitters, grandparents
- Some conditions require aspirin (Kawasaki) — managed by specialist with appropriate precautions
- Get flu vaccine annually
- Get varicella vaccine
Recognize warning signs after viral illness:
- Persistent vomiting
- Unusual sleepiness, confusion
- Combative or irrational behavior
- Seizures
- Loss of consciousness
- → GO TO ER IMMEDIATELY
If diagnosed:
- Long ICU stay likely
- Outcome depends on severity at presentation
- Early recognition saves lives
- Long-term follow-up for any neurological effects
- Genetic evaluation (some patients have inborn errors of metabolism that mimic Reye)
- Avoid all salicylates lifelong
- Family support
Interprofessional Care
- Pediatric ICU (primary)
- Pediatric neurology
- Pediatric gastroenterology/hepatology
- Pediatric metabolism/genetics
- Pediatric pharmacy
- Pediatric infectious disease
- Rehabilitation services
- Pediatric primary care (prevention education)
- Pediatric mental health
- Liver transplant team (rare)
- Pediatric neuropsychology (survivors)
Alterations in Health (Diagnosis)
Most common inherited bleeding disorder (1% of population). Deficiency or dysfunction of von Willebrand factor (vWF) — a protein needed for platelet adhesion and as carrier for Factor VIII. Three types: Type 1 (partial deficiency — mildest, most common), Type 2 (qualitative defect), Type 3 (complete deficiency — most severe).
Pathophysiology Related to Client Problem
vWF binds platelets to damaged endothelium (initiates clotting) and stabilizes Factor VIII. Deficiency/dysfunction → impaired platelet adhesion → mucocutaneous bleeding. In Type 3, also low Factor VIII → joint bleeding similar to hemophilia.
Health Promotion and Disease Prevention
- Genetic counseling for affected families
- Avoid trauma when possible
- Pre-procedural treatment
- Avoid antiplatelet drugs (aspirin, NSAIDs)
- Family screening if positive history
Risk Factors
- Family history (autosomal dominant — most types)
- Both sexes affected equally (unlike hemophilia)
- Type 3 autosomal recessive (rare, severe)
- Acquired vWD (some autoimmune, lymphoproliferative — rare)
Expected Findings
- Mucocutaneous bleeding (vs. joint bleeding in hemophilia):
- Easy bruising
- Epistaxis (nosebleeds — common, prolonged)
- Gum bleeding (especially with dental work)
- Heavy menstrual bleeding (menorrhagia — common in adolescent girls; often presenting feature)
- Prolonged bleeding from cuts
- Postoperative bleeding
- GI bleeding
- Postpartum hemorrhage
- Severe Type 3: joint bleeds, deep tissue bleeds (like hemophilia)
- Often mild; may go undiagnosed for years
- Worsens during periods of stress, illness
Laboratory Tests
- vWF antigen (quantitative)
- vWF activity (ristocetin cofactor activity)
- Factor VIII level (often low)
- vWF multimer analysis (subtype identification)
- PT: normal
- PTT: may be prolonged (low Factor VIII)
- Bleeding time: prolonged (not commonly used now)
- Platelet function tests (PFA-100): prolonged
- Platelet count: usually normal (may be low in Type 2B)
- Iron studies (chronic blood loss → iron deficiency, especially menorrhagia)
Diagnostic Procedures
- Detailed bleeding history (personal and family)
- Bleeding assessment tools (ISTH-BAT)
- Hematology consult
- Lab testing as above
- Genetic testing in some cases
Safety Considerations
- Avoid aspirin and NSAIDs (increase bleeding)
- Avoid IM injections; use SC route
- Bleeding precautions: soft toothbrush, electric razor, no contact sports for severe
- Medical alert bracelet
- Pre-procedure treatment planning (with hematology)
- Watch for menorrhagia in adolescent girls
- Iron deficiency screening
- Family screening
- Pregnancy planning (Factor VIII rises in pregnancy — often less bleeding; but postpartum bleeding risk)
Complications
- Excessive bleeding with surgery, dental work
- Postpartum hemorrhage
- Iron deficiency anemia (chronic blood loss)
- Heavy menstrual bleeding
- Quality of life impact (avoiding activities)
- Joint damage (severe Type 3)
- Anaphylaxis to plasma-derived products (rare)
- Inhibitors (rare, Type 3)
- Thrombosis (rare paradox)
Nursing Care
- Comprehensive bleeding history
- Bleeding precautions
- Apply pressure to bleeding sites longer than usual
- Avoid IM injections
- Pre-procedure assessment
- Administer DDAVP or vWF/Factor VIII concentrate as ordered
- Monitor for bleeding
- Hgb/Hct monitoring
- Iron supplementation
- Education on disease management
- Address menorrhagia (adolescent girls)
- Coordinate dental, surgical care with hematology
- Pregnancy management
Medications
- Desmopressin (DDAVP): IV, SC, or intranasal (Stimate) — releases stored vWF from endothelium; works for Type 1 and some Type 2
- Test response (some patients don't respond)
- Watch for: hyponatremia (especially in children — restrict fluids), headache, flushing, tachycardia
- vWF/Factor VIII concentrates (Humate-P, Wilate, Vonvendi): for Type 3, Type 2B, surgery, severe bleeding
- Antifibrinolytics: tranexamic acid, aminocaproic acid — useful for mucosal bleeding, menorrhagia, dental procedures
- Combined oral contraceptives: menorrhagia (raise vWF, regulate cycle)
- Iron supplementation for anemia
- Topical hemostatic agents (Surgicel, fibrin glue)
Therapeutic Procedures
- Bleeding episode management
- Pre-procedure prophylaxis
- Long-term management (severe types may need prophylactic infusions)
- Surgery/dental coordination with hematology
- Menorrhagia management
- Pregnancy/delivery planning
- Iron management
- Genetic counseling
- Hematology follow-up
Client Education
- Inherited bleeding disorder — usually mild but lifelong
- Often runs in family — encourage family screening
- Most live normal lives with awareness
- Bleeding precautions:
- - Avoid aspirin, NSAIDs (use acetaminophen)
- - Use soft toothbrush, electric razor (older)
- - Avoid contact sports if severe (Type 3); milder types OK
- - Wear protective gear
- Medical alert bracelet
- Inform all providers, dentists
- Pre-procedure planning critical (DDAVP or factor concentrate before)
- Recognize bleeding: prolonged, more than expected, signs of internal bleeding
- Pregnancy: Factor levels rise — usually safer; postpartum monitoring
- Adolescent girls: heavy periods normal feature; OCPs help; tranexamic acid
- Iron supplementation for anemia
- Apply pressure 10-15 minutes for bleeding
- Hematology follow-up
- Support: National Hemophilia Foundation also supports vWD
- Living with vWD: most activities OK; focus on safety
Interprofessional Care
- Pediatric hematology (primary)
- Adolescent gynecology (menorrhagia)
- Pediatric dentistry
- Genetic counseling
- Obstetrics (pregnancy)
- Anesthesia (pre-procedure)
- School nurse
- National Hemophilia Foundation
Alterations in Health (Diagnosis)
Inherited disorder of decreased beta-globin chain synthesis → reduced hemoglobin → microcytic anemia. Spectrum based on severity: Thalassemia minor (trait) — mild; Thalassemia intermedia — moderate; Thalassemia major (Cooley anemia) — severe, transfusion-dependent. Common in Mediterranean, Middle Eastern, South Asian populations.
Pathophysiology Related to Client Problem
Beta-globin gene mutations (chromosome 11) → ↓ or absent beta-globin production → α-chain excess → ineffective erythropoiesis (RBCs destroyed in marrow) and peripheral hemolysis → severe anemia. Bone marrow expansion → bony deformities. Iron overload from chronic transfusions → cardiac, hepatic, endocrine dysfunction (transfusion-dependent forms).
Health Promotion and Disease Prevention
- Genetic counseling for at-risk populations
- Pre-pregnancy/prenatal screening (high-risk ethnic groups)
- Prenatal diagnosis available (CVS, amniocentesis)
- Couples both carriers — counseling about offspring risk
- Carrier screening (Mediterranean, Middle Eastern, South Asian, African heritage)
Risk Factors
- Family history
- Ethnic background: Mediterranean (Italian, Greek), Middle Eastern, South Asian, North African, Southeast Asian
- Consanguinity
- Two carrier parents = 25% risk of major form
Expected Findings
Thalassemia major (presents 6-24 months as fetal Hgb declines):
- Severe anemia
- Pallor
- Failure to thrive
- Hepatosplenomegaly (large)
- Jaundice
- Frontal bossing, prominent maxilla ("chipmunk facies") — bone marrow expansion
- Pathologic fractures
- Delayed puberty, short stature
- Growth delay
- Hemochromatosis features (from transfusions): bronze skin, diabetes, heart failure
- Cardiac issues
Thalassemia minor:
- Usually asymptomatic
- Mild microcytic anemia (often mistaken for iron deficiency)
- Discovered on routine labs
Laboratory Tests
- Microcytic, hypochromic anemia (↓ Hgb, ↓ MCV, ↓ MCH)
- Target cells, nucleated RBCs, basophilic stippling on smear
- Reticulocytes: high
- Iron studies: NORMAL or HIGH iron (vs. iron deficiency which is low) — important differentiator
- Hemoglobin electrophoresis: ↑ HbA2 and HbF (trait); little/no HbA, high HbF (major)
- Genetic testing (beta-globin gene)
- Bilirubin elevated (hemolysis)
- LDH elevated
- ↑ Ferritin (iron overload from transfusions)
- Endocrine workup if applicable
- Cardiac MRI for iron load
Diagnostic Procedures
- Family history
- CBC, peripheral smear
- Iron studies (rule out iron deficiency)
- Hemoglobin electrophoresis (definitive)
- Genetic testing
- X-rays: bony changes (skull, long bones — "hair on end" appearance)
- Echocardiogram, cardiac MRI for iron loading
- Liver MRI for iron
- Endocrine evaluation (growth, puberty, glucose, thyroid)
- Bone density
Safety Considerations
- Transfusion safety (right type, screening for reactions)
- Avoid iron supplementation (iron overload risk!)
- Watch for transfusion reactions
- Iron chelation adherence critical
- Splenectomy considerations (overwhelming infection risk if done)
- Vaccination status (especially encapsulated organisms if splenectomy: pneumococcal, Hib, meningococcal)
- Infection precautions
- Bone fracture risk
- Endocrine monitoring
- Cardiac monitoring
Complications
- Severe anemia, growth failure (untreated)
- Iron overload (hemochromatosis):
- - Cardiac (cardiomyopathy, heart failure — leading cause of death)
- - Liver (cirrhosis, hepatocellular carcinoma)
- - Endocrine: hypothyroidism, hypogonadism, diabetes, growth hormone deficiency
- - Hyperpigmentation
- Hepatosplenomegaly
- Bony deformities, pathologic fractures
- Hemolysis, gallstones
- Osteoporosis
- Transfusion reactions
- Alloantibody formation
- Hepatitis B, C (from old transfusions)
- Infection (after splenectomy)
- Pulmonary hypertension
- Thrombosis
- Death (untreated thalassemia major)
Nursing Care
- Comprehensive assessment
- Growth and development monitoring
- Transfusion administration: pre-medicate (acetaminophen, diphenhydramine), monitor vital signs, watch for reaction
- Iron chelation administration and adherence support
- Endocrine monitoring
- Cardiac assessment
- Nutrition: low iron diet (avoid iron-fortified foods, iron supplements)
- Vitamin C should be limited (increases iron absorption) and only with chelator
- Folate supplementation
- Vaccinations (especially if splenectomized)
- Family support
- Address chronic illness burden
- Adolescent transition to adult care
- Coordinate transfusion schedule
Medications
Chronic transfusion therapy (every 3-4 weeks for major):
- Maintain Hgb ~9-10 g/dL
- Prevent growth failure, bone deformities
Iron chelation (started after several transfusions when ferritin rises):
- Deferasirox (Jadenu, Exjade): oral; daily
- Deferoxamine (Desferal): SC infusion 5-7 nights/week (older method)
- Deferiprone: oral
- Side effects: GI, hepatotoxicity (deferasirox), agranulocytosis (deferiprone), retinopathy, ototoxicity (deferoxamine)
Other:
- Folic acid supplementation
- Hydroxyurea (in some cases — increases HbF)
- Luspatercept (newer — improves erythropoiesis, reduces transfusion needs)
- Vitamin D, calcium (bone health)
- Hormone replacement (endocrine deficiencies)
- Vaccinations
Therapeutic Procedures
- Chronic transfusion therapy
- Iron chelation
- Hematopoietic stem cell transplant (curative): best for young patients with matched sibling donor
- Gene therapy: emerging — Casgevy, Lyfgenia (gene editing/lentiviral)
- Splenectomy (selected): reduces transfusion needs but increases infection risk
- Cardiac, endocrine treatment as needed
Client Education
Family:
- Lifelong genetic condition
- Genetic counseling crucial for family planning
- Thalassemia trait — carrier; usually no symptoms but offspring risk if partner also carrier
- Major — lifelong transfusions; major commitment
- Cure possible (stem cell transplant, gene therapy)
Treatment management:
- Transfusions every 3-4 weeks usually
- Iron chelation EVERY DAY (don't skip — iron buildup is fatal long-term)
- Take chelator as directed; report side effects
- Routine labs to monitor ferritin, organ function
- Annual cardiac, liver MRI for iron
- Annual endocrine workup
Diet:
- Limit iron-rich foods: red meat, organ meats, iron-fortified cereals
- Avoid iron supplements
- Limit vitamin C (increases iron absorption) — only take WITH chelator
- Tea/coffee may reduce iron absorption (some)
- Folate supplementation
- Calcium, vitamin D for bones
Watch for:
- Transfusion reaction signs
- Cardiac symptoms
- Diabetes signs
- Growth, puberty delays
- Infection (especially if splenectomy)
Life:
- Normal childhood activities with good management
- School coordination for transfusions, fatigue
- Fertility considerations (delayed puberty common)
- Pregnancy planning
- Support organizations (Cooley's Anemia Foundation)
Interprofessional Care
- Pediatric hematology (primary)
- Pediatric endocrinology (multiple deficiencies)
- Pediatric cardiology (iron loading)
- Pediatric hepatology
- Pediatric dietitian
- Transfusion medicine
- Genetic counseling
- Pediatric orthopedics (bone issues)
- Stem cell transplant team
- Adolescent gynecology, fertility
- Mental health, social work
- Adult hematology (transition)
- Cooley's Anemia Foundation
Alterations in Health (Diagnosis)
Bone marrow failure → pancytopenia (low RBCs, WBCs, platelets) from hypocellular bone marrow. Can be inherited (Fanconi anemia, others) or acquired (idiopathic ~50%, drugs, infections, autoimmune). Severe aplastic anemia is life-threatening without treatment.
Pathophysiology Related to Client Problem
Immune-mediated destruction (or congenital defect) of hematopoietic stem cells → bone marrow becomes hypocellular and fatty → pancytopenia.
Health Promotion and Disease Prevention
- Limit exposures: certain drugs (chloramphenicol, NSAIDs occasionally, sulfa, anticonvulsants), benzene, pesticides, radiation
- Family screening if inherited (Fanconi)
- Genetic counseling
- Treat infections promptly
Risk Factors
Inherited:
- Family history
- Fanconi anemia (most common inherited)
- Dyskeratosis congenita
- Schwachman-Diamond syndrome
- Diamond-Blackfan anemia (RBCs only)
Acquired:
- Idiopathic (~50%)
- Drugs: chloramphenicol, sulfa drugs, NSAIDs, anticonvulsants (carbamazepine, phenytoin), chemo
- Toxins: benzene, pesticides, radiation
- Viruses: parvovirus B19, EBV, hepatitis (especially non-A, non-B, non-C), HIV
- Autoimmune (lupus, etc.)
- Paroxysmal nocturnal hemoglobinuria (PNH)
- Pregnancy (rare)
Expected Findings
From pancytopenia:
- Anemia (low RBCs): pallor, fatigue, dyspnea, tachycardia
- Thrombocytopenia (low platelets): easy bruising, petechiae, mucosal bleeding (epistaxis, gum bleeding), heavy menses, GI bleeding, intracranial hemorrhage (severe)
- Leukopenia (low WBCs): infections (especially with neutropenia — fever, severe infections)
No specific findings for cause (unlike leukemia: no blasts, lymphadenopathy, organomegaly)
Fanconi anemia specific:
- Short stature
- Skin pigmentation (café au lait)
- Thumb/radial abnormalities
- Microcephaly
- Renal anomalies
- Hyperpigmentation
Laboratory Tests
- CBC: pancytopenia (↓ Hgb, ↓ WBC, ↓ platelets, ↓ reticulocytes)
- Normocytic or macrocytic RBCs
- ↓ Reticulocyte count (key — body not making cells)
- Bone marrow biopsy: hypocellular marrow (< 25% normal cellularity), replaced by fat; no blasts
- Cytogenetics (rule out MDS, leukemia)
- HLA typing (transplant candidates)
- Iron studies, B12, folate (rule out other causes)
- Viral serologies: HIV, hepatitis, EBV, CMV, parvovirus
- ANA
- Flow cytometry (PNH)
- Fanconi screen (chromosomal breakage with diepoxybutane — DEB test)
- Telomere length (dyskeratosis)
Diagnostic Procedures
- Comprehensive history (drug, toxin exposure)
- Physical exam
- CBC, reticulocytes
- Bone marrow biopsy (definitive)
- Cytogenetics
- HLA typing for self and siblings
- Viral testing
- Fanconi screen (especially < 30 years, anomalies)
- Severity grading:
- - Severe: 2 of (granulocytes < 500, platelets < 20K, reticulocytes < 60K)
- - Very severe: granulocytes < 200
Safety Considerations
- Neutropenic precautions (infection risk)
- Bleeding precautions
- Avoid IM injections, rectal temperatures, suppositories
- Soft toothbrush
- Hand hygiene
- Limit visitors
- Avoid aspirin, NSAIDs
- Pre-medication for transfusions
- CMV-negative or irradiated blood products (transplant candidates)
- Cancer screening (Fanconi — high cancer risk)
- Live vaccines contraindicated
- Watch for infection signs
Complications
- Severe infections (sepsis, opportunistic — leading cause of death)
- Bleeding (intracranial hemorrhage — devastating)
- Cardiac failure (severe anemia)
- Iron overload (chronic transfusions)
- Transformation to MDS, leukemia (especially Fanconi)
- Solid tumor risk (Fanconi — squamous cell of head/neck, esophagus)
- Transplant complications: GVHD, infection, rejection
- Immunosuppression complications
- Death (especially severe untreated)
Nursing Care
- Neutropenic precautions (during severe neutropenia):
- - Private room
- - Hand hygiene, limit visitors
- - No fresh flowers, no fresh fruits/vegetables (some protocols)
- - Daily VS, watch for fever (fever in neutropenic patient = emergency)
- - Routine cultures with fever
- Bleeding precautions:
- - No IM, IV pushes carefully
- - Pad bed rails
- - Soft toothbrush, electric razor
- - Avoid invasive procedures
- Transfusion administration
- Iron chelation if chronic transfusions
- Watch for fever — start broad-spectrum antibiotics immediately (neutropenic fever)
- Pre-transplant support
- Family education and support
- Adolescent transition planning
- Long-term cancer surveillance (Fanconi)
- Psychosocial support
- Address fertility (chemo, radiation may affect)
Medications
Immunosuppressive therapy (IST):
- Anti-thymocyte globulin (ATG) + cyclosporine + corticosteroids — first-line for those without donor
- Eltrombopag: TPO-receptor agonist, ↑ all cell lines
Supportive:
- RBC, platelet transfusions (leukoreduced, irradiated, CMV-negative for transplant candidates)
- Antibiotics for infections (and prophylaxis)
- Antifungal prophylaxis
- PCP prophylaxis (TMP-SMX)
- Antiviral prophylaxis (acyclovir for HSV)
- Iron chelation if needed
- Growth factors (G-CSF, EPO) — generally not used (concerns about leukemia)
- Vaccinations (avoid live)
- Hormones
Therapeutic Procedures
- HSCT (hematopoietic stem cell transplant) — curative: matched sibling donor preferred; first-line for severe AA in pediatrics with matched donor
- Without matched donor: immunosuppressive therapy
- Supportive transfusion therapy
- Treat underlying cause if identified
- Avoid offending drugs/toxins
- Long-term cancer surveillance (especially Fanconi)
- Endocrine evaluation
- Fertility preservation discussion
- Psychosocial
Client Education
Family:
- Aplastic anemia is treatable; many children do well
- HSCT can cure
- Treatment is long, complex
- Identify and avoid offending agents
- Fanconi anemia: lifelong cancer surveillance
Infection prevention:
- Hand hygiene
- Avoid sick contacts
- Vaccinations (no live)
- Watch for fever ≥ 38.3°C — ER immediately
- Watch for any infection signs
- Avoid raw foods (some protocols)
- Cook meat thoroughly
- Wash produce
- Avoid fresh flowers
- Mask in public, crowded places
Bleeding prevention:
- Soft toothbrush, electric razor
- Avoid contact sports
- Don't use aspirin, NSAIDs
- Apply pressure to bleeding 10+ min
- Watch for bruising, petechiae, bleeding gums, dark urine/stool
- Headache, vision changes (intracranial bleed) → ER
Activity:
- Activity restrictions based on counts
- School: usually attend when counts adequate, mask if neutropenic
- 504 plan for accommodations
Long-term:
- Lifelong follow-up
- Cancer surveillance (Fanconi)
- Endocrine follow-up
- Address fertility
- Psychosocial support
- Support organizations: Aplastic Anemia Foundation
Interprofessional Care
- Pediatric hematology/oncology (primary)
- BMT/HSCT team
- Pediatric infectious disease
- Pediatric pharmacy
- Pediatric endocrinology
- Genetic counseling
- Pediatric otolaryngology, GI, dermatology (Fanconi cancer surveillance)
- Fertility specialist
- Mental health
- Social work
- Aplastic Anemia & MDS International Foundation
Alterations in Health (Diagnosis)
Protrusion of organ/tissue through abnormal opening. Common types in pediatrics:
- Inguinal hernia: abdominal contents protrude through inguinal canal — most common (1-5% of children); higher in preemies; usually unilateral; surgical repair always needed
- Umbilical hernia: at umbilicus — common (10-20% of infants); often closes spontaneously by age 3-5
- Epigastric hernia: through linea alba above umbilicus
- Diaphragmatic (congenital): abdominal contents in chest — neonatal surgical emergency
- Hiatal hernia: stomach through diaphragm into chest
Pathophysiology Related to Client Problem
Inguinal: failure of processus vaginalis to close (boys: along path of testicular descent). Umbilical: failure of umbilical ring to close. Congenital diaphragmatic hernia (CDH): defect in diaphragm formation → abdominal organs herniate into chest → impaired lung development on affected side.
Health Promotion and Disease Prevention
- No specific prevention (mostly congenital)
- Avoid increased intra-abdominal pressure (treat chronic cough, constipation)
- Avoid abdominal "binding" or "taping" of umbilical hernias (myth — doesn't work)
- Early recognition and referral
Risk Factors
- Prematurity (higher rate of inguinal)
- Family history
- Male sex (inguinal — 6:1)
- African American (umbilical more common)
- Conditions ↑ abdominal pressure: ascites, cystic fibrosis, chronic cough, constipation
- Connective tissue disorders
- Cryptorchidism (with inguinal)
- Down syndrome (umbilical)
- Hypothyroidism (umbilical)
Expected Findings
Inguinal:
- Bulge in groin or scrotum (may be intermittent — with crying, standing)
- May reduce spontaneously
- Painless usually
- If incarcerated: painful, firm bulge, irritability, vomiting
- If strangulated: severe pain, vomiting, fever, ↓ blood flow, discoloration, peritonitis signs
Umbilical:
- Soft, reducible bulge at umbilicus
- More prominent with crying, straining
- Usually small, painless
- Easily reduced
Diaphragmatic (CDH):
- Severe respiratory distress in newborn
- Cyanosis
- Scaphoid abdomen (intestines in chest)
- Bowel sounds in chest
- Heart shifted (mediastinal shift)
- Often diagnosed prenatally
Laboratory Tests
- Usually clinical diagnosis
- Pre-op labs as appropriate
Diagnostic Procedures
- Physical examination
- Ultrasound (sometimes — inguinal hernia confirmation, fluid vs hernia)
- CDH: prenatal ultrasound, postnatal CXR (bowel in chest)
- If incarcerated/strangulated: emergency evaluation
Safety Considerations
Inguinal — watch for:
- Incarceration: not reducible, painful, irritability, vomiting (boys often will not let you press groin)
- Strangulation: surgical emergency — necrosis can begin within hours
Umbilical:
- Generally low-risk
- Don't tape, bind, or apply pressure — doesn't help and may cause skin breakdown
- Most close on their own
CDH:
- Don't mask-ventilate (worsens — air to abdominal contents in chest)
- Immediate intubation
- OG/NG tube to decompress GI tract
- Pulmonary hypertension precautions
- Permissive hypercapnia ventilation strategy
- ECMO often needed
Complications
Inguinal:
- Incarceration (~30% in untreated infants)
- Strangulation, bowel necrosis
- Testicular ischemia/atrophy (boys with incarcerated hernia)
- Infertility (if testis damaged)
- Recurrence (low, < 1%)
- Hydrocele
Umbilical:
- Rarely incarcerates (< 5%)
- Cosmetic concerns if very large
- Most close spontaneously by 3-5 years
CDH:
- Pulmonary hypoplasia (lifelong lung issues)
- Pulmonary hypertension
- GERD
- Developmental delay
- Hearing loss
- Recurrence
- Mortality 20-30%
Nursing Care
Inguinal:
- Assess hernia (reducible? size? tenderness?)
- Reduce with gentle pressure if able (Trendelenburg, calm baby, gentle pressure)
- If incarcerated and won't reduce: NPO, IV, surgical consult emergent
- Pre-op teaching
- Post-op: pain management, wound care, monitor scrotum for swelling (boys), assess for testicular position
- Activity restriction post-op (no straddle toys × 2-6 weeks)
- Diaper care
Umbilical:
- Reassure family (will likely close)
- Watch (rare) for incarceration
- Surgical repair if persists past 4-5 years or large/symptomatic
CDH:
- NICU care, ventilation
- Don't bag-mask
- Immediate intubation
- OG/NG decompression
- Surfactant, gentle ventilation
- Inhaled nitric oxide (pulmonary HTN)
- ECMO often
- Surgical repair after stabilization
- Long-term follow-up: PT, GI, lung function
Medications
- Pre-op routine
- Post-op pain: acetaminophen, ibuprofen, opioids briefly
- Antibiotics for infection
- CDH: surfactant, iNO, sildenafil, sedation, paralysis
Therapeutic Procedures
- Inguinal: always surgical repair — high ligation of hernia sac; laparoscopic or open; outpatient for older infants; soon after diagnosis to prevent incarceration
- Umbilical: watchful waiting; surgical repair if persists past 4-5 years, large defect (> 1.5 cm), or symptomatic
- CDH: surgical repair after stabilization (usually within days-weeks) via thoracotomy or laparoscopy; ECMO bridge; long-term respiratory care
Client Education
Inguinal hernia:
- Will not get better on its own — needs surgery
- Outpatient procedure usually
- Watch for incarceration: painful bulge, child crying, won't reduce, vomiting → ER!
- Don't try forceful reduction at home
- Pre-op: NPO instructions
- Post-op: small incision; pain manageable; bath restriction 2-3 days; activity restriction:
- - No straddle toys, riding toys, jumping × 2-6 weeks
- - No contact sports × 4-6 weeks
- Wound care: keep clean and dry; report redness, drainage
- Return for: fever, bleeding, severe pain, swelling, no urine
Umbilical hernia:
- Common in infants — usually closes by 3-5 years
- DO NOT tape, bind, or apply coins — doesn't work and may cause skin issues
- Crying or straining makes it more prominent but doesn't cause it
- Rarely incarcerates
- Surgery only if doesn't close by school age or causes problems
- Cosmetic concern only typically
CDH:
- Serious condition requiring NICU care
- Long hospitalization (weeks-months)
- Survivors may have chronic lung issues, GERD, developmental delays
- Multidisciplinary follow-up
- Most children grow up to live good lives
- Family support important
- Support organizations (CHERUBS for CDH)
Interprofessional Care
- Pediatric surgery
- Pediatric ED
- Pediatric primary care
- NICU (CDH)
- Pediatric pulmonology (CDH)
- Pediatric cardiology (CDH — pulmonary HTN)
- PT, OT (CDH)
- Genetic counseling (some CDH syndromic)
- Family support
Alterations in Health (Diagnosis)
Most common congenital anomaly of GI tract (2% of population). Remnant of omphalomesenteric (vitelline) duct — true diverticulum of the ileum. "Rule of 2s": 2% population, 2:1 male:female, within 2 feet of ileocecal valve, often 2 inches long, presents before age 2, contains 2 types of ectopic tissue (gastric or pancreatic).
Pathophysiology Related to Client Problem
Failure of complete obliteration of omphalomesenteric duct in fetal development → outpouching of ileum. May contain ectopic gastric mucosa (most clinically relevant — secretes acid → ulceration of adjacent ileal mucosa → bleeding) or pancreatic tissue. Most are asymptomatic (incidental finding); 2-4% cause complications.
Health Promotion and Disease Prevention
- No specific prevention
- Awareness of presentation
- Consider in differential for painless GI bleeding in young children
Risk Factors
- Male sex (2:1)
- Most present before age 2
- Age < 5 years for symptoms typically
Expected Findings
Most common: painless rectal bleeding (in child < 5 yr):
- Painless rectal bleeding — classic presentation
- Bright red or "currant jelly" stools or dark/maroon
- Often massive bleeding
- Pallor, tachycardia, hypotension (with significant bleed)
Other presentations:
- Intestinal obstruction (intussusception, volvulus around diverticulum)
- Diverticulitis (mimics appendicitis)
- Perforation, peritonitis
- Umbilical fistula (rare)
Laboratory Tests
- CBC: anemia (chronic blood loss or acute)
- Type and screen, crossmatch
- Coagulation studies
- BUN/Cr (volume status)
Diagnostic Procedures
- Meckel scan (technetium-99m pertechnetate scan): identifies ectopic gastric mucosa (sensitivity 80-90%); pretreatment with H2 blocker improves yield
- CT (less specific, used for complications)
- Ultrasound (some)
- Tagged RBC scan (active bleeding)
- Angiography (rarely)
- Capsule endoscopy
- Surgical exploration (definitive if other tests inconclusive)
- Pathology after resection
Safety Considerations
- Hemodynamic monitoring
- Replace blood loss
- NPO if bleeding
- IV access, fluid resuscitation
- Type and crossmatch
- Watch for shock signs
- Pre-op preparation
- Watch for complications: obstruction, perforation
Complications
- Significant GI bleeding (hypovolemic shock if untreated)
- Anemia
- Intestinal obstruction
- Intussusception (diverticulum as lead point)
- Diverticulitis (mimics appendicitis)
- Perforation, peritonitis
- Volvulus around persistent omphalomesenteric remnant
- Surgical complications
- Recurrence (very rare after complete resection)
Nursing Care
- Assess bleeding extent
- Hemodynamic monitoring
- IV access × 2 large bore
- Type and crossmatch
- Fluid/blood resuscitation
- Strict I&O
- NPO
- Pain assessment
- Pre-op preparation
- Post-op: vital signs, pain, wound, return of bowel function, advance diet
- Discharge teaching
- Follow-up
- Family support and education
Medications
- Pre-op IV fluids
- Blood products if needed
- Pre-op antibiotics
- H2 blocker before Meckel scan (improves sensitivity)
- Post-op analgesia
- Iron supplementation if anemic
Therapeutic Procedures
- Surgical resection (definitive) — diverticulectomy or partial ileal resection
- Laparoscopic or open approach
- Resection of incidentally found Meckel: controversial in adults (usually leave alone if < 40 yo asymptomatic, no high-risk features); in children, often resect if found incidentally
- Transfusion if needed
Client Education
- Meckel diverticulum is a congenital anomaly
- Most people have one and never know
- When symptomatic, surgery is curative
- Painless rectal bleeding in young children — important to investigate
- Recovery typically straightforward
- Post-op care:
- - Wound care, monitor for infection
- - Pain management as ordered
- - Diet advancement as tolerated
- - Activity restrictions × few weeks
- - Watch for: fever, severe pain, vomiting, no stool, wound problems → call provider
- - Return to school in 1-2 weeks
- Long-term: excellent prognosis
- Iron supplementation if anemic until levels normalize
- Routine follow-up with surgeon and pediatrician
Interprofessional Care
- Pediatric surgery (primary)
- Pediatric gastroenterology
- Pediatric ED
- Pediatric radiology (Meckel scan)
- Pediatric anesthesia
- Pediatric hematology (if significant blood loss)
Alterations in Health (Diagnosis)
Inflammation of liver caused by viral infection. Five main types in pediatrics:
- Hepatitis A (HAV): fecal-oral; self-limited; vaccine available
- Hepatitis B (HBV): blood/body fluids, perinatal; can become chronic; vaccine
- Hepatitis C (HCV): blood-borne; often chronic; no vaccine; treatable now (DAAs)
- Hepatitis D (HDV): requires HBV co-infection
- Hepatitis E (HEV): fecal-oral; self-limited (severe in pregnancy)
Pathophysiology Related to Client Problem
Virus infects hepatocytes → immune-mediated hepatocellular damage → ↑ liver enzymes, jaundice. HAV/HEV: acute only. HBV/HCV: can become chronic → cirrhosis, hepatocellular carcinoma. Perinatal HBV → high chronicity rate (90% become chronic).
Health Promotion and Disease Prevention
- Hepatitis A vaccine (routine at 12-23 months, 2 doses)
- Hepatitis B vaccine (routine starting at birth, 3 doses by 6 months)
- HBV maternal screening + HBIG + HBV vaccine at birth for HBsAg+ mothers
- HBV vaccine for at-risk adolescents and household contacts
- Hand hygiene, food/water safety (HAV, HEV)
- Safe blood supply (HBV, HCV)
- Universal precautions
- Don't share needles, drugs (adolescents)
- Safe sex education (HBV)
- HCV screening for at-risk (perinatal exposure, IDU)
- Post-exposure: HBIG, IG
- NO vaccine yet for HCV
Risk Factors
HAV:
- Contaminated food/water
- Travel to endemic areas
- Daycare settings
- Poor sanitation
- MSM (adolescent)
- IV drug use
HBV:
- Perinatal transmission (HBsAg+ mother) — major in pediatrics
- Household contact with HBV
- IV drug use
- Unprotected sex
- Healthcare worker exposure
- Tattoos, piercings (non-sterile)
- Hemodialysis
- Blood products (rare now)
HCV:
- Perinatal transmission
- IV drug use (sharing needles)
- Blood products (pre-1992)
- Tattoos, piercings (non-sterile)
- Healthcare worker exposure
Expected Findings
Acute hepatitis (similar across types):
- Prodromal: fatigue, malaise, anorexia, nausea, vomiting, low-grade fever, RUQ pain
- Icteric phase: jaundice, dark urine, light/clay-colored stools, pruritus
- Hepatomegaly, tenderness
- Children < 6 years often asymptomatic or mild (especially HAV)
- Some have splenomegaly
- Atypical rash, arthralgia (HBV)
Chronic (HBV, HCV):
- Often asymptomatic for years
- Fatigue
- Anorexia
- Eventually: cirrhosis signs (ascites, varices, encephalopathy)
- Hepatocellular carcinoma (long-term)
Fulminant hepatitis (rare):
- Severe jaundice
- Encephalopathy
- Coagulopathy
- Multi-organ failure
Laboratory Tests
- LFTs: ↑↑ ALT, AST (often > 1000 in acute); ↑ bilirubin
- ↑ Alkaline phosphatase
- ↑ PT/INR (severe — synthetic function)
- ↓ Albumin (severe)
- Specific serology:
- HAV: anti-HAV IgM (acute), IgG (past infection or vaccination)
- HBV: HBsAg (active infection), anti-HBs (immunity from vaccine or recovery), anti-HBc (IgM acute, IgG past), HBeAg/anti-HBe (replication), HBV DNA
- HCV: anti-HCV (screening), HCV RNA (confirmation), HCV genotype
- HDV: anti-HDV (with HBV)
- HEV: anti-HEV IgM
- CBC
- Coagulation
- Glucose
- Ammonia (encephalopathy)
Diagnostic Procedures
- Clinical + serology
- Ultrasound abdomen
- Liver biopsy (chronic, suspected fibrosis)
- FibroScan (non-invasive fibrosis assessment)
- HCC surveillance (chronic): ultrasound + AFP every 6 months
- Vaccination history
Safety Considerations
- Standard precautions
- HAV/HEV: enteric/contact precautions
- HBV/HCV: bloodborne precautions
- Avoid hepatotoxic medications (acetaminophen with caution; avoid alcohol)
- Watch for fulminant hepatitis
- Encephalopathy monitoring (severe)
- Don't share personal items (toothbrush, razor)
- Pregnancy considerations (HBV transmission)
- School/daycare exclusion (HAV until 1 week after onset)
- Reportable to health department
- Contact tracing, post-exposure prophylaxis
Complications
HAV:
- Usually self-limited
- Fulminant hepatitis (rare)
- Relapse (uncommon)
HBV:
- Chronic hepatitis B (90% perinatal infections, 5% in adults)
- Cirrhosis
- Hepatocellular carcinoma (10-100× ↑ risk)
- Death from chronic complications
HCV:
- Chronic hepatitis C (~50-80%)
- Cirrhosis (~30% in 20-30 years)
- Hepatocellular carcinoma
- Cryoglobulinemia
HDV:
- Severe hepatitis
- ↑ risk of fulminant hepatitis
- ↑ risk of cirrhosis
HEV:
- Usually self-limited
- Severe in pregnancy (high mortality)
Nursing Care
- Assessment: liver function, hydration, weight
- Standard + appropriate precautions
- Rest (during acute symptomatic phase)
- Nutrition: small frequent meals, avoid fatty foods
- Adequate fluids
- Avoid acetaminophen (hepatotoxic if high doses)
- Skin care (pruritus)
- Monitor for complications (mental status, bleeding)
- Vaccination of contacts
- Post-exposure prophylaxis (HBIG, vaccine, IG)
- Education about transmission
- Reporting to public health
- Long-term follow-up (chronic forms)
- HCC surveillance
- Family support, psychosocial
Medications
HAV/HEV:
- Supportive only
- Post-exposure: immunoglobulin + vaccine
HBV chronic:
- Entecavir, tenofovir (first-line in children)
- Lamivudine (rarely now — resistance)
- Interferon-α (less common in pediatrics)
- HBIG + HBV vaccine for newborns of HBsAg+ mothers
HCV (CURABLE now):
- Direct-acting antivirals (DAAs): sofosbuvir + ledipasvir, glecaprevir/pibrentasvir
- Approved for children ≥ 3 years
- 8-12 week course
- Cure rates > 95%
Other:
- Antiemetics
- IV fluids
- Vitamin K (coagulopathy)
- Avoid hepatotoxic drugs
- Lactulose, rifaximin (encephalopathy)
Therapeutic Procedures
- Supportive care (acute hepatitis)
- Antiviral therapy (chronic HBV, HCV)
- Liver transplant (fulminant hepatitis, end-stage cirrhosis)
- HCC surveillance and treatment
- Variceal banding (portal hypertension)
- Vaccinations
- Counseling
Client Education
Family (acute hepatitis):
- Rest during acute illness
- Adequate fluids, small frequent meals
- Avoid alcohol (adolescents)
- Avoid acetaminophen unless needed (max doses)
- Hand hygiene crucial (HAV)
- Don't share personal items
- Contacts vaccinated
- School exclusion (HAV ≥ 1 week after onset of jaundice)
- Standard precautions
- Notify dentist, providers
Chronic HBV/HCV:
- Most people live normal lives with treatment
- Lifelong follow-up
- Cancer screening
- HBV: family vaccinated; HCV: no vaccine
- Don't share needles, razors, toothbrushes
- Safe sex (HBV)
- Avoid alcohol (accelerates liver damage)
- Limit acetaminophen
- Routine vaccinations including HAV
- Healthy weight (NAFLD risk)
- Notify all providers, dentists
HCV cure:
- DAAs now cure > 95%
- 8-12 week oral treatment
- Few side effects
- Major advance — most children with HCV will be cured
Prevention:
- Vaccinate (HAV, HBV)
- Hand hygiene
- Food/water safety
- Don't share needles
- Safe tattoos/piercings
- Safe sex
- Universal precautions
Adolescents:
- Disclosure considerations (HBV, HCV — to partners, sometimes employers)
- Confidentiality protected
- Reproductive counseling
- Mental health support
Interprofessional Care
- Pediatric GI/hepatology
- Pediatric infectious disease
- Pediatric primary care
- Pediatric pharmacy
- Public health (reportable diseases)
- Liver transplant team (severe)
- Hepatocellular carcinoma surveillance team
- Adolescent medicine
- Mental health
- School coordinator
Alterations in Health (Diagnosis)
Rare severe congenital anomaly (1 in 30,000-50,000 births): bladder is open and exposed on the lower abdominal wall. Part of the exstrophy-epispadias complex ranging from isolated epispadias to classic bladder exstrophy to cloacal exstrophy (most severe). Multiple surgical repairs needed.
Pathophysiology Related to Client Problem
Failure of the abdominal wall to close in midline during embryonic development → bladder mucosa exposed; associated with separation of pubic bones, epispadias, abnormal genitalia, abdominal wall defect.
Health Promotion and Disease Prevention
- Limited prevention
- Adequate prenatal care
- Folic acid in pregnancy
- Prenatal diagnosis allows planning
- Genetic counseling if recurrence concern
Risk Factors
- Male slight predominance
- Family history (slight ↑)
- Generally sporadic, no clear cause
- Multifactorial (genetic + environmental)
Expected Findings
Classic bladder exstrophy:
- Open, exposed bladder on lower abdomen
- Wide pubic diastasis (separated pubic bones)
- Epispadias (urethral opening on dorsum)
- Abnormal genitalia (split scrotum, bifid clitoris)
- Umbilicus low-set or absent
- Imperforate anus or anal anomalies (some)
- Abdominal wall defect
- Constant urine drainage onto exposed mucosa
- Hip displacement (from pubic diastasis)
Cloacal exstrophy (most severe):
- Bladder + bowel exposed
- Omphalocele
- Imperforate anus
- Spinal anomalies
- Limb anomalies
- Severe genitourinary anomalies
Laboratory Tests
- Renal function
- Electrolytes
- Karyotype if ambiguous
Diagnostic Procedures
- Prenatal ultrasound may detect
- Postnatal physical exam (obvious)
- Renal ultrasound
- VCUG (after closure)
- Spine MRI (especially cloacal)
- Echocardiogram
- Genetic evaluation
- Renal function
Safety Considerations
- Protect exposed bladder mucosa: cover with plastic wrap (Saran wrap)
- Don't use gauze or absorbent material (sticks to mucosa)
- Don't irrigate or scrub mucosa
- Avoid trauma to exposed bladder
- Position infant appropriately
- Diapers placed BELOW exposed bladder
- NPO appropriate
- IV access
- Transport to specialized center
- Multidisciplinary planning
Complications
- Recurrent UTI
- Renal damage (VUR, hydronephrosis)
- Incontinence
- Sexual dysfunction
- Infertility concerns
- Inguinal hernias
- Orthopedic issues (pelvic instability, hip)
- Need for multiple surgeries (~ 5 lifetime average)
- Bladder cancer (rare, long-term, especially with bowel reconstruction)
- Psychosocial: body image, gender identity, sexuality
- Surgical complications: dehiscence, fistula, stricture
- Quality of life
Nursing Care
Newborn period:
- Cover exposed bladder with plastic wrap immediately (until surgery)
- Position to prevent trauma
- Diapers below bladder
- Strict I&O
- Pain management
- IV access, fluids
- Maintain temperature
- Family education and support (devastating)
- Coordinate with surgical team
- Transfer to specialized center
Post-op (after each stage):
- Wound care
- Catheter care (often multiple)
- Strict I&O
- Immobilization (Buck traction, spica cast for pelvic stability — months)
- Pain management
- Prevention of complications
- Skin care (immobilization)
- Family support during long hospitalization
- Multidisciplinary coordination
Long-term:
- UTI prevention
- Continence training
- Multiple surgeries planning
- Psychosocial support
- Body image, sexuality
- School coordination
Medications
- Pre-op antibiotics
- Post-op antibiotics (often prolonged)
- Prophylactic antibiotics (UTI)
- Pain management
- Anticholinergics (overactive bladder)
- Stool softeners
Therapeutic Procedures
Staged surgical reconstruction:
- Stage 1 (newborn): bladder closure + epispadias repair (some) + pelvic osteotomies; within 72 hours or after 6 weeks
- Stage 2 (toddler): epispadias repair if not done
- Stage 3 (4-5 years): bladder neck reconstruction for continence
- Alternative: complete primary repair of exstrophy (single stage at birth)
- If reconstruction fails or unsuitable: continent diversion or ileal conduit
- Bladder augmentation (if small capacity)
- CIC (clean intermittent catheterization) often needed
- Lifelong urologic care
Client Education
Family — devastating diagnosis:
- Rare condition; complex care
- Best outcomes at specialized centers (only a few in country)
- Multiple surgeries lifetime
- Most children grow up with manageable continence and quality of life
- Sexual function and fertility usually preserved with modern techniques
- Genetic counseling
- Connect with support organizations (Association for the Bladder Exstrophy Community — A-BE-C)
Acute (newborn):
- Cover bladder with plastic wrap, change frequently
- Avoid trauma
- Diapers below bladder
- Specialty center transfer
- Long hospitalization expected
Post-op care:
- Wound care
- Catheter care (sometimes multiple)
- Immobilization for healing (Buck traction or spica)
- Activity restrictions during healing
- Watch for complications: drainage, fever, urine output changes
Long-term:
- Continence training
- CIC techniques (sometimes lifelong)
- UTI prevention
- Routine urology follow-up
- Bladder cancer surveillance (if reconstruction with bowel)
- Address school accommodations
- Body image, sexuality discussions as child grows
- Pregnancy planning for women
- Lifelong commitment
Interprofessional Care
- Pediatric urology (highly specialized, at exstrophy center)
- Pediatric orthopedics (pelvic osteotomy)
- Pediatric general surgery
- Pediatric anesthesia
- NICU
- Pediatric primary care
- Genetics
- PT, OT
- Pediatric gynecology (girls)
- Mental health, psychology
- Social work
- Stoma nurse (if diversion)
- A-BE-C (support organization)
- Adult urology (transition)
Alterations in Health (Diagnosis)
Collection of fluid around the testis within the tunica vaginalis. Communicating hydrocele: connection to peritoneal cavity (associated with inguinal hernia). Non-communicating: isolated fluid collection. Very common in newborns (often resolves spontaneously by 1 year).
Pathophysiology Related to Client Problem
Failure of processus vaginalis to fully close after testicular descent → fluid in tunica vaginalis. May open intermittently allowing fluid (communicating) or be sealed off (non-communicating).
Health Promotion and Disease Prevention
- No specific prevention
- Routine assessment of male infants
- Recognition and appropriate evaluation
Risk Factors
- Newborn (very common; up to 10%)
- Premature
- Male (only)
- Family history
- Older children: trauma, infection, tumor (rule out)
Expected Findings
- Scrotal swelling — soft, smooth, fluctuant
- Usually painless
- Transilluminates with light (fluid)
- May change size during day (communicating — larger when standing/crying, smaller when supine/sleeping)
- Non-communicating: constant size
- May be unilateral or bilateral
- Testis palpable (rule out tumor)
- If associated hernia: bowel sounds, reducibility
- Sudden onset in older child suspect: trauma, infection, torsion, tumor
Laboratory Tests
- Usually not needed
- If suspect infection: CBC, UA
Diagnostic Procedures
- Physical examination
- Transillumination (fluid)
- Scrotal ultrasound (if uncertain — distinguishes from solid mass, hernia, testicular torsion)
- Doppler if torsion suspected
Safety Considerations
- Distinguish from inguinal hernia (may need repair if hernia)
- Rule out testicular tumor, torsion if older child or sudden change
- Avoid trauma
- Watch for signs requiring evaluation
Complications
- Usually none
- Associated inguinal hernia (with communicating)
- Rarely: discomfort, cosmetic concerns
- Older children: missed underlying pathology (tumor, infection)
- Surgical complications (if repaired)
Nursing Care
- Reassure parents (most resolve)
- Routine assessment at well visits
- Document size, characteristics
- Identify communicating vs non-communicating
- Refer if persistent or symptomatic
- Pre/post-op care if surgery
- Educate family on when to seek care
- Address parental anxiety
Medications
- Usually none
- Post-op pain management if surgery
Therapeutic Procedures
- Observation: most resolve by 12-18 months
- Surgical repair (hydrocelectomy):
- Indications: persists past 12-18 months, large/symptomatic, communicating (associated hernia), suspicion of underlying pathology
- Inguinal approach typically (similar to hernia repair)
- Outpatient procedure
- Sclerotherapy (rarely in pediatrics)
Client Education
- Hydrocele is common in newborns and usually resolves on its own
- Most close by age 1
- Don't squeeze or push on it
- Will be monitored at well visits
- Surgery only if persists, large, or causes problems
- Watch for:
- - Increasing size
- - Redness, warmth
- - Pain
- - Sudden onset in older child
- - Hard mass — call provider
Post-op (if surgery):
- Small incision, outpatient procedure
- Pain manageable with acetaminophen, ibuprofen
- Tub bath restriction 2-3 days
- Activity restriction × 2-4 weeks: no straddle toys, riding
- Wound care
- Watch for: fever, drainage, swelling, severe pain → call provider
- Recurrence rare
- Follow-up appointment
Interprofessional Care
- Pediatric primary care
- Pediatric urology or pediatric surgery (if persistent)
- Pediatric anesthesia (if surgery)
Alterations in Health (Diagnosis)
Abnormal dilation of pampiniform venous plexus in the scrotum — essentially varicose veins of the spermatic cord. More common in adolescents. ~85% on left side (anatomic reasons — left testicular vein drains into left renal vein at right angle). Most are asymptomatic but can affect fertility.
Pathophysiology Related to Client Problem
Incompetent valves in testicular vein or compression → venous reflux → dilation of pampiniform plexus → increased scrotal temperature (impairs spermatogenesis), oxidative stress → potential fertility issues.
Health Promotion and Disease Prevention
- Routine adolescent male physical exam
- Education about self-examination
- Avoid prolonged standing, lifting if has varicocele
- Athletic supporter for sports
Risk Factors
- Male, adolescent and young adult
- Family history
- Tall, thin stature (some evidence)
- Rarely: retroperitoneal mass causing venous compression (concerning if right-sided or new in older male)
Expected Findings
- Usually asymptomatic — often found on physical exam
- Scrotal mass or swelling
- Classic "bag of worms" texture on palpation
- Larger when standing or with Valsalva
- Decreases when lying down (vs. tumor or hernia)
- Heaviness, dull ache (some) — worse with prolonged standing, activity, end of day
- Affected testis may be smaller (testicular atrophy)
- Usually left-sided (~85%)
- Right-sided alone → workup for retroperitoneal mass
Grading:
- Subclinical: detected on ultrasound only
- Grade 1: palpable only with Valsalva
- Grade 2: palpable when standing
- Grade 3: visible through skin
Laboratory Tests
- Usually clinical diagnosis
- Semen analysis (older adolescents — fertility evaluation)
- Hormones if testicular atrophy (FSH, LH, testosterone)
Diagnostic Procedures
- Physical exam (standing and supine, Valsalva)
- Scrotal ultrasound with Doppler (confirms diagnosis, measures testicular size)
- Abdominal/retroperitoneal imaging if isolated right varicocele or sudden onset (rule out mass)
Safety Considerations
- Watch for testicular atrophy (size discrepancy > 20%)
- Monitor testicular size on follow-up
- Right-sided varicocele → evaluation for retroperitoneal pathology
- Sudden new varicocele in older male → investigate
Complications
- Testicular atrophy
- Infertility (varicocele is a common reversible cause of male infertility)
- Decreased sperm count, motility
- Discomfort, pain
- Cosmetic concerns
- Hydrocele formation post-surgery (most common complication)
- Recurrence after surgery
- Psychological impact
Nursing Care
- Assessment in standing and supine positions
- Documentation of size and grade
- Educate on self-monitoring
- Athletic supporter for activity, sports
- Pre/post-op care if surgery
- Fertility counseling for adolescents
- Psychosocial support
Medications
- NSAIDs for discomfort
- Post-op pain management if surgery
Therapeutic Procedures
Observation:
- Most asymptomatic adolescents
- Annual monitoring of testicular size
Surgical repair (varicocelectomy):
- Indications: testicular atrophy (size discrepancy > 20%), pain, abnormal semen analysis, bilateral varicocele
- Approaches: open (inguinal, retroperitoneal, subinguinal), laparoscopic, microsurgical (gold standard)
- Catheter-based: percutaneous embolization (interventional radiology — no incision)
Client Education
- Varicocele is common in adolescent boys (15%)
- Most don't cause problems
- Some affect testicular growth or future fertility
- Annual monitoring at well visits
- Wear athletic supporter for sports
- Avoid prolonged standing or heavy lifting if symptomatic
- Cold packs for discomfort (avoid direct skin contact)
- Self-monitor for changes
- Surgery considered if:
- - Pain
- - Affected testis significantly smaller
- - Abnormal sperm count (adolescents/adults)
- - Bilateral
Post-op (if surgery):
- Pain management
- Scrotal support
- Activity restrictions × 2-4 weeks
- Wound care
- Watch for: fever, drainage, hydrocele formation, severe pain
- Most resolve testicular size catch-up over months
- Semen analysis improvement may take months
Fertility:
- Reassurance — most varicocele do not cause infertility
- Sperm banking option for older adolescents if concerned
- Specialist evaluation when planning family
Interprofessional Care
- Pediatric/adolescent urology
- Pediatric primary care
- Reproductive specialist (fertility concerns later)
- Interventional radiology (embolization)
Alterations in Health (Diagnosis)
Phimosis: inability to retract foreskin over glans penis. Physiologic (normal in uncircumcised infants and young children — usually resolves by 5-7 years) vs pathologic (scarring from infection, balanitis xerotica obliterans). Paraphimosis: retracted foreskin gets stuck behind glans and cannot be reduced — surgical urgency due to constriction.
Pathophysiology Related to Client Problem
Physiologic phimosis: normal natural adhesions between foreskin and glans gradually separate over years. Pathologic phimosis: scarring/fibrosis from recurrent infection (balanitis), forced retraction, or BXO (lichen sclerosus) → tight, non-retractile ring. Paraphimosis: tight foreskin retracted causes venous congestion → swelling → strangulation of glans.
Health Promotion and Disease Prevention
- DO NOT FORCIBLY RETRACT infant foreskin — causes scarring, pathologic phimosis
- Allow natural separation
- Teach proper hygiene as foreskin retracts naturally
- Always reduce foreskin to normal position after retraction (prevent paraphimosis)
- Treat infections promptly
- Education for caregivers
Risk Factors
Phimosis:
- Uncircumcised males
- Forced premature retraction
- Recurrent balanitis
- Lichen sclerosus (BXO)
- Poor hygiene
- Diabetes
Paraphimosis:
- Foreskin retracted and not returned (catheter, exam, sexual activity)
- Tight phimosis ring
Expected Findings
Phimosis:
- Inability to retract foreskin
- Ballooning of foreskin during urination (mild — usually normal)
- If severe: weak stream, dribbling
- Pathologic: white scarring, fibrous ring, painful retraction attempts
- BXO: pearly-white induration of foreskin
- Recurrent balanitis: redness, swelling, discharge
Paraphimosis:
- Painful swelling of glans
- Foreskin retracted, swollen ring behind glans
- Glans appears edematous, dusky, discolored
- Inability to reduce foreskin
- Pain, anxiety
- If prolonged: ischemia, necrosis
Laboratory Tests
- Usually clinical diagnosis
- Glucose if recurrent infections (diabetes)
- Culture if balanitis
Diagnostic Procedures
- Physical examination (don't force retraction)
- Document foreskin retractability
- Look for scarring
- Differentiate physiologic vs pathologic
- Biopsy if BXO suspected
Safety Considerations
- NEVER forcibly retract foreskin (especially infants/young children)
- Always return foreskin to natural position after retraction (foley catheter, exam)
- Paraphimosis is a UROLOGIC URGENCY — reduce ASAP
- Pain management
- Pediatric urology consultation if symptomatic
- BXO requires biopsy and likely circumcision
Complications
Phimosis:
- Recurrent balanitis
- UTI
- Voiding difficulties
- BXO (lichen sclerosus)
- Penile cancer (rare, long-term)
- Sexual dysfunction (adolescents)
Paraphimosis:
- Ischemia of glans
- Tissue necrosis
- Gangrene
- Need for emergency surgery
- Pain
Nursing Care
Phimosis:
- Education on natural separation timeline
- Don't force retraction
- Teach hygiene
- Apply topical steroid if prescribed (gentle massage)
- Monitor for infections
- Pre/post-op care if circumcision
Paraphimosis (emergency):
- Reduce foreskin: apply ice pack to ↓ swelling (5-10 min), then manual reduction with lubrication and gentle pressure (squeeze glans, pull foreskin forward)
- If unable: notify urology emergently
- Pain management
- NPO if surgery needed
- IV access
- Post-reduction: assess perfusion, instruct on prevention
Medications
- Topical corticosteroid (betamethasone 0.05%) — twice daily for 4-8 weeks; resolves 80% of cases without surgery
- Antibiotics if balanitis
- Pain medication
- Lidocaine jelly (paraphimosis reduction)
Therapeutic Procedures
- Topical steroid (first-line for symptomatic phimosis)
- Manual stretching (with steroid)
- Manual reduction (paraphimosis) — emergent
- Circumcision: definitive for pathologic phimosis, recurrent balanitis, BXO, recurrent paraphimosis
- Preputioplasty: foreskin-preserving alternative
- Dorsal slit: emergency for paraphimosis if unable to reduce
Client Education
Family of uncircumcised boy:
- Inability to retract foreskin in infants/young children is NORMAL
- Foreskin separates naturally over time (often by 5-7 years, may be teens)
- DO NOT FORCIBLY RETRACT — causes scarring
- Wash external surface only when young
- Gentle washing under foreskin once it retracts naturally
- After cleaning, always replace foreskin to natural position
- Watch for: redness, swelling, discharge, painful urination → see provider
If treating with topical steroid:
- Apply to tight ring twice daily as directed
- Gentle massage and gradual stretching
- 4-8 week course usually
- Often avoids need for circumcision
Post-circumcision:
- Petroleum jelly with each diaper change
- Watch for: excessive bleeding, infection, voiding
- Return for: fever, redness, discharge, no urination
Paraphimosis prevention:
- ALWAYS return foreskin to natural position after retraction
- Important after foley insertion, exam, sexual activity
- If foreskin stuck and swollen → ER
- Recognize as emergency
Interprofessional Care
- Pediatric urology
- Pediatric primary care
- Pediatric ED (paraphimosis)
- Pediatric dermatology (BXO)
- Pediatric anesthesia
Alterations in Health (Diagnosis)
Inflammatory skin reaction in diaper area. Most common: irritant contact dermatitis from prolonged contact with urine/stool, friction, moisture. Other types: candidal (yeast) diaper dermatitis, seborrheic, allergic contact, atopic. Very common in infants and toddlers.
Pathophysiology Related to Client Problem
Urine + stool + prolonged occlusion + friction → skin barrier breakdown → inflammation. Ammonia from urine breakdown of urea irritates. Stool enzymes (proteases, lipases) damage skin. Warm, moist environment promotes Candida growth (especially after antibiotics or in skin folds).
Health Promotion and Disease Prevention
- Frequent diaper changes (every 2-3 hours, immediately after stool)
- Gentle cleaning with water (avoid wipes with alcohol, fragrance)
- Pat dry, don't rub
- Air-dry time
- Diaper-free time daily
- Apply barrier ointment with each change (zinc oxide, petrolatum)
- Loose-fitting diapers, breathable
- Avoid plastic pants
- Treat diarrhea promptly
Risk Factors
- Age 4-15 months (peak)
- Infrequent diaper changes
- Diarrhea (frequent stool exposure)
- Antibiotics (alter flora → Candida)
- Introduction of solid foods
- Teething
- Skin sensitivity
- Recent illness
- Inadequate cleansing
Expected Findings
Irritant (most common):
- Erythema on convex surfaces in diaper area
- Spares skin folds
- Mild scaling
- Dry, glazed appearance
- Discomfort
Candidal:
- Beefy red rash
- Involves skin folds (intertriginous)
- Satellite lesions (red papules/pustules outside main rash) — classic
- Possibly white plaques
- Often follows antibiotic use
- May have oral thrush (consistent presentation)
Other types:
- Atopic: dry, scaly, itchy; child usually has atopy elsewhere
- Seborrheic: greasy, yellow scales
- Allergic: well-demarcated, where contact occurred
Laboratory Tests
- Usually clinical diagnosis
- KOH prep (Candida — pseudohyphae)
- Bacterial culture if secondary infection
Diagnostic Procedures
- History (diaper changing frequency, products used, recent illness/antibiotics)
- Physical exam
- Identify pattern (convex vs folds, satellite lesions)
Safety Considerations
- Identify and address underlying cause
- Watch for signs of secondary infection (warmth, drainage, fever, systemic illness)
- Concern for child abuse if severe, neglected, unusual pattern
- Treat thrush if present
- Address diaper rash within reasonable time — prevent significant skin breakdown
Complications
- Secondary bacterial infection (impetigo, cellulitis)
- Candidiasis
- Erosions, ulcerations
- Discomfort
- Disrupted sleep
- Family stress
Nursing Care
- Educate caregivers on prevention and treatment
- Frequent diaper changes
- Gentle cleansing
- Air-dry, diaper-free time
- Apply prescribed/recommended topical treatment
- Document characteristics
- Watch for response to treatment
- Address concerns
Medications
Barrier protection (irritant):
- Zinc oxide (Desitin, Balmex) — thick layer with each change
- Petroleum jelly
- Lanolin
Candidal:
- Topical antifungal: nystatin, clotrimazole, miconazole — apply with each diaper change × 7-10 days
- Apply BEFORE barrier ointment (so it can absorb)
- Treat thrush if present (oral nystatin)
Inflammation (severe):
- Low-potency topical steroid (hydrocortisone 1%) — short course only
- Don't use high-potency or prolonged steroids in diaper area (skin atrophy)
- Combination antifungal + steroid (like Lotrisone) NOT recommended in diaper area
Bacterial superinfection:
- Topical mupirocin
- Oral antibiotics if systemic
Therapeutic Procedures
- Education on prevention
- Frequent diaper changes
- Topical treatment per type
- Most resolve in 2-3 days with proper care
Client Education
Prevention and treatment:
- Change diapers frequently — every 2-3 hours during day, immediately after stool
- Use warm water or gentle wipes (alcohol-free, fragrance-free)
- Pat dry — don't rub
- Apply thick layer of zinc oxide or petroleum jelly
- Diaper-free time daily (15-30 minutes) — air helps healing
- Avoid: powders (inhalation risk), corn starch (feeds Candida), perfumed products
Active rash:
- Treat as above but more aggressively
- Apply thick barrier with each change
- If candidal: use antifungal cream BEFORE barrier ointment, twice daily × 7-10 days
- Watch for improvement in 2-3 days
When to call provider:
- Rash worsens despite treatment
- Blistering, pus, drainage
- Fever
- Rash extending beyond diaper area
- Bleeding
- Rash with oral thrush
- Severe pain
- Doesn't improve in 3-7 days
Considerations:
- Diarrhea worsens — treat the underlying cause
- Antibiotics may cause candidal rash — anticipate
- Teething may worsen rashes
- Some children have sensitive skin — try different diaper brand
- Cloth diapers require frequent changes
- Avoid forceful wiping
Interprofessional Care
- Pediatric primary care
- Pediatric dermatology (severe, persistent)
- Caregiver education
Alterations in Health (Diagnosis)
Chronic inflammatory skin condition in areas rich in sebaceous glands. In infants: "cradle cap" on scalp; also face, diaper area, behind ears. Usually resolves by 1 year. In adolescents: dandruff, face involvement. Cosmetic concern primarily — not contagious, not allergic.
Pathophysiology Related to Client Problem
Multifactorial — overproduction of sebum + Malassezia furfur (yeast normally on skin) → inflammatory response → flaking, redness. In infants, maternal hormones may stimulate sebaceous glands.
Health Promotion and Disease Prevention
- Regular gentle washing
- Don't scrub or pick scales
- Use mild shampoo
- Routine skin care
Risk Factors
- Infants (2-12 weeks especially)
- Adolescents/adults
- Family history
- Immunosuppression
- Parkinson disease (adults)
- Stress
- Cold, dry weather
Expected Findings
Infants ("cradle cap"):
- Greasy, yellow scales on scalp
- Thick, adherent crusts
- Mild erythema underneath
- May involve forehead, eyebrows, behind ears, neck, axillae, diaper area
- Usually not itchy in infants (unlike atopic dermatitis)
- Child appears comfortable
- Usually resolves by 1 year
Adolescents/adults:
- Dandruff (white-yellow flakes on scalp)
- Scalp itching
- Erythema, scaling on: nasolabial folds, eyebrows, behind ears, chest
- "Seborrheic" appearance — greasy
- Worsens with stress, cold weather
Laboratory Tests
- Usually clinical diagnosis
- KOH prep if Candida suspected
Diagnostic Procedures
- Physical examination
- Differentiate from atopic dermatitis (very itchy, usually different locations)
Safety Considerations
- Reassure family — common, benign, self-limiting in infants
- Don't pick or scrub scales
- Don't use harsh products
- Watch for superinfection
Complications
- Generally none
- Secondary bacterial infection (rare)
- Hair loss usually does not occur (some temporary)
- Cosmetic concerns
- Family anxiety
Nursing Care
- Education and reassurance
- Gentle treatment recommendations
- Don't use harsh products
- Watch for resolution or worsening
- Distinguish from atopic dermatitis (different treatment)
Medications
Infants:
- Apply baby oil, mineral oil, or petroleum jelly 15-30 min before bath (loosens scales)
- Gentle brushing with soft brush
- Mild shampoo
- Antifungal shampoo (ketoconazole 2%) — if severe or persistent
- Low-potency topical steroid (hydrocortisone 1%) — short course for inflamed face
Adolescents:
- Antifungal shampoo (ketoconazole, selenium sulfide, pyrithione zinc) — 2-3× weekly
- Topical steroid (low-potency) for face flares
- Topical calcineurin inhibitors (tacrolimus, pimecrolimus) — alternatives
Therapeutic Procedures
- Conservative care usually sufficient (infants)
- Antifungal shampoo
- Topical anti-inflammatory if needed
- Most resolve in infants by age 1
Client Education
Infants:
- Cradle cap is common and harmless
- Not caused by poor hygiene
- Not contagious
- Doesn't bother baby
- Usually resolves on its own by 1 year
- To soften scales: apply baby oil or petroleum jelly 15-30 min before bath
- Then gently brush with soft brush or washcloth
- Use mild baby shampoo
- Don't pick or aggressively scrub
- If severe or doesn't resolve, see provider for medicated shampoo
Adolescents:
- Common — many have dandruff
- Antifungal/medicated shampoo: leave on 5 minutes before rinsing
- Use 2-3× weekly
- Alternative products if not working
- Avoid harsh scrubbing
- Stress management may help
- Topical steroid for face — short courses only (skin thinning if prolonged)
- Chronic condition — manage flares
Interprofessional Care
- Pediatric primary care
- Pediatric dermatology (refractory)
Alterations in Health (Diagnosis)
Disorder of insulin resistance + relative insulin deficiency → hyperglycemia. Historically adult disease, but increasing rapidly in adolescents due to obesity epidemic. Now ~30% of new pediatric diabetes diagnoses. Distinguished from T1DM (autoimmune) by features and labs.
Pathophysiology Related to Client Problem
Insulin resistance (peripheral tissues + liver) → pancreas increases insulin → eventually beta cell exhaustion → relative insulin deficiency → hyperglycemia. Strong genetic component + obesity + sedentary lifestyle. May present with DKA (less common than T1DM but possible).
Health Promotion and Disease Prevention
- Healthy lifestyle: balanced diet, regular physical activity, healthy weight
- Limit sugar-sweetened beverages
- Reduce screen time
- Family-based interventions
- School wellness programs
- Screen at-risk children: BMI ≥ 85th percentile + risk factors (family history, ethnicity, signs of insulin resistance, maternal GDM/T2DM) at age 10 or puberty
- Address social determinants
Risk Factors
- Obesity (most important — strong correlation)
- Family history of T2DM
- Ethnicity: Native American, African American, Hispanic, Asian/Pacific Islander, South Asian
- Puberty (insulin resistance physiologic)
- Female sex (slight predominance, especially with PCOS)
- Maternal gestational diabetes
- Low birth weight
- Sedentary lifestyle
- Poor diet (high sugar, processed foods)
- Signs of insulin resistance: acanthosis nigricans, PCOS, NAFLD, hypertension, dyslipidemia
- Antipsychotic medications (some)
Expected Findings
- Usually obese (vs. T1DM typically not obese)
- Often asymptomatic — discovered on screening
- Classic diabetes symptoms (may be less severe than T1DM):
- - Polyuria
- - Polydipsia
- - Polyphagia
- - Weight loss (sometimes — less common than T1DM)
- - Fatigue
- Acanthosis nigricans (velvety hyperpigmentation on neck, axillae, groin) — sign of insulin resistance
- Skin tags
- Acne, hirsutism (PCOS in girls)
- Irregular menses
- HTN
- Dyslipidemia
- NAFLD (fatty liver)
- OSA
- DKA at presentation (~10% — less common than T1DM)
- HHS rare but more severe than DKA
Laboratory Tests
Diagnostic criteria (any one):
- Fasting glucose ≥ 126 mg/dL
- Random glucose ≥ 200 with symptoms
- OGTT 2-hour glucose ≥ 200
- HbA1c ≥ 6.5%
Distinguishing from T1DM:
- C-peptide: elevated or normal in T2DM (low/absent in T1DM)
- Insulin levels: high in T2DM
- Diabetes autoantibodies: NEGATIVE in T2DM (positive in T1DM — GAD, IA-2, ICA, insulin)
- Lipid panel (often dyslipidemia)
- LFTs (NAFLD common)
- Microalbumin/creatinine ratio
- TSH
- Vitamin D
Diagnostic Procedures
- Comprehensive history and physical
- BMI, vital signs (BP)
- Acanthosis nigricans assessment
- Tanner staging
- Diagnostic labs above
- Initial screening for complications: dilated eye exam, microalbumin, lipid panel, LFTs, foot exam
- Sleep study (OSA)
- Ultrasound (NAFLD)
Safety Considerations
- Watch for DKA (less common than T1DM but possible)
- HHS more severe than DKA in T2DM
- Hypoglycemia (especially on insulin or sulfonylureas)
- BP and lipid management critical
- Address mental health (depression, eating disorders common)
- Pregnancy considerations (girls — fetal anomalies if uncontrolled)
- Medication safety
Complications
- Faster progression of complications than adult T2DM:
- Diabetic ketoacidosis
- HHS
- Hypoglycemia (especially with insulin)
- Microvascular: retinopathy, nephropathy, neuropathy (can occur within years)
- Macrovascular: coronary artery disease, stroke (early onset)
- Hypertension, dyslipidemia (often present at diagnosis)
- NAFLD → cirrhosis
- OSA
- PCOS
- Mental health: depression, eating disorders
- Pregnancy complications (women)
- Reduced life expectancy
- Pediatric T2DM has WORSE prognosis than adult-onset
Nursing Care
- Comprehensive diabetes education (family-based)
- Lifestyle counseling: nutrition, activity
- Blood glucose monitoring training
- Medication education and administration
- Insulin teaching if needed
- BP monitoring
- Address obesity (referral to weight management)
- Mental health screening, support
- Address barriers (financial, food access)
- School coordination (medications, snacks, hypoglycemia plan)
- Coordinate complication screening
- Adolescent transition planning
- Family support
- Address cultural considerations
Medications
First-line:
- Metformin — FDA-approved for ≥ 10 years; start 500 mg daily, titrate; ↓ hepatic glucose production, ↑ insulin sensitivity
- Side effects: GI (nausea, diarrhea), B12 deficiency (long-term)
- Hold for IV contrast, surgery
- Lactic acidosis (rare)
Insulin:
- If HbA1c high (> 9%), DKA at presentation, ketosis, or metformin alone inadequate
- Long-acting basal (glargine, detemir, degludec)
- Rapid-acting prandial as needed
Newer agents:
- GLP-1 receptor agonists: liraglutide, semaglutide (Wegovy/Ozempic) — approved for adolescents; ↓ weight, ↓ glucose
- SGLT-2 inhibitors: empagliflozin (adolescents) — newer in pediatrics
For complications:
- ACE inhibitor/ARB (HTN, albuminuria)
- Statin (dyslipidemia)
- Aspirin (rare, ↑ CV risk)
Therapeutic Procedures
Lifestyle (CORNERSTONE):
- Nutrition: balanced, portion control, limit added sugars, refined carbs
- Aim for 5+ servings fruits/veggies daily
- Whole grains
- Limit sugary drinks, processed foods
- Family meals
- Physical activity: 60 min daily moderate-vigorous
- Limit screen time < 2 hours/day
- Weight management (5-10% reduction can dramatically improve glucose)
Medications (above)
Bariatric surgery:
- Consider in severe adolescent obesity with T2DM
- Highly effective
- Specialized centers
Complication screening (annually):
- Dilated eye exam
- Microalbumin/creatinine ratio
- Lipid panel
- BP
- Foot exam
- NAFLD evaluation
- PCOS evaluation (girls)
Client Education
Diabetes education essentials:
- T2DM is a chronic condition but manageable
- Often improves dramatically with weight loss and exercise
- Family-based intervention most effective
- Daily medication if prescribed
- Blood glucose monitoring
- Targets: fasting 80-130, postprandial < 180, HbA1c < 7%
- Recognize hypoglycemia (especially on insulin): symptoms, treatment (15-15 rule)
- Sick day management
Nutrition:
- Work with registered dietitian
- Balanced meals: half plate vegetables, quarter protein, quarter whole grains
- Avoid sugary drinks (single biggest impact)
- Limit fast food, processed foods
- Eat at regular times
- Smaller portions
- Family eats the same way
Activity:
- 60 minutes daily moderate-vigorous
- Find activities child enjoys
- Family activities
- Reduce screen time
- Walking, biking, dancing all count
Mental health:
- Diabetes distress, depression common
- Eating disorders risk (especially girls)
- Don't shame about weight — focus on health
- Support groups
Complications prevention:
- Annual screening
- Don't smoke
- BP control
- Lipid management
- Foot care
School:
- 504 plan
- Snack access
- Glucose monitoring permission
- Hypoglycemia plan
- Educate school staff
Adolescent:
- Confidential support
- Pregnancy planning (girls)
- Address body image
- Sexual health, PCOS if applicable
- Substance use prevention
- Transition to adult care
Interprofessional Care
- Pediatric endocrinology (primary)
- Pediatric diabetes educator
- Registered dietitian
- Pediatric mental health (high comorbidity)
- Pediatric ophthalmology
- Pediatric nephrology (if albuminuria)
- Pediatric cardiology (BP, lipids)
- Pediatric gastroenterology (NAFLD)
- Pediatric gynecology (PCOS)
- Pediatric obesity/weight management
- Bariatric surgery team (selected)
- School nurse
- Adult endocrinology (transition)
- Family support
Alterations in Health (Diagnosis)
Acute bacterial infection caused by Corynebacterium diphtheriae. Produces a toxin → severe systemic illness. Rare in vaccinated populations, but resurgence in undervaccinated areas. Forms grayish pseudomembrane in pharynx/larynx → airway obstruction. Toxin damages heart, nerves, kidneys.
Pathophysiology Related to Client Problem
Bacteria multiply in upper respiratory tract → produce exotoxin → local tissue necrosis (forms pseudomembrane) + systemic toxicity (myocarditis, neuropathy, nephropathy). Toxin inhibits cellular protein synthesis. Spread via respiratory droplets, skin contact.
Health Promotion and Disease Prevention
- DTaP vaccine (childhood): 2, 4, 6, 15-18 months, 4-6 years
- Tdap booster (11-12 years, then every 10 years)
- Td/Tdap for adults
- Maternal Tdap during pregnancy
- Universal vaccination achieves herd immunity
- Post-exposure: vaccination, prophylactic antibiotics for close contacts
- Travel precautions to endemic areas
Risk Factors
- Unvaccinated or undervaccinated
- Travel to endemic regions (parts of Africa, Asia, Eastern Europe, South America)
- Crowded living conditions
- Poor sanitation
- Close contact with infected person
- Immunocompromise
Expected Findings
Respiratory diphtheria (most common):
- Gradual onset 2-5 days after exposure
- Sore throat, mild fever, malaise
- Gray-white pseudomembrane on tonsils, pharynx, larynx — adherent, bleeds when removed
- Dysphagia
- Cervical lymphadenopathy ("bull neck")
- Severe sore throat
- Hoarseness
- Stridor (laryngeal)
- Airway obstruction possible
- Cough
- Foul breath
Systemic (toxin effects, occur 1-2 weeks in):
- Myocarditis (most serious complication, 10-25%): tachycardia, arrhythmia, HF
- Neuropathy: palatal paralysis (early), peripheral neuropathy (late)
- Kidney damage
Cutaneous diphtheria:
- Skin ulcers with gray membrane
- Tropical climates, IV drug use
- Less likely to cause systemic toxicity
Laboratory Tests
- Throat culture (Loeffler medium, tellurite plate)
- Toxin testing (Elek test, PCR)
- CBC (leukocytosis)
- ECG (myocarditis)
- Cardiac enzymes
- Albumin (kidney damage)
- BUN/Cr
Diagnostic Procedures
- Clinical suspicion based on pseudomembrane
- Throat culture (notify lab — special media needed)
- Public health notification (reportable disease)
- ECG, echocardiogram
- Investigate contacts
Safety Considerations
- Strict respiratory droplet isolation
- Single room, mask, gown, gloves
- Notify public health IMMEDIATELY
- Identify and treat contacts
- Maintain airway — be prepared for emergent intubation/tracheostomy
- Don't scrape pseudomembrane (bleeding)
- Cardiac monitoring (myocarditis)
- Strict bed rest (myocarditis risk)
- Equipment for airway emergency at bedside
Complications
- Airway obstruction (pseudomembrane in larynx)
- Myocarditis (10-25% — leading cause of death)
- Cardiac failure, arrhythmias
- Peripheral neuropathy
- Palatal paralysis (early — nasal regurgitation)
- Diaphragmatic paralysis
- Kidney damage
- Sepsis
- Death (mortality 5-10% even with treatment, > 50% without)
Nursing Care
- Strict isolation (droplet)
- PPE (N95 or surgical mask, gown, gloves)
- Frequent vital signs
- Cardiac monitoring
- Watch for respiratory distress — airway emergency equipment
- Suction available (but don't disturb pseudomembrane)
- Bed rest (minimize cardiac demand)
- Quiet environment
- Soft/liquid diet (dysphagia)
- Tube feeding if needed
- Administer antitoxin and antibiotics on time
- IV fluids
- Watch for myocarditis signs (3-4 weeks)
- Neurological assessments
- Family education and isolation precautions
- Notify public health and trace contacts
- Encourage immunization compliance
Medications
Diphtheria antitoxin (DAT):
- HORSE-derived — test for hypersensitivity first
- Administer ASAP (before culture results) — toxin binds tissue quickly
- IV preferred for severe
- Higher dose for severe disease
Antibiotics:
- Erythromycin or penicillin × 14 days
- Eliminates organism, prevents transmission
- Repeat cultures to confirm clearance
Supportive:
- IV fluids
- Oxygen
- Cardiac medications (HF, arrhythmias)
- Pain medications
- Antiemetics
- Vaccination of patient and contacts after recovery (disease doesn't confer immunity)
Close contacts:
- Antibiotics prophylactically (erythromycin × 7-10 days or single dose IM penicillin)
- Vaccinate or boost
- Cultures
Therapeutic Procedures
- Antitoxin (cornerstone — neutralizes toxin)
- Antibiotics (eliminate organism)
- Airway management (intubation, tracheostomy if needed)
- Surgical removal of pseudomembrane (rare, with care)
- Supportive care
- Cardiac care for myocarditis
- Rehabilitation for neurological deficits
- Public health follow-up
Client Education
Prevention is paramount:
- VACCINATION prevents diphtheria
- DTaP schedule for children
- Tdap booster for adolescents
- Tdap during pregnancy
- Td booster every 10 years
- Vaccinate before international travel to endemic areas
- Most rare in vaccinated populations
If diagnosed:
- Serious illness — strict treatment compliance
- Isolation until cultures negative
- Family/contacts evaluated and treated
- Long recovery
- Cardiac monitoring for weeks
- Watch for myocarditis (3-4 weeks)
- Symptoms of cardiac problems → ER
- Symptoms of neuropathy → physician
- Activity restrictions during recovery
- Patient still needs vaccination after recovery (illness doesn't confer full immunity)
Public health:
- Reportable disease
- Contact investigation
- Outbreak management
Interprofessional Care
- Pediatric infectious disease (primary)
- Pediatric ICU (severe)
- Pediatric ENT (airway)
- Pediatric cardiology (myocarditis)
- Pediatric neurology (neuropathy)
- Public health (reportable, contact tracing)
- Pediatric primary care (prevention)
- Vaccination programs
- WHO/CDC
Alterations in Health (Diagnosis)
Most common primary intraocular malignancy of childhood. Arises from retinal precursor cells. Two forms: hereditary (~40% — bilateral, multifocal, germline RB1 mutation, predisposed to other cancers) and sporadic (~60% — unilateral, single focus). Diagnosis usually before age 5 (mean 18 months).
Pathophysiology Related to Client Problem
Mutation in RB1 tumor suppressor gene (chromosome 13q14) → loss of cell cycle regulation → unchecked retinal cell proliferation. Hereditary: germline mutation + "second hit" → multiple, bilateral tumors. Sporadic: two somatic hits in single retinal cell → unifocal, unilateral.
Health Promotion and Disease Prevention
- Genetic counseling for affected families
- RB1 mutation testing for relatives of affected individuals
- Early screening of newborns from affected families
- Prenatal diagnosis available
- Recognize early signs (leukocoria)
- Routine red reflex examination at well visits
Risk Factors
- Family history (hereditary form)
- Germline RB1 mutation (40%)
- Age: ~95% diagnosed before age 5
- Sporadic mutations (60% of cases)
Expected Findings
- Leukocoria (white pupillary reflex) — classic, present in 60% (often noted in photos with red-eye effect on one side and white on affected side)
- Strabismus (~20% — eye doesn't track)
- Decreased vision
- Eye pain (advanced)
- Hyphema (blood in anterior chamber)
- Glaucoma signs
- Proptosis (advanced)
- Red, painful eye
- Heterochromia
- Iris discoloration
- May involve one or both eyes (hereditary often bilateral)
- Often asymptomatic until visible findings
Laboratory Tests
- Diagnostic imaging primary
- RB1 genetic testing (especially if bilateral, family history)
- CBC, CMP for treatment monitoring
Diagnostic Procedures
- Examination under anesthesia (EUA) — by pediatric ophthalmologist (gold standard)
- RetCam imaging (digital retinal photography)
- Ultrasound of eye
- MRI head/orbits (extent, optic nerve involvement, intracranial extension)
- CT (less commonly — radiation concern in hereditary form)
- RB1 genetic testing
- Lumbar puncture (CSF for malignancy if advanced)
- Bone marrow biopsy (advanced)
- NEVER biopsy intraocular tumor (seeds tumor)
Safety Considerations
- NEVER biopsy (intraocular biopsy → tumor seeding through orbit)
- Routine red reflex screening at well visits
- Family education on warning signs
- Hereditary form: lifetime cancer screening (osteosarcoma, melanoma, soft tissue sarcomas)
- Sun protection
- Avoid radiation when possible (hereditary form — secondary malignancy risk)
- Vision protection (other eye)
- Vaccination status
- Family genetic counseling
Complications
- Vision loss
- Eye loss (enucleation)
- Optic nerve, orbital, intracranial extension
- Metastasis (CNS, bone, marrow)
- Death (rare in developed countries, > 95% survival; up to 70% mortality globally due to late presentation)
- Treatment complications: vision loss, secondary cataracts, retinal detachment
- Chemo side effects: ototoxicity (carboplatin), secondary cancers
- Radiation side effects: secondary cancers (especially in hereditary form), facial growth issues, cataracts
- Hereditary form lifetime cancer risk:
- - Osteosarcoma (especially after radiation)
- - Soft tissue sarcomas
- - Melanoma
- - Other
- Psychosocial: appearance (after enucleation), body image
Nursing Care
- Comprehensive assessment, pre-op preparation
- EUA preparation
- Post-op care (enucleation or other surgery): pain management, dressing care, monitor for infection
- Prosthetic eye care education
- Chemotherapy administration and monitoring
- Family education on warning signs
- Genetic counseling coordination
- Lifetime cancer surveillance education
- Sun protection education
- Address psychosocial concerns
- School coordination, vision support
- Address sibling needs
- Long-term follow-up
- Support organizations
Medications
- Systemic chemotherapy: carboplatin, vincristine, etoposide
- Intra-arterial chemotherapy (via ophthalmic artery) — newer, very effective
- Intravitreal chemotherapy (directly into eye)
- Supportive: antiemetics, hydration, G-CSF if needed
- Pain management
- Topical eye medications
Therapeutic Procedures
Goals: save life, save eye, save vision (in that order)
- Chemotherapy: systemic, intra-arterial, intravitreal
- Focal therapy:
- - Laser photocoagulation
- - Cryotherapy
- - Thermotherapy
- - Brachytherapy (plaque radiation)
- External beam radiation: less common now (secondary cancer risk in hereditary)
- Enucleation: for advanced, unsalvageable eye; or in unilateral disease with no vision potential
- Prosthetic eye placement
- Genetic counseling
- Survivorship clinic
- Lifetime cancer surveillance (hereditary)
Client Education
Key prevention/early detection:
- Routine red reflex examination at every well visit (catches retinoblastoma)
- Family screening if hereditary form
- Photo screening — if "red eye" effect is white in one eye on photos → see ophthalmologist immediately
- Watch for: leukocoria, strabismus, vision problems, eye pain
Family education:
- Treatable, often curable
- Multiple treatment modalities
- Save life first, then eye, then vision
- Excellent prognosis with early detection (95%+ survival)
- Long, complex treatment
- Genetic counseling important
If hereditary:
- Lifelong cancer surveillance: bones (osteosarcoma), soft tissues, skin (melanoma)
- Sun protection critical
- Avoid radiation when possible
- Annual skin exams, regular cancer surveillance
- Genetic testing for siblings, offspring
If enucleation:
- Prosthetic eye fits well, looks natural
- Care of prosthesis (cleaning, replacement)
- Protect remaining eye (eye protection during sports)
- School support
- Body image, self-esteem
Long-term:
- Regular ophthalmology follow-up
- Vision support services
- School coordination, low vision aids
- Address body image (especially adolescent)
- Connect with retinoblastoma support organizations
Interprofessional Care
- Pediatric ophthalmology (primary)
- Pediatric hematology/oncology
- Pediatric genetics, genetic counseling
- Ocular oncology
- Pediatric radiation oncology
- Pediatric anesthesia (multiple EUAs)
- Interventional radiology (intra-arterial chemo)
- Prosthetics specialist
- Pediatric audiology (chemo)
- Low vision specialist
- School coordinator
- Mental health
- Survivorship clinic
- Retinoblastoma support organizations
Alterations in Health (Diagnosis)
Complex congenital heart defect — incomplete formation of central heart structures: ASD (primum type) + VSD + abnormal AV valves. Result: large left-to-right shunt, AV valve regurgitation. Strongly associated with Down syndrome (~40% of AV canal defects). Symptoms: severe heart failure in infancy.
Pathophysiology Related to Client Problem
Failure of endocardial cushions to fuse during embryonic development → defects in atrial septum (primum ASD), ventricular septum, and AV valves (often single common valve). Massive left-to-right shunting → pulmonary overcirculation → CHF, pulmonary HTN, Eisenmenger syndrome if uncorrected.
Health Promotion and Disease Prevention
- Adequate prenatal care
- Genetic counseling (especially if Down syndrome or family history)
- Fetal echocardiogram if Down syndrome suspected prenatally
- Newborn cardiac assessment for all infants with Down syndrome
- Folic acid in pregnancy
- Avoid in utero exposures
Risk Factors
- Down syndrome (trisomy 21) — 40-50% have congenital heart defect; AV canal is most common
- Other trisomies
- Family history
- Heterotaxy syndromes
- Maternal diabetes
Expected Findings
- CHF symptoms in early infancy (weeks-months):
- Poor feeding, fatigue with feeds
- Diaphoresis with feeds
- Failure to thrive
- Tachypnea, dyspnea
- Retractions
- Tachycardia, gallop
- Hepatomegaly
- Pulmonary edema
- Murmur: systolic murmur (VSD), holosystolic at apex (mitral regurg), mid-diastolic at apex (mitral inflow); accentuated S2
- Recurrent respiratory infections
- Cyanosis: minimal initially; develops with pulmonary HTN, Eisenmenger
- Down syndrome features if present
Laboratory Tests
- BNP elevated
- CBC
- Electrolytes
Diagnostic Procedures
- Echocardiogram (definitive)
- EKG: superior axis (left axis deviation) — CLASSIC
- CXR: cardiomegaly, ↑ pulmonary vascularity, pulmonary edema
- Cardiac catheterization
- Cardiac MRI
- Karyotype if Down syndrome features
Safety Considerations
- Treat CHF promptly
- Adequate caloric intake (high-calorie formula)
- NG/G-tube feedings if oral inadequate
- Monitor for respiratory deterioration
- Avoid dehydration
- RSV prophylaxis (palivizumab — heart failure indication)
- Vaccinations on schedule
- Infection precautions
- Endocarditis prophylaxis (before repair for some)
- Surgery timing critical — don't delay too long (pulmonary HTN risk)
Complications
- Heart failure
- Failure to thrive
- Recurrent respiratory infections
- Pulmonary hypertension (early in Down syndrome — within months)
- Eisenmenger syndrome (if untreated)
- Surgical complications: arrhythmias, residual lesions, heart block, valve dysfunction
- Mitral valve regurgitation (residual)
- Left ventricular outflow tract obstruction
- Death (without surgery, especially Down syndrome — pulmonary HTN)
Nursing Care
- Comprehensive assessment, cardiac and respiratory
- Strict I&O, daily weights
- Monitor for CHF
- Feeding support: small frequent feeds, high-calorie formula, NG/G-tube if needed
- Administer cardiac medications
- Diuretic monitoring
- Position: HOB elevated
- Cluster care
- Pre-op preparation
- Post-op cardiac ICU care
- Family education and support
- Down syndrome-specific care (developmental, comorbidities)
- Coordinate multidisciplinary care
- Anticipate longer hospitalization
Medications
- Diuretics: furosemide
- ACE inhibitors: captopril, enalapril
- Digoxin
- Beta-blockers (sometimes)
- Aldosterone antagonist: spironolactone
- Pre-op antibiotics
- Endocarditis prophylaxis (before repair)
- Pulmonary vasodilators (sildenafil) if pulmonary HTN
- RSV prophylaxis (palivizumab)
Therapeutic Procedures
Surgical repair — typically by 3-6 months of age (don't delay due to pulmonary HTN risk):
- Patch closure of ASD and VSD
- Repair of common AV valve (or formation of two valves)
- Cardiopulmonary bypass
- Long-term cardiology follow-up
- Heart transplant if severe valve dysfunction (rare)
- Address Down syndrome comorbidities
Client Education
Family:
- AV canal is a serious heart defect requiring surgery
- Surgery typically at 3-6 months
- Without surgery, develops pulmonary HTN quickly (especially Down syndrome)
- With surgery, most children do well long-term
- Long-term cardiac follow-up
Down syndrome plus AV canal:
- Higher risk of pulmonary HTN — early surgery essential
- May have other comorbidities
- Comprehensive Down syndrome care
- Early intervention services
- Family support resources
Pre-surgery management:
- High-calorie feeds, frequent small meals
- Daily medications (diuretics, ACE, digoxin)
- Monitor weight, breathing
- Watch for: increased breathing effort, poor feeding, cyanosis, lethargy → contact provider
- Avoid sick contacts
- Vaccinations including RSV, flu, COVID
- Palivizumab if eligible
Post-surgery:
- Recovery 2-3 weeks initially
- Activity gradually returns
- Continue some medications initially
- Watch for: fever, drainage, breathing problems, arrhythmias
- Lifelong cardiology follow-up
- Endocarditis prophylaxis for dental work × 6 months (sometimes lifelong with valve issues)
Long-term:
- Most have normal activity tolerance
- Watch for late complications: valve dysfunction, arrhythmias
- Adult congenital heart disease team (transition)
- Address developmental needs (especially Down syndrome)
- School support
Interprofessional Care
- Pediatric cardiology
- Pediatric cardiothoracic surgery
- Pediatric cardiac ICU
- Pediatric anesthesia
- Pediatric pulmonology (pulmonary HTN)
- Pediatric nutrition
- Down syndrome team (if applicable):
- - Developmental pediatrics
- - Pediatric endocrinology
- - Audiology
- - Ophthalmology
- - Early intervention
- Genetic counseling
- Adult congenital heart disease (transition)
- Family support, social work
Alterations in Health (Diagnosis)
Narrowing of aortic valve area causing left ventricular outflow obstruction. Types: valvular (most common — bicuspid valve in 50%+), subvalvular (below valve), supravalvular (above — associated with Williams syndrome). Spectrum from asymptomatic to critical AS in newborn (PDA-dependent).
Pathophysiology Related to Client Problem
Narrowed aortic valve → ↑ LV pressure to maintain cardiac output → LV hypertrophy → eventually LV failure. Severe/critical: inadequate cardiac output, pulmonary edema. Bicuspid valve: prone to early calcification and progressive stenosis in adulthood.
Health Promotion and Disease Prevention
- Adequate prenatal care
- Genetic counseling for at-risk families
- Genetic counseling for Williams syndrome
- Routine cardiac screening
- Endocarditis prophylaxis as indicated
Risk Factors
- Male (3:1)
- Family history
- Bicuspid aortic valve (often familial)
- Williams syndrome (supravalvular)
- Turner syndrome
- Other CHD
Expected Findings
Mild-moderate:
- Often asymptomatic
- Heart murmur (often discovered at well visit)
- Systolic ejection murmur — right upper sternal border, radiates to neck/carotids
- Ejection click (valvular)
- Thrill at base or in neck
- Normal exercise tolerance usually
Severe:
- Exercise intolerance
- Chest pain, syncope with exertion (concerning — sudden death risk)
- Dyspnea
- Fatigue
- Heart failure signs
Critical AS in newborn:
- PDA-dependent for systemic flow
- Cardiogenic shock as ductus closes
- Hypotension
- Pallor
- Decreased pulses (especially femoral)
- Acidosis
Laboratory Tests
- BNP if HF
- Lactate (poor perfusion in critical AS)
- Genetic testing (Williams syndrome — FISH or microarray)
Diagnostic Procedures
- Echocardiogram (definitive): valve anatomy, gradient, LV function, LVH
- EKG: LVH, strain pattern
- CXR: prominent aorta, cardiomegaly
- Cardiac catheterization (gradient, intervention)
- Exercise stress test (older children — exercise tolerance, BP response)
- Cardiac MRI
Safety Considerations
- Avoid intense isometric exercise (weight lifting, severe AS)
- Cardiology clearance for sports
- Watch for symptoms: chest pain, syncope (sudden death risk)
- Endocarditis prophylaxis (high-risk valve lesions per AHA)
- Critical AS newborn: PGE1 IMMEDIATELY
- Avoid dehydration
- Pregnancy planning (women)
Complications
- Progressive stenosis
- LV hypertrophy → dysfunction
- Heart failure
- Pulmonary edema
- Arrhythmias
- Sudden death (severe AS)
- Endocarditis (especially bicuspid valve)
- Aortic regurgitation (after balloon valvuloplasty)
- Aortic dissection/aneurysm (bicuspid valve — adult)
- Need for valve replacement
Nursing Care
- Comprehensive assessment
- Vital signs, including pulses, BP in arms and legs
- Murmur documentation
- Monitor for exercise tolerance, symptoms
- Cardiac assessment
- Pre/post-procedure care
- Endocarditis prophylaxis education
- Activity counseling per cardiology
- Family education
- Long-term follow-up
- Critical AS: PGE1, ICU care, prepare for intervention
Medications
- Most mild-moderate need no medications
- Beta-blockers (some)
- ACE inhibitors
- Critical AS newborn: PGE1, inotropes, diuretics
- Endocarditis prophylaxis for dental work in select cases
- Antiplatelet/anticoagulant if prosthetic valve
Therapeutic Procedures
- Balloon aortic valvuloplasty: first-line for moderate-severe in children (catheter-based)
- Indications: gradient > 60 mmHg, symptoms, EKG changes
- Surgical valve repair
- Aortic valve replacement:
- - Mechanical valve (lifetime anticoagulation)
- - Bioprosthetic (limited durability)
- - Ross procedure (own pulmonary valve to aortic position, homograft to pulmonary)
- Critical AS newborn: emergent balloon valvuloplasty or surgery
- Adult congenital follow-up
Client Education
- Aortic stenosis varies from mild to severe
- Regular cardiology follow-up critical
- Activity restrictions based on severity (cardiology recommends)
- Most mild cases: no restrictions
- Severe AS: avoid intense isometric exercise (weight lifting, wrestling)
- Recognize warning signs: chest pain with exertion, syncope, palpitations, severe SOB → call cardiologist
- Endocarditis prophylaxis (some): antibiotics before dental work
- Bicuspid valve in family → screen siblings, parents
- Vaccinations on schedule
Post-intervention:
- Balloon valvuloplasty: outpatient or short stay
- Surgery: 1-2 weeks initial recovery, longer return to full activity
- Activity restrictions per cardiology
- Watch for: fever, chest pain, breathing problems → call provider
- Lifelong follow-up
- May need re-intervention
- Mechanical valve: lifelong warfarin, INR monitoring
Long-term:
- Bicuspid valve commonly progresses in adulthood
- Regular adult cardiology
- Aortic dilation surveillance (bicuspid)
- Pregnancy considerations for women (specialized care)
- Family screening
Interprofessional Care
- Pediatric cardiology
- Pediatric cardiothoracic surgery
- Interventional cardiology
- Pediatric anesthesia
- Adult congenital heart disease
- Pediatric genetics (Williams syndrome)
- Pediatric endocrinology (Williams)
- Dentistry (endocarditis prophylaxis)
Alterations in Health (Diagnosis)
Narrowing of pulmonary valve or right ventricular outflow tract. Most common right-sided obstructive lesion. Types: valvular (most common), supravalvular, subvalvular. Spectrum from mild (asymptomatic) to critical PS in newborn (cyanotic, ductal-dependent). Associated with Noonan syndrome and others.
Pathophysiology Related to Client Problem
Narrowed pulmonary outflow → ↑ RV pressure → RV hypertrophy → eventually RV failure. Severe/critical: inadequate pulmonary blood flow → cyanosis. Mild PS often non-progressive; moderate-severe may progress over time.
Health Promotion and Disease Prevention
- Adequate prenatal care, fetal echo
- Genetic counseling (Noonan syndrome, Williams)
- Routine cardiac screening
- Vaccinations
Risk Factors
- Family history
- Noonan syndrome (50% of Noonan have PS)
- Williams syndrome
- Other CHD (TOF, etc.)
- Congenital rubella
Expected Findings
Mild-moderate:
- Usually asymptomatic — found on murmur at well visit
- Systolic ejection murmur — upper left sternal border, radiates to back
- Ejection click (valvular)
- Loud P2 (mild) or soft P2 (severe)
- RV heave
- Normal exercise tolerance
Severe:
- Exercise intolerance
- Cyanosis with exertion or rest
- Right-sided heart failure: hepatomegaly, edema, JVD
- Syncope
Critical PS newborn:
- Cyanosis (depends on PDA for pulmonary flow)
- Deteriorates as ductus closes
- Tachypnea, distress
Laboratory Tests
- BNP if HF
- Genetic testing (Noonan — RAS pathway genes)
Diagnostic Procedures
- Echocardiogram (definitive): valve, gradient, RV function, RV hypertrophy
- EKG: RVH, RAD
- CXR: prominent main PA (post-stenotic dilation), normal heart size (mild) to cardiomegaly
- Cardiac catheterization (gradient, intervention)
- Cardiac MRI (some)
Safety Considerations
- Activity counseling (depends on severity)
- Endocarditis prophylaxis (less commonly than aortic)
- Critical PS newborn: PGE1 IMMEDIATELY
- Monitor symptoms
- Pregnancy considerations
Complications
- Progressive stenosis (some)
- RV hypertrophy, dysfunction
- RV failure
- Cyanosis (severe)
- Pulmonary regurgitation (after intervention)
- Arrhythmias
- Endocarditis
- Need for re-intervention
Nursing Care
- Assessment, murmur documentation
- Cardiac assessment
- SpO₂ monitoring
- Pre/post-procedure care
- Activity counseling
- Long-term follow-up
- Family education
- Critical PS newborn: PGE1, ICU care
- Multidisciplinary care if syndromic
Medications
- Mild-moderate: usually no medications
- Critical PS newborn: PGE1
- Diuretics if RV failure
- Endocarditis prophylaxis in select cases
Therapeutic Procedures
- Balloon pulmonary valvuloplasty — first-line, very effective for valvular PS
- Indications: gradient > 40-50 mmHg, symptoms, critical PS
- Surgical repair for subvalvular, supravalvular, or failed balloon
- Most mild PS: just monitor
- Long-term cardiology follow-up
Client Education
- Pulmonic stenosis varies from mild to severe
- Mild often needs no intervention — just monitoring
- Moderate-severe: balloon valvuloplasty very effective
- Long-term outcome generally excellent
- Activity guidance from cardiology
- Mild: usually no restrictions
- Severe (before intervention): activity restrictions per cardiology
- Recognize: increased SOB, exercise intolerance, cyanosis → call cardiologist
- Lifelong cardiology follow-up
- Endocarditis prophylaxis in select cases for dental work
- Noonan syndrome features: family genetic counseling
- Most lead normal lives after treatment
- Pregnancy planning for women
Post-procedure:
- Balloon valvuloplasty: outpatient or overnight stay
- Activity restrictions briefly
- Pulmonary regurgitation common after — usually well tolerated
- Monitor for complications
- Follow-up appointments
Interprofessional Care
- Pediatric cardiology
- Pediatric cardiothoracic surgery
- Interventional cardiology
- Pediatric anesthesia
- Pediatric genetics (Noonan, Williams)
- Adult congenital heart disease
Alterations in Health (Diagnosis)
Disease of heart muscle resulting in cardiac dysfunction. Pediatric types: dilated (most common — ↓ contractility, dilated ventricles), hypertrophic (thickened ventricle walls — often genetic), restrictive (rigid walls), arrhythmogenic right ventricular. May lead to heart failure, arrhythmias, sudden death, or need for transplant.
Pathophysiology Related to Client Problem
Multiple causes: genetic (especially hypertrophic), viral myocarditis (often progresses to dilated CM), metabolic disorders, toxins (anthracyclines), nutritional, inflammatory. Each type has distinct functional changes affecting cardiac output and rhythm.
Health Promotion and Disease Prevention
- Genetic counseling for familial forms
- Cardiac screening for relatives of affected (especially hypertrophic)
- Vaccinate against viral triggers
- Cardiac monitoring during anthracycline chemotherapy
- Sports pre-participation screening (detects hypertrophic CM — sudden death risk)
- Address obesity, hypertension
Risk Factors
- Family history (hypertrophic — autosomal dominant)
- Viral infection (Coxsackie B, parvovirus)
- Anthracycline chemotherapy (doxorubicin)
- Radiation to chest
- Metabolic disorders
- Muscular dystrophy (Duchenne)
- Nutritional deficiency (carnitine, selenium)
- Iron overload (thalassemia)
Expected Findings
Dilated CM: HF signs (dyspnea, fatigue, poor feeding/FTT in infants), tachycardia, gallop, hepatomegaly, edema, arrhythmias, sometimes presents as cardiac arrest.
Hypertrophic CM: often asymptomatic; systolic murmur (LVOT obstruction), chest pain/syncope with exertion (concerning), exercise intolerance, palpitations, sudden death (sometimes presenting feature in athletes), S4 gallop.
Restrictive CM: HF with preserved EF, atrial enlargement, right-sided HF prominent.
Laboratory Tests
- BNP/NT-proBNP elevated
- Troponin (myocarditis)
- Viral serology
- Genetic testing
- Metabolic workup (carnitine, acylcarnitines)
- Thyroid function
Diagnostic Procedures
- Echocardiogram (mainstay)
- EKG: LVH, arrhythmias
- CXR: cardiomegaly
- Cardiac MRI
- Holter monitor
- Exercise stress test (HCM)
- Endomyocardial biopsy (myocarditis)
- Genetic testing
- Family screening
Safety Considerations
- Activity restrictions per cardiology (HCM — competitive sports often contraindicated)
- AICD for high-risk hypertrophic
- Avoid dehydration, stimulants (caffeine, decongestants)
- Endocarditis prophylaxis (some)
- Pregnancy considerations
- Family screening
- Transplant evaluation if severe
Complications
- Heart failure, cardiogenic shock
- Arrhythmias (VT)
- Sudden cardiac death (especially HCM)
- Stroke (thromboembolism from dilated LV)
- Need for transplant
- Death
- Familial transmission
Nursing Care
- Cardiac assessment, vitals, weight
- Monitor for HF, arrhythmias
- Medication administration
- Activity counseling
- Fluid/sodium restriction (HF)
- Family education, genetic counseling coordination
- Pre/post-transplant care
- AICD education
- Family screening coordination
- Adolescent transition
Medications
Dilated CM/HF: ACE inhibitors, beta-blockers (carvedilol), diuretics (furosemide, spironolactone), digoxin, SGLT-2 inhibitors, anticoagulation if low EF.
HCM: beta-blockers (mainstay), calcium channel blockers (verapamil), disopyramide, mavacamten (newer). AVOID: ACE inhibitors, vasodilators, digoxin (worsen LVOT obstruction).
Arrhythmias: amiodarone, sotalol. Post-transplant: tacrolimus, mycophenolate, prednisone.
Therapeutic Procedures
- Medical management
- AICD (sudden death prevention)
- Septal myectomy or alcohol septal ablation (HCM with LVOT obstruction)
- VAD (bridge or destination)
- ECMO
- Heart transplant for refractory cases
- Family screening
Client Education
- Chronic heart condition — many manageable with treatment
- Strict medication adherence
- Daily weights — report sudden gain (HF)
- Sodium/fluid restriction
- Activity restrictions per cardiology — HCM may need to avoid competitive/intense sports (sudden death risk)
- Watch for: chest pain, syncope (especially with exertion), new SOB, palpitations, weight gain → call provider
- Avoid stimulants: caffeine, ADHD meds (some), decongestants
- Family screening important (especially HCM)
- AICD: education on shocks
- Pregnancy planning for women (specialized care)
- Children's Cardiomyopathy Foundation
- Mental health support
Interprofessional Care
- Pediatric cardiology
- Pediatric CT surgery
- Pediatric heart transplant team
- Cardiac electrophysiology
- Pediatric heart failure team
- Genetics
- Pharmacy
- Cardiac rehab, dietitian, mental health
- Children's Cardiomyopathy Foundation
- Adult cardiology (transition)
Alterations in Health (Diagnosis)
Bleeding into brain ventricles of premature infants from fragile germinal matrix. Most common in infants < 32 weeks, < 1500g. Graded I-IV (I = subependymal, II = blood in ventricles without dilation, III = ventricular dilation, IV = parenchymal extension — worst prognosis).
Pathophysiology Related to Client Problem
Germinal matrix (highly vascular, fragile area at base of ventricles) poorly developed in preemies. Fluctuations in cerebral blood flow (hypoxia, hypotension, hypertension, acidosis, infection, ventilation changes) → rupture → bleeding into ventricles. May extend into parenchyma (grade IV).
Health Promotion and Disease Prevention
- Prevent preterm birth
- Antenatal corticosteroids for women in preterm labor (matures germinal matrix vessels)
- Gentle delivery (avoid trauma)
- Minimize fluctuations in cerebral blood flow: stable BP, blood gas, avoid rapid volume expansion, avoid hypothermia, gentle ventilation, cluster care
- Magnesium sulfate (neuroprotection in preterm)
- Delayed cord clamping
Risk Factors
- Prematurity (< 32 weeks, < 1500g — highest)
- Very low birth weight
- Birth asphyxia
- RDS
- Pneumothorax
- Sepsis
- Mechanical ventilation
- Hypotension/hypertension swings
- PDA
- Acidosis, hypoxia
- Rapid fluid infusion
- Coagulopathy
- Maternal chorioamnionitis
Expected Findings
Catastrophic (grade IV): sudden deterioration, bulging fontanel, apnea/bradycardia, seizures, decreased tone/lethargy, falling Hct (anemia), acidosis, glucose instability.
Saltatory (gradual): subtle ↓ activity/tone, abnormal eye movements, apneas, color changes, drop in Hct.
Asymptomatic: many small IVHs are clinically silent — detected on routine screening US.
Laboratory Tests
- CBC (anemia)
- Coagulation studies
- ABG (acidosis)
- Glucose, electrolytes
- Bilirubin (rise from Hgb breakdown)
Diagnostic Procedures
- Head ultrasound (cranial US): definitive in neonates (open fontanels); routine screening at 7-10 days then weekly in at-risk
- MRI: detailed anatomy, prognosis
- CT (less common — radiation)
- Follow-up imaging for hydrocephalus
Safety Considerations
- Minimize handling, cluster care
- Avoid rapid position changes
- HOB neutral/midline
- Gentle suctioning
- Avoid stimuli
- Adequate sedation
- Stable ventilator support
- Avoid hyperventilation, hypocapnia
- Daily head circumference
- Watch for hydrocephalus development
- Long-term developmental monitoring
Complications
- Post-hemorrhagic hydrocephalus (10-25% of severe IVH)
- Cerebral palsy
- Seizures
- Developmental delay
- Cognitive impairment
- Visual/hearing impairment
- Death (grade IV — significant)
- 80-90% of grade IV survivors have significant neurodevelopmental impairment
Nursing Care
- NICU with minimal handling, cluster care
- HOB elevated 30°, neutral position
- Gentle suctioning
- Maintain stable BP, blood gas, temperature
- Daily head circumference
- Palpate fontanel, sutures
- Watch for seizures
- Treat anemia (transfusion)
- Coagulopathy management
- Routine head ultrasound
- Watch for hydrocephalus
- Family support (devastating)
- Coordinate with neurosurgery
- Long-term follow-up arrangement
Medications
- Antiseizure: phenobarbital, levetiracetam
- Sedation: fentanyl, morphine
- Vasopressors if hypotension
- Surfactant if RDS
- Blood products (anemia)
- Vitamin K
- Caffeine for apnea
- Indomethacin (some — controversial prophylaxis)
Therapeutic Procedures
- Supportive NICU care
- Treat seizures
- Manage hydrocephalus: serial LPs (mild), ventricular drains (temporizing), VP shunt (if persistent — usually after ≥ 1500-2000g)
- Long-term: PT, OT, speech, developmental support
- Early intervention
- Special education
Client Education
Family: IVH is common in prematurity. Severity (grade) determines prognosis — grades I-II often have good outcomes, grades III-IV higher risk of long-term issues. Long-term developmental follow-up essential.
Watch for: bulging fontanel, rapid head growth, vomiting/irritability, seizures, developmental delay → call provider.
If shunt placed: shunt malfunction signs — ↑ ICP (vomiting, irritability, full fontanel, sundowning eyes), redness/swelling along shunt. Shunt infection: fever, irritability. Regular neurosurgery follow-up. Shunt revisions common.
Developmental support: early intervention (PT, OT, speech). Use corrected age. Routine assessments. Vision/hearing screening. Eventually IEP for school. Many achieve good outcomes with appropriate support.
Interprofessional Care
- Neonatology / NICU
- Pediatric neurology
- Pediatric neurosurgery (shunt)
- Pediatric ophthalmology (ROP)
- Pediatric audiology
- Developmental pediatrics
- PT, OT, speech
- Early intervention, special education
- Family support, social work
- Mental health
Alterations in Health (Diagnosis)
Abnormal retinal vascular development in premature infants → can cause vision loss or blindness. Risk highest in very preterm (< 30 weeks) infants exposed to oxygen. Stages 1-5 (5 = total retinal detachment). Most regress; severe cases need treatment.
Pathophysiology Related to Client Problem
Premature retinal vessels stop developing → with exposure to high O2 → vasoconstriction; then on returning to room air → relative hypoxia → abnormal proliferation of new vessels (neovascularization) → can cause traction on retina → detachment.
Health Promotion and Disease Prevention
- Prevent preterm birth
- Minimize O2 exposure (target SpO2 90-95%)
- Avoid fluctuations
- Adequate nutrition
- Treat hypoxia/hypotension promptly
- Routine ROP screening at appropriate time (4-6 weeks chronologic, 31 weeks corrected — whichever later)
- Until retinal vascularization complete
Risk Factors
- Prematurity (especially < 30 weeks)
- Very low birth weight (< 1500g)
- Prolonged supplemental oxygen
- SpO2 fluctuations
- Apnea, bradycardia
- Sepsis
- IVH
- BPD
- Blood transfusions (multiple)
Expected Findings
No clinical signs visible — detected only on screening eye exam. Severe untreated → leukocoria, strabismus, vision impairment.
Staging: Stage 1 = demarcation line; Stage 2 = ridge with width/height; Stage 3 = ridge with extraretinal fibrovascular proliferation; Stage 4 = partial retinal detachment; Stage 5 = complete retinal detachment. Plus disease: vessel tortuosity and dilation — indicates severe.
Laboratory Tests
- None specific
Diagnostic Procedures
- Dilated retinal exam by pediatric ophthalmologist
- Indirect ophthalmoscopy
- RetCam imaging (some centers)
- Screening schedule based on gestational age and birth weight
- First exam typically 4-6 weeks chronologic age
- Repeat every 1-3 weeks until vascularization complete
Safety Considerations
- Routine ROP screening for at-risk infants
- SpO2 alarms appropriate (avoid hyperoxia)
- Cluster care during exam (stressful)
- Pain management during exam (sucrose, gentle handling)
- Lifelong eye follow-up for survivors of severe ROP
Complications
- Retinal detachment
- Vision impairment
- Blindness
- Strabismus
- Amblyopia
- Myopia (very common in former preemies)
- Late retinal complications (lattice degeneration, holes, late detachment)
- Cataracts (rare)
Nursing Care
- Routine ROP screening per protocol
- Maintain target SpO2 (typically 90-95%)
- Avoid fluctuations
- Eye exam preparation: pupil dilation (cyclopentolate, phenylephrine) — watch for systemic effects (HR, BP, GI)
- Pain management during exam: sucrose, swaddling
- Monitor for adverse effects (apnea/bradycardia post-exam common)
- Family education
- Connect with pediatric ophthalmology follow-up
- Long-term vision follow-up
- Glasses as prescribed
Medications
- Dilating drops for exam: cyclopentolate + phenylephrine
- Sucrose for comfort during exam
- Anti-VEGF intravitreal injection: bevacizumab (Avastin), ranibizumab — for severe ROP
- Topical antibiotics post-procedure
Therapeutic Procedures
- Most ROP regresses spontaneously
- For severe ROP (Type 1):
- - Laser photocoagulation (gold standard)
- - Cryotherapy (older, less used)
- - Intravitreal anti-VEGF (newer option)
- Vitrectomy for retinal detachment
- Lifelong vision follow-up
- Glasses, vision aids
- Vision rehabilitation services
Client Education
- ROP is common complication of prematurity
- Most cases regress without intervention
- Severe cases need treatment to prevent blindness
- Regular eye exams crucial until cleared
- Even without active ROP, preemies have ↑ risk of:
- - Strabismus, amblyopia, myopia, astigmatism
- Glasses common in former preemies
- Watch for: eye misalignment, abnormal eye movements, white reflex on photos
- Annual eye exams lifelong
- Premature children with severe ROP may have visual impairment — early intervention important
- Vision support services available
Interprofessional Care
- NICU
- Pediatric ophthalmology
- Retina specialist (severe)
- Vision rehabilitation
- Early intervention (vision)
- Optician
- Pediatric primary care
- School support (vision IEP)
- Family support
Alterations in Health (Diagnosis)
Asymmetric flattening of infant skull from external pressure (positioning). Increased since "back to sleep" campaign for SIDS prevention. Different from craniosynostosis (premature suture closure — requires surgery; positional doesn't).
Pathophysiology Related to Client Problem
Sustained pressure on one area of soft, malleable infant skull → flattening. Often associated with torticollis (head turning preference). Asymmetry typically resolves with repositioning and physical therapy.
Health Promotion and Disease Prevention
- Back to sleep (safe sleep), tummy to play
- Tummy time 30-60 min daily while awake and supervised
- Alternate head position during sleep
- Limit time in car seats, swings, bouncers
- Hold and carry infant in different positions
- Alternate which arm holds baby
- Position toys to encourage head turning to both sides
- Identify torticollis early (PT referral)
- Pediatrician screening at well visits
Risk Factors
- Back sleeping (necessary for SIDS prevention but creates positional risk)
- Prolonged container time
- Torticollis
- Multiple gestation
- Prematurity (softer skull)
- Male (slight)
- Decreased tummy time
- Hypotonia
Expected Findings
- Asymmetric flattening of head (usually one side of back)
- Forehead may bulge on same side (parallelogram)
- Ear shifted forward on flat side
- Plagiocephaly: mild (minor asymmetry), moderate (clear asymmetry, often forehead bulging), severe (significant, possibly facial asymmetry)
- Brachycephaly: symmetric flattening across whole back (broad, short head)
- Torticollis: shortened SCM, head tilted to affected side, chin to opposite
- NORMAL anterior fontanel, NORMAL sutures (key — differentiates from craniosynostosis)
- Developmental milestones normal
Laboratory Tests
- None typically needed
Diagnostic Procedures
- Physical examination (definitive)
- Palpate sutures (open in positional, closed in craniosynostosis)
- Cranial measurements (some)
- Imaging ONLY if craniosynostosis suspected
- Assess for torticollis
- Developmental screening
Safety Considerations
- STILL back to sleep (SIDS prevention overrides plagiocephaly concern)
- Don't use positional devices in crib
- Don't use special positioners for sleep (SIDS risk)
- Differentiate from craniosynostosis (true sutural fusion — requires surgery)
- Helmet therapy considerations
Complications
- Cosmetic concern (most resolve)
- Facial asymmetry (severe untreated)
- Possible developmental delay (association, not causation)
- Torticollis if untreated → ongoing issues
- Rarely: craniosynostosis missed
- Family concern
Nursing Care
- Education on prevention
- Tummy time guidance
- Repositioning strategies
- Recognize and refer torticollis
- Refer to PT if needed
- Refer to orthotist if helmet considered
- Address family concerns (cosmetic)
- Reassurance — usually resolves
- Developmental monitoring
Medications
- None
Therapeutic Procedures
Repositioning (first-line): tummy time during waking, alternate head position, reduce container time, position toys/mobiles to encourage head turning. Most mild-moderate cases resolve with this alone.
Physical therapy: for torticollis — stretching, strengthening, family training.
Helmet therapy (cranial molding orthosis): for moderate-severe persistent after repositioning. Typically 4-12 months age. Custom helmet worn 23 hours/day for several months. Controversial — effectiveness varies; mostly cosmetic benefit.
Surgery: NOT for positional plagiocephaly; ONLY for craniosynostosis.
Client Education
Prevention: Back to sleep ALWAYS (SIDS prevention) BUT tummy time when awake. Alternate baby's head direction in crib night to night. Limit time in car seats, swings, bouncers. Hold baby in different positions, alternate arms. Position interesting things on different sides. Watch for head turning preference (torticollis) — see provider.
If diagnosed: usually resolves with repositioning. Most pronounced at 4-6 months, improves after. Doesn't cause brain damage or affect development. Cosmetic concern primarily. Consistent repositioning is key. Hair growth eventually covers asymmetry.
If torticollis: PT for stretching exercises. Address head turning preference. Position to encourage turning to non-preferred side.
Helmet therapy: discuss with provider — helmet vs continued repositioning. Best results 4-8 months. 23 hours/day for months. Mostly cosmetic benefit.
Interprofessional Care
- Pediatric primary care
- Physical therapy (torticollis, exercises)
- Pediatric neurosurgery (rule out craniosynostosis if questionable)
- Orthotist (helmet)
- Developmental pediatrics (if delays)
Alterations in Health (Diagnosis)
Inadequate thyroid hormone production in newborn. Most common preventable cause of intellectual disability. Newborn screening detects (every state screens). Treatment with levothyroxine within first 2 weeks of life → normal development. Untreated → severe intellectual disability.
Pathophysiology Related to Client Problem
Causes: thyroid dysgenesis (85% — agenesis, ectopic, hypoplasia), dyshormonogenesis (10-15% — enzyme defects), transient (maternal antibodies, iodine deficiency or excess). Inadequate thyroid hormone → impaired brain development, growth failure.
Health Promotion and Disease Prevention
- Universal newborn screening (heel stick at 24-48 hours)
- Early detection critical
- Adequate maternal iodine (pregnancy and lactation)
- Avoid excessive iodine in pregnancy
- Treat maternal thyroid disease
Risk Factors
- Family history of thyroid disease
- Female (2:1)
- Down syndrome
- Maternal autoimmune thyroid disease
- Maternal iodine deficiency
- Iodine exposure (povidone-iodine, contrast)
- Premature infants
- Hispanic, Asian populations (higher rate)
Expected Findings
Newborn (often subtle or asymptomatic — screening catches!): prolonged jaundice, macroglossia (large tongue), hoarse cry, open posterior fontanel, umbilical hernia, hypothermia, constipation, poor feeding, hypotonia, lethargy, excessive sleeping, coarse facial features, dry skin, slow growth, mottled skin, bradycardia, goiter (some).
Untreated (historically): severe intellectual disability, growth failure, delayed milestones, coarse features. This is now PREVENTABLE with newborn screening.
Laboratory Tests
- Newborn screen: ↑ TSH (or ↓ T4)
- Confirmatory: TSH and free T4
- ↑ TSH, ↓ free T4 = primary hypothyroidism
- Thyroid antibodies (autoimmune)
- Thyroglobulin
- Genetic testing (some)
Diagnostic Procedures
- Newborn screening
- Confirmatory TSH and FT4 (venous blood)
- Thyroid ultrasound (agenesis, ectopic)
- Thyroid scan (uptake, location)
- Bone age X-ray (delayed in hypothyroidism)
- Genetic testing for inherited forms
Safety Considerations
- Start treatment within 2 weeks of life for best outcomes
- Don't delay if screen positive
- Crush levothyroxine tablets for infants
- Don't mix with soy formula (interferes with absorption)
- Don't give with calcium, iron (interferes)
- Consistent timing daily
- Maintain therapeutic levels
- Lifelong therapy for permanent forms
Complications
- Intellectual disability (untreated or late-treated)
- Growth failure
- Developmental delay
- Cardiovascular issues
- Cretinism (severe untreated)
- Overtreatment: hyperthyroidism symptoms, advanced bone age, craniosynostosis
Nursing Care
- Newborn screening (every newborn)
- Prompt follow-up if positive screen
- Educate family on importance of treatment
- Administer levothyroxine — crush tablets, mix with small amount of breast milk, formula, or water
- Give 30 min before feeds for best absorption
- Avoid mixing with soy formula, calcium, iron
- Routine TSH/T4 monitoring (frequent in infancy)
- Growth monitoring
- Developmental screening
- Family support
Medications
- Levothyroxine (Synthroid, Levoxyl) — synthetic T4
- Dose: 10-15 mcg/kg/day initially, adjust based on labs
- Tablets crushed for infants
- Give 30 minutes before feeding
- Lifelong for permanent forms
- Monitor TSH, FT4: every 1-2 months in first year, every 2-3 months until age 3, then every 6-12 months
- Adjust dose for growth
Therapeutic Procedures
- Hormone replacement (levothyroxine) — cornerstone
- Routine monitoring
- Lifelong therapy (most cases)
- Re-evaluation at age 3 if congenital (transient form possible)
- Developmental support if needed
- Family education and support
Client Education
Family: Congenital hypothyroidism is common (~1 in 2000-4000 births) and very treatable. With early treatment, child develops normally. Lifelong medication (most cases). EVERY DAY without missing.
Medication administration: crush levothyroxine tablet between two spoons; mix with small amount (1-2 mL) of breast milk, formula, or water; administer with syringe; give 30 minutes before feeding (better absorption); DON'T mix with soy formula, calcium-fortified foods, iron supplements (decrease absorption); consistent administration daily; if missed dose: give as soon as remembered (unless close to next dose); don't double dose.
Monitoring: routine TSH/T4 tests (every 1-2 months in infancy); growth measurements; developmental milestones; endocrinology appointments.
Watch for: UNDER-treatment — lethargy, poor feeding, constipation, poor growth. OVER-treatment — irritability, poor sleep, sweating, rapid heart rate, diarrhea. Call provider with concerns.
Long-term: most develop normally with appropriate treatment. Lifelong endocrinology follow-up.
Interprofessional Care
- Pediatric endocrinology (primary)
- Pediatric primary care
- Newborn screening program
- Pediatric pharmacy
- Pediatric developmental specialists
- Genetics (some forms)
- Adult endocrinology (transition)
- Obstetrics (pregnancy)
Alterations in Health (Diagnosis)
Sudden, brief (< 1 min, almost always < 20 sec), now-resolved event in infant < 1 year involving ≥ 1 of: cyanosis/pallor, absent/decreased/irregular breathing, marked change in tone (hyper/hypotonia), altered responsiveness. Replaces older term "ALTE." Most BRUEs are "lower risk" with benign outcomes.
Pathophysiology Related to Client Problem
Multiple potential etiologies: GERD with apnea, breath-holding, vagal response, seizure, infection, child abuse (rare), inborn errors of metabolism (rare), cardiac arrhythmia (rare). Most "idiopathic" with no cause found.
Health Promotion and Disease Prevention
- Safe sleep practices
- Vaccinations
- Treat GERD if symptomatic
- Identify and address risk factors
- Avoid passive smoke exposure
- Avoid abusive head trauma (family education)
Risk Factors
Lower-risk BRUE (per AAP): age > 60 days; born ≥ 32 weeks; corrected age ≥ 45 weeks; no CPR by trained provider; first event; duration < 1 minute.
Higher risk: age < 2 months; prematurity; required CPR; multiple events; concerning history/exam findings.
Expected Findings
- Event already resolved at presentation (or being witnessed)
- Cyanosis or pallor
- Apnea or breathing change
- Tone change (limp or stiff)
- Altered responsiveness
- Examination typically NORMAL at presentation (key)
- If abnormal exam — investigate cause
Laboratory Tests
Lower-risk BRUE: minimal workup recommended.
Higher-risk: based on history — CBC, electrolytes, glucose, LFTs, ammonia, lactate, tox screen, pertussis testing, viral panel.
Diagnostic Procedures
- Detailed history (most important — what exactly happened, before/during/after)
- Physical examination (often normal)
- If lower-risk per criteria → minimal workup; observe, educate, follow-up
- Higher-risk or concerning: ECG, EEG, swallow study, neuroimaging, metabolic workup, child abuse evaluation
- Skeletal survey if abuse suspected
- Polysomnography (if obstructive apnea suspected)
- ECG (long QT)
Safety Considerations
- Differentiate from witnessed event (true apnea, seizure, choking)
- Safe sleep counseling
- Infant CPR training for family
- Don't routinely use home monitors (no SIDS prevention proven)
- Address shaken baby syndrome considerations
- Follow-up arranged
- Recognize concerning patterns (multiple events, lasting longer, requiring stimulation)
Complications
- Most BRUEs are benign with no sequelae
- Underlying cause (when identified) — treat accordingly
- Recurrent events
- Family anxiety, hypervigilance
- Rarely: child abuse missed (always consider)
- SIDS risk minimally elevated
Nursing Care
- Calm, thorough history taking
- Detailed event description
- Comprehensive physical exam
- Vital signs
- Consider risk stratification (lower vs higher)
- Lower-risk: brief observation, education, discharge with follow-up
- Higher-risk: admission, monitoring, workup
- Family education on safe sleep, infant CPR
- Reassurance vs appropriate investigation
- Connect with primary care for follow-up
- Mental health support for anxious family
- Document carefully
- Watch for inconsistent histories (abuse concern)
Medications
- Generally none unless treating identified cause
- GERD medications if reflux confirmed
- Anticonvulsants if seizures
- Treatment of underlying cause
Therapeutic Procedures
- Treatment of identified cause
- Observation for higher-risk
- Education and reassurance for lower-risk
- Safe sleep counseling
- Infant CPR training
- Home monitoring usually NOT recommended
- Follow-up
Client Education
Family: BRUE means the event was brief and resolved — exam now normal. Most BRUEs are isolated events with no serious cause. Most lower-risk infants do well. Reassurance with appropriate vigilance.
Safe sleep: back to sleep on firm surface; no soft bedding, bumpers, toys in crib; separate sleep surface; no bed-sharing; room-sharing (not bed-sharing) for first 6 months; no overheating; no smoke exposure.
Infant CPR training: all family members and caregivers; free/low-cost classes (American Red Cross, AHA); refresher periodically.
When to call/come back: another event, recurrent events, longer event, required stimulation, color changes during sleep or feeding, worsening or persistent symptoms, any concerns.
Address anxiety: frightening to witness; most children do well; avoid over-monitoring; follow up with primary care; counseling if persistent anxiety.
Interprofessional Care
- Pediatric ED
- Pediatric primary care
- Pediatric neurology (if seizures)
- Pediatric cardiology (if arrhythmia)
- Pediatric GI (if reflux)
- Pediatric pulmonology
- Genetic/metabolic specialist
- Social work / child abuse pediatrician (if abuse concern)
- Mental health (family support)
Alterations in Health (Diagnosis)
Heat-related illnesses: heat cramps (mildest), heat exhaustion (moderate), heat stroke (life-threatening — body temp > 40°C / 104°F + CNS dysfunction). Hypothermia: core temp < 35°C (95°F); ranges from mild to severe. Children especially vulnerable due to body surface area to mass ratio, immature thermoregulation.
Pathophysiology Related to Client Problem
Heat stroke: failure of thermoregulation → core body temperature rises → cellular dysfunction → multi-organ failure. Hypothermia: body heat loss exceeds production → metabolic slowing, cardiac dysfunction, arrhythmias. Children dehydrate faster and lose/gain heat faster than adults.
Health Promotion and Disease Prevention
Heat: Hydration before/during/after exercise; avoid exertion in extreme heat/humidity; acclimatization (1-2 weeks); cool clothing; sunscreen; rest in shade; NEVER leave child in parked car; athletic protocols (heat index, hydration breaks); watch high-risk children (CF, obese).
Cold: Appropriate clothing layers; limit outdoor exposure in extreme cold; cover head, hands, feet; stay dry; adequate calories before cold exposure; don't drink alcohol; don't leave infant exposed; warm car before transporting infant.
Risk Factors
Heat: age < 4 years and adolescent athletes; exertion in heat/humidity; dehydration; inadequate acclimatization; obesity; cystic fibrosis; heavy uniforms/equipment; certain medications (anticholinergics, stimulants); closed cars in hot weather; prior heat illness.
Cold: age < 2 years, premature infants (poor thermoregulation); cold exposure with inadequate clothing; wet conditions; submersion in cold water; homelessness; alcohol/drug use (adolescents); malnutrition; endocrine disorders.
Expected Findings
Heat cramps: painful muscle cramps; often after exertion; sweating; normal mental status; normal/slightly elevated temp.
Heat exhaustion: profuse sweating; pale, cool, clammy skin; headache, dizziness, weakness; nausea, vomiting; tachycardia; orthostatic hypotension; temp normal to 39°C; normal mental status (mostly).
Heat stroke (LIFE-THREATENING): temp > 40°C; CNS dysfunction (altered mental status, confusion, agitation, seizures, coma); hot, often DRY skin (classic) OR sweating (exertional); rapid pulse/breathing; hypotension; multi-organ failure signs; EMERGENCY.
Hypothermia stages: Mild (32-35°C): shivering, ↑ HR/RR/BP, alert. Moderate (28-32°C): ↓ shivering, lethargy, slurred speech, paradoxical undressing, ↓ HR, J wave on ECG. Severe (< 28°C): no shivering, coma, arrhythmias (VF), apnea. Frostbite: white/gray skin, hard/waxy, numb, blistering on rewarming.
Laboratory Tests
- Glucose, electrolytes (Na, K, Ca, Mg)
- BUN/Cr
- CK (rhabdomyolysis in heat stroke)
- LFTs (heat stroke)
- Coagulation (DIC)
- ABG, lactate
- Urinalysis (myoglobinuria)
- CBC, ECG
Diagnostic Procedures
- Vital signs including rectal core temperature (not axillary or tympanic — inaccurate in extremes)
- Mental status assessment
- Skin exam (for cold injury extent)
- Continuous monitoring
- Imaging if trauma
- Toxicology if suspected
Safety Considerations
Heat: Remove from heat source IMMEDIATELY; heat stroke is medical emergency — cool aggressively; monitor for arrhythmias, seizures; watch for organ failure.
Cold: Handle gently (cardiac irritability — VF risk); remove wet clothing; don't rub frostbitten skin; don't rewarm with snow, hot water; gradual rewarming; "not dead until warm and dead" — continue resuscitation in hypothermia (longer arrest tolerable); ABCs; watch for "rewarming shock."
Complications
Heat: heat stroke → death (10-50% mortality); multi-organ failure (brain, kidney/rhabdomyolysis → AKI, liver, heart); DIC; seizures; permanent neurologic damage; dehydration; electrolyte imbalances.
Cold: death; arrhythmias (VF, asystole); pulmonary edema; frostbite → amputation; compartment syndrome; renal failure; DIC; rhabdomyolysis; hypoglycemia.
Nursing Care
Heat: Move to cool environment; remove excess clothing; ABCs; continuous core temp (rectal); IV access, fluid resuscitation; heat exhaustion — cool environment, fluids; heat stroke — aggressive cooling (ice packs to neck/armpits/groin; cool water immersion; misting + fans; cooling blankets); goal: cool to ~39°C before stopping; monitor mental status, vitals, urine output; antipyretics don't work; ICU admission for heat stroke.
Cold: Remove wet clothing; warm dry blankets; handle gently; passive rewarming for mild; active external rewarming (warm blankets, warm IV fluids, warm humidified O2); active core rewarming for severe (warmed peritoneal/pleural lavage, hemodialysis, ECMO); continuous core temp; cardiac monitoring; glucose monitoring; resuscitate even if appears dead — warm before declaring; treat frostbite with warm water bath (37-39°C), no rubbing, pain management, tetanus, antibiotics if blister.
Medications
- IV fluids (warmed for hypothermia)
- Glucose (often hypoglycemic in both)
- Benzodiazepines for seizures or shivering
- Dantrolene (refractory heat stroke)
- Vasopressors
- Antiarrhythmics (cardiac arrest — caution)
- Sodium bicarb (severe acidosis)
- Tetanus for frostbite
- Antibiotics if infection
Therapeutic Procedures
- Heat: rapid cooling, fluid resuscitation, organ support
- Cold: rewarming, supportive care, ECMO for severe
- Frostbite: gradual warming, possibly debridement, amputation if severe
- ICU care for severe cases
Client Education
Heat illness prevention: hydrate before/during/after activity; avoid heat of day; acclimatize gradually; loose, light-colored, breathable clothing; frequent breaks in shade; identify high-risk children; NEVER LEAVE CHILD IN PARKED CAR (temperatures rise 20°F in 10 minutes); watch for early signs (cramps, headache, dizziness, nausea) and stop.
Cold injury prevention: dress in layers (avoid cotton — retains moisture); cover extremities, ears, nose; stay dry; limit outdoor time in extreme cold; adequate calories and hydration; recognize early warning (pale skin, numbness, shivering); if shivering stops in cold without warming — emergency; bring child inside, remove wet clothing; don't rub frostbitten areas — gentle rewarming with warm (not hot) water.
If illness occurs: move to safety; remove offending exposure; heat — cool, hydrate; cold — warm, dry; call 911 for severe symptoms; don't give alcohol; CPR if needed; hospital evaluation; follow-up.
Interprofessional Care
- Pediatric ED
- Pediatric ICU
- Athletic trainers, coaches
- School nurse
- Pediatric primary care
- Rehabilitation (severe injuries)
- Public health (prevention messaging)
- EMS
Alterations in Health (Diagnosis)
Maladaptive use of substances (alcohol, marijuana, opioids, stimulants, nicotine/vaping, hallucinogens, inhalants) causing significant impairment. Adolescent brain particularly vulnerable — earlier substance use → higher risk of addiction, mental health issues, academic and social problems. Often co-occurring with mental health disorders.
Pathophysiology Related to Client Problem
Substances affect brain reward pathways → dopamine release → reinforcement. Adolescent brain (prefrontal cortex still developing through age 25) more susceptible to addiction. Genetic + environmental factors.
Health Promotion and Disease Prevention
- School-based prevention programs
- Universal screening at adolescent well visits (CRAFFT)
- Open family communication
- Family meals, time together
- Limit access to alcohol, prescription drugs in home (lock up)
- Avoid early initiation (delay onset)
- Address risk factors: trauma, mental health, peer influences
- Address bullying, school issues
- Brief interventions in primary care (SBIRT)
- Address LGBTQ+ stressors
Risk Factors
- Family history of addiction
- Mental health disorders (depression, anxiety, ADHD, trauma)
- Conduct problems
- Peer substance use
- Access to substances
- ACEs (early childhood adversity)
- Trauma, abuse
- Parental substance use
- School problems
- LGBTQ+ youth (↑ risk due to stressors)
- Foster care
- Native American/Indigenous youth (higher rates of some substances)
- Low socioeconomic status
Expected Findings
General: behavior changes (withdrawal, secretiveness, mood swings); academic decline; new peer group; loss of interest in activities; physical signs (bloodshot eyes, dilated/constricted pupils, slurred speech, unsteady gait, weight changes); money problems, stealing; smell of alcohol, marijuana, smoke; drug paraphernalia; mental health changes; sleep changes; decline in hygiene; driving incidents; legal problems.
Specific substances: Alcohol — slurred speech, ataxia, blackouts. Marijuana — red eyes, slowed reaction, hunger. Opioids — pinpoint pupils, slowed breathing, sedation. Stimulants — dilated pupils, agitation, ↑ HR/BP, weight loss. Vaping — residue on fingers, fruity smells, devices. Hallucinogens — dilated pupils, altered perception, paranoia. Inhalants — chemical smell, rash around mouth/nose. Benzos — drowsiness, ataxia.
Laboratory Tests
- Urine drug screen (UDS) — some substances missed
- Confirmatory testing as needed
- Liver function (alcohol — ↑ GGT, AST > ALT)
- Hepatitis B, C, HIV screening (IV drug use)
- STI testing
- Pregnancy test (females)
- Mental health screening (PHQ-9, GAD-7)
Diagnostic Procedures
- Confidential interview without parent (HEEADSSS, CRAFFT)
- CRAFFT screening tool — > 2 = positive
- Diagnostic criteria (DSM-5) for substance use disorder
- Mental health assessment
- School, family assessment
- Physical exam
- Trauma screening
Safety Considerations
- Confidentiality (with limits — disclosure for safety)
- Mandatory reporting if abuse
- Mental health assessment (depression, suicidality common)
- Overdose risk: education on naloxone
- Driving safety: don't use and drive
- STI/pregnancy prevention
- HIV/HCV prevention if IV use
- Safe storage of medications in home
- Identify and treat co-occurring mental health
- Address trauma
Complications
- Addiction, dependence
- Overdose (death, especially opioids — fentanyl)
- Withdrawal (severe with alcohol, benzos — life-threatening)
- Mental health worsening
- Academic failure, school dropout
- Legal problems
- Family disruption
- STIs, unplanned pregnancy
- HIV, hepatitis C (IV use)
- Suicide
- Accidents (MVA, drowning)
- Violence (perpetrator or victim)
- Chronic medical: liver, lung, cardiac (cocaine), neurological
- Lung injury (EVALI — vaping)
- Increased risk of adult substance use disorder
Nursing Care
- Confidential, non-judgmental approach
- Screen all adolescents (CRAFFT)
- Motivational interviewing
- Address specific substance use
- Mental health screening
- Trauma screening
- Safety assessment
- Referral to treatment as needed
- Brief interventions for moderate-risk
- Education and harm reduction
- Family involvement (with adolescent permission)
- Address barriers (insurance, transportation)
- Naloxone distribution and education
- School involvement (with permission)
- Long-term follow-up
- Address co-occurring conditions
- Pregnancy considerations
Medications
Medication-Assisted Treatment (MAT):
Opioid use disorder: Buprenorphine (Suboxone), Methadone, Naltrexone (Vivitrol). All can be used in adolescents per AAP.
Alcohol use disorder: Naltrexone, Acamprosate, Disulfiram.
Nicotine: Nicotine replacement (gum, patches, lozenges), Varenicline (limited pediatric use), Bupropion.
Overdose reversal: Naloxone (Narcan) — IM, intranasal — REVERSES OPIOID OVERDOSE; family should have at home.
Withdrawal management: Alcohol — benzodiazepines, thiamine. Opioid — buprenorphine, clonidine, supportive. Stimulant — supportive.
Mental health comorbidities: SSRIs for depression/anxiety; treat ADHD (carefully — stimulant abuse concern); mood stabilizers; antipsychotics if psychotic features.
Therapeutic Procedures
- Behavioral therapies (cornerstone): CBT, motivational interviewing, contingency management, family therapy, 12-step programs (AA, NA), DBT
- Levels of care: outpatient, intensive outpatient (IOP), partial hospitalization, residential treatment, inpatient detox
- MAT (above)
- Mental health treatment
- School support, GED options
- Sober peer support
- Long-term recovery support
- Treatment of complications
Client Education
Adolescent (with confidentiality): Substance use during adolescence is risky — brain still developing. Earlier use = higher addiction risk. Treatment works — recovery is possible. Mental health and substance use are often connected. Use safer practices if using: never use alone (overdose), test strips for fentanyl, don't mix substances, carry naloxone, don't drive after using. Reach out — 988 for crisis.
Family: Substance use disorder is a disease, not a choice. Family can support recovery. Open communication without judgment. Lock up medications, alcohol. Carry naloxone. Recognize warning signs. Get support (Al-Anon, Nar-Anon). Self-care. Don't enable.
Overdose: Naloxone available without prescription. Call 911 if overdose suspected. Good Samaritan laws protect callers. Recognize signs: pinpoint pupils, slow breathing, blue lips, unresponsive.
Recovery: Long-term process. Relapse is part of disease — not failure. Continue treatment, support. Address co-occurring conditions. Build sober community. Identify triggers.
Interprofessional Care
- Adolescent medicine
- Pediatric/adolescent mental health
- Addiction medicine
- Therapist (CBT, motivational interviewing)
- Pediatric pharmacy (MAT)
- Pediatric primary care
- School counselor, social worker
- Pediatric infectious disease (HIV, HCV)
- Adolescent gynecology
- Crisis services
- 988 Suicide and Crisis Lifeline
- SAMHSA Helpline (1-800-662-HELP)
- Family support (Al-Anon, Nar-Anon)
- Peer support, sober community
- Adult addiction services (transition)
Alterations in Health (Diagnosis)
Repeated aggressive behavior involving real or perceived power imbalance. Types: physical, verbal, social/relational, cyberbullying. Affects ~20-30% of school-age children. Profound impact on mental health. Cyberbullying is 24/7 and pervasive with social media use.
Pathophysiology Related to Client Problem
Multifactorial — individual factors (temperament, social skills), family factors (parenting, attachment), peer dynamics, school climate, social media. Both victims and perpetrators (and bystanders) affected. Long-term mental health and developmental consequences.
Health Promotion and Disease Prevention
- School-based anti-bullying programs (Olweus, others)
- Bystander intervention training
- School climate initiatives
- Adult supervision in unstructured times (cafeteria, recess, bus)
- Clear school policies and enforcement
- Family communication, modeling kindness
- Social skills development
- Address risk factors (LGBTQ+, disability, weight, etc.)
- Digital citizenship education
- Limit social media exposure
- Routine screening at well visits
- Address mental health
- Address ACEs
- Empowerment, self-esteem
Risk Factors
Victim: LGBTQ+ youth; disability (physical, developmental, learning); differences (race, religion, weight, appearance); anxiety, depression; low self-esteem; few friends; family discord; smaller stature.
Perpetrator: family discord, harsh parenting; aggression history; conduct disorder; witnessed/experienced abuse; peer influence; need for control.
Cyberbullying: heavy social media use; anonymous online platforms; late-night phone use.
Expected Findings
Victim: reluctance to go to school; frequent somatic complaints (headaches, stomachaches); school performance decline; anxiety, depression; sleep disturbances; appetite changes; withdrawal from friends/activities; unexplained bruises, torn clothing; lost or damaged belongings; self-harm, suicidal ideation; substance use; sudden changes in friend group; aggressive behavior at home.
Perpetrator: aggressive behavior; need for control; lack of empathy; defiance; school discipline issues.
Cyberbullying: distress related to phone/computer use; avoiding devices or compulsive checking; sudden withdrawal from online activities.
Laboratory Tests
- None specific
- Standard mental health screening
Diagnostic Procedures
- Confidential interview with adolescent
- HEEADSSS interview
- Mental health screening (PHQ-9, GAD-7)
- Suicide risk assessment (Columbia, ASQ)
- School functioning assessment
- Specific bullying questions
- Cyberbullying inquiry (social media)
- Address LGBTQ+ youth specifically
- Family involvement (with adolescent input)
Safety Considerations
- Mental health risk: depression, anxiety, suicide
- Routine suicide screening for bullied youth
- Address physical safety if assaults
- School involvement (per family)
- Cyberbullying: document, save evidence, report to platforms and school
- Mandatory reporting if criminal acts (assault, sexual)
- Resources: 988 for crisis
- Address bullying perpetrator behavior (don't ignore)
- Don't blame victim
- Limit retaliation
Complications
- Depression, anxiety
- Suicide ideation, attempts, completion
- PTSD
- Self-harm
- Substance use
- School avoidance, dropout
- Academic decline
- Social isolation
- Eating disorders
- Long-term mental health effects (into adulthood)
- Bullying perpetrators also have higher rates of: substance use, criminal behavior, mental health issues, relationship problems
- Bystanders also affected
- School violence (extreme cases)
Nursing Care
- Routine screening at well visits
- Confidential, validating approach
- Take seriously — never minimize
- Comprehensive mental health assessment
- Suicide risk assessment
- Safety planning
- Coordinate with family (per youth)
- School advocacy
- Connect to mental health resources
- Empowerment, problem-solving
- Build coping skills
- Address comorbid conditions
- Follow-up
- Address LGBTQ+ youth specifically
- Resources: Trevor Project, StopBullying.gov
Medications
- Treat comorbid mental health conditions:
- SSRIs for depression/anxiety
- Sleep aids if needed
- Treatment of PTSD
- No specific medications for bullying
Therapeutic Procedures
- Mental health therapy (CBT, trauma-focused)
- Family therapy
- School involvement and advocacy
- Anti-bullying intervention
- Safety planning
- Group therapy / support groups
- Develop coping strategies
- Build self-esteem
- Social skills training (if applicable)
- Help build positive peer connections
- Address comorbid conditions
Client Education
Family — recognizing bullying: Watch for signs (reluctance to school, somatic complaints, mood changes, social withdrawal). Ask directly. Listen without judgment. Take it seriously. Document incidents. Work with school. Don't encourage retaliation. Help develop coping strategies.
Cyberbullying: Save evidence (screenshots). Block, report to platforms. Report to school. If illegal (threats, sexual content of minors) → police. Monitor online use without invading privacy. Have open conversations. Set limits on social media if causing distress. No devices in bedroom; off-screen during meals.
Empowerment: Help develop strong friendships. Activities that build self-esteem. Coping skills (deep breathing, distraction, journaling). Therapy for processing. Mental health support.
If you suspect your child is bullying: Address directly. Consequences. Mental health assessment (often underlying issues). Family therapy. Don't enable. Help develop empathy.
Resources: StopBullying.gov; 988 Suicide and Crisis Lifeline; Trevor Project (LGBTQ+ youth — 1-866-488-7386); Cyberbullying Research Center; school counselor; mental health professional.
Interprofessional Care
- Adolescent medicine
- Pediatric/adolescent mental health
- Therapist (CBT)
- School counselor, school psychologist
- Social worker
- 988 crisis line
- Trevor Project (LGBTQ+)
- Family therapy
- Anti-bullying organizations
- Legal advocacy (if criminal acts)
- Pediatric primary care
Description of Procedure
Use of fluorescent or LED blue light to break down unconjugated bilirubin in the skin into water-soluble photoisomers that can be excreted in urine and bile without conjugation. Standard treatment for moderate-to-severe neonatal hyperbilirubinemia.
Types:
- Standard overhead phototherapy lamps
- Fiber-optic blanket (Biliblanket) — allows parent contact
- Intensive phototherapy (multiple light sources)
Indications
- Neonatal hyperbilirubinemia at threshold per Bhutani nomogram or AAP guidelines
- Hemolytic disease of the newborn (Rh, ABO incompatibility)
- G6PD deficiency
- Sepsis-related hyperbilirubinemia
- Breastfeeding/breast milk jaundice when conservative measures inadequate
- Preterm infants at lower thresholds
Outcomes/Evaluation
- Decreased serum bilirubin level (target reduction varies by gestational age and risk factors)
- Prevention of kernicterus (bilirubin encephalopathy)
- No signs of bilirubin-induced neurologic dysfunction (BIND)
Nursing Interventions (pre, intra, post)
- Eye protection — opaque eye patches at all times under lights; remove during feedings
- Skin care — undress to diaper only to maximize exposure; reposition q2h for even exposure
- Temperature — monitor q2–4h; phototherapy can cause hyperthermia or hypothermia
- Maintain hydration; offer feedings q2–3h
- Track I&O, weight daily
- Bilirubin level q4–12h depending on severity
- Distance and intensity per protocol
- Cover male infant's genitals if exposed
- Discontinue lights briefly for parent bonding when stable
Potential Complications
- Eye damage if eyes not properly shielded
- Hyperthermia or hypothermia
- Dehydration (insensible water loss ↑)
- Loose, green stools (bilirubin excretion)
- Erythematous skin rash
- Bronze baby syndrome (rare; with cholestatic jaundice)
- Disruption of parent-infant bonding
- Lactose intolerance (transient)
Nursing Interventions
- Monitor vital signs and clinical status closely
- Assess for adverse effects related to the procedure
- Provide post-procedure care per protocol; reposition and reassess regularly
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Why phototherapy is needed (bilirubin breakdown)
- Importance of frequent feedings to promote bilirubin excretion
- Continue breastfeeding (or formula feeding) per plan
- Eye patches must stay on under lights
- Expected loose green stools and possible mild rash
- Return for follow-up bilirubin checks after discharge
- Recognize signs of worsening jaundice (yellow extending to palms/soles, poor feeding, lethargy) and call provider
Description of Procedure
External immobilization device using plaster or fiberglass to maintain bone alignment after fracture, dislocation, or surgical repair. Allows healing while keeping bones in proper position.
Types: short-arm, long-arm, short-leg, long-leg, spica (hip), body cast.
Indications
- Fracture immobilization
- Postoperative immobilization (e.g., clubfoot serial casting per Ponseti method)
- Soft tissue injury requiring immobilization
- Correction of musculoskeletal deformity
Outcomes/Evaluation
- Proper bone alignment and healing
- No neurovascular compromise (intact pulses, color, capillary refill, sensation, movement)
- Skin remains intact
- No signs of infection
- Pain controlled
Nursing Interventions (pre, intra, post)
Initial care (first 24–48 hours):
- Elevate extremity above heart level to reduce swelling
- Apply ice (cool pack on top of cast, not under)
- Allow cast to dry — handle with palms, not fingers (prevents dents)
- Plaster takes 24–48 hours to dry; fiberglass dries in 5–15 min
Ongoing care:
- Neurovascular checks (5 Ps) q1–2h initially, then q4h: Pain (especially with passive movement — out of proportion to expected), Pallor, Pulselessness, Paresthesia, Paralysis
- Check capillary refill (< 3 sec) and skin temperature/color of digits
- "Petal" rough cast edges with tape or moleskin
- Keep cast clean and dry; cover during bathing
- Inspect skin around cast edges for breakdown
Potential Complications
- Compartment syndrome — surgical emergency; 5 Ps; bivalve or split cast
- Neurovascular compromise
- Skin breakdown under cast
- Infection (foul smell, drainage, fever)
- Disuse atrophy
- Cast too tight (swelling) or too loose (after swelling resolves)
Nursing Interventions
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Perform neuro checks; institute seizure precautions if appropriate; report changes in LOC
- Reposition every 2 hr; pressure-relief devices; daily skin assessment; nutritional support
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Never insert objects inside the cast for itching — use cool air from hair dryer instead
- Keep cast dry — cover with plastic for bathing; no swimming until cleared
- Elevate above heart level for first 48 hours
- Report immediately: increasing pain, numbness/tingling, blue or pale color, cool skin, foul odor, drainage, fever, inability to move fingers/toes
- Encourage normal activity within cast limits
- Follow-up X-rays as scheduled
- Cast removal: cast saw vibrates, does NOT cut skin (reduces fear)
Description of Procedure
Maintenance care for a surgical opening in the trachea (tracheostomy) through which a tube is placed to maintain a patent airway. Care includes suctioning, cleaning the stoma, changing dressings and ties, and managing the tracheostomy tube.
Indications
- Long-term mechanical ventilation
- Upper airway obstruction (subglottic stenosis, tumor, severe craniofacial anomalies)
- Neuromuscular weakness requiring airway support
- Inability to manage secretions
- Recurrent aspiration with severe respiratory compromise
- BPD with chronic respiratory failure
Outcomes/Evaluation
- Patent airway maintained
- Clear breath sounds, adequate oxygenation
- Stoma intact, no signs of infection
- Skin under ties intact
- No accidental decannulation
- Effective communication with child/family
Nursing Interventions (pre, intra, post)
Suctioning:
- Sterile technique
- Hyperoxygenate before suctioning (per protocol)
- Insert catheter without suction; apply suction only on withdrawal
- Suction no longer than 5 seconds per pass
- Allow recovery between passes; monitor SpO₂, HR
- Use appropriate catheter size (no larger than half tracheostomy tube ID)
Site care:
- Clean stoma q8h and PRN with normal saline and sterile gauze
- Change dressing and ties (per protocol; usually 2-person process for ties)
- Inspect skin for breakdown, redness, drainage
- Keep stoma area dry
Equipment at bedside:
- Extra tracheostomy tube SAME SIZE for emergency replacement
- Extra trach tube ONE SIZE SMALLER
- Suction supplies
- Bag-valve-mask with adapter for trach
- Obturator and ties
- Scissors, hemostat
- Oxygen source
Potential Complications
- Accidental decannulation — most common emergency
- Tube obstruction (mucus plug)
- Bleeding (early — surgical, late — tube erosion of artery)
- Stomal infection
- Skin breakdown around stoma
- Granulation tissue formation
- Tracheal stenosis
- Tracheomalacia
- Tracheoesophageal fistula (rare)
- Aspiration
- Swallowing difficulties
- Speech delay (especially if cuffed)
Nursing Interventions
- Monitor for bleeding (assess site, vital signs, Hgb/Hct); apply pressure as indicated; notify provider for hemodynamic instability
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Assess respiratory rate, effort, and SpO₂; position to optimize ventilation; have suction/oxygen ready
- Reposition every 2 hr; pressure-relief devices; daily skin assessment; nutritional support
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
For caregivers (must learn ALL skills before discharge):
- Trach suctioning technique
- Stoma cleaning
- Changing trach ties (2-person)
- Emergency tube change (caregiver must be able to do this)
- Use of resuscitation bag
- Recognize signs of distress: difficulty breathing, ↑ secretions, color change, restlessness, ↑ HR/RR, retractions, fever
- Recognize tube obstruction or decannulation — emergency action
- Always keep emergency supplies with child
- Care of equipment at home
- Activity precautions: NO swimming, beach (sand into trach), avoid water on trach during bath
- Cover trach with stoma cover (filters air, prevents foreign material)
- Communication strategies (speaking valve, sign language for infants)
- Travel preparation
- School coordination, nursing care plan
- CPR training
- 24/7 access to provider
Description of Procedure
Removal of secretions from the airway to maintain patency, improve oxygenation, and prevent infection. Includes oral, nasal, nasopharyngeal, and tracheal suctioning.
Indications
- Audible or visible secretions
- Decreased SpO₂
- Increased work of breathing, retractions
- Cough that doesn't clear secretions
- Restlessness, agitation
- Pre-feeding (especially infants)
- Before extubation
- Trach care
Outcomes/Evaluation
- Clear airway, audible breath sounds
- Improved oxygenation (SpO₂ > 92%)
- Decreased work of breathing
- Stable HR and RR
- No trauma to airway
Nursing Interventions (pre, intra, post)
Bulb syringe (infants):
- Compress bulb BEFORE inserting (avoids blowing secretions in)
- Insert into side of mouth or nare
- Release to suction
- Empty bulb before next pass
- Mouth before nose — suctioning nose first can trigger gasp and aspiration of oral secretions
Mechanical suctioning:
- Hand hygiene, sterile technique for deep suctioning
- Hyperoxygenate before suctioning (100% O₂ for 30 seconds — per protocol)
- Insert catheter WITHOUT suction
- Apply suction only on WITHDRAWAL (rotating motion)
- Each pass no longer than 5–10 seconds
- Allow rest between passes (oxygenate, monitor)
- Catheter size: outer diameter no more than half the inner diameter of artificial airway
- Suction pressure: infants 60–80 mmHg, children 80–100 mmHg
- Limit number of passes (no more than 2–3 to avoid hypoxia)
- Document amount, color, consistency of secretions
Potential Complications
- Hypoxia (most common)
- Bradycardia (especially in infants — vagal stimulation)
- Tachycardia
- Trauma to mucosa, bleeding
- Aspiration
- Atelectasis (excessive suction)
- Increased ICP (consider in patients with brain injury)
- Infection (poor technique)
- Cardiac arrhythmias
Nursing Interventions
- Monitor for bleeding (assess site, vital signs, Hgb/Hct); apply pressure as indicated; notify provider for hemodynamic instability
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Assess respiratory rate, effort, and SpO₂; position to optimize ventilation; have suction/oxygen ready
- Continuous cardiac monitoring; have emergency cart available; report rhythm changes
- Implement fall precautions; bed in low position; call light in reach; assess fall risk regularly
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Bulb syringe technique for parents:
- Compress bulb FIRST, then insert
- Suction mouth first, then nose
- Side of mouth (not center — gag reflex)
- Clean bulb between uses
- Suction before feeds and sleep
- Recognize signs of need for suctioning: noisy breathing, work of breathing, restlessness
- Don't over-suction — can worsen secretions, cause trauma
- Saline drops can help loosen thick secretions
- When to call provider: persistent distress despite suctioning, blood in secretions, fever
Description of Procedure
Application of pulling force to a body part to align fractured bones, reduce muscle spasm, prevent contractures, or maintain alignment after fracture reduction. Pediatric traction types include manual, skin, and skeletal.
Types:
- Manual traction: applied by hand temporarily during reduction
- Skin traction: tape, boots, halters; weights up to 5–7 lb
- Bryant traction (children < 2 yr, < 30 lb): hip flexed 90°, buttocks elevated off bed
- Buck traction: lower extremity, leg extended, weights at foot
- Russell traction: similar to Buck but with knee sling
- Cervical traction: head halter or skull tongs
- Skeletal traction: pins, wires, or screws through bone; allows heavier weights
Indications
- Fracture reduction and alignment
- Fracture immobilization until other treatment possible
- Reduce muscle spasm
- Prevent or correct contractures, deformities
- Treat dislocations (especially hip)
- Treat hip subluxation/DDH (older infants)
- Stabilize cervical spine injuries (rarely in children)
- Femoral fracture stabilization
Outcomes/Evaluation
- Proper bone alignment
- Reduced pain
- Reduced muscle spasm
- No skin breakdown
- Adequate neurovascular function
- Successful healing of fracture
- No infection
Nursing Interventions (pre, intra, post)
General principles:
- Maintain alignment — child centered in bed, body in proper position
- Weights hanging freely — must NOT touch floor or bed
- Ropes in pulleys, no twists
- Never lift or interrupt weights without provider order
- Counter-traction maintained (often body weight)
Frequent assessments:
- Neurovascular checks (CMS: color, motion, sensation, capillary refill, pulses, temperature) — q1–2h initially, then q4h
- Pain assessment
- Skin assessment — pressure points, area under boot/halter
- Signs of infection at pin sites (skeletal traction)
- Position in bed — slipping down toward foot is common
Pin site care (skeletal traction):
- Inspect daily for drainage, redness, loosening
- Clean per protocol (often saline; some institutions use chlorhexidine)
- Don't apply ointment unless ordered (can trap bacteria)
Comfort and developmental:
- Pain management
- Position changes within constraints (turn upper body, log roll)
- Pressure-relieving mattress
- Skin care, especially heels and sacrum
- ROM to unaffected joints
- Age-appropriate activities (books, electronics, TV, visitors)
- Child life specialist involvement
- Maintain hygiene, bathe, brush teeth
- Encourage family participation
- School work for older children
- Adequate nutrition, fluids
- Bowel management (immobility constipation)
Special considerations:
- Bryant traction: both legs up, buttocks should be SLIGHTLY OFF bed (slip hand under to verify)
- Check distal extremity carefully — compromised circulation has been reported
Potential Complications
- Skin breakdown, pressure injuries
- Neurovascular compromise (most concerning) — compartment syndrome
- Infection (pin site for skeletal)
- Osteomyelitis
- Constipation
- Urinary stasis, UTI
- Joint contractures
- Muscle atrophy
- Pneumonia (immobility)
- DVT (older patients, immobility)
- Psychosocial: developmental regression, anxiety
- Sleep disturbance
- Pin loosening, migration
Nursing Interventions
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Assess for signs of clot (Homans sign, dyspnea, chest pain); encourage mobility/SCDs; administer anticoagulants per protocol
- Perform neuro checks; institute seizure precautions if appropriate; report changes in LOC
- Monitor urine output and characteristics; assess BUN/creatinine; report output <30 mL/hr
- Reposition every 2 hr; pressure-relief devices; daily skin assessment; nutritional support
- Provide therapeutic communication; reduce environmental stressors; involve family; offer anxiolytics if ordered
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
Family:
- Why traction is necessary
- Expected duration (often days to weeks)
- How to maintain proper alignment
- Importance of weights remaining free (don't lift, don't let touch floor)
- Don't adjust traction
- Pin site care if going home with skeletal traction
- Recognize complications: severe pain, swelling, color changes, fever, drainage
- Importance of nutrition, hydration
- Activities to do in bed (with child life specialist input)
- School coordination
- Sibling visits when possible
Older child:
- Need to stay positioned correctly
- Call for help with bedpan, hygiene
- Don't play with weights
- Activities encouraged (within limits)
- Pain reporting
Description of Procedure
Physical maneuvers performed on the chest wall to mobilize secretions from peripheral airways to central airways for clearance. Used as part of airway clearance therapy (ACT). Includes percussion, vibration, and postural drainage.
Indications
- Cystic fibrosis (most common indication; performed 2–4 times daily)
- Bronchiectasis
- Atelectasis
- Pneumonia (some cases)
- Bronchopulmonary dysplasia
- Neuromuscular disease with impaired clearance
- Pre/post operative
- Patients with thick secretions or impaired cough
Outcomes/Evaluation
- Mobilization and clearance of pulmonary secretions
- Improved gas exchange
- Decreased work of breathing
- Reduced atelectasis
- Decreased risk of pneumonia
- Improved aeration
Nursing Interventions (pre, intra, post)
Timing:
- Best performed BEFORE meals or 1–2 hours AFTER meals (avoid vomiting)
- Schedule before bedtime
- For CF: 2–4 times daily typically
- Before bronchodilator: bronchodilator opens airways
- After mucolytic (e.g., dornase alfa): loosens mucus before clearance
Steps:
- Position child for postural drainage of specific lung segment to be cleared
- Use pillows, towels for comfort
- Percuss chest wall over affected area with cupped hand for 1–3 minutes per position (creates vibrations that loosen secretions)
- Vibrate the chest wall during exhalation
- Encourage deep breathing, then huff cough or controlled cough
- Move to next position
- Total session 20–30 minutes
Positioning by lung segment:
- Upper lobes: sitting upright
- Right middle lobe / lingula: left side, head down (Trendelenburg)
- Lower lobes: prone or supine, head down
- Each position: 3–5 minutes
- Avoid head-down positions in infants and patients with reflux — modify protocol
Alternative airway clearance methods (often preferred today):
- Vest (high-frequency chest wall oscillation) — preferred by many CF patients (independent, less time-consuming)
- PEP (positive expiratory pressure) device
- Flutter, Acapella devices (oscillating PEP)
- Autogenic drainage
- Active cycle of breathing technique
Nursing considerations:
- Auscultate before and after
- Assess oxygen saturation
- Monitor pain, tolerance
- Encourage hydration
- Have suction available for infants
- Use cupped hand (NOT flat hand)
- Percuss on bare skin or thin clothing (T-shirt)
- Avoid percussion over spine, sternum, kidneys, abdomen
- Avoid CPT after surgery on chest, recent fractures, severe osteoporosis
Potential Complications
- Aspiration if not in proper position or done too close to feeding
- Decreased oxygen saturation during head-down positions
- Worsening reflux
- Rib fractures (vigorous percussion, fragile bones)
- Bronchospasm (especially in asthmatics)
- Vomiting
- Increased intracranial pressure (head-down)
- Hypotension (infants, head-down)
- Bruising of chest wall
- Discomfort, anxiety
Nursing Interventions
- Assess pain (location, character, scale) frequently; administer ordered analgesia; reposition for comfort
- Assess respiratory rate, effort, and SpO₂; position to optimize ventilation; have suction/oxygen ready
- Monitor vital signs and intake/output; maintain IV access; administer fluids/vasopressors as ordered
- Administer antiemetics as ordered; small frequent intake; monitor for dehydration and electrolyte loss
- Provide therapeutic communication; reduce environmental stressors; involve family; offer anxiolytics if ordered
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- CPT is part of daily routine for CF
- Multiple times per day (consistency essential)
- Continue lifelong
- Teach family to perform at home
- Encourage child participation as they grow (control of own care)
- Use age-appropriate methods (vest is popular for school-age and adolescents)
- Hydration helps thin secretions
- Coughing during/after is expected and desired (clearing secretions)
- If becoming too sick to perform CPT comfortably, call provider
- Recognize lung infection signs: ↑ cough, ↑ sputum, color change of sputum, fever, ↓ exercise tolerance
- Various devices available — discuss with respiratory therapist what works best
- Vest typically used 30 minutes 2–4× daily
Description of Procedure
Soft, dynamic harness used to treat developmental dysplasia of the hip (DDH) in infants younger than 6 months. Maintains hip flexion (90°+) and abduction → allows femoral head to seat properly in acetabulum and stimulates normal hip joint development.
Indications
- DDH diagnosed in infants < 6 months
- Mild to moderate DDH (positive Ortolani or Barlow, hip subluxation, mild dysplasia)
- Some preterm infants with hip instability
- NOT used in severe dislocation, older infants (closed reduction + spica needed)
Outcomes/Evaluation
- Successful hip reduction maintained
- Femoral head develops properly in acetabulum
- Normal hip anatomy on follow-up imaging
- No avascular necrosis
- No skin breakdown
- Successful weaning from harness
Nursing Interventions (pre, intra, post)
Application by orthopedist or trained practitioner:
- Harness fitted to infant's size
- Shoulder straps hold harness in place
- Chest band positioned at nipple line
- Anterior (flexion) straps hold legs at 90°+ flexion
- Posterior (abduction) straps maintain abduction
- Marker line drawn so parents can re-position if accidentally moved
Wear schedule:
- 23 hours/day initially (off for bathing only)
- Worn for weeks to months depending on response
- Weaned gradually under provider direction
Daily care:
- Check skin under harness DAILY
- Look for redness, breakdown at:
- Shoulder straps
- Behind knees
- Anterior chest (chest band)
- Apply onesie or T-shirt UNDER harness (cotton, thin)
- Diaper UNDERNEATH straps (so straps stay clean)
- Long socks to prevent leg strap rubbing
- Lotion to dry skin (NOT on straps)
- No powders (cake under straps)
Bathing:
- Sponge baths only initially
- Once stable, may remove for brief bath (per provider)
- If removed, re-apply to MARKER positions
Activity:
- Continue tummy time
- Hold and play normally
- Use car seat that accommodates harness
- Use specialty diapers or large size to fit around harness
- Encourage parent-infant bonding (despite harness)
Provider visits:
- Initially every 1–2 weeks
- Adjustments as infant grows
- Ultrasound or X-ray to monitor
Potential Complications
- Skin breakdown under harness
- Femoral nerve palsy (if hip too flexed)
- Avascular necrosis of femoral head (if too tight or strap mispositioned)
- Persistent dislocation despite harness
- Need for transition to spica casting if Pavlik fails
- Pressure injuries
- Decreased compliance → relapse
Nursing Interventions
- Perform neuro checks; institute seizure precautions if appropriate; report changes in LOC
- Reposition every 2 hr; pressure-relief devices; daily skin assessment; nutritional support
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
- Wear 23 hours daily — compliance is essential for success
- Off only for daily skin check and brief bathing
- Check skin daily for redness, breakdown
- Don't adjust straps yourself — let provider do this
- If markings are off, contact provider
- Use onesie or thin cotton shirt under
- Place diaper under straps
- Continue tummy time
- Hold and bond normally with baby
- Use appropriate car seat
- Larger or specialty diapers
- Continue feeding, comforting normally
- Adjustments needed as baby grows — frequent visits
- Recognize problems: redness, breakdown, increased fussiness, decreased movement of legs
- Treatment typically several weeks to a few months
- Pavlik harness is treatment of choice and very successful for young infants
- Long-term: most have normal hip development
- Follow-up imaging important
Description of Procedure
Surgical removal of palatine tonsils (tonsillectomy) and/or adenoids (adenoidectomy). Common pediatric surgery. Performed under general anesthesia, typically outpatient.
Indications
- Recurrent tonsillitis/strep pharyngitis (≥ 7 episodes in 1 year, 5/year × 2 years, or 3/year × 3 years)
- Peritonsillar abscess
- Obstructive sleep apnea (OSA) from enlarged tonsils/adenoids — most common indication now
- Chronic otitis media (adenoidectomy)
- Recurrent ear infections
- Failure to thrive from chronic adenotonsillar disease
Outcomes/Evaluation
- Successful wound healing
- Resolution of sleep apnea, snoring
- Reduced infection frequency
- Improved ear function (adenoidectomy)
- Adequate hydration and nutrition
- Effective pain control
- No post-op hemorrhage
Nursing Interventions (pre, intra, post)
Pre-operative:
- NPO per protocol
- Routine pre-op labs, including coagulation screen if history of bleeding
- Education about procedure and recovery
- Allow comfort items
- Premedication for anxiety if needed
Post-operative care (key points):
- Position lateral or prone with head turned to side until alert (allows secretion drainage)
- Once alert, position with head elevated
- Monitor for bleeding: frequent swallowing, restlessness, vomiting bright red blood, pallor
- Ice collar to neck for comfort
- NO straws, suctioning, tongue blades (could disturb operative site and trigger bleeding)
- Cold liquids and ice chips (avoid red or brown liquids — mimic blood)
- NO citrus (irritates), NO milk/dairy (causes coating, throat clearing)
- Soft, bland diet advance as tolerated (popsicles, gelatin, applesauce, mashed potatoes)
- Avoid hot, spicy, rough foods (toast, chips, crackers) for 1–2 weeks
- Pain management around-the-clock for first 24–48 hours
- Acetaminophen + opioids if severe (NO aspirin or NSAIDs — bleeding risk; debate about ibuprofen)
- Encourage rest, limit activity for 1–2 weeks
- Monitor for signs of dehydration
- Educate that pain may be worse on days 3–5 (scabs form), then improves
Discharge criteria:
- Stable VS
- Pain controlled
- Tolerating fluids
- Voiding
- No bleeding
Potential Complications
Post-tonsillectomy hemorrhage (most serious complication):
- Primary (immediate, within 24 hr): typically from surgical site, surgical management
- Secondary (5–10 days post-op, when scabs slough): can be sudden and severe
- Signs: frequent swallowing (most reliable EARLY sign — swallowing blood), bright red bleeding, restlessness, pallor, tachycardia, hypotension (late)
- Bleeding: emergency — return to hospital immediately; surgical re-exploration may be needed
Other complications:
- Dehydration (poor intake)
- Pain (especially days 3–5)
- Nausea, vomiting
- Anesthesia complications
- Infection (rare)
- Airway obstruction (rare, especially with severe OSA)
- Velopharyngeal insufficiency (hypernasal speech — rare, usually transient)
- Otalgia (referred ear pain — common)
Nursing Interventions
- Monitor for bleeding (assess site, vital signs, Hgb/Hct); apply pressure as indicated; notify provider for hemodynamic instability
- Monitor temperature, WBC, and site for signs of infection (erythema, drainage, warmth); obtain cultures as ordered; administer antibiotics on time
- Assess pain (location, character, scale) frequently; administer ordered analgesia; reposition for comfort
- Assess respiratory rate, effort, and SpO₂; position to optimize ventilation; have suction/oxygen ready
- Monitor vital signs and intake/output; maintain IV access; administer fluids/vasopressors as ordered
- Administer antiemetics as ordered; small frequent intake; monitor for dehydration and electrolyte loss
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
Pre-operative:
- What to expect during procedure
- NPO instructions
- Bring comfort items
- Outpatient typically
Post-operative at home:
- Watch for bleeding — frequent swallowing, bright red blood in saliva or vomit → ER immediately
- Bleeding can occur up to 10 days post-op (when scabs slough)
- Pain typically worse days 3–5
- Adequate fluids essential (popsicles, ice chips, juice, soft drinks — avoid red/brown)
- Soft, bland diet × 1–2 weeks
- NO citrus, hot, rough, spicy foods
- NO aspirin or other NSAIDs (debate about ibuprofen — follow surgeon's instructions)
- Pain medication ON SCHEDULE first 1–2 days, then PRN
- Avoid heavy activity, sports × 2 weeks
- Don't swim × 2 weeks
- Avoid coughing forcefully, throat clearing
- Bad breath is normal (from scabs)
- White/gray membrane in throat is NORMAL (scab) — don't worry, will slough
- Slight fever (< 101°F) normal first few days
- Call provider: persistent fever > 101°F, severe pain unrelieved, signs of dehydration (no urine 6+ hours, sunken fontanel in infant), bleeding
- Stay home from school 7–10 days typically
- Follow-up appointment 2–4 weeks
Description of Procedure
Continuous subcutaneous insulin infusion (CSII) device that delivers rapid-acting insulin (typically aspart or lispro) via a small cannula inserted into subcutaneous tissue. Provides basal rate (small continuous infusion mimicking pancreatic basal release) plus bolus doses (for meals and corrections). Newer systems include automated insulin delivery (AID, also called "hybrid closed-loop" or "artificial pancreas") which adjusts insulin based on CGM (continuous glucose monitoring) data.
Indications
- Type 1 diabetes mellitus (most common indication in pediatrics)
- Some type 2 diabetes
- Patient/family preference and ability to manage
- Frequent hypoglycemia
- Hypoglycemia unawareness
- Wide glucose variability despite multiple daily injections
- Dawn phenomenon
- Active lifestyle, school/sports flexibility
- Preference for fewer injections
- Difficulty with multiple daily injections (needle phobia, lifestyle)
- Pregnancy in adolescents (newer)
- Toddlers/young children (allows precise dosing)
Outcomes/Evaluation
- Improved A1C (often 0.3-0.5% reduction in well-managed pump use)
- ↓ frequency and severity of hypoglycemia (especially with AID systems)
- ↓ glycemic variability — more time in range (70-180 mg/dL)
- Improved quality of life
- Flexibility with meals, activity, sleep
- Better post-prandial control
- Reduced injection burden
- Improved school/sports participation
- Patient/family confidence in management
Potential Complications
- Diabetic ketoacidosis (DKA) — RAPID onset (within hours) if pump failure interrupts insulin delivery (no long-acting insulin in pump therapy)
- Hyperglycemia from: site failure, kinked tubing, occluded cannula, empty reservoir, dead battery
- Hypoglycemia from: overdosing, miscalculating carbs, exercise
- Infection at infusion site (cellulitis, abscess)
- Skin reactions at site, scarring, lipohypertrophy
- Cannula displacement
- Tubing leaks, blockages
- Pump malfunction
- Costly equipment and supplies
- Site changes uncomfortable
- Body image concerns (visible device)
- Bolus dose errors
- Weight gain (with overuse of corrections)
- "Diabetes burnout" / pump fatigue
- Infusion set fracture/breakage
Nursing Interventions
- Monitor temperature, WBC, and site for signs of infection; obtain cultures as ordered; administer antibiotics on time
- Assess for allergic reaction; have epinephrine, oxygen, and emergency equipment at bedside
- Document findings, interventions, and patient response; notify provider of unexpected outcomes
Client Education
Pump basics:
- Wear pump 24/7 (with brief disconnection allowed for showering, swimming, contact sports — but never > 1-2 hours)
- Basal rate runs continuously
- Bolus for meals (carb counting + ratio)
- Correction bolus for high glucose
- NEVER stop pump for more than 1 hour without giving insulin (DKA risk)
Site care:
- Change infusion site every 2-3 days
- Rotate sites: abdomen, thigh, upper buttock, upper arm
- Avoid waistband, scar tissue, lipodystrophy areas
- Use new site if redness, pain, leaking, or hyperglycemia
- Clean skin with alcohol before insertion
- Maintain good site hygiene
Carb counting:
- Count carbs at each meal/snack
- Insulin-to-carb ratio (I:C) — e.g., 1 unit per 15 g carbs
- Use pump calculator (built-in bolus wizard)
- Adjust for protein, fat in larger meals (extended bolus may be needed)
- Read food labels
- Restaurant menus can be tricky
Sick day management:
- NEVER stop insulin during illness
- Check glucose frequently (q2-4 h)
- Check ketones if BG > 240 or persistent or unexplained hyperglycemia
- Adequate hydration
- Increase fluids; small frequent carbs if not eating
- Use sick day rules for ↑ basal/corrections
- If BG > 250 with ketones, give correction by INJECTION (not pump — site failure possible) and change pump site
- Contact provider if not improving, persistent ketones, vomiting, can't keep fluids down
- Have backup insulin pen/syringe always available
Activity/exercise:
- Reduce basal rate during exercise (preset programs)
- Disconnect for contact sports (≤ 1-2 hours)
- Check BG before, during, after
- Carry fast-acting carbs
- Adjust insulin for prolonged or intense exercise
- Post-exercise hypoglycemia possible hours later — monitor
Travel:
- Carry extra supplies (2× usual amount)
- Backup pen/syringes
- Letter from provider
- Don't pack supplies in checked luggage
- Time zone changes — discuss with care team
- Carry snacks, fast-acting carbs
- Consider pump removal during airport security x-ray (per manufacturer)
School:
- 504 plan or Diabetes Medical Management Plan (DMMP)
- School nurse trained on pump
- Allow checking, bolus access
- Snacks accessible
- Recognize hypoglycemia
Recognize problems:
- Persistent hyperglycemia: check pump, site, tubing, reservoir
- Frequent hypoglycemia: review settings with care team
- Site infection: redness, pain, drainage, fever → contact provider
Emergency backup:
- Long-acting insulin (glargine) on hand if pump fails for > 4 hours
- Pen needles, syringes
- Glucagon kit (Baqsimi nasal or Gvoke pen)
- Fast-acting glucose (tabs, juice)
- Medical ID
Nursing Interventions (pre, intra, post)
Pre-procedure / pre-initiation:
- Confirm patient/family understand diabetes management
- Assess readiness, motivation, and ability for pump therapy
- Comprehensive education plan
- Carb counting proficiency
- Insulin sensitivity
- Hands-on training with pump and supplies
- Calculate insulin dose, basal rates, I:C ratios, correction factors
- Insurance coverage, supply procurement
- Coordinate with diabetes educator
Pump initiation:
- Hospital/clinic supervised first pump start (some)
- Saline trial period (some programs)
- Initial basal rates usually 50-60% of prior total daily dose
- I:C ratio: ~500 rule (500/total daily dose = grams per unit)
- Correction factor: ~1800 rule for rapid-acting
- Watch closely first 48-72 hours
- Frequent BG checks
Ongoing care:
- Endocrine visits every 3 months
- Pump downloads to review patterns
- Adjust basal rates, ratios as needed
- Monitor A1C, time in range, hypoglycemia frequency
- Skin/site assessment
- Address pump fatigue, burnout
- Annual: lipids, kidney function, retinal exam, foot exam, BP
- Mental health screening
- Transitions: school, sports, growing pump skills, eventual adult care
Site management:
- Teach proper insertion technique
- Rotate sites
- Watch for site reactions
- Address skin issues (consider patches, films)
- Use cleanser before insertion
Family support:
- Coordinate care with parents, school, siblings
- Encourage age-appropriate independence in care
- Address financial stress
- Peer support groups (camps, online)
- Mental health if needed (diabetes distress, depression common)
Special situations:
- Pre-op: discuss pump management with surgical team (continue, switch to IV insulin, or pause)
- Imaging: MRI requires pump removal; CT may be OK
- Illness/DKA: switch to IV insulin in hospital; document settings
- Skin testing for allergies — caution with insulin allergy
Coming soon
Worked examples for this template type haven't been added yet.
Check back in a future update.